SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO02823  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA003513
Annotation
PREDICTED:_nicotinate_phosphoribosyltransferase_isoform_X2_[Bombyx_mori]
Full name
Nicotinate phosphoribosyltransferase      
Location in the cell
Cytoplasmic   Reliability : 1.144 PlasmaMembrane   Reliability : 1.549
 

Sequence

CDS
ATGGCTCGACAAAACGGTATTGTGCAACCACTTTTAACTGACCTTTATCAAATAACTATGGCGTATGCATATTGGAAATCAGGAAAAGTAAATGATGTCGCTGTATTTGATTTATTTTTTCGAACAAATCCATTCCAAGGTGAATTCACTATATTTGCTGGATTAGAGGAGTGTATGAAATTTTTAGAAAACTTTCATTATTCTAACAGCGATATCAAATATTTGAAGCAAACATTACCTGAAAACATTGAACCTGAATTTTATTTATATCTCAAAGAACTAACTTGCAAGGACATTATTGTAAGTGCTATTGAAGAAGGATCTGTGGTGTTTCCGAGGGTGCCATTGTTGAGAGTTGAAGGTCCGCTCATTGTGGCACAGCTATTGGAGACCACTCTGCTAACATTAGTCAACTTTGCCAGTTTGATGGCCACGAACGCTGCGAGATATCGGATGGTGGCCGGTAAAAATGTATCCCTACTCGAATTCGGACTACGGAGAGCGCAAGGACCCGATGGAGGGCTATCGGCGTCCAAATATGCGTACATCGGTGGGTTTGACGGGACCAGCAACGTTCTGGCGGGAAAGATGTTCAATATACCGGTAAAGGGCACCCACGCGCATTCGTTCGTTACATCCTTCAGTACTTTAGACGACATACATAGAGTGACGCTGACGCACGCGCAGACACGAGAGCCGTGTAATCTTCTAGAGTCGGCAATGGAATGGCGGAGTCGCGTCTCTACCGTTATCGATGTATCGACAGAGGAATCCAGCGATGGCGAACTGGCCGCCCTAATATCATACGCCATAGCCTTTCCGACGGGTTTCTTGGCTTTAGTGGATACGTACGATGTCAAGAGGAGTGGACTACTGAACTTTTGTGCTGTGGCCCTAGCGTTAAACGATTGTGGCTACAGAGCCGTGGGCATTAGGATCGATAGTGGTGATTTGGCGTATCTATCAGTACTGGCCAGGGAGACGTTCGAAAAGGTCGGGGAAACATTCAACGTCCCTTGGTTCGCTAAACTAACAATCGTCGCATCCAATGATATTAATGAAGAAACCATTCTAAGTTTAAACGAGCAGGGTCATAAAATCGATTGTTTCGGCATCGGAACGCATTTAGTGACATGTCAGCGGCAACCTGCTCTCGGTTGCGTCTACAAGTTGGTCGAAATAAACGGCCAGCCGCGTATAAAGCTCAGCCAGGACGTTGGCAAAGTAACCATACCCGGACACAAAGAGGCATATCGGCTGTTCGGTGCGGATGGACACGCGCTTATAGATTTACTGCAGAGATCTTCGGAACCAGCGCCGGTCGTCGGTCAGAAAGTGCTCTGCCGACATCCGTTCCAAGAGTCGAAACGAGCCTACGTTATCCCCAGCTATGTCGAACATCTTTATAAGATATGCTGGAAAGATGGACGCGTTTGTACGGCACCAAAACCCTTGTCAAAGGTTAGAGAGAGGGTACAGTCGTCTCTAAGGACACTTCGTCAAGACATTAAACGTAACTTGAATCCTACGCCTTATAAGGTGGCCGTCAGCGACGATCTATACAACTTTATCCACGACTTGTGGCTTCAGAATGCACCCATTGGTGAACTCTCATGA
Protein
MARQNGIVQPLLTDLYQITMAYAYWKSGKVNDVAVFDLFFRTNPFQGEFTIFAGLEECMKFLENFHYSNSDIKYLKQTLPENIEPEFYLYLKELTCKDIIVSAIEEGSVVFPRVPLLRVEGPLIVAQLLETTLLTLVNFASLMATNAARYRMVAGKNVSLLEFGLRRAQGPDGGLSASKYAYIGGFDGTSNVLAGKMFNIPVKGTHAHSFVTSFSTLDDIHRVTLTHAQTREPCNLLESAMEWRSRVSTVIDVSTEESSDGELAALISYAIAFPTGFLALVDTYDVKRSGLLNFCAVALALNDCGYRAVGIRIDSGDLAYLSVLARETFEKVGETFNVPWFAKLTIVASNDINEETILSLNEQGHKIDCFGIGTHLVTCQRQPALGCVYKLVEINGQPRIKLSQDVGKVTIPGHKEAYRLFGADGHALIDLLQRSSEPAPVVGQKVLCRHPFQESKRAYVIPSYVEHLYKICWKDGRVCTAPKPLSKVRERVQSSLRTLRQDIKRNLNPTPYKVAVSDDLYNFIHDLWLQNAPIGELS

Summary

Description
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Catalytic Activity
5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
Similarity
Belongs to the NAPRTase family.
Keywords
Alternative splicing   Complete proteome   Ligase   Magnesium   Manganese   Metal-binding   Phosphoprotein   Pyridine nucleotide biosynthesis   Reference proteome   Transferase  
Feature
chain  Nicotinate phosphoribosyltransferase
splice variant  In isoform 2.
EC Number
6.3.4.21
EMBL
NWSH01004297    PCG65251.1    CH379060    KRT03926.1    NEVH01016332    PNF25493.1    + More
KA649566    AFP64195.1    PNF25494.1    GECZ01025472    GECZ01018863    JAS44297.1    JAS50906.1    GANO01000774    JAB59097.1    GEBQ01002499    JAT37478.1    CH902624    KPU74487.1    CM002910    KMY88026.1    CH954177    KQS70075.1    CM000157    KRJ97245.1    GBXI01014780    GBXI01014645    GBXI01006210    JAC99511.1    JAC99646.1    JAD08082.1    AE014134    AY119468    CH963852    EDW75536.2    APCN01000743    AAAB01008964    PNF25496.1    GECZ01014625    JAS55144.1    GAMC01015552    JAB91003.1    GEBQ01016431    JAT23546.1    EZ423112    ADD19388.1    CH940649    KRF81401.1    CH933807    KRG02580.1    GFDF01002171    JAV11913.1    GFTR01007011    JAW09415.1    AGB92551.1    KQS70074.1    KRJ97246.1    GECL01001005    JAP05119.1    KRF98267.1    GBBI01002320    JAC16392.1    GAKP01013625    GAKP01013621    JAC45331.1    GFDL01003569    JAV31476.1    GDHC01016507    JAQ02122.1    GEDC01016306    JAS20992.1    GGFM01003320    MBW24071.1    GGFM01003319    MBW24070.1    GGFJ01004354    MBW53495.1    AY214334    AAP69612.1    EAA43816.3    GGFJ01004353    MBW53494.1    GDHC01013230    JAQ05399.1    GGFK01006910    MBW40231.1    AAZO01005538    DS235793    EEB17146.1    GGFL01004336    MBW68514.1    GDHC01011068    JAQ07561.1    GEDC01015773    JAS21525.1    PNF25495.1    GBHO01035269    GBRD01016039    JAG08335.1    JAG49787.1    GEDC01008843    JAS28455.1    GBHO01035267    JAG08337.1    GEZM01057006    JAV72511.1    GBHO01035268    JAG08336.1    JH431887    GFXV01003372    MBW15177.1    GBYB01004177    JAG73944.1    GBHO01029588    JAG14016.1    GDRN01064315    JAI64861.1    LRGB01002580    KZS07054.1    GGMS01016052    MBY85255.1    LJIJ01000030    ODN05065.1    ABLF02017331    GL732569    EFX76281.1    KQ971307    EFA10857.2    KK120589    KFM78613.1    APGK01047183    APGK01047184    APGK01047185    KB741077    KB631792    ENN74206.1    ERL86165.1    GDIP01044461    GDIQ01011008    JAM59254.1    JAN83729.1    GBYB01008266    JAG78033.1    MWRG01033973    PRD20752.1    KB632375    ERL93855.1    KQ971374    EEZ97420.1    LBMM01004870    KMQ92026.1    GGMR01015408    MBY28027.1    GFPF01010180    MAA21326.1    GEDV01009195    JAP79362.1    GACK01001808    JAA63226.1    GACK01001882    JAA63152.1    GFJQ02002320    JAW04650.1    GFWV01009968    MAA34697.1    JH815810    EKC24433.1    GEDV01009194    JAP79363.1    GGLE01001502    MBY05628.1    GDIQ01086605    JAN08132.1    GDIQ01088343    JAN06394.1    GEDV01012018    JAP76539.1    GFAC01003602    JAT95586.1    GBBM01000781    JAC34637.1    GEFM01003968    JAP71828.1    ABJB010140890    ABJB010866274    DS857340    EEC13820.1    GDIQ01224849    JAK26876.1    GDIQ01150764    JAL00962.1    HACA01006897    CDW24258.1    PZQS01000004    PVD32044.1    APGK01016134    KB739754    ENN82128.1   
Pfam
PF04095   NAPRTase        + More
PF17956   NAPRTase_C
PF17767   NAPRTase_N
Interpro
IPR041525   N/Namide_PRibTrfase        + More
IPR013785   Aldolase_TIM       
IPR007229   Nic_PRibTrfase-Fam       
IPR006405   Nic_PRibTrfase_pncB       
IPR036068   Nicotinate_pribotase-like_C       
IPR040727   NAPRTase_N       
IPR041619   NAPRTase_C       
SUPFAM
SSF51690   SSF51690       
Gene 3D
PDB
4YUB     E-value=6.85462e-139,     Score=1267

Ontologies

Topology

Length:
538
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.2295
Exp number, first 60 AAs:
0.11637
Total prob of N-in:
0.03233
outside
1  -  538
 
 

Population Genetic Test Statistics

Pi
219.077855
Theta
181.222258
Tajima's D
0.59827
CLR
1.07407
CSRT
0.544172791360432
Interpretation
Uncertain
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