Gene

KWMTBOMO02783

Pre Gene Modal

BGIBMGA003496

Annotation

PREDICTED:_GPI_ethanolamine_phosphate_transferase_1_[Amyelois_transitella]

Location

Bomo_Chr5(+):10735170-10749611      View in EpiBrowser

Full name

GPI ethanolamine phosphate transferase 1      

Alternative Name

MCD4 homolog
Phosphatidylinositol-glycan biosynthesis class N protein

Location in the cell

PlasmaMembrane   Reliability : 4.984

CDS

ATGCCATTCTTAAGGTCTGTAGCAAATTCTAAAGGAAGATGGGGTATATCTAGAACTCAAGTTCCTACAGAGTCTAGGCCCGGTCATGTGGCTATTGCAGCCGGCTTTTATGAAGATCCTTCAGCTGTTGTAAAGGGGTGGAAAGAAAACCCAGTTGATTTTGATTCTGTATTCAACCAATCACAGTTCACTTGGTGTTGGGGTGCCTATGATATCATTAATATATTTACCAAAGACCATAATGCTGAAGAGGATGTAAATCTTCTTGCTAAATTGAAGAAAAATAAAATAGTATTTTTCTTGCACTTACTAGGAACTGATACATCTGGTCACACACACAAACCTCAAACAAGGAACTTTTTAACAACACTTAGATTTGTTGATGAAGGTATCAAAATTATAGAAGGAGTGATAAATACATTTTATAATGATGATGGAAAAACTACATTTCTTATGACTTCAGATCATGGAATGACAGACTGGGGATCACATGGTGCAGGCGATAATTATGAAACGGAGACGCCCTATGTGTTGTGGGGCTCTGGTGTGAACCAAGTTAATGAAACTAGACCGGACTCTGAAACTCTGCTTATGTCTTCAGAGCATAGATTTGATATTAACCAAATAGATTTGGCACCAATAATGGCAACGTTTATCTCTATACCGGTTCCTGTCAATTCTTTGGGTCAAGTGAAGACTGATTTATTGAACATGACACTGGCTAATAAAGCTAAAGCAGTTTATGGTAATAGTAGACAAATAGCTGCACAATACGATAAGAAGAGACATGATGTTGAATCAAATGCCATATCAATGCTTTACAAACCTTATGAACCACTGACCAAGAAAAAATACGAGGAAATAATAAATTTTGCAGAAACATTGTTAATTAAAGGAGAATATGAAAAGTTAATTATATGCAGTGAAGAAATCATGCAATTGAGTTTAAGAGGATTGAGATACTATAATGATTATTATCAAAAACCACTTCTTATTCTAGTTACTTTATCATTTATGGGATGGATTGTTTATTTATTGAAATTATTATCTGAACAAAAGATTCATACACATGCAGATACGTGTACAGCTAGTTGTGTAAGGGGAACTAAAATTCTAGTCAAGCAGTCTATTAATATTATTTTCTTAATTATTTTTGGATTTTCCATATACATAGTTTATGTGCAAAGTTTGCCAGTACAATATTTTGTATATTTTCTGATGCCCACTGCCTTGTGGTGGTATGCGATGTTATCAATGGAAGTTTGGTTTCAAATATACAAAAAAATTAAAAGGGACAAAGAACTGACATCAGTGCTATTACAAATTGTTTGTTATGGATTAGGGAGCATAGCAATGGGTTTATCATTTACCTACCGCTGGATGTTGAGCTTACCATTACTAGGTATGGCTCTGTGGCCATTCATGTCATCAACAAAATATCATTTAACTAATCCAGTGTTGTTGATCTGGTCAGGTGGATCTCTGCTACTTAGCATTTTTTCGTTCATGCCTGTTGTGGGAAAAAATGTGGTTATTTCATTAGTTATTGCTGCCGGCGTGCTTTGGATATTCGTGATAACAATATTCATTTACAAGATACTGATGCCGTTCCGTTACAATAAGGTTGAGAAACAAAGGGAAATGTATTTGTTCTCGATACAAATATTGTTATTACTTATTTCGTGTCATAACATTTACGTGCAGTCTAAACGGTTTGAACAAGGCACACCCGTATCAGCTTTCTATCAGACGGAAGCTTGGATTGTAGCAGTGACCTCATTGATCATGCCTTTCCTGTTTTCTAGAAGATTAATGTGTCGATTGATGGCGATAAATACGGGACTTATAAATTTCTATCTTTTGATGTCAGTTTCGCATGAAGGTCTGTTCATGGTTGCACTCATTATAAACGTAATGAGCTGGGTTTTTATTGAATTTAGACTTCTTCACGTGAAGGACGTAAAGATAATTGACTGCGCGTTTATTGAAGACACAAATGAAGAAAAAATTGGTCTTCAGATCGAAAGGAGTATTACTAGTCAAGACTTTAGAAGAGCTTTCTTTTTCGTATCCTTTACAAAATTGCGTCTAAAATATTATCATCAAATAATTCGACAAAGGTCCTCCATGTCTAAATCCACTGTTTTCAAGACACAAGTTGCGACCCTTAGAAATTACGCTGAACAACAAGAGCCGTACAGTTTGTCACTAAGGCACCACTTGGCTGTTTGA

Protein

MPFLRSVANSKGRWGISRTQVPTESRPGHVAIAAGFYEDPSAVVKGWKENPVDFDSVFNQSQFTWCWGAYDIINIFTKDHNAEEDVNLLAKLKKNKIVFFLHLLGTDTSGHTHKPQTRNFLTTLRFVDEGIKIIEGVINTFYNDDGKTTFLMTSDHGMTDWGSHGAGDNYETETPYVLWGSGVNQVNETRPDSETLLMSSEHRFDINQIDLAPIMATFISIPVPVNSLGQVKTDLLNMTLANKAKAVYGNSRQIAAQYDKKRHDVESNAISMLYKPYEPLTKKKYEEIINFAETLLIKGEYEKLIICSEEIMQLSLRGLRYYNDYYQKPLLILVTLSFMGWIVYLLKLLSEQKIHTHADTCTASCVRGTKILVKQSINIIFLIIFGFSIYIVYVQSLPVQYFVYFLMPTALWWYAMLSMEVWFQIYKKIKRDKELTSVLLQIVCYGLGSIAMGLSFTYRWMLSLPLLGMALWPFMSSTKYHLTNPVLLIWSGGSLLLSIFSFMPVVGKNVVISLVIAAGVLWIFVITIFIYKILMPFRYNKVEKQREMYLFSIQILLLLISCHNIYVQSKRFEQGTPVSAFYQTEAWIVAVTSLIMPFLFSRRLMCRLMAINTGLINFYLLMSVSHEGLFMVALIINVMSWVFIEFRLLHVKDVKIIDCAFIEDTNEEKIGLQIERSITSQDFRRAFFFVSFTKLRLKYYHQIIRQRSSMSKSTVFKTQVATLRNYAEQQEPYSLSLRHHLAV

Description

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.

Similarity

Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.

Keywords

Complete proteome   Disease mutation   Endoplasmic reticulum   Epilepsy   Glycoprotein   GPI-anchor biosynthesis   Membrane   Polymorphism   Reference proteome   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  GPI ethanolamine phosphate transferase 1
sequence variant  In dbSNP:rs17069506.

Uniprot

A0A2A4JXS1   A0A2H1VR59   A0A212ETA3   A0A194QVN5   A0A067RPH7   A0A2P8YAW0   + More
A0A1B6FHP6   A0A210QQ19   A0A1B6L1H3   E7EXW2   A0A0L8HIE9   A0A1S3H469   A0A293LEF9   A0A2G8LAY8   V3ZGL6   R7U986   A0A147BRH6   A0A131XWR2   A0A250YLR4   A0A2K5RAR6   A0A2D0PTK1   A0A2J8NDD0   A0A2K6T6D5   H0WT04   A0A2K5RAV8   A0A2K5EY07   A0A2K6T6J1   A0A2K6T6I7   A0A2K6CJP7   A0A2K5EXV6   A0A1B6HFW5   A0A1E1X5F0   A0A0F7ZDT4   A0A2K5EXY4   A0A1W2PQZ1   G1PUC4   A0A131Z2N9   A0A2I3SK40   A0A2J8W3G6   A0A1E1XPK6   A0A224YVQ4   A0A1S2ZTE0   L7M6U1   A0A2I2ZJG6   H9EVK7   A0A2R8M9W8   A0A2K5VNQ4   A0A2K6MMP5   A0A131XAH2   A0A2I3TGD6   A0A0D9S006   G7PWW5   G3QQS9   A0A2I3TW05   A0A2K5J9X8   A0A2K6NNF1   A0A2K5YX69   A0A2R8PL21   A0A2R9BVL4   A0A2I3S836   S7NIZ4   A0A3N0Y917   A0A2J8NDD7   A0A2I2ZW78   A0A2K5YWP8   A0A2K6NND4   A0A2I3RAS4   A0A2J8NDE3   A0A2J8NDE5   A0A2K5VNI4   A0A2K6MMI4   A0A2K5NYQ2   A0A2K5JA28   A0A1W2PNR0   I3MD84   A0A2K5YWT2   A0A2K6NNE1   A0A2K5NYN8   A0A024R2C3   O95427   A0A2K6CKU1   G3SR92   B2RCI8   A0A1W2PS19   F7FX72   A0A2K5NYU2   A0A1B6C8V4   A0A2K6CKL3   A0A1B6CUA4   A0A2K5NYU5   A0A2J8W3E9   A0A2J8W3E0   A0A1W2PQA9   A0A2J8W3I5   A0A0P6J835   A0A2K6CKK8   G1RB70  

EC Number

2.-.-.-

Pubmed

22118469    26354079    24845553    29403074    28812685    23594743    + More
29023486    23254933    29652888    28087693    28503490    16177791    21993624    26830274    16136131    29209593    28797301    25576852    22398555    25319552    28049606    22002653    25362486    22722832    11181995    10069808    15489334    17974005    23446422    21493957    17495919   

EMBL

NWSH01000438    PCG76434.1    ODYU01003919    SOQ43278.1    AGBW02012631    OWR44684.1    + More
KQ461181    KPJ07616.1    KK852502    KDR22535.1    PYGN01000747    PSN41373.1    GECZ01020052    JAS49717.1    NEDP02002420    OWF50840.1    GEBQ01022439    JAT17538.1    BX640462    KQ418168    KOF88545.1    GFWV01001519    MAA26249.1    MRZV01000143    PIK57412.1    KB202444    ESO90338.1    AMQN01009923    KB306612    ELT99695.1    GEGO01002048    JAR93356.1    GEFM01004092    JAP71704.1    GFFW01000231    JAV44557.1    NBAG03000231    PNI69778.1    AAQR03056653    AAQR03056654    AAQR03056655    AAQR03056656    AAQR03056657    GECU01034126    JAS73580.1    GFAC01004740    JAT94448.1    GBEX01001431    JAI13129.1    AC090354    AC090396    AC105183    FP340563    KF456430    AAPE02014648    GEDV01003831    JAP84726.1    AACZ04062428    NDHI03003401    PNJ64302.1    GFAA01002187    JAU01248.1    GFPF01010551    MAA21697.1    GACK01005269    JAA59765.1    CABD030109837    CABD030109838    CABD030109839    CABD030109840    CABD030109841    CABD030109842    CABD030109843    CABD030109844    CABD030109845    JU322660    AFE66416.1    AQIA01031925    AQIA01031926    AQIA01031927    AQIA01031928    AQIA01031929    GEFH01004498    JAP64083.1    PNI69781.1    AQIB01127725    AQIB01127726    CM001293    EHH58938.1    AJFE02095763    AJFE02095764    AJFE02095765    AJFE02095766    AJFE02095767    GABC01005387    GABF01003366    JAA05951.1    JAA18779.1    PNI69755.1    PNI69757.1    PNI69760.1    PNI69766.1    PNI69767.1    PNI69768.1    PNI69788.1    KE164355    EPQ17389.1    RJVU01049572    ROL42647.1    PNI69790.1    PNI69784.1    PNI69773.1    PNI69785.1    AGTP01028278    AGTP01028279    CH471096    EAW63119.1    AF109219    BC028363    AL137607    AK315134    BAG37585.1    GEDC01027361    JAS09937.1    GEDC01020232    JAS17066.1    PNJ64305.1    PNJ64281.1    PNJ64283.1    PNJ64284.1    PNJ64285.1    PNJ64293.1    PNJ64294.1    PNJ64303.1    PNJ64306.1    GEBF01003895    JAN99737.1    ADFV01021533    ADFV01021534    ADFV01021535    ADFV01021536    ADFV01021537    ADFV01021538    ADFV01021539    ADFV01021540   

Proteomes

UP000218220    UP000007151    UP000053240    UP000027135    UP000245037    UP000242188    + More
UP000000437    UP000053454    UP000085678    UP000230750    UP000030746    UP000014760    UP000233040    UP000221080    UP000233220    UP000005225    UP000233020    UP000233120    UP000005640    UP000001074    UP000002277    UP000079721    UP000001519    UP000008225    UP000233100    UP000233180    UP000029965    UP000009130    UP000233080    UP000233200    UP000233140    UP000240080    UP000233060    UP000005215    UP000007646    UP000002280    UP000001073   

PRIDE

O95427    B2RCI8   

Pfam

PF01663   Phosphodiest        + More
PF04987   PigN
PF00884   Sulfatase
PF01676   Metalloenzyme

Interpro

IPR007070   GPI_EtnP_transferase_1        + More
IPR017852   GPI_EtnP_transferase_1_C       
IPR002591   Phosphodiest/P_Trfase       
IPR037671   PIGN_N       
IPR017850   Alkaline_phosphatase_core_sf       
IPR000917   Sulfatase_N       
IPR006124   Metalloenzyme       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16020  GPI_EPT_1

ProteinModelPortal

A0A2A4JXS1   A0A2H1VR59   A0A212ETA3   A0A194QVN5   A0A067RPH7   A0A2P8YAW0   + More
A0A1B6FHP6   A0A210QQ19   A0A1B6L1H3   E7EXW2   A0A0L8HIE9   A0A1S3H469   A0A293LEF9   A0A2G8LAY8   V3ZGL6   R7U986   A0A147BRH6   A0A131XWR2   A0A250YLR4   A0A2K5RAR6   A0A2D0PTK1   A0A2J8NDD0   A0A2K6T6D5   H0WT04   A0A2K5RAV8   A0A2K5EY07   A0A2K6T6J1   A0A2K6T6I7   A0A2K6CJP7   A0A2K5EXV6   A0A1B6HFW5   A0A1E1X5F0   A0A0F7ZDT4   A0A2K5EXY4   A0A1W2PQZ1   G1PUC4   A0A131Z2N9   A0A2I3SK40   A0A2J8W3G6   A0A1E1XPK6   A0A224YVQ4   A0A1S2ZTE0   L7M6U1   A0A2I2ZJG6   H9EVK7   A0A2R8M9W8   A0A2K5VNQ4   A0A2K6MMP5   A0A131XAH2   A0A2I3TGD6   A0A0D9S006   G7PWW5   G3QQS9   A0A2I3TW05   A0A2K5J9X8   A0A2K6NNF1   A0A2K5YX69   A0A2R8PL21   A0A2R9BVL4   A0A2I3S836   S7NIZ4   A0A3N0Y917   A0A2J8NDD7   A0A2I2ZW78   A0A2K5YWP8   A0A2K6NND4   A0A2I3RAS4   A0A2J8NDE3   A0A2J8NDE5   A0A2K5VNI4   A0A2K6MMI4   A0A2K5NYQ2   A0A2K5JA28   A0A1W2PNR0   I3MD84   A0A2K5YWT2   A0A2K6NNE1   A0A2K5NYN8   A0A024R2C3   O95427   A0A2K6CKU1   G3SR92   B2RCI8   A0A1W2PS19   F7FX72   A0A2K5NYU2   A0A1B6C8V4   A0A2K6CKL3   A0A1B6CUA4   A0A2K5NYU5   A0A2J8W3E9   A0A2J8W3E0   A0A1W2PQA9   A0A2J8W3I5   A0A0P6J835   A0A2K6CKK8   G1RB70  

KEGG

101742026    K05285 GPI ethanolamine phosphate transferase 1 [EC:2.7.-.-] | (RefSeq) GPI ethanolamine phosphate t

PATHWAY

00563    Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005789   GO:0016021   GO:0006506   GO:0051377   GO:0008484   GO:0005829   GO:0005886   GO:0016740   GO:0016254   GO:0016020   GO:0046872   GO:0003824   GO:0008152   GO:0004889   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR12250  

Subcellular location

Endoplasmic reticulum membrane  

Length:

743

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

202.16691

Exp number, first 60 AAs:

3e-05

Total prob of N-in:

0.01452

outside

1  -  330

TMhelix

331  -  350

inside

351  -  370

TMhelix

371  -  393

outside

394  -  402

TMhelix

403  -  425

inside

426  -  437

TMhelix

438  -  460

outside

461  -  479

TMhelix

480  -  502

inside

503  -  508

TMhelix

509  -  531

outside

532  -  545

TMhelix

546  -  565

inside

566  -  577

TMhelix

578  -  600

outside

601  -  628

TMhelix

629  -  651

inside

652  -  743

 

 

Pi

265.070454

Theta

19.597392

Tajima's D

0.454418

CLR

1.919906

CSRT

0.508924553772311

Interpretation

Uncertain