Gene

KWMTBOMO02781  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003700

Annotation

PREDICTED:_ras_GTPase-activating-like_protein_IQGAP1_[Bombyx_mori]

Location

Bomo_Chr5(-):10712198-10728369      View in EpiBrowser

Full name

Ras GTPase-activating-like protein IQGAP1      

Alternative Name

p195

Location in the cell

Nuclear   Reliability : 3.158

CDS

ATGTTTGCCGCAAATGTTGACGAAATTCGAATTGGAAAAATTGATGATGGTTCAAGTGATGCAGATGTTCGCAAAACTGGACAGGAGATGGACCTCATAAGACAAAGGACTATTGCTTATGAATATCTTTGTCGTCTTGAAGAAGCGAAGACGTGGTTAGAAGCTTGCCTGAAAGAGAAACTCCCTCCCGCCACTGAATTTGAGGAAAGCTTGCGTAATGGAGTGTATTTGGCCAAGTTGGGAAATTTTATTAGTCCTGAGTCACTTCCTTTAAATAAAATATTTGACATTGATCTTAAGAGATACAAGGTCTTAGGTCTTCAATTTAAACACACTGATAATATTAATCAATTTCTTCAAATACTGAAGAAAACAGAGCTACCCGTAACGTTTCAACCAGAAACGACCGACATTTATGATAAAAAGAACATGCCTCGTGTAATTTATTGCATACATGCTTTAAGTTCGCATCTCTTTAAACTTGGAAAAGCTCCACTTATTCATGACGTGTTTGGCAAAATTGCCTTCACAGACGATGAATTAGACGTCGTGTCAAAGGATTTACAAAAATGTGAACAACCAATGCCAATGTTCCAAAAGATAGGTGGAATTTTATCAATCAATAATAAAGGGGATGGTTCTGTTATGCTTAAAGCTCTTATTGAATTAAACAGATTACTTGATACAGAAAAGTCTATAACGGCTGCGATTCTGAACCCACAGCTAAAGTTGAAGCATGTTCAAAATCGGCTAATAGATGAATACAAAAAAGCTTTACATATTGCCAAGCAAGATAAAATTCAGGCTGCTCATAATCGTTCTCTTAATGATAGCTATTTACCAGACGAATATGATGAACTTTTAACTACGGTAGAAATACAAGGGCACATCACAGCAGTTAATTATAAATATTTATGGAAAAATCTTTGTTCTGCCTCTAAACATAACGATGTCAAGAGCTTACACAAAATCTTTACTGAAGAATGGGTCCATATAAAGGGTTACGACCATCATAATTTAGATTTTTACTGTGATGTAGTTCAAGAGACTATTGAATGTAACAAAGACATTGATGTCGAAAGTGTTCCGAATTGGCATAAAATATTTCAAAACATAATCAATGAAGGAAATCGCAAATCTCTTGAGCACACAGATCATAAAAGCGCTATTGCAAATGTAAATAAAGTGTTGGAAGAGGGTTCTCCGACCGATTTGTATAAAGCATTAATCAATCCTCATTTAGAATTAAACATCAAGGTTGACGAATTTGCTGCTCCTTTGTTGTATGAAGAGATGAGATTGGAGAGATGCGAGTTAGAAAAAAATCTTAATGAAAACGAAATTGCTGCTTCAGTCTCTTATTTATCGGCCGTAGCGACTGTGTCACACGCTGTAGACAGAGGTGATGAATTAGCAGTTTGGAATGCTCTGAATTCGAAACAAATTCAGCTTGAAGGATTGCGAGCTCATTGCAGACGCAGATACCTATCCGCGTTAGCAACCGCTTTACAAATAAAGATAAAAGAACAGTGTGCATGTCCGCTTCTGACTTTTGAAGATATCCATGACACAATTCAAATGGTGAACATGAAAGATGACGAAAACGAAGAGCTGATTCTTGTAATAGACGGTATAAATAAGGCGGTATTGGAGGATGATGTGGAGTCACTGATGATATTATTAAACAGTTCAAGTTTGAAATTGCCTTCCCGTTTGCATAAAGAAGAAAAACATCTATATTTACGCATGCTGAAAAAATTGTTACTAGGAAAAGAATCCCAAAATCTTTGGATCGATGATGTTTTGGATGTAATCAACCAAGTTAATGTAGAGTCATACAAAGTAAAAGAGTTGACTGAGGCTATAGTCCAACTGAATGTAGCTGTGTTGAAAAATAACGTTGATAGTTTTTTTAATACGATCAGAAATCCAGTTTTGGCAATTTCTGATAATGTAGAAGCATCATGTAAGGATGTATATTTTCAAATGTTTTCAAAAGCATTGAAAAAGAAAGGTCAATTTATTTGTCCTTGGATAGTTTGCCACACGGATGTTGGGAACACTGTCTACATAGACGTCGAATCATATACGTATAGCTGGACAACTCCTAAAGACTTCGTACCGTATGCACGATATTTGACTACGAAAGATATCTCTGGAATAGTAGAGAAAACTAATAAACACCACGTAAATAAATACAAACAAACGTTAATAGAAAGATCTGTCGTAAAACTCCAAGCATATTGCAAAGGATATCTGCTTAGGAAACGAATGACTGACAGACTGAAGTTGTTTATGGCAAATGAAGAATACGTTATTAAAATTCAAGCTTGGTGGAGAATGCTGTTGGTTTACAAGCGATACGGGACATTAATAAAAATGAAAACAATTGAAGCAAAATTGAAACGGGAACGCAAACAAAATCCAATGGCATGGTACAAAAGTCAGGAACACAAAATAGTGAAAATTCAAGCAATGTGGAGAGGTCGTCGCGCTCGTCAATGTTTCACTGCTTTATTTCACTCGCGGAATCCACCGCTCAGAATCGTTAAAAAGTTCATTCCATTACTAGATTTCTCGACTGAAGACTACGACAGGGAAATTGAATTACAATCACTGAAATCGGAAGTCGTGCAGTCTATCCGAAAGAATCAGGAGCTATCCAAGCAAATCGATGACATGGATTTAAAAATAGGTCTGCTGGTACAAAACCGTATAGCTTTACAGGACGTTGCGGCATTTGGTCTAAAGTTAAATAATCTAGTCAAACATCATTCGATGACTAAACTTGTCTTTCAAAATCGCCCTGATGGCAAAGGCTCTTTCATGACAGTTACAACAGCCGTTAAAGGCTTAAAATCCCTCACTAAAGAATCCAAAAGACTTTTAGACGGATACCAACATCTGTTCTATGAACTGCAAACAAACCCCACTTACTTGTCCAAATTACTGTTTTGTATACCGCAAAATAAAACTAATTTCTTCTTACAAAACGTCGTACTTAGCCTTTACAACTTTGGGGCTTACACAAGAGATGAGTATCTGCTTCTGAAGCTATTTAGATTTACATTGGAGGAAGAAATAAGTTGTAAGGTTGTTAAACCTTTTGATATTATCTCGTCGACTCCGCTGGTACTAAAAATGGCGGTAAGCCTTTCGAGACAGCTTTCTGGACTGAACAGCCTGCAAACAATTATAGGACCCCTGGTCGAAAAAATGTTAAGGGACAAAGATTTAAATATTGAAACGGGTCCAGTAGAAATCTATAAAGCTTGGAGAAATGAAAACGAGATGAAAACTGGGAAAATATCAAATCTTCCATACTCTGTTACACAAGAAGAAGCACTGACATACCCAGAAGTCAAAGCTAGATTACAAACGGCCCTTGGTCAATTAAAAACGATTGTGACAATATTTCTGGATAAAATAACAAGATCGACGGAGCTTTTACCTTTTTGCATAACGTATATGGCTAGAGTGTTGCACAGAGCTCTAACTACGAAATTTCCGTATACACCAGAAAAAGATATCTTAAAAGTTATCGGTAATTTGATTTACTACCAGTTCTTGAACGCCGCAATAGTAGCTCCCGATGCATTTCATATTGTAAACTTACCGAATGGCTGTGAACTGACCACAGATCAGAGAAAAAACCTCGCCTCTGTTGCGAAAATTTTGCATTTTTCTGCCGCAAAAAAAGGCTTTGGTGAAGAGTCAAGTCACCTGCGTTGCTTAAATCCATTTATCGTCGAATGCCACGAGAAAATGAAGGAGCTATTTAGGCGTTGTTGTCGCGGTCCAACGCTTGAAGAGTACTTTGCTGTTGACGAATATACCGAAGCCACGCTACTTCATCATCCGCATATATGTATAACTGTTCAGGAAATCGTAGACACTCACTCGCTACTGATTGAATACCAAGATATAATAGCACCGGATCCAAGCGATCGTTTAAACGAACTATTGGACGACTTGGGAGAAGTGCCGACCATCGCGCAACTAGCCGCTAGGGACGTGGACGGATCCATGGGAGAGACTATTGAAGAGAATGCTAGACTTGAAGTGTGTTTGGCTCTCGTGAATAAATTTCAAACACCTGCTGATGATATGGCAGATCTGAATAAACTATTTATCAAAACCAAAGAGTTATGTGTCGCCATACTTCCATATTTGAATGGTGAACACTTGCTAGAGGCACTGGTTATCGGTACTACGAAAGAACAGCAGGAGCAATATGCTCAAAAAATACAAAAGCGCATCTACTCCGGACAATCGAAGCAAGACGAAGCCATGACATTGCGAGAGCATATTTCCAAGCTACGTAGGAACTTACAAATGCTTGAAGATGAAGGATACGTCACGAGAGAAGATGGCTATCAAGCGATAGTCACATCCATAGCACTTGATCTCTGTAATAAAAGTAAATATAGGCAGGCCCAAAAACGAGCACTAGCAACACTAACACGTGCTAAACAAAGCCTACTTGAAAAAACTAAATATTATGAAGAAAAATGTAAATCTTATGATGAATACATTAAATCATGTCTTGCTAATCTTCATGCTGGTAAAAGGAGTGTGCACGCGTGCTTACGGAGATCCGGAAAGGATATGCAAAAACTAAAATCGAAATTAACAGTCAAATATTCGGGTGCGAAATTGTTGGAAAGGGGTGTACTATTAGAAATTGACGGACTTTCGCCATCACAGTTCAAAAATGTTCAATTTGAAATAACGCCAACTGATCTTAATGGAGTGTTCACAGTGAAGGGGAAATTCATGGGTATTGAAATGGAATCAATTGACATCGACATACAAGATTTATTGCAAAAACAATATGAAGGCTGTGCAGTTATGGATATGTTCGGTAAAGCTAAAATCAATGTGAACTTATTGATATTCTTGTTAAATAGTAAGTTTTATGGTAAATCCTGA

Protein

MFAANVDEIRIGKIDDGSSDADVRKTGQEMDLIRQRTIAYEYLCRLEEAKTWLEACLKEKLPPATEFEESLRNGVYLAKLGNFISPESLPLNKIFDIDLKRYKVLGLQFKHTDNINQFLQILKKTELPVTFQPETTDIYDKKNMPRVIYCIHALSSHLFKLGKAPLIHDVFGKIAFTDDELDVVSKDLQKCEQPMPMFQKIGGILSINNKGDGSVMLKALIELNRLLDTEKSITAAILNPQLKLKHVQNRLIDEYKKALHIAKQDKIQAAHNRSLNDSYLPDEYDELLTTVEIQGHITAVNYKYLWKNLCSASKHNDVKSLHKIFTEEWVHIKGYDHHNLDFYCDVVQETIECNKDIDVESVPNWHKIFQNIINEGNRKSLEHTDHKSAIANVNKVLEEGSPTDLYKALINPHLELNIKVDEFAAPLLYEEMRLERCELEKNLNENEIAASVSYLSAVATVSHAVDRGDELAVWNALNSKQIQLEGLRAHCRRRYLSALATALQIKIKEQCACPLLTFEDIHDTIQMVNMKDDENEELILVIDGINKAVLEDDVESLMILLNSSSLKLPSRLHKEEKHLYLRMLKKLLLGKESQNLWIDDVLDVINQVNVESYKVKELTEAIVQLNVAVLKNNVDSFFNTIRNPVLAISDNVEASCKDVYFQMFSKALKKKGQFICPWIVCHTDVGNTVYIDVESYTYSWTTPKDFVPYARYLTTKDISGIVEKTNKHHVNKYKQTLIERSVVKLQAYCKGYLLRKRMTDRLKLFMANEEYVIKIQAWWRMLLVYKRYGTLIKMKTIEAKLKRERKQNPMAWYKSQEHKIVKIQAMWRGRRARQCFTALFHSRNPPLRIVKKFIPLLDFSTEDYDREIELQSLKSEVVQSIRKNQELSKQIDDMDLKIGLLVQNRIALQDVAAFGLKLNNLVKHHSMTKLVFQNRPDGKGSFMTVTTAVKGLKSLTKESKRLLDGYQHLFYELQTNPTYLSKLLFCIPQNKTNFFLQNVVLSLYNFGAYTRDEYLLLKLFRFTLEEEISCKVVKPFDIISSTPLVLKMAVSLSRQLSGLNSLQTIIGPLVEKMLRDKDLNIETGPVEIYKAWRNENEMKTGKISNLPYSVTQEEALTYPEVKARLQTALGQLKTIVTIFLDKITRSTELLPFCITYMARVLHRALTTKFPYTPEKDILKVIGNLIYYQFLNAAIVAPDAFHIVNLPNGCELTTDQRKNLASVAKILHFSAAKKGFGEESSHLRCLNPFIVECHEKMKELFRRCCRGPTLEEYFAVDEYTEATLLHHPHICITVQEIVDTHSLLIEYQDIIAPDPSDRLNELLDDLGEVPTIAQLAARDVDGSMGETIEENARLEVCLALVNKFQTPADDMADLNKLFIKTKELCVAILPYLNGEHLLEALVIGTTKEQQEQYAQKIQKRIYSGQSKQDEAMTLREHISKLRRNLQMLEDEGYVTREDGYQAIVTSIALDLCNKSKYRQAQKRALATLTRAKQSLLEKTKYYEEKCKSYDEYIKSCLANLHAGKRSVHACLRRSGKDMQKLKSKLTVKYSGAKLLERGVLLEIDGLSPSQFKNVQFEITPTDLNGVFTVKGKFMGIEMESIDIDIQDLLQKQYEGCAVMDMFGKAKINVNLLIFLLNSKFYGKS

Description

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.

Subunit

Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:15355962). Interacts with RAC1 (PubMed:15355962). Does not interact with RHOA. Interacts with TSG101 (PubMed:17853893). Interacts with PAK6 (PubMed:18642328). Interacts with TMEM14B; this interaction increases IQGAP1 phosphorylation and induces its nuclear translocation (PubMed:29033352).
(Microbial infection) Interacts with ebolavirus vp40.
Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:16968698). Interacts with RAC1 (By similarity). Does not interact with RHOA (By similarity). Interacts with TSG101 (By similarity). Interacts with PAK6 (By similarity).
(Microbial infection) In case of infection, interacts with S.typhimurium protein sseI (PubMed:19956712).

Keywords

3D-structure   Acetylation   Calmodulin-binding   Cell membrane   Complete proteome   Cytoplasm   Direct protein sequencing   Host-virus interaction   Membrane   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Repeat  

Feature

chain  Ras GTPase-activating-like protein IQGAP1
sequence variant  In dbSNP:rs12324924.

Uniprot

H9J2G3   A0A2H1W5M2   A0A2A4JWN9   A0A194PNK8   A0A212ET63   A0A194QQI7   + More
A0A0L7L887   A0A2A3EPF9   A0A0C9RMV3   A0A154PM28   A0A088A7Z6   A0A232FFP2   A0A0L7RBE3   A0A0N0U5G1   F4X4S7   E2B615   A0A1B6HW78   A0A158NWB1   A0A195ES45   E2AX92   A0A1B6DIS6   A0A151X570   A0A151HYI7   A0A3L8D3E1   A0A026W882   A0A151II71   E9J4Q3   A0A2S2PK80   A0A067QV30   J9K9F6   A0A0L8H5M0   A0A0P4WQY3   A0A2S2Q4X5   A0A1V4JDU6   A0A210QG69   A4QPB0   A0A024RC65   P46940   A0A2I2ZQ18   H2QA32   A0A2J8VX99   G1RN50   A0A0B7B822   H2NP70   A0A091EUR3   A0A2R9BWN0   U3KA75   A0A2I0M708   A0A0D9RWS9   F7FX61   H9G1C0   B7ZRI7   A0A2K5VLI7   A0A096NNA5   A0A2K5NWK5   A0A1D5QS65   V9K8I3   A0A087VD78   A0A2U4C744   A0A094KD89   A0A2K6Q865   A0A2K5IW77   R0J9G5   A0A218UEE6   H9G7W7   A0A093CT34   A0A341D5F1   A0A1S3AQS0   A0A091VCC3   A0A093BMZ5   A0A2K6A8D7   A0A093QDS9   A0A2I0U3R2   H0ZJI3   A0A091JVS9   A0A093NZF2   A0A087R472   A0A2I2UQN3   A0A093LJA4   A0A099ZVT2   A0A2Y9MRI6   A0A3B3T8T4   F7H0Q8   A0A091HL72   A0A1U7SI08   A0A3Q0E1N6   Q9JKF1   A0A3B3T8H4   F7DI41   U3IUX2   Q6ZQK2   G3V7Q7   A0A2K6BSA2   A0A1U7QNY2   A0A2K6T3H9   A0A1L8GSR1   A0A1D5PIZ8   A0A287D1L3   Q80UW7   A0A2K5D2Z0  

Pubmed

19121390    26354079    22118469    26227816    28648823    21719571    + More
20798317    21347285    30249741    24508170    21282665    24845553    28812685    15489334    11181995    8051149    7584044    15355962    15695813    8670801    17081983    17853893    18669648    18642328    20068231    21269460    20883816    22223895    22814378    23186163    23637409    24275569    25944712    29033352    22398555    16136131    22722832    23371554    17495919    25319552    27762356    17431167    24402279    25362486    21881562    20360741    17975172    29240929    19468303    15592455    16968698    19956712    21183079    23749191    14621295    15057822    15632090    22673903    15592404   

EMBL

BABH01007921    BABH01007922    BABH01007923    ODYU01006495    SOQ48381.1    NWSH01000438    + More
PCG76435.1    KQ459597    KPI94902.1    AGBW02012631    OWR44686.1    KQ461181    KPJ07614.1    JTDY01002375    KOB71549.1    KZ288203    PBC33394.1    GBYB01008371    JAG78138.1    KQ434977    KZC12883.1    NNAY01000305    OXU29340.1    KQ414617    KOC68158.1    KQ435793    KOX74201.1    GL888679    EGI58500.1    GL445900    EFN88876.1    GECU01028831    JAS78875.1    ADTU01027863    KQ981993    KYN31075.1    GL443520    EFN61975.1    GEDC01011736    JAS25562.1    KQ982522    KYQ55474.1    KQ976730    KYM76452.1    QOIP01000014    RLU14769.1    KK107405    EZA51229.1    KQ977505    KYN02278.1    GL768112    EFZ12213.1    GGMR01017242    MBY29861.1    KK853230    KDR09638.1    ABLF02017639    ABLF02017641    KQ419180    KOF84379.1    GDRN01069856    JAI63986.1    GGMS01003584    MBY72787.1    LSYS01007908    OPJ70224.1    NEDP02003800    OWF47735.1    BC139731    AAI39732.1    CH471101    EAX02103.1    L33075    D29640    BC151834    CABD030097847    CABD030097848    CABD030097849    CABD030097850    CABD030097851    AACZ04026168    AACZ04026169    GABC01000170    GABD01000007    GABE01000270    NBAG03000308    JAA11168.1    JAA33093.1    JAA44469.1    PNI42846.1    NDHI03003407    PNJ62145.1    ADFV01044654    ADFV01044655    ADFV01044656    ADFV01044657    ADFV01044658    ADFV01044659    ADFV01044660    HACG01042308    CEK89173.1    ABGA01009773    ABGA01009774    ABGA01009775    ABGA01009776    ABGA01009777    ABGA01009778    ABGA01009779    ABGA01009780    ABGA01009781    ABGA01009782    KK717966    KFO53415.1    AJFE02022761    AJFE02022762    AJFE02022763    AJFE02022764    AJFE02022765    AJFE02022766    AJFE02022767    AGTO01022091    AKCR02000033    PKK25461.1    AQIB01128821    AQIB01128822    AQIB01128823    AQIB01128824    AQIB01128825    AQIB01128826    AQIB01128827    AQIB01128828    AQIB01128829    AQIB01128830    JU336926    JU477661    JV048590    AFE80679.1    AFH34465.1    AFI38661.1    BC170181    CM004470    AAI70181.1    OCT89671.1    AQIA01063766    AQIA01063767    AQIA01063768    AQIA01063769    AQIA01063770    AQIA01063771    AHZZ02031558    AHZZ02031559    AHZZ02031560    JSUE03039057    JSUE03039058    JSUE03039059    JW861392    AFO93909.1    KL488969    KFO10570.1    KL343894    KFZ54608.1    KB745374    EOA93825.1    MUZQ01000379    OWK52036.1    AAWZ02033960    KL247037    KFV15462.1    KK733882    KFR00977.1    KN126163    KFU87108.1    KL672868    KFW87108.1    KZ506221    PKU40697.1    ABQF01056401    ABQF01056402    ABQF01056403    KK501513    KFP15676.1    KL224907    KFW65427.1    KL226089    KFM08276.1    AANG04002993    KK605741    KFW09011.1    KL869714    KGL85852.1    KL217594    KFO96636.1    AF240630    AC109257    AC127594    CH466543    ADON01140653    AK129044    BAC97854.1    AABR07004428    CH473980    EDM08655.1    CM004471    OCT86880.1    AADN05000047    AGTP01016423    AGTP01016424    AGTP01016425    AGTP01016426    BC046385    AAH46385.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000242457    UP000076502    UP000005203    UP000215335    UP000053825    UP000053105    UP000007755    UP000008237    UP000005205    UP000078541    UP000000311    UP000075809    UP000078540    UP000279307    UP000053097    UP000078542    UP000027135    UP000007819    UP000053454    UP000190648    UP000242188    UP000005640    UP000001519    UP000002277    UP000001073    UP000001595    UP000052976    UP000240080    UP000016665    UP000053872    UP000029965    UP000002280    UP000186698    UP000233100    UP000028761    UP000233060    UP000006718    UP000245320    UP000233200    UP000233080    UP000197619    UP000001646    UP000252040    UP000079721    UP000053605    UP000233140    UP000053258    UP000007754    UP000053119    UP000054081    UP000053286    UP000011712    UP000053858    UP000248483    UP000261540    UP000054308    UP000189705    UP000189704    UP000000589    UP000008225    UP000016666    UP000002494    UP000233120    UP000189706    UP000233220    UP000000539    UP000005215    UP000233020   

PRIDE

H9J2G3    A4QPB0    A0A024RC65    P46940    Q9JKF1    Q6ZQK2    + More
A0A1D5PIZ8    Q80UW7   

Pfam

PF00307   CH        + More
PF00612   IQ
PF00616   RasGAP
PF03836   RasGAP_C
PF01286   XPA_N
PF05181   XPA_C

Interpro

IPR027417   P-loop_NTPase        + More
IPR001936   RasGAP_dom       
IPR000593   RasGAP_C       
IPR008936   Rho_GTPase_activation_prot       
IPR000048   IQ_motif_EF-hand-BS       
IPR001715   CH-domain       
IPR036872   CH_dom_sf       
IPR022658   XPA_CS       
IPR009061   DNA-bd_dom_put_sf       
IPR022652   Znf_XPA_CS       
IPR000465   XPA       
IPR037129   XPA_sf       
IPR022656   XPA_C       
IPR001202   WW_dom       
IPR023152   RasGAP_CS       

SUPFAM

SSF48350   SSF48350        + More
SSF52540   SSF52540       
SSF47576   SSF47576       
SSF46955   SSF46955       

Gene 3D

1.10.418.10     3.90.530.10    

CDD

cd00014  CH
cd00201  WW

ProteinModelPortal

H9J2G3   A0A2H1W5M2   A0A2A4JWN9   A0A194PNK8   A0A212ET63   A0A194QQI7   + More
A0A0L7L887   A0A2A3EPF9   A0A0C9RMV3   A0A154PM28   A0A088A7Z6   A0A232FFP2   A0A0L7RBE3   A0A0N0U5G1   F4X4S7   E2B615   A0A1B6HW78   A0A158NWB1   A0A195ES45   E2AX92   A0A1B6DIS6   A0A151X570   A0A151HYI7   A0A3L8D3E1   A0A026W882   A0A151II71   E9J4Q3   A0A2S2PK80   A0A067QV30   J9K9F6   A0A0L8H5M0   A0A0P4WQY3   A0A2S2Q4X5   A0A1V4JDU6   A0A210QG69   A4QPB0   A0A024RC65   P46940   A0A2I2ZQ18   H2QA32   A0A2J8VX99   G1RN50   A0A0B7B822   H2NP70   A0A091EUR3   A0A2R9BWN0   U3KA75   A0A2I0M708   A0A0D9RWS9   F7FX61   H9G1C0   B7ZRI7   A0A2K5VLI7   A0A096NNA5   A0A2K5NWK5   A0A1D5QS65   V9K8I3   A0A087VD78   A0A2U4C744   A0A094KD89   A0A2K6Q865   A0A2K5IW77   R0J9G5   A0A218UEE6   H9G7W7   A0A093CT34   A0A341D5F1   A0A1S3AQS0   A0A091VCC3   A0A093BMZ5   A0A2K6A8D7   A0A093QDS9   A0A2I0U3R2   H0ZJI3   A0A091JVS9   A0A093NZF2   A0A087R472   A0A2I2UQN3   A0A093LJA4   A0A099ZVT2   A0A2Y9MRI6   A0A3B3T8T4   F7H0Q8   A0A091HL72   A0A1U7SI08   A0A3Q0E1N6   Q9JKF1   A0A3B3T8H4   F7DI41   U3IUX2   Q6ZQK2   G3V7Q7   A0A2K6BSA2   A0A1U7QNY2   A0A2K6T3H9   A0A1L8GSR1   A0A1D5PIZ8   A0A287D1L3   Q80UW7   A0A2K5D2Z0  

PDB

3FAY     E-value=5.80415e-101,     Score=945

KEGG

101742168    K16848 Ras GTPase-activating-like protein IQGAP1 | (RefSeq) ras GTPase-activating-like protein IQGAP

GO

GO:0043087   GO:0007165   GO:0005634   GO:0003684   GO:0006289   GO:0051019   GO:1900006   GO:0035305   GO:1904754   GO:0005911   GO:1990904   GO:0030426   GO:0001817   GO:0015629   GO:0044877   GO:1900086   GO:0048008   GO:0043406   GO:0036120   GO:0015630   GO:0048365   GO:0005737   GO:0008543   GO:0007173   GO:0005925   GO:0045121   GO:1990776   GO:0016328   GO:0051894   GO:0071364   GO:0031252   GO:1903829   GO:0005884   GO:0045860   GO:0043005   GO:0031267   GO:0030424   GO:0005509   GO:0005874   GO:0005886   GO:0016032   GO:0030667   GO:0019903   GO:0031234   GO:0070062   GO:0043539   GO:0036464   GO:0005547   GO:0001726   GO:0019901   GO:0060090   GO:0019904   GO:0045296   GO:0044548   GO:0005829   GO:0005095   GO:0030496   GO:0005516   GO:0071277   GO:0005096   GO:0043312   GO:0072015   GO:1990138   GO:0016477   GO:0007346   GO:0036057   GO:0017048   GO:0044344   GO:0032991   GO:0005515   GO:0016021   GO:0016627   GO:0004889   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Cell membrane   Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).   With evidence from 21 publications.
Nucleus   Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).   With evidence from 21 publications.
Cytoplasm   Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).   With evidence from 21 publications.

Length:

1643

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0704799999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00047

outside

1  -  1643

 

 

Pi

191.033237

Theta

207.43785

Tajima's D

0.278927

CLR

0.680556

CSRT

0.451277436128194

Interpretation

Uncertain