Gene

KWMTBOMO02780

Pre Gene Modal

BGIBMGA003701

Annotation

PREDICTED:_metallophosphoesterase_1_homolog_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr5(-):10703895-10707879      View in EpiBrowser

Full name

Metallophosphoesterase 1       + More
Metallophosphoesterase 1 homolog      

Alternative Name

Post-GPI attachment to proteins factor 5
Post-GPI attachment to proteins 5 ortholog

Location in the cell

Nuclear   Reliability : 3.245

CDS

ATGTTGCAGTCATTAAAAAGTGCGGTCGAATATGTATCTACAGAAGATTTGAAGAAGTGGAAGAAGGTGGTAACGAAACGCAGAAAAGTAATGAAAGAAGATTGGGAGCGGATCGTCCGATTTGATAATATTTGCGATCAAGAGCTTATAATAAATTTACAAGATTGTTTTAGCGATGCAGAAACTGATTCAGAAATATATTTGTGGTTTATAGCGCAGTGTAATTGGCCTGTTACAAATGACACACATAAAAGTATACAGAGTTTGAAAGCCCTTATGATATCAGACACCCATCTACTGGGACCAAGAAGAGGGCATTGGCTGGATAAAATGAGACGCGAGTGGCAGATGCATCAAGCATTTCAAACTATAATGATGATGCTGAGCCCTGACGTTGTATTTGTTTTAGGTGATTTATTTGATGAAGGAGAATGGACAAATAATAAAGAGTTTCAAGAGTATGTTGAACGTTTCTATAGATTATTTATGGTACCACCCCACGTGAAGATGTATGTTGTTGCAGGGAATCATGATATTGGATTTCATAATTACATAAGAAAGGGAGCTATCCAAAGATTTTACAAGCTCCTGAACACGTCATCAGTTGAATTTGTCACTTTGAAAGACATTCATTTTGTACTTTTGAATTCAATGGCAATGGAGGGAGATTCCTGTCAATTGTGTAGTGAAGCACGGAATGATATACAACATATATCAGGAAGACTAAAATGTTCAGAGGACCCTAAGTATTGTTTCGGAAATAAATTCAAATCCCTGAATTATAGTCGTCCAATCCTTTTACAGCATTTCCCATTATACAGAAAATCTGATTCAATGTGTACAGAACCAGATTCACCGCCATTGCCTGAACGGGACAAGCCGTTCAGACTCAAAATCGACGCTCTGTCTAAAGAGGCTTCAGAGTTCCTAGTAAGCAAAATCAAACCAAGGGCTGTTTTCGGAGGGCACACACATCACGGTTGTCTTTTACATCACAAATACGAAAATCTAGGGCAGCTAGAATTTAAGGAGTATTCAATACCATCATTCTCTTGGAGAAATAGACCAGATCCAAAGTATATGTTGGTAACATTAACGCCAAACGACTACAACGTACAGAAATGTGGACTACCTCAAGAAGCTACGATAGTCATTACTGCTATATCAATGCTTCTAATACTTGCATGTTTTATTGCAAAGAGGAAATATATAGGAAGGTGA

Protein

MLQSLKSAVEYVSTEDLKKWKKVVTKRRKVMKEDWERIVRFDNICDQELIINLQDCFSDAETDSEIYLWFIAQCNWPVTNDTHKSIQSLKALMISDTHLLGPRRGHWLDKMRREWQMHQAFQTIMMMLSPDVVFVLGDLFDEGEWTNNKEFQEYVERFYRLFMVPPHVKMYVVAGNHDIGFHNYIRKGAIQRFYKLLNTSSVEFVTLKDIHFVLLNSMAMEGDSCQLCSEARNDIQHISGRLKCSEDPKYCFGNKFKSLNYSRPILLQHFPLYRKSDSMCTEPDSPPLPERDKPFRLKIDALSKEASEFLVSKIKPRAVFGGHTHHGCLLHHKYENLGQLEFKEYSIPSFSWRNRPDPKYMLVTLTPNDYNVQKCGLPQEATIVITAISMLLILACFIAKRKYIGR

Description

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
Metallophosphoesterase.

Cofactor

Mn(2+)

Subunit

Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity).

Similarity

Belongs to the metallophosphoesterase superfamily. MPPE1 family.

Keywords

Complete proteome   ER-Golgi transport   Golgi apparatus   GPI-anchor biosynthesis   Hydrolase   Manganese   Membrane   Metal-binding   Reference proteome   Transmembrane   Transmembrane helix   Transport   Alternative splicing  

Feature

chain  Metallophosphoesterase 1
splice variant  In isoform 2.

Uniprot

H9J2G4   A0A2H1W5L6   A0A212ET80   A0A194PN91   A0A2A4JFF8   A0A2H1X198   + More
A0A0A9WNJ7   A0A0A9WS93   A0A023F336   A0A194PU72   A0A0N0PC24   V5HTK6   J9L1W7   A0A1B6C6R9   E0VC39   A0A2J7Q7Q9   A0A067RJK9   A0A3Q0IKV5   A0A224YYP0   L7M1A4   F6XU00   A0A310SK47   A0A088A1E3   V5HDR6   A0A2I2UL78   A0A1S4E770   A0A131YFK5   A0A0L7QVY0   A0A182Q9E5   A0A1D2NFJ1   A0A1Y1KCC5   E2C2S4   B4MVX2   A0A2Y9GHU4   A0A2U3WKS5   A0A2U3YZD9   A0A0M9A4P4   A0A2A3EIH6   R0LK38   A0A2P6LB90   M3XZJ6   U3IYE3   A0A224XFU0   A0A0P5MQY5   Q16HW6   A0A0P6DQT1   A0A182VUJ8   A0A1S4G0A0   A0A0P6HB29   A0A0P6FGV9   A0A0N8DJW2   G3MSF5   A0A023GDZ4   A0A0P5ZSE6   A0A182VAK9   Q7PVE7   A0A182T103   A0A1S4H1I0   A0A1Z5LAN5   G1LNH7   A0A226F3Q2   D2I2M6   W5J8Y5   B3N716   A0A0Q5WBM3   A0A182LY21   A0A182MZ21   F1LBC3   A0A232F6G9   T1EB03   A0A093LAM1   A0A1Z5L2V3   A0A0K8V4N5   A0A094LG59   A0A2Y9IRJ0   L5LW21   A0A212F733   A0A182P9G5   B4Q6B2   A0A091MPY0   A0A2M4BRP8   A0A0J9QYE7   B3MPI5   F1KS81   A0A0K8TT47   A0A2M4BRB8   Q9VLR9   Q9VLR9-2   K7IQV4   A0A034WAC4   S7MXE3   A0A2R2MIX8   A0A0P6J2Q9   A0A099ZM14   F4WK18   A0A3L8DLL8   A0A0B6ZV66   G1PHL5   A0A2Y9IVG2  

EC Number

3.1.-.-

Pubmed

19121390    22118469    26354079    25401762    26823975    25474469    + More
25765539    20566863    24845553    28797301    25576852    16341006    17975172    26830274    27289101    28004739    20798317    17994087    23749191    17510324    22216098    12364791    28528879    20010809    20920257    23761445    18057021    21685128    28648823    22936249    26369729    10731132    12537572    12537569    20075255    25348373    21719571    30249741    21993624   

EMBL

BABH01007923    ODYU01006495    SOQ48380.1    AGBW02012631    OWR44687.1    KQ459597    + More
KPI94901.1    NWSH01001661    PCG70506.1    ODYU01012677    SOQ59115.1    GBHO01034250    GDHC01015120    JAG09354.1    JAQ03509.1    GBHO01034251    GDHC01003712    JAG09353.1    JAQ14917.1    GBBI01003176    JAC15536.1    KQ459598    KPI94685.1    KQ460709    KPJ12723.1    GANP01002734    JAB81734.1    ABLF02014628    GEDC01028131    JAS09167.1    DS235047    EEB10945.1    NEVH01017440    PNF24623.1    KK852432    KDR24002.1    GFPF01009673    MAA20819.1    GACK01007402    JAA57632.1    AAEX03005517    KQ765234    OAD54015.1    GANP01002733    JAB81735.1    AANG04003715    GEDV01010518    JAP78039.1    KQ414722    KOC62711.1    AXCN02000792    LJIJ01000061    ODN03855.1    GEZM01091105    JAV57096.1    GL452203    EFN77759.1    CH963857    EDW75842.1    KQ435748    KOX76406.1    KZ288250    PBC31082.1    KB742642    EOB06064.1    MWRG01000528    PRD35857.1    AEYP01011404    AEYP01011405    AEYP01011406    ADON01029504    GFTR01005089    JAW11337.1    GDIQ01152632    JAK99093.1    CH478133    EAT33852.1    GDIQ01074058    JAN20679.1    GDIQ01031418    JAN63319.1    GDIQ01057462    JAN37275.1    GDIP01026551    JAM77164.1    JO844806    AEO36423.1    GBBM01003346    JAC32072.1    GDIP01039974    LRGB01000084    JAM63741.1    KZS21114.1    AAAB01008984    EAA14828.3    GFJQ02002722    JAW04248.1    ACTA01116556    LNIX01000001    OXA63821.1    GL194190    ADMH02002094    ETN59264.1    CH954177    EDV59312.1    KQS70748.1    KQS70749.1    AXCM01002487    JI176273    ADY47427.1    NNAY01000802    OXU26431.1    GAMD01000548    JAB01043.1    KK569097    KFW06256.1    GFJQ02005576    JAW01394.1    GDHF01018749    JAI33565.1    KL357111    KFZ62954.1    KB106856    ELK30624.1    AGBW02009947    OWR49519.1    CM000361    CM002910    EDX04188.1    KMY88971.1    KK834900    KFP79291.1    GGFJ01006598    MBW55739.1    KMY88973.1    CH902620    EDV31281.1    JI165018    ADY40735.1    GDAI01000280    JAI17323.1    GGFJ01006469    MBW55610.1    AE014134    AY094655    GAKP01006416    JAC52536.1    KE162428    EPQ08200.1    GEBF01006062    JAN97570.1    KL894559    KGL81850.1    GL888190    EGI65468.1    QOIP01000007    RLU21082.1    HACG01025634    CEK72499.1    AAPE02018921   

Proteomes

UP000005204    UP000007151    UP000053268    UP000218220    UP000053240    UP000007819    + More
UP000009046    UP000235965    UP000027135    UP000079169    UP000002254    UP000005203    UP000011712    UP000053825    UP000075886    UP000094527    UP000008237    UP000007798    UP000248481    UP000245340    UP000245341    UP000053105    UP000242457    UP000000715    UP000016666    UP000008820    UP000075920    UP000076858    UP000075903    UP000007062    UP000075901    UP000008912    UP000198287    UP000000673    UP000008711    UP000075883    UP000075884    UP000215335    UP000248482    UP000075885    UP000000304    UP000007801    UP000000803    UP000002358    UP000085678    UP000053641    UP000007755    UP000279307    UP000001074   

PRIDE

H9J2G4    L7M1A4    G3MSF5    Q9VLR9   

Pfam

PF00149   Metallophos        + More
PF01182   Glucosamine_iso

Interpro

IPR029052   Metallo-depent_PP-like        + More
IPR033308   PGAP5/Cdc1/Ted1       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR039541   MPP_MPPE1       
IPR037171   NagB/RpiA_transferase-like       
IPR006148   Glc/Gal-6P_isomerase       
IPR018321   Glucosamine6P_isomerase_CS       
IPR004547   Glucosamine6P_isomerase       

SUPFAM

SSF100950   SSF100950       

Gene 3D

3.60.21.10    

CDD

cd08165  MPP_MPPE1
cd01399  GlcN6P_deaminase

ProteinModelPortal

H9J2G4   A0A2H1W5L6   A0A212ET80   A0A194PN91   A0A2A4JFF8   A0A2H1X198   + More
A0A0A9WNJ7   A0A0A9WS93   A0A023F336   A0A194PU72   A0A0N0PC24   V5HTK6   J9L1W7   A0A1B6C6R9   E0VC39   A0A2J7Q7Q9   A0A067RJK9   A0A3Q0IKV5   A0A224YYP0   L7M1A4   F6XU00   A0A310SK47   A0A088A1E3   V5HDR6   A0A2I2UL78   A0A1S4E770   A0A131YFK5   A0A0L7QVY0   A0A182Q9E5   A0A1D2NFJ1   A0A1Y1KCC5   E2C2S4   B4MVX2   A0A2Y9GHU4   A0A2U3WKS5   A0A2U3YZD9   A0A0M9A4P4   A0A2A3EIH6   R0LK38   A0A2P6LB90   M3XZJ6   U3IYE3   A0A224XFU0   A0A0P5MQY5   Q16HW6   A0A0P6DQT1   A0A182VUJ8   A0A1S4G0A0   A0A0P6HB29   A0A0P6FGV9   A0A0N8DJW2   G3MSF5   A0A023GDZ4   A0A0P5ZSE6   A0A182VAK9   Q7PVE7   A0A182T103   A0A1S4H1I0   A0A1Z5LAN5   G1LNH7   A0A226F3Q2   D2I2M6   W5J8Y5   B3N716   A0A0Q5WBM3   A0A182LY21   A0A182MZ21   F1LBC3   A0A232F6G9   T1EB03   A0A093LAM1   A0A1Z5L2V3   A0A0K8V4N5   A0A094LG59   A0A2Y9IRJ0   L5LW21   A0A212F733   A0A182P9G5   B4Q6B2   A0A091MPY0   A0A2M4BRP8   A0A0J9QYE7   B3MPI5   F1KS81   A0A0K8TT47   A0A2M4BRB8   Q9VLR9   Q9VLR9-2   K7IQV4   A0A034WAC4   S7MXE3   A0A2R2MIX8   A0A0P6J2Q9   A0A099ZM14   F4WK18   A0A3L8DLL8   A0A0B6ZV66   G1PHL5   A0A2Y9IVG2  

KEGG

101742462    K23362 ethanolamine phosphate phosphodiesterase [EC:3.1.-.-] | (RefSeq) metallophosphoesterase 1 hom

GO

GO:0006506   GO:0016021   GO:0016787   GO:0051301   GO:0004527   GO:0005654   GO:0005794   GO:0008081   GO:0006888   GO:0005793   GO:0005783   GO:0034235   GO:0033116   GO:0070971   GO:0030145   GO:0005801   GO:0006044   GO:0005975   GO:0004342   GO:0046872   GO:0005737   GO:0006629   GO:0016627   GO:0004889   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR13315   PTHR11280  

Subcellular location

Golgi apparatus   Also localizes to endoplasmic reticulum exit site.   With evidence from 1 publications.
cis-Golgi network membrane   Also localizes to endoplasmic reticulum exit site.   With evidence from 1 publications.
Endoplasmic reticulum-Golgi intermediate compartment membrane   Also localizes to endoplasmic reticulum exit site.   With evidence from 1 publications.
Membrane  

Length:

406

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.56779

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00305

outside

1  -  380

TMhelix

381  -  398

inside

399  -  406

 

 

Pi

21.862011

Theta

23.621268

Tajima's D

-2.0807

CLR

62.150713

CSRT

0.0100494975251237

Interpretation

Uncertain