Gene

KWMTBOMO02753

Pre Gene Modal

BGIBMGA003715

Annotation

nicotinic_acetylcholine_receptor_subunit_alpha_7_isoform_2_precursor_[Bombyx_mori]

Location

Bomo_Chr5(-):10097934-10108406      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.575

CDS

ATGGGCGGGCGGGCGCGCTGCTCGCTACTGGCGGCGCCCGCAGGCCTTCTGCTACTACTGCTGGGCCTGCTGTGGCCGAGGGGGGTGTGCGGCGGTCACCACGAGAAGCGGTTGTTGCACCATCTGCTGGACCACTACAACGTGCTGGAGCGCCCTGTGGTCAACGAGAGCGACCCGCTGCAGCTGTCCTTCGGCCTCACGCTCATGCAGATCATTGACGTGGATGAAAAGAACCAGCTTTTGATAACAAACATTTGGCTCAAATTAGAATGGAATGATATGAATTTGAGGTGGAACACTTCAGATTTCGGCGGAGTTAAAGATTTAAGAGTACCACCTCACAGACTATGGAAACCAGATGTTCTTATGTACAACAGTGCGGACGAAGGCTTCGACAGCACGTACCCAACCAATGTTGTGGTGCGGAACAACGGCTCGTGCCTTTACGTCCCACCCGGCATATTCAAGAGCACATGCAAAATAGACATCACGTGGTTTCCATTCGATGACCAACGCTGCGAAATGAAGTTTGGCAGTTGGACATATGACGGCTATCAATTGGATCTTCAATTACAAGATGAAGCGGGTGGGGATATAAGCAGTTTTGTCACGAATGGCGAGTGGGAGTTAATCGGAGTACCAGGCAAGCGGAACGAAATCTATTACAATTGCTGCCCAGAACCGTATATAGACATAACATTCGCGGTCGTTATCCGTCGAAAAACGTTATACTATTTCTTCAATCTCATAGTACCGTGTGTCTTAATCGCATCAATGGCGCTACTCGGGTTCACACTGCCACCGGATTCTGGAGAAAAGCTATCTTTAGGTGTCACAATTCTATTGTCGTTGACGGTGTTTCTGAACATGGTGGCCGAAACGATGCCCGCAACATCAGATGCTGTGCCTCTGCTCGGTACTTACTTCAACTGCATCATGTTCATGGTCGCCTCTTCCGTGGTCTCCACTATACTCATCCTGAATTATCACCACAGACATGCAGACACGCATGAAATGAGTGACTGGATCCGGTGTGTGTTTCTGTACTGGTTGCCTTGGATCCTGCGTATGTCAAGGCCGGGTTCGGCGACGACGCCGCCGCCGGCTCGAGCGCCCCCCCCTCCCGACCTGGAGCTACGTGAGCGCTCCTCCAAGTCACTCCTCGCTAACGTGCTCGACATCGACGACGACTTCCGGCACGCGCAATCGCAGCAGCCGCCCTGCTGCCGCTACTACAGGGGGGGCGAAGAAAATGGAGCAGGCTTAGCGGCGCACAGCTGTTTCGGTGTCGACTACGAGCTGTCGCTCATATTGAAGGAAATCCGAGTCATCACAGATCAGATGCGCAAAGATGACGAAGATGCGGACATATCGCGCGACTGGAAATTTGCCGCCATGGTCGTGGACAGACTGTGCCTTATTATCTTTACCCTGTTCACAATCATCGCCACGCTAGCCGTGCTGCTGTCCGCGCCGCACATCATGGTGTCGTAG

Protein

MGGRARCSLLAAPAGLLLLLLGLLWPRGVCGGHHEKRLLHHLLDHYNVLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNTSDFGGVKDLRVPPHRLWKPDVLMYNSADEGFDSTYPTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGYQLDLQLQDEAGGDISSFVTNGEWELIGVPGKRNEIYYNCCPEPYIDITFAVVIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRHADTHEMSDWIRCVFLYWLPWILRMSRPGSATTPPPARAPPPPDLELRERSSKSLLANVLDIDDDFRHAQSQQPPCCRYYRGGEENGAGLAAHSCFGVDYELSLILKEIRVITDQMRKDDEDADISRDWKFAAMVVDRLCLIIFTLFTIIATLAVLLSAPHIMVS

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.

Uniprot

A8CGM5   A8HTC8   A0A0H4TRG2   A8HTC5   Q9XZI3   A0A0H4TQC6   + More
A0A0B5GNX1   A0A194RGP8   A0A2H1W7E5   A0A212FIW5   A0A2A4K153   A0A2A4K033   A0A346IHV2   B4JD77   A0A1S4G7N3   A0A084VFG0   A0A1S4GZF8   Q29KA5   Q7PHY7   Q8T7V5   B3MMS1   A0A084VN01   A0A0J9R2A0   Q7KT97   B4M8Q7   B4P0I6   B3NA88   A0A1W4UXW1   Q7QI13   A0A1J1IWW5   A8DIU0   A8HTF2   B4MVM6   A9XFY4   A0A0L7LQI0   B4Q5H4   B4KEK2   B4HXE7   A0A0L0BUB3   A0A240SWJ8   E1JJR2   A0A0R1EB74   Q86MN7   B3NVM9   Q9VWI9   A0A3B0KMX8   B4PZJ0   B4MGC3   A4GXC7   A0A1W4VG42   B4L7L9   W8B2K3   A0A0C5I2P3   A0A348BSW2   B8X4G9   B4JJS4   A0A1W4X2L4   A0A348BSW4   A0A1Y1MEU7   A0A023GVG5   A0A348BSW3   A0A1D8GS61   G9CU47   K4JEQ6   A0A0R3P102   A0A3B0KA18   A0A0P5EP72   A0A2S2PZX2   A0A162CYS9   A0A0U2GQ98   A0A1I8PTD7   J9JT17   E9GTK4   A0A2J7PVE3   A0A1I8PTI3   W6EL40   A0A1I8PNY4   A0A182KMG8   A0A2A4JGH6   A0A2W1BAC7   A0A0H4TMF2   A0A158NJP1   A0A0Q9X676   K4JF52   A0A0H4U7U0   A8CGL6   A0A1I8NYF7   A0A0P8ZHV2   G9CU48   A0A0Q9W8H3   A5H032  

Pubmed

17868469    19121390    26354079    22118469    17994087    24438588    + More
12364791    15632085    14747013    15676276    17210077    11973307    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    18057021    17880682    18362917    19320762    19820115    18092998    26227816    26108605    16494528    24495485    28004739    23185243    21292972    25701599    20966253    28756777    21347285    17439546   

EMBL

BABH01007977    BABH01007978    EU082084    ABV45520.2    EU143798    ABV72689.1    + More
KP711056    AKQ12752.1    EU143797    ABV72688.1    AF143846    AAD32697.1    KP711049    RSAL01000017    AKQ12745.1    RVE52946.1    KM884875    AJF23047.1    KQ460207    KPJ16762.1    ODYU01006685    SOQ48752.1    AGBW02008321    OWR53672.1    NWSH01000300    PCG77624.1    PCG77625.1    MH138166    AXP17107.1    CH916368    EDW03250.1    ATLV01012387    ATLV01012388    KE524787    KFB36704.1    AAAB01008944    CH379061    EAL33270.2    AY705399    AAU12508.1    EAA44351.2    AF272778    AAM13390.1    CH902620    EDV31962.1    ATLV01014657    ATLV01014658    KE524978    KFB39345.1    CM002910    KMY90213.1    AE014134    AAS64702.2    AAS64703.1    AFH03701.1    CH940654    EDW57583.2    CM000157    EDW88980.1    CH954177    EDV58590.1    KQS70451.1    KQS70453.1    AY705402    AAAB01008811    AAU12511.1    EAA04911.3    CVRI01000063    CRL04701.1    EF526089    EU937796    KQ971307    ABS86911.1    ACP31301.1    EFA12057.1    EU143806    ABV72697.1    CH963857    EDW75746.2    EF203213    ABY40460.1    JTDY01000311    KOB77753.1    CM000361    EDX05018.1    CH933807    EDW11881.2    CH480818    EDW51727.1    JRES01001455    KNC22799.1    AE014298    ACZ95329.1    CM000162    KRK06589.1    AJ554210    CAD86936.1    CH954180    EDV46694.2    AAF48950.4    AAS65409.1    AHN59906.1    OUUW01000011    SPP86491.1    EDX02146.2    CH940672    EDW57446.2    EF458626    ABO26063.1    CH933814    EDW05732.2    GAMC01019089    GAMC01019088    JAB87466.1    KP090397    AJP36493.1    LC389186    BBE49565.1    FJ167396    ACL14949.1    CH916370    EDV99826.1    LC389188    BBE49567.1    GEZM01036763    JAV82396.1    JQ973830    AFN73052.1    LC389187    BBE49566.1    KU557781    AOT81843.1    JF731242    AEA40428.1    JX466891    AFU82562.1    KRT04867.1    KRT04868.1    KRT04869.1    OUUW01000006    SPP82496.1    GDIQ01269329    JAJ82395.1    GGMS01001872    MBY71075.1    LRGB01000024    KZS21319.1    KT328074    ALB27752.1    ABLF02027371    ABLF02027373    GL732564    EFX77198.1    NEVH01020963    PNF20307.1    KF873587    AHJ11216.1    NWSH01001615    PCG70684.1    KZ150420    PZC70934.1    KP711055    AKQ12751.1    ADTU01018111    ADTU01018112    ADTU01018113    ADTU01018114    ADTU01018115    ADTU01018116    ADTU01018117    ADTU01018118    ADTU01018119    ADTU01018120    KRG03750.1    JX466888    AFU82559.1    KP711048    AKQ12744.1    EU082082    ABV45518.1    CH902624    KPU74285.1    JF731243    KP725465    AEA40429.1    AKV94622.1    CH940649    KRF81069.1    DQ498130    ABJ09669.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000007151    UP000218220    UP000001070    + More
UP000030765    UP000001819    UP000007062    UP000007801    UP000000803    UP000008792    UP000002282    UP000008711    UP000192221    UP000183832    UP000007266    UP000007798    UP000037510    UP000000304    UP000009192    UP000001292    UP000037069    UP000092443    UP000268350    UP000192223    UP000076858    UP000095300    UP000007819    UP000000305    UP000235965    UP000075882    UP000005205   

PRIDE

A8CGM5    A8HTC8    A8HTC5    Q8T7V5    Q7KT97    E1JJR2    + More
Q86MN7    Q9VWI9    A4GXC7    A8CGL6   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR036719   Neuro-gated_channel_TM_sf        + More
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036734   Neur_chan_lig-bd_sf       
IPR006029   Neurotrans-gated_channel_TM       
IPR006202   Neur_chan_lig-bd       
IPR006201   Neur_channel       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR000742   EGF-like_dom       

SUPFAM

SSF90112   SSF90112        + More
SSF63712   SSF63712       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8CGM5   A8HTC8   A0A0H4TRG2   A8HTC5   Q9XZI3   A0A0H4TQC6   + More
A0A0B5GNX1   A0A194RGP8   A0A2H1W7E5   A0A212FIW5   A0A2A4K153   A0A2A4K033   A0A346IHV2   B4JD77   A0A1S4G7N3   A0A084VFG0   A0A1S4GZF8   Q29KA5   Q7PHY7   Q8T7V5   B3MMS1   A0A084VN01   A0A0J9R2A0   Q7KT97   B4M8Q7   B4P0I6   B3NA88   A0A1W4UXW1   Q7QI13   A0A1J1IWW5   A8DIU0   A8HTF2   B4MVM6   A9XFY4   A0A0L7LQI0   B4Q5H4   B4KEK2   B4HXE7   A0A0L0BUB3   A0A240SWJ8   E1JJR2   A0A0R1EB74   Q86MN7   B3NVM9   Q9VWI9   A0A3B0KMX8   B4PZJ0   B4MGC3   A4GXC7   A0A1W4VG42   B4L7L9   W8B2K3   A0A0C5I2P3   A0A348BSW2   B8X4G9   B4JJS4   A0A1W4X2L4   A0A348BSW4   A0A1Y1MEU7   A0A023GVG5   A0A348BSW3   A0A1D8GS61   G9CU47   K4JEQ6   A0A0R3P102   A0A3B0KA18   A0A0P5EP72   A0A2S2PZX2   A0A162CYS9   A0A0U2GQ98   A0A1I8PTD7   J9JT17   E9GTK4   A0A2J7PVE3   A0A1I8PTI3   W6EL40   A0A1I8PNY4   A0A182KMG8   A0A2A4JGH6   A0A2W1BAC7   A0A0H4TMF2   A0A158NJP1   A0A0Q9X676   K4JF52   A0A0H4U7U0   A8CGL6   A0A1I8NYF7   A0A0P8ZHV2   G9CU48   A0A0Q9W8H3   A5H032  

PDB

4BOT     E-value=1.34621e-84,     Score=799

KEGG

100126156    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa7, Achra7; nicotinic acetylch

GO

GO:0030054   GO:0045211   GO:0016021   GO:0004888   GO:0022848   GO:0005887   GO:0045202   GO:0043005   GO:0007165   GO:0042391   GO:0007268   GO:0034220   GO:0050877   GO:0042166   GO:0005892   GO:0006812   GO:0005230   GO:0060079   GO:0007632   GO:0014069   GO:0030425   GO:0043197   GO:0007630   GO:0007271   GO:0006811   GO:0016020   GO:0006810   GO:0004889   GO:0005216   GO:0006281   GO:0048384  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

SignalP

Position:   1 - 31,         Likelihood:  0.913090

 

 

Length:

497

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

108.09138

Exp number, first 60 AAs:

21.18621

Total prob of N-in:

0.83224

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  243

TMhelix

244  -  266

inside

267  -  272

TMhelix

273  -  295

outside

296  -  304

TMhelix

305  -  327

inside

328  -  471

TMhelix

472  -  494

outside

495  -  497

 

 

Pi

219.67232

Theta

178.06205

Tajima's D

1.502576

CLR

0.114315

CSRT

0.786260686965652

Interpretation

Uncertain