Gene

KWMTBOMO02752

Pre Gene Modal

BGIBMGA003716

Annotation

nicotinic_acetylcholine_receptor_subunit_beta_1_isoform_1_precursor_[Bombyx_mori]

Location

Bomo_Chr5(-):10088247-10092326      View in EpiBrowser

Full name

Acetylcholine receptor subunit beta-like 1      

Alternative Name

Nicotinic acetylcholine receptor beta 1

Location in the cell

PlasmaMembrane   Reliability : 4.8

CDS

ATGTACCCGCATCCGGCAGTGCCCGCTGCAATGTCGTGCGTATCGCGCGCTTTCCTCGCCACCACCCTACTGGCCATCCTGTATTCAGGATGGTGTTCAGAAGACGAAGAACGTTTAGTTCGCGACCTTTTCAGAGGATACAATAAATTAATACGACCTGTCCAAAACATGACACAGAAAGTGGATGTGAGATTTGGTCTTGCGTTTGTACAACTCATTAACGTCAATGAGAAGAACCAAATTATGAAATCAAACGTTTGGCTCCGTTTGGTTTGGATGGATTACCAGTTGATGTGGGACGAAGCTGACTACGGCGGTATTGGCGTATTAAGATTACCGCCTGACAAGGTTTGGAAGCCAGATATAGTTCTTTTCAATAACGCTGACGGAAATTACGAAGTCCGATATAAATCAAACGTGCTTATATATCCTAATGGAGAAGTACTTTGGGTCCCACCAGCTATATATCAGAGCTCGTGCACGATTGACGTAACCTACTTTCCATTTGACCAGCAAACGTGTATCATGAAATTCGGATCTTGGACGTTCAATGGGGACCAAGTATCACTGGCGCTATACAACAACAAGAACTTTGTTGATCTTTCCGATTATTGGAAGTCAGGAACATGGGATATCATAGAAGTACCGGCTTATTTGAACATTTATGAAGGCAATCATCCAACTGAAACTGATATTACGTTCTACATTATAATTCGACGGAAAACATTGTTTTACACTGTAAACTTAATATTGCCGACTGTTTTAATTTCGTTTCTTTGTGTACTTGTATTTTATTTGCCAGCTGAAGCTGGTGAAAAGGTAACCTTGGGTATCAGCATTTTACTTTCTCTGGTTGTGTTCCTGCTTCTGGTATCGAAGATTCTTCCACCGACATCGCTTGTACTTCCACTTATCGCTAAATATTTATTATTCACATTCATTATGAATACTGTCAGTATTCTGGTTACGGTTATCATAATCAATTGGAACTTCAGAGGACCCAGAACTCATAGGATGCCATTATGGATTCGAAGCGTTTTCCTGCATTATTTACCAGCTATGCTGCTTATGCGGAGACCGAGAAAAACTAGATTGCGCTGGATGATGGAAATGCCCGGAATGGGTGCTCCACCCCATGCAGCGGCACCACACGACCTCCCGAAACATATAAGCAAAATGGAGGCAATGGAGCTATCGGACCTACATCATCCAAATTGCAAAATAAACCGTGCTGCCGGCGGAGGTGAAGTTGGCGCTCTTGGAGATCTTGGTGCACTGGGTGGTCTGGGACTTGGAGGAGAAAGACGCGAATCGGAAAGTTCGGATTCACTTCTACTTTCTCCTGAAGCGGCAAAGGCTACGGAAGCAGTCGAATTCATTGCGGAACATTTACGAAATGAAGATCTTTACATTCAGACTCGCGAAGACTGGAAATACGTGGCAATGGTTATTGACAGATTACAGCTGTACATTTTCTTCATAGTCACCACAGCAGGAACGGTTGGGATACTGATGGATGCACCACATATTTTCGAATATGTTGACCAAGATCGTATTATTGAAATTTATCGAGGAAAATAA

Protein

MYPHPAVPAAMSCVSRAFLATTLLAILYSGWCSEDEERLVRDLFRGYNKLIRPVQNMTQKVDVRFGLAFVQLINVNEKNQIMKSNVWLRLVWMDYQLMWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPNGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNIYEGNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPLWIRSVFLHYLPAMLLMRRPRKTRLRWMMEMPGMGAPPHAAAPHDLPKHISKMEAMELSDLHHPNCKINRAAGGGEVGALGDLGALGGLGLGGERRESESSDSLLLSPEAAKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.

Keywords

Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Polymorphism   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Acetylcholine receptor subunit beta-like 1

Uniprot

A8HTD6   A8CGJ8   A0A2H1W6U0   A0A212FIW5   O96633   V5ULZ2   + More
A0A2A4K0T0   A0A346IHV5   A0A194RLA2   A7UHB4   A0A0H4TM39   A0A182RH67   A0A1B0FB86   W5JBF0   A0A182PPX6   A0A182MEW2   A0A182V2W0   A0A182TNK2   A0A182XNI3   Q7QI10   A0A182MZW4   A0A182QXM9   A0A182IJQ9   A0A084VN07   A0A182W452   A8DIV7   D7EIM1   A0A182IDN6   A0A1A9V495   A0A1A9W4T0   A0A182YRJ4   A0A1Y1NKI0   A0A1B0DLT1   A0A3B0J6I3   C3TS68   B4KX76   Q16SL2   A0A1W4VAZ3   B4MN11   B4LGV9   A0A1J1HTP9   B0X9Y9   A0A0J9RQG6   A0A0Q9XAQ7   A0A3B0K2J2   B4PI73   B3NC38   E8NHB5   A0A0Q5U785   P04755   A0A0K8UGV2   A0A0K1U4A8   Q29EC6   B4HU63   A0A348BSW8   B3M928   A0A2H4U2F6   A0A034VYY8   W8ARB5   A0A2Z4N5Q8   B6VAH8   A0A0G3VJ88   A0A0A1X5B9   A0A0P8ZTC8   A0A0J7P1B2   A0A195E3M5   Q30DN7   A0A1I8M6L9   A0A1W4X3R6   A0A195D2I7   W6EL29   A0A154P0V3   A0A3L8DSH3   A0A1I8PPB4   T1PA71   A0A158P1F1   F6JX92   A0EIZ8   A0A151I0X7   A0A0C9QPC9   A0A195EXD0   H9J2H9   A0A182FIN7   O46135   A0A310SUJ8   E0VP62   T1IAD6   A0A151XHB4   A0A0A7RQC5   D3UA25   A0A1D8GS81   F4WV01   A0A1S5VZ00   A0A1B0B7V4   J9QIC9   A0A0U2GT18   A0A224AUJ9   A0A2S2N7R3   Q9NFX8   J9K5U1  

Pubmed

17868469    22118469    26354079    20920257    23761445    12364791    + More
14747013    15676276    17210077    24438588    17880682    18362917    19820115    25244985    28004739    19320762    17994087    17510324    22936249    17550304    16453690    3136037    2832736    10731132    12537572    15632085    18057021    25348373    24495485    19254762    25830018    25315136    25701599    30249741    21347285    21618599    17065616    19121390    9660807    20566863    25504620    20087392    20075255    21719571    28187830   

EMBL

EU143801    ABV72692.1    EU082071    ABV45508.1    ODYU01006685    SOQ48753.1    + More
AGBW02008321    OWR53672.1    AF096880    AAD09810.1    KF668454    AHB78808.1    NWSH01000300    PCG77626.1    MH138169    AXP17110.1    KQ460207    KPJ16761.1    EU070937    EU101456    ABU41521.1    ABU85033.1    KP711052    RSAL01000017    AKQ12748.1    RVE52947.1    CCAG010009347    ADMH02001869    ETN60728.1    AXCM01005037    AY705405    AAAB01008811    AAU12514.1    EAA04968.3    AXCN02002024    ATLV01014666    KE524978    KFB39351.1    EF526094    ABS86916.1    KQ971307    EFA12056.2    GEZM01000477    JAV98401.1    AJVK01006807    AJVK01006808    OUUW01000002    SPP77607.1    EU937811    ACP31316.1    CH933809    EDW17534.1    CH477672    EAT37452.1    CH963847    EDW73567.1    CH940647    EDW68429.1    CVRI01000014    CRK89854.1    DS232556    EDS43415.1    CM002912    KMY97609.1    KRG05606.1    SPP77608.1    CM000159    EDW93415.1    CH954178    EDV50926.1    BT125991    ADX35970.1    KQS43588.1    X04016    X07956    X07957    X07958    M20316    AE014296    GDHF01026526    JAI25788.1    KP725467    AKV94624.1    CH379070    EAL30135.2    CH480817    EDW50484.1    LC389192    BBE49571.1    CH902618    EDV38972.1    KPU77787.1    KY293419    ATZ35994.1    GAKP01012214    JAC46738.1    GAMC01015165    JAB91390.1    MF612140    AWX65628.1    FJ358493    ACJ07013.1    KP339870    AKL79440.1    GBXI01008467    GBXI01008196    GBXI01000170    JAD05825.1    JAD06096.1    JAD14122.1    KPU77786.1    LBMM01000399    KMQ98445.1    KQ979709    KYN19474.1    DQ153040    ABA39253.1    KQ976986    KYN06589.1    KF873577    AHJ11206.1    KQ434796    KZC05556.1    QOIP01000004    RLU23395.1    KA645589    AFP60218.1    ADTU01006423    ADTU01006424    HM049634    HM049635    ADH15832.1    DQ026038    KJ939597    AAY87897.1    AJE70268.1    KQ976633    KYM78882.1    GBYB01002547    JAG72314.1    KQ981928    KYN32883.1    BABH01007978    AJ000393    CAA04055.1    KQ759901    OAD62012.1    DS235356    EEB15168.1    ACPB03019553    KQ982138    KYQ59600.1    KP101249    AJA39825.1    FJ821444    ACY82698.1    KU557782    AOT81844.1    GL888382    EGI61968.1    KX602254    AQP31213.1    JXJN01009725    JXJN01009726    JXJN01009727    JN681174    AFP55243.1    KT328076    ALB27754.1    LC215870    BBA21165.1    GGMR01000632    MBY13251.1    AJ251838    CAB87995.1    ABLF02038405   

Proteomes

UP000007151    UP000218220    UP000053240    UP000283053    UP000075900    UP000092444    + More
UP000000673    UP000075885    UP000075883    UP000075903    UP000075902    UP000076407    UP000007062    UP000075884    UP000075886    UP000075880    UP000030765    UP000075920    UP000007266    UP000078200    UP000091820    UP000076408    UP000092462    UP000268350    UP000009192    UP000008820    UP000192221    UP000007798    UP000008792    UP000183832    UP000002320    UP000002282    UP000008711    UP000000803    UP000001819    UP000001292    UP000007801    UP000036403    UP000078492    UP000095301    UP000192223    UP000078542    UP000076502    UP000279307    UP000095300    UP000005205    UP000005203    UP000078540    UP000078541    UP000005204    UP000069272    UP000009046    UP000015103    UP000075809    UP000002358    UP000007755    UP000092460    UP000007819   

PRIDE

A8HTD6    A8CGJ8    E8NHB5    P04755    H9J2H9   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb
PF00100   Zona_pellucida

Interpro

IPR002394   Nicotinic_acetylcholine_rcpt        + More
IPR036719   Neuro-gated_channel_TM_sf       
IPR006202   Neur_chan_lig-bd       
IPR006029   Neurotrans-gated_channel_TM       
IPR036734   Neur_chan_lig-bd_sf       
IPR006201   Neur_channel       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR001507   ZP_dom       

SUPFAM

SSF90112   SSF90112        + More
SSF63712   SSF63712       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8HTD6   A8CGJ8   A0A2H1W6U0   A0A212FIW5   O96633   V5ULZ2   + More
A0A2A4K0T0   A0A346IHV5   A0A194RLA2   A7UHB4   A0A0H4TM39   A0A182RH67   A0A1B0FB86   W5JBF0   A0A182PPX6   A0A182MEW2   A0A182V2W0   A0A182TNK2   A0A182XNI3   Q7QI10   A0A182MZW4   A0A182QXM9   A0A182IJQ9   A0A084VN07   A0A182W452   A8DIV7   D7EIM1   A0A182IDN6   A0A1A9V495   A0A1A9W4T0   A0A182YRJ4   A0A1Y1NKI0   A0A1B0DLT1   A0A3B0J6I3   C3TS68   B4KX76   Q16SL2   A0A1W4VAZ3   B4MN11   B4LGV9   A0A1J1HTP9   B0X9Y9   A0A0J9RQG6   A0A0Q9XAQ7   A0A3B0K2J2   B4PI73   B3NC38   E8NHB5   A0A0Q5U785   P04755   A0A0K8UGV2   A0A0K1U4A8   Q29EC6   B4HU63   A0A348BSW8   B3M928   A0A2H4U2F6   A0A034VYY8   W8ARB5   A0A2Z4N5Q8   B6VAH8   A0A0G3VJ88   A0A0A1X5B9   A0A0P8ZTC8   A0A0J7P1B2   A0A195E3M5   Q30DN7   A0A1I8M6L9   A0A1W4X3R6   A0A195D2I7   W6EL29   A0A154P0V3   A0A3L8DSH3   A0A1I8PPB4   T1PA71   A0A158P1F1   F6JX92   A0EIZ8   A0A151I0X7   A0A0C9QPC9   A0A195EXD0   H9J2H9   A0A182FIN7   O46135   A0A310SUJ8   E0VP62   T1IAD6   A0A151XHB4   A0A0A7RQC5   D3UA25   A0A1D8GS81   F4WV01   A0A1S5VZ00   A0A1B0B7V4   J9QIC9   A0A0U2GT18   A0A224AUJ9   A0A2S2N7R3   Q9NFX8   J9K5U1  

PDB

6CNK     E-value=2.06552e-91,     Score=858

KEGG

100126169    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRb1, Achrb1; nicotinic acetylch

GO

GO:0030054   GO:0045211   GO:0004888   GO:0016021   GO:0022848   GO:0045202   GO:0005887   GO:0043005   GO:0007165   GO:0042391   GO:0050877   GO:0007268   GO:0034220   GO:0007271   GO:0005892   GO:0006811   GO:0004889   GO:0005216   GO:0016020   GO:0005230   GO:0006810   GO:0006281   GO:0048384  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

526

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

124.06553

Exp number, first 60 AAs:

18.59015

Total prob of N-in:

0.09647

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  242

TMhelix

243  -  265

outside

266  -  279

TMhelix

280  -  302

inside

303  -  308

TMhelix

309  -  331

outside

332  -  340

TMhelix

341  -  358

inside

359  -  488

TMhelix

489  -  511

outside

512  -  526

 

 

Pi

207.846011

Theta

170.306126

Tajima's D

0.913785

CLR

0.46917

CSRT

0.635818209089546

Interpretation

Uncertain