Gene

KWMTBOMO02750

Pre Gene Modal

BGIBMGA003483

Annotation

PREDICTED:_protein_ariadne-2_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr5(+):10067047-10073106      View in EpiBrowser

Full name

RBR-type E3 ubiquitin transferase       + More
Potential E3 ubiquitin-protein ligase ariadne-2      

Alternative Name

Protein ariadne-2
RING-type E3 ubiquitin transferase ariadne-2

Location in the cell

Nuclear   Reliability : 2.645

CDS

ATGTCTGCGGAGTCTGATATGGAATATTCTGACAATGACGGCGATGATTATGATTACTACGGTGAACACGAAGATTGTGATATGGAAGTAGCCGATCGCACTAAGTCAGATCCTGAGTATTTTGTGTTTTCTTGTCTGAAAGTTGAAGAAGTGGAAAAATTACTCAACGAATCTATTGAATTACTTAGTAACAGCCTTCAGATAACACCATCACTCGCCAAGGTAGCACTACATGCATATGAATGGAATGCTCAAGAAATAATTAACAAATATAAAGAAAATGCAAATGAAGTGTTGGTTTTCAGTAGGGTGAAGCCACAAGTGCCTTCACAAAGTATATCAAGCAGATCAAGTTGTGCTGTTTGTGCCAGCACACCTCAACTGCACAAGTATAGTGCACTAGCATGTGGACATTATTTTTGCAACGACTGTTGGGCAATGCATTTTGAAGTTCAAATAATGCAAGGAGTCTCAAATACAATACGCTGCATGGCTCAAAACTGTGAGGTCAGAGCGCCAGAGGATTTTGTTCTGTCACATGTTACTAAACCAGCATTAAGGGACCGATACCAACAATTCATGTTTAAAGATCATGTTAAATCTCACCCACAACTTAGATTCTGCCCTGGTCCTAACTGTCAGTGGATTTTTCGAGCATTCATTCGTGAAGGAGCACGCCGTGTTGAATGCAAAGGTTGTGAATCATTGACATGCTTCTCATGCGGGGCTCCTCATCATGCTCCTACTGACTGTGCTACAATTCGACAATGGTTAACCAAATGTGCTGATGACTCTGAAACTGCAAACTATATTAGTGCCCACACTAAGGATTGTCCTAAATGTCAAATTTGCATTGAGAAAAATGGGGGGTGCAATCATATGCAGTGCGGATCGTGCAGACATGATTTCTGTTGGGTTTGTTTGGGAGATTGGAAAGCTCATGGATCTGAATACTATGAATGTAGTCGGTATAAGGAAGACCCAAATTTGACTACTGATAGCCAACATGCTCAGGCACGTGAAGCCTTGAAGAAATATTTGCATTATTATGAAAGATGGGAAAATCATGCTCGATCTCTGAAGTTAGAAGAGCAGACATTGGAAAGTCTTAAAAGCAGAATAAACGAAAAGGTTATGGCTGGGGAAGGTACATGGATTGATTGGCAATATCTTTGGGATGCTGCTAAACTTCTCAAGCGCTGTAGATATACTCTTCAATATACCTATCCTTATGCATACTACATGGAGGTTGGTCCTAGAAAAGAATTATTTGAATATCAGCAGGCTCAACTTGAAGCTGAGATAGAGAATTTGTCATGGAAGATTGAAAGGGCTGAAACAACCCATAGGGGTGACTTGGAAAATCAAATGGATATAGCAGAAAAAAGGCGGACAACACTACTAAAAGATTTTCTAGAATTTAGTTCAAAGTCAAATAATAGTAGTAAAGTTTAA

Protein

MSAESDMEYSDNDGDDYDYYGEHEDCDMEVADRTKSDPEYFVFSCLKVEEVEKLLNESIELLSNSLQITPSLAKVALHAYEWNAQEIINKYKENANEVLVFSRVKPQVPSQSISSRSSCAVCASTPQLHKYSALACGHYFCNDCWAMHFEVQIMQGVSNTIRCMAQNCEVRAPEDFVLSHVTKPALRDRYQQFMFKDHVKSHPQLRFCPGPNCQWIFRAFIREGARRVECKGCESLTCFSCGAPHHAPTDCATIRQWLTKCADDSETANYISAHTKDCPKCQICIEKNGGCNHMQCGSCRHDFCWVCLGDWKAHGSEYYECSRYKEDPNLTTDSQHAQAREALKKYLHYYERWENHARSLKLEEQTLESLKSRINEKVMAGEGTWIDWQYLWDAAKLLKRCRYTLQYTYPYAYYMEVGPRKELFEYQQAQLEAEIENLSWKIERAETTHRGDLENQMDIAEKRRTTLLKDFLEFSSKSNNSSKV

Catalytic Activity

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.

Subunit

Interacts with UbcD10.

Similarity

Belongs to the RBR family.
Belongs to the RBR family. Ariadne subfamily.

Keywords

Coiled coil   Complete proteome   Metal-binding   Nucleus   Reference proteome   Repeat   Transferase   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  Potential E3 ubiquitin-protein ligase ariadne-2

Uniprot

H9J1U6   A0A2A4K0P5   A0A1E1VXW5   A0A194RG18   S4PYB0   A0A194PPG5   + More
A0A212FIW8   A0A1E1VYW2   A0A195ET43   E2C5A6   A0A158NWA6   A0A151X4W6   A0A151HY96   A0A151IC41   A0A2J7QMF7   A0A026W7C4   E2A0S1   A0A0C9QGJ0   A0A0C9RKN7   A0A0C9RGI4   A0A1B6GPF7   A0A154PNK8   A0A1B6JQU4   A0A1B6F2L8   A0A131XGL7   A0A2A3ENW7   A0A2J7QMG8   A0A1W4XB21   A0A224YTU6   L7MAJ2   A0A1E1XG30   A0A131YJN0   A0A088A7V0   A0A1Y1MSK7   D6W8E8   V5IF71   Q0IEL5   V5IJ56   A0A0L7RBG8   A0A1B6D4X5   A0A232EQ92   A0A2R5LI98   U5ELC0   N6TIR3   A0A0K8TRY4   F4X4T5   A0A1J1IB86   A0A293MX45   Q7Q687   A0A1W4VD90   A0A067RGN9   B4I821   B4QH37   O76924   A0A2P8Z7K2   A0A182NIK3   B4P7G1   B3NNF1   A0A226E5K7   Q8MRP8   A0A0M9A1Z8   A0A087URQ5   B3MGI9   U4UNT7   A0A023F4X6   A0A0K8UM51   A0A0R3NWW2   A0A146KRU1   B4GHI1   Q28XS5   A0A0P4VSZ9   T1HDH4   A0A3B0J5M2   A0A1D2MGQ4   A0A224XDF1   A0A336LNE2   A0A0J7L234   R7V8I0   A0A1L8DT19   A0A023EWB8   A0A0T6B8P0   B0XBC4   A0A182GBJ6   A0A1S4FGF2   Q0IF09   A0A1B0CX10   A0A182GZU3   A0A1Q3F9W5   A0A1S4FMJ5   A0A0M4EV30   A0A1B0FPP8   A0A1A9ZL14   B4J9P8   A0A1B0BFN1   B4MFQ8   A0A0N7ZCR7   A0A1A9W994   B4KS81   A0A1S3HIN4  

EC Number

2.3.2.31

Pubmed

19121390    26354079    23622113    22118469    20798317    21347285    + More
24508170    30249741    28049606    28797301    25576852    28503490    26830274    28004739    18362917    19820115    25765539    17510324    28648823    23537049    26369729    21719571    12364791    24845553    17994087    22936249    10880484    10731132    12537572    29403074    17550304    25474469    15632085    26823975    23185243    27129103    27289101    23254933    24945155    26483478   

EMBL

BABH01007979    NWSH01000300    PCG77629.1    GDQN01011525    GDQN01006312    JAT79529.1    + More
JAT84742.1    KQ460207    KPJ16758.1    GAIX01003603    JAA88957.1    KQ459597    KPI94868.1    AGBW02008321    OWR53674.1    GDQN01011136    JAT79918.1    KQ981993    KYN31082.1    GL452770    EFN76839.1    ADTU01027856    KQ982522    KYQ55465.1    KQ976730    KYM76445.1    KQ978069    KYM97345.1    NEVH01013208    PNF29781.1    KK107364    QOIP01000007    EZA51893.1    RLU20309.1    GL435626    EFN72974.1    GBYB01013678    JAG83445.1    GBYB01007471    JAG77238.1    GBYB01007470    JAG77237.1    GECZ01005480    JAS64289.1    KQ434977    KZC12810.1    GECU01006191    JAT01516.1    GECZ01025329    JAS44440.1    GEFH01002288    JAP66293.1    KZ288203    PBC33417.1    PNF29780.1    GFPF01006106    MAA17252.1    GACK01004861    JAA60173.1    GFAC01000948    JAT98240.1    GEDV01009907    JAP78650.1    GEZM01025387    JAV87480.1    KQ971307    EFA10875.1    GANP01008947    JAB75521.1    CH477586    EAT38630.1    GANP01002022    JAB82446.1    KQ414617    KOC68183.1    GEDC01016554    JAS20744.1    NNAY01002789    OXU20559.1    GGLE01005093    MBY09219.1    GANO01001471    JAB58400.1    APGK01024814    KB740562    ENN80324.1    GDAI01000499    JAI17104.1    GL888679    EGI58508.1    CVRI01000043    CRK96238.1    GFWV01019192    MAA43920.1    AAAB01008960    EAA11275.4    KK852519    KDR22168.1    CH480824    EDW56746.1    CM000362    CM002911    EDX08183.1    KMY95752.1    AJ010169    AE013599    PYGN01000161    PSN52466.1    CM000158    EDW92106.1    CH954179    EDV55575.1    LNIX01000006    OXA52893.1    AY119482    AAM50136.1    KQ435793    KOX74179.1    KK121235    KFM80044.1    CH902619    EDV35732.1    KB632399    ERL94777.1    GBBI01002629    JAC16083.1    GDHF01024562    JAI27752.1    CM000071    KRT02934.1    GDHC01020949    JAP97679.1    CH479183    EDW35951.1    EAL26241.3    GDKW01000872    JAI55723.1    ACPB03000298    OUUW01000001    SPP75093.1    LJIJ01001303    ODM92178.1    GFTR01005979    JAW10447.1    UFQT01000086    SSX19486.1    LBMM01001190    KMQ96746.1    AMQN01004718    KB294243    ELU14864.1    GFDF01004574    JAV09510.1    GAPW01000914    JAC12684.1    LJIG01009235    KRT83485.1    DS232624    EDS44215.1    JXUM01008913    KQ560271    KXJ83407.1    CH477440    EAT40872.1    AJWK01033098    AJWK01033099    AJWK01033100    JXUM01002814    KQ560145    KXJ84182.1    GFDL01010709    JAV24336.1    CP012524    ALC41407.1    CCAG010006472    CH916367    EDW01462.1    JXJN01013592    CH940667    EDW57229.1    GDRN01061518    JAI65200.1    CH933808    EDW08363.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000078541    + More
UP000008237    UP000005205    UP000075809    UP000078540    UP000078542    UP000235965    UP000053097    UP000279307    UP000000311    UP000076502    UP000242457    UP000192223    UP000005203    UP000007266    UP000008820    UP000053825    UP000215335    UP000019118    UP000007755    UP000183832    UP000007062    UP000192221    UP000027135    UP000001292    UP000000304    UP000000803    UP000245037    UP000075884    UP000002282    UP000008711    UP000198287    UP000053105    UP000054359    UP000007801    UP000030742    UP000001819    UP000008744    UP000015103    UP000268350    UP000094527    UP000036403    UP000014760    UP000002320    UP000069940    UP000249989    UP000092461    UP000092553    UP000092444    UP000092445    UP000001070    UP000092460    UP000008792    UP000091820    UP000009192    UP000085678   

PRIDE

H9J1U6    O76924    Q8MRP8   

Pfam

PF01485   IBR        + More
PF00097   zf-C3HC4

Interpro

IPR031127   E3_UB_ligase_RBR        + More
IPR002867   IBR_dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR017907   Znf_RING_CS       
IPR031126   Ariadne-2       
IPR001878   Znf_CCHC       
IPR001841   Znf_RING       
IPR018957   Znf_C3HC4_RING-type       

Gene 3D

3.30.40.10    

ProteinModelPortal

H9J1U6   A0A2A4K0P5   A0A1E1VXW5   A0A194RG18   S4PYB0   A0A194PPG5   + More
A0A212FIW8   A0A1E1VYW2   A0A195ET43   E2C5A6   A0A158NWA6   A0A151X4W6   A0A151HY96   A0A151IC41   A0A2J7QMF7   A0A026W7C4   E2A0S1   A0A0C9QGJ0   A0A0C9RKN7   A0A0C9RGI4   A0A1B6GPF7   A0A154PNK8   A0A1B6JQU4   A0A1B6F2L8   A0A131XGL7   A0A2A3ENW7   A0A2J7QMG8   A0A1W4XB21   A0A224YTU6   L7MAJ2   A0A1E1XG30   A0A131YJN0   A0A088A7V0   A0A1Y1MSK7   D6W8E8   V5IF71   Q0IEL5   V5IJ56   A0A0L7RBG8   A0A1B6D4X5   A0A232EQ92   A0A2R5LI98   U5ELC0   N6TIR3   A0A0K8TRY4   F4X4T5   A0A1J1IB86   A0A293MX45   Q7Q687   A0A1W4VD90   A0A067RGN9   B4I821   B4QH37   O76924   A0A2P8Z7K2   A0A182NIK3   B4P7G1   B3NNF1   A0A226E5K7   Q8MRP8   A0A0M9A1Z8   A0A087URQ5   B3MGI9   U4UNT7   A0A023F4X6   A0A0K8UM51   A0A0R3NWW2   A0A146KRU1   B4GHI1   Q28XS5   A0A0P4VSZ9   T1HDH4   A0A3B0J5M2   A0A1D2MGQ4   A0A224XDF1   A0A336LNE2   A0A0J7L234   R7V8I0   A0A1L8DT19   A0A023EWB8   A0A0T6B8P0   B0XBC4   A0A182GBJ6   A0A1S4FGF2   Q0IF09   A0A1B0CX10   A0A182GZU3   A0A1Q3F9W5   A0A1S4FMJ5   A0A0M4EV30   A0A1B0FPP8   A0A1A9ZL14   B4J9P8   A0A1B0BFN1   B4MFQ8   A0A0N7ZCR7   A0A1A9W994   B4KS81   A0A1S3HIN4  

PDB

4KC9     E-value=2.03949e-58,     Score=573

KEGG

101745249    K11969 ariadne-2 [EC:2.3.2.31] | (RefSeq) protein ariadne-2

GO

GO:0004842   GO:0046872   GO:0008270   GO:0003676   GO:0016874   GO:0000209   GO:0005737   GO:0006511   GO:0032436   GO:0031624   GO:0000151   GO:0061630   GO:0005634  

PANTHER

PTHR11685   PTHR11685:SF233   PTHR11685:SF230  

Subcellular location

Nucleus  

Length:

484

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00022

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00270

outside

1  -  484

 

 

Pi

243.668127

Theta

174.258519

Tajima's D

1.416064

CLR

0.142674

CSRT

0.765711714414279

Interpretation

Uncertain