Gene

KWMTBOMO02749  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003717

Annotation

PREDICTED:_ATP-dependent_6-phosphofructokinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):10051876-10065016      View in EpiBrowser

Full name

ATP-dependent 6-phosphofructokinase      

Alternative Name

Phosphohexokinase

Location in the cell

Cytoplasmic   Reliability : 1.764

CDS

ATGGACGGGTCAGCTACTCAGAAATTTATTGGCCGCGGCTCTCATAAAGGCAAGGGGCTTGCTGTGTTTACTAGCGGTGGAGATTCTCAGGGAATGAATGCCGCTGTGCGATCAGTCGTGCGTATGGGCATATACTTAGGGTGTAAAGTATATTTTATTCGTGAAGGATACCAGGGCATGGTAGATGGAGGTGATAACATTGAAGAAGCGAACTGGTCTTCTGTTAGCTCTATAATTCACAAAGGAGGCACTATAATTGGATCAGCTAGGTGCATGGAGTTCATTAAAAAAGAAGGTCGTCTCAAAGCCGCATATAACTTAGTGAGCCGTGGTATAACCAATCTTGTGGTTATTGGTGGTGATGGTTCGCTGACTGGTGCCAATTTGTTCCGACAAGAATGGTCTAGCCTTCTTGATGAATTGCTGGAGAACAACAAAATTACTAAAGATCAAAGGGAAAAATATAAATTTTTGCACATAGCTGGAATGGTTGGTTCAATTGACAATGATTTTTGTGGTACAGACATGACAATAGGTACTGATTCAGCCTTGCATAGAATCATTGAAGCTATTGATGCAATTGTAAGCACTGCTTATTCACATCAAAGAACATTTATTATGGAGGTCATGGGTCGCAACTGTGGTTATTTGGCCCTTGTCGCTGCTCTGGCGAGCGAGGCAGACCAAGTATTTATACCTGAAGACCCTGTTCCCAATAATTGGGTTGAAAAACTTTGCAAAAGATTGCAACAGGAGAGGCGTTCTGGTCAACGTTTGAATATTATCATTGTGGCCGAGGGTGCGATCGACCGCGAAGGTAAGCCTATCACCGCCGAGTTGGTGAAGAAGGTGGTGGTTGATAACCTGCAGCAGGATACCCGTATTACCGTGTTGGGTCACGTCCAACGAGGAGGATCTCCCTCCGCCTTCGACAGAATTTTGGGATGTCGTATGGGAGCAGAGGCGGTTATGGCTTTAATGGAGGCCACCCCGGAAACCGAACCGTGTGTTGTTTCGCTCGACGGTAACCAAGCTGTTCGTTTGCCGTTAATGGAATGCGTTCGACGAACGAAAGCTGTCTCACAGGCAATGGCTGATAAAAATTGGGACCTAGCTGTACAGCTCCGCGGTCGTAGTTTTGCACGTAATTTGGAGACATATAAGATGTTGACCCGTTTGAAGCCACCAAAGGGAGCGTTTGATGAATCCGGAAAACCTTCTGAAGGTTTGACGCTGGCCGTGATGCATGTGGGCGCGCCGGCGTGCGGCATGAATGCGGCCGTACGTTCGTTTGTACGGAATTGTATTTACCGAGGCGATACCGTCCTTGGCATTCACGACGGCATTGAAGGTTTCATTAACGGGAACATCGTCCAAATGGAATGGTCGGATGTAACGGGTTGGGTTGCTCAAGGAGGCGCTTTTCTTGGTACAAAGAGGACTTTGCCCGGCAATAGGAAGAGTGACATCGCTGCGCGGATAAAGCAGTTCAATATTCAAGGCTTACTCATCATCGGTGGTTTTGAGGCCTACCAAGCTAGTTTGGAACTATACGAATCTCGCGCTGAATTCCCGGAGTTCTGCATTCCTCTGGTCGTCATCCCGTCCACGATAAGTAACAACGTGCCCGGGACGGATTTCTCTCTGGGAGCCGACACTGCGCTCAATGAAATAACTGAGATCTGCGATCGCATTCGTCAGTCGGCACAGGGTACCAAGCGTCGTGTGTTCGTCATCGAAACCATGGGCGGTTACTGCGGTTACCTCGCTACCTTGGCTGGTTTGGCCGGCGGTGCTGATGCCGCATACATTTACGAGGAGAAGTTCTCCATCAAGGATCTGCAACAGGACGTTTATCACATGGCGTCTAAAATGACCGGCGGCATTCAGCGCGGCCTCATCCTGCGCAATGAGAAAGCGAACGATAACTACAACACGGAGTTCATTTACCGACTGTACTCTGAAGAGGGCAAAGGACTGTTTACAGCTCGCATGAATGTGCTCGGTCACATGCAACAGGGCGGCTCTCCGACGCCATTTGATCGTAACATGGGTACTAAGATGGCGGCCAAATGTCTTCATTGGCTCGTTGAGAAAATTCAGGAAGGTCCCTCGAACTCTGCCGACTCTGCTTGTTTACTTGGTGTTGTTAAACGCCAGTACAAATTCACTCCACTCGAAGAACTCAAAACTCAAACTAATTTTGCTCAAAGAATAGCAAAACAGCAATGGTGGATGAAACTGCGTCCATTGCTTCGTATCCTGGCGAAGCACGATTCTACATACGAAGAAGAAGGAATGTATATGACAGTTGAACAAGGAGAAATCGACTCTGAGAACGTTATTTAA

Protein

MDGSATQKFIGRGSHKGKGLAVFTSGGDSQGMNAAVRSVVRMGIYLGCKVYFIREGYQGMVDGGDNIEEANWSSVSSIIHKGGTIIGSARCMEFIKKEGRLKAAYNLVSRGITNLVVIGGDGSLTGANLFRQEWSSLLDELLENNKITKDQREKYKFLHIAGMVGSIDNDFCGTDMTIGTDSALHRIIEAIDAIVSTAYSHQRTFIMEVMGRNCGYLALVAALASEADQVFIPEDPVPNNWVEKLCKRLQQERRSGQRLNIIIVAEGAIDREGKPITAELVKKVVVDNLQQDTRITVLGHVQRGGSPSAFDRILGCRMGAEAVMALMEATPETEPCVVSLDGNQAVRLPLMECVRRTKAVSQAMADKNWDLAVQLRGRSFARNLETYKMLTRLKPPKGAFDESGKPSEGLTLAVMHVGAPACGMNAAVRSFVRNCIYRGDTVLGIHDGIEGFINGNIVQMEWSDVTGWVAQGGAFLGTKRTLPGNRKSDIAARIKQFNIQGLLIIGGFEAYQASLELYESRAEFPEFCIPLVVIPSTISNNVPGTDFSLGADTALNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMTGGIQRGLILRNEKANDNYNTEFIYRLYSEEGKGLFTARMNVLGHMQQGGSPTPFDRNMGTKMAAKCLHWLVEKIQEGPSNSADSACLLGVVKRQYKFTPLEELKTQTNFAQRIAKQQWWMKLRPLLRILAKHDSTYEEEGMYMTVEQGEIDSENVI

Description

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic Activity

ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)

Cofactor

Mg(2+)

Subunit

Homotetramer.

Similarity

Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.

Keywords

Allosteric enzyme   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Glycolysis   Kinase   Magnesium   Metal-binding   Nucleotide-binding   Reference proteome   Transferase  

Feature

chain  ATP-dependent 6-phosphofructokinase
splice variant  In isoform A.

Uniprot

H9J2I0   A0A2H1W9K4   A0A194PQ53   A0A0F6TNF4   A0A194RH42   A0A2A4K1T8   + More
A0A212FIX8   S4NSV3   A0A2M4BEL6   A0A182FIA4   A0A2M4A324   A0A2M4A375   W5JTT0   A0A1C7CZ10   A0A2M4BEC6   A0A1Y9IXF3   A0A1Y9IRG4   A0A182I3Q9   A0A1Y9I2A6   A0A2M4BED7   A0A182XZI2   A0A1Q3FML9   A0A2M3Z2T4   A0A2M4A337   A0A240PN31   A0A1Y9H0Y5   A0A2K6V9F9   A0A084VFB0   A0A2K6V9F7   A0A182RFP8   A0A023EV74   A0A182MUK8   A0A1B6CPV7   A0A1Y9H9G2   A0A1B6DHL7   A0A182WIS9   A0A1B6DAI8   A0A1Y9IXX5   A0A1Y9IRZ8   A0A1S4GVQ5   A0A1Y9GIZ8   A0A182KRV4   A0A1Y9IS69   A0A1Y9GJI9   A0A182X6F6   Q5TX32   A0A1Q3FMX3   A0A240PNR8   A0A240PPG1   A0A1Q3FMW2   U5EUA4   A0A182P3I4   J9JNX0   A0A1Y9H0J2   A0A1Y9HAX6   A0A182NHK2   A0A1L8E2A1   A0A1Y9HAX5   A0A2C9GUF9   A0A1Y9HA64   A0A1Y9HAY6   Q174J0   A0A2C9GUI7   A0A1Y9IUN1   A0A1Y9IUM9   A0A0K8TN59   A0A182J6F9   A0A240PMF4   A0A336LMI2   B0WNP9   A0A2H8TYE0   W8B915   A0A034V1J7   A0A067QZR7   A0A0K8VIR0   A0A2J7QM39   A0A1W5YLK2   A0A2Z5RE15   A0A0A1X4W6   E0W457   A0A1I8MFB5   V5GLY8   A0A1I8MFB9   A0A1I8MFC8   A0A0K8V1T2   A0A034V5U4   A0A0A1X492   T1PDK0   A0A1I8NRU4   A0A1I8NRU1   A0A1I8NRU9   A0A1B0B232   A0A1A9WMU0   A0A1A9VY37   A0A1B0AGU6   B4KSJ9   A0A1A9YNY9   A0A0J9R9B9   P52034-3   C7LA80  

EC Number

2.7.1.11

Pubmed

19121390    26354079    22118469    23622113    20920257    23761445    + More
20966253    12364791    25244985    24438588    24945155    26483478    14747013    17210077    17510324    26369729    24495485    25348373    24845553    26760975    25830018    20566863    25315136    17994087    22936249    7929140    10731132    12537572    10731138    12537569    2935142   

EMBL

BABH01007979    ODYU01007126    SOQ49626.1    KQ459597    KPI94869.1    KP253076    + More
AKE50539.1    KQ460207    KPJ16759.1    NWSH01000300    PCG77630.1    AGBW02008321    OWR53675.1    GAIX01013897    JAA78663.1    GGFJ01002260    MBW51401.1    GGFK01001895    MBW35216.1    GGFK01001916    MBW35237.1    ADMH02000160    ETN67536.1    GGFJ01002259    MBW51400.1    APCN01000218    AAAB01008807    GGFJ01002261    MBW51402.1    GFDL01006186    JAV28859.1    GGFM01002081    MBW22832.1    GGFK01001902    MBW35223.1    ATLV01012372    KE524785    KFB36654.1    JXUM01042935    JXUM01042936    JXUM01042937    GAPW01000248    KQ561343    JAC13350.1    KXJ78899.1    AXCM01004236    GEDC01022015    JAS15283.1    AXCN02000593    GEDC01020516    GEDC01012156    JAS16782.1    JAS25142.1    GEDC01014581    GEDC01003943    JAS22717.1    JAS33355.1    EAL41738.3    GFDL01006222    JAV28823.1    GFDL01006232    JAV28813.1    GANO01001572    JAB58299.1    ABLF02041209    ABLF02041211    GFDF01001372    JAV12712.1    CH477410    EAT41468.1    GDAI01001796    JAI15807.1    UFQT01000063    SSX19272.1    DS232014    EDS31890.1    GFXV01007518    MBW19323.1    GAMC01016889    JAB89666.1    GAKP01021821    JAC37131.1    KK852854    KDR15026.1    GDHF01013540    JAI38774.1    NEVH01013227    PNF29623.1    KX147660    ARI45064.1    FX983726    BAX07225.1    GBXI01011096    GBXI01008564    JAD03196.1    JAD05728.1    DS235886    EEB20413.1    GALX01003377    JAB65089.1    GDHF01033073    GDHF01019749    JAI19241.1    JAI32565.1    GAKP01021822    JAC37130.1    GBXI01008380    JAD05912.1    KA646210    AFP60839.1    JXJN01007398    JXJN01007399    CH933808    EDW09504.2    CM002911    KMY92688.1    L27653    AE013599    AF145673    BT001354    BT099630    ACU64819.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000069272    + More
UP000000673    UP000075882    UP000076407    UP000075903    UP000075840    UP000076408    UP000075885    UP000075884    UP000030765    UP000075900    UP000069940    UP000249989    UP000075883    UP000075886    UP000075920    UP000007062    UP000075880    UP000007819    UP000008820    UP000002320    UP000027135    UP000235965    UP000009046    UP000095301    UP000095300    UP000092460    UP000091820    UP000078200    UP000092445    UP000009192    UP000092443    UP000000803   

PRIDE

H9J2I0    P52034    C7LA80   

Pfam

PF00365   PFK

Interpro

IPR035966   PKF_sf        + More
IPR022953   ATP_PFK       
IPR009161   6-Pfructokinase_euk       
IPR015912   Phosphofructokinase_CS       
IPR000023   Phosphofructokinase_dom       

SUPFAM

SSF53784   SSF53784       

ProteinModelPortal

H9J2I0   A0A2H1W9K4   A0A194PQ53   A0A0F6TNF4   A0A194RH42   A0A2A4K1T8   + More
A0A212FIX8   S4NSV3   A0A2M4BEL6   A0A182FIA4   A0A2M4A324   A0A2M4A375   W5JTT0   A0A1C7CZ10   A0A2M4BEC6   A0A1Y9IXF3   A0A1Y9IRG4   A0A182I3Q9   A0A1Y9I2A6   A0A2M4BED7   A0A182XZI2   A0A1Q3FML9   A0A2M3Z2T4   A0A2M4A337   A0A240PN31   A0A1Y9H0Y5   A0A2K6V9F9   A0A084VFB0   A0A2K6V9F7   A0A182RFP8   A0A023EV74   A0A182MUK8   A0A1B6CPV7   A0A1Y9H9G2   A0A1B6DHL7   A0A182WIS9   A0A1B6DAI8   A0A1Y9IXX5   A0A1Y9IRZ8   A0A1S4GVQ5   A0A1Y9GIZ8   A0A182KRV4   A0A1Y9IS69   A0A1Y9GJI9   A0A182X6F6   Q5TX32   A0A1Q3FMX3   A0A240PNR8   A0A240PPG1   A0A1Q3FMW2   U5EUA4   A0A182P3I4   J9JNX0   A0A1Y9H0J2   A0A1Y9HAX6   A0A182NHK2   A0A1L8E2A1   A0A1Y9HAX5   A0A2C9GUF9   A0A1Y9HA64   A0A1Y9HAY6   Q174J0   A0A2C9GUI7   A0A1Y9IUN1   A0A1Y9IUM9   A0A0K8TN59   A0A182J6F9   A0A240PMF4   A0A336LMI2   B0WNP9   A0A2H8TYE0   W8B915   A0A034V1J7   A0A067QZR7   A0A0K8VIR0   A0A2J7QM39   A0A1W5YLK2   A0A2Z5RE15   A0A0A1X4W6   E0W457   A0A1I8MFB5   V5GLY8   A0A1I8MFB9   A0A1I8MFC8   A0A0K8V1T2   A0A034V5U4   A0A0A1X492   T1PDK0   A0A1I8NRU4   A0A1I8NRU1   A0A1I8NRU9   A0A1B0B232   A0A1A9WMU0   A0A1A9VY37   A0A1B0AGU6   B4KSJ9   A0A1A9YNY9   A0A0J9R9B9   P52034-3   C7LA80  

PDB

4OMT     E-value=0,     Score=2463

KEGG

101745490    K00850 6-phosphofructokinase 1 [EC:2.7.1.11] | (RefSeq) ATP-dependent 6-phosphofructokinase

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
00052    Galactose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)
03018    RNA degradation - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0003872   GO:0005737   GO:0006002   GO:0005524   GO:0070095   GO:0006007   GO:0016208   GO:0005945   GO:0048029   GO:0042802   GO:0030388   GO:0051289   GO:0061621   GO:0016021   GO:0009744   GO:0042593   GO:0007520   GO:0007525   GO:0006096   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm  

Length:

782

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.08559

Exp number, first 60 AAs:

0.0302

Total prob of N-in:

0.01212

outside

1  -  782

 

 

Pi

305.224967

Theta

194.923481

Tajima's D

1.609517

CLR

0.00316

CSRT

0.809459527023649

Interpretation

Uncertain