Gene

KWMTBOMO02741

Pre Gene Modal

BGIBMGA003720

Annotation

PREDICTED:_sphingomyelin_phosphodiesterase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):9946112-9959446      View in EpiBrowser

Full name

Sphingomyelin phosphodiesterase      

Location in the cell

Lysosomal   Reliability : 1.368

CDS

ATGATCATTAGAATATTATGGCTTCTACTACTGGTGATTGTTTCAGTAAGCCCCTGGACATTAGGTAACCCAATATTCCTACAGAAGCCTGGTAAGCCAAACAGACCTGTGATAAAATGGAATCCTCCAACGGACACGTGGAACTGGACTACGAATCCCCGAAACGAGGAACCGTTTTTTGTACCGTCAAATTTTACGCATAAATTGCCACCATCGGCCAATGAAACCGAACTCATAGCTCACATGGCAGCTTTGAAACGTAACTATTCGCGGCTCCTCTGGGATAACGATAAAGGCACGAATTTACCTATGTTCGTTGAAAAAGCATTAAAACTACTCAACTTGAAACAGGTTTATTACGAAGTTGAGCATTCGGTGATGTCCAAAGTGTCGTGCACCGCGTGTAAGGCAGGCGCAGGACTGCTGCAGCACTATATAAGGCTCGGTAAAAGTAAAGATGAGATCAACAAAATGATTTTTCAATTTTGCGTTTCTTTAAAGATTCAATCCGCTCGAGTTTGTGAAGGAATAACGAGATTATTCGGGAGCGAAGTGGTATATGTTTTGAAAAGAATAACAATTGGCCCGGACGAAATATGCAGTTTTGTGATTGGTGACGCTTGTGGCGATGTTTATAATCCATATCACGAATGGGAAGTGGCTTTCCCTCCGGTGCCCAAGCCGACTGTGCGACCTCTCGAATCACCGTTAGAAAAGGCACCCACATTCAAAGTATTGCAGATTTCAGATACGCATTTCGATCCTTATTATGCAGAAGGTGCTAATGCCGAGTGTAATGAACCACTTTGTTGTCGTGCGTCTAACGGACCCGCTCTGACCCCGGGTGGCGGAGCAGGACGTTGGGGAGACTATAGAAAATGTGACACACCGAAGCGCACTATTGATCACATGTTGAAGCACATTGCTGACACACATACAGACATAGACTATATATTGTGGACCGGAGATTTACCACCACATGACGTTTGGAATCAAACGAAGGAAGAAAATCTCAAAGTTTTACAAGAGACTGTTGCACAAATGTCAGATATGTTTCCTGGAGTACCAATTTTCCCAGCTCTAGGAAATCACGAATCTTCTCCGGTAAATAGTTTTCCACCGCCCTACATATCTTCGCCGGACCAAAACATCGCTTGGCTATATGACGAACTTGACACGCAATGGCGACGTTGGCTTCCTGCTGGCGTGTCGCACACCGTACGCCGGGGCGCATTCTACTCGGTACTAGTGAGGCCTGGCTTCCGTATAATATCGCTTAACATGAACTACTGCAATAATAAAAACTGGTTAGTTTTTGTAATTATTACCCAAAAAATTTTTTTTACGTTTTAA

Protein

MIIRILWLLLLVIVSVSPWTLGNPIFLQKPGKPNRPVIKWNPPTDTWNWTTNPRNEEPFFVPSNFTHKLPPSANETELIAHMAALKRNYSRLLWDNDKGTNLPMFVEKALKLLNLKQVYYEVEHSVMSKVSCTACKAGAGLLQHYIRLGKSKDEINKMIFQFCVSLKIQSARVCEGITRLFGSEVVYVLKRITIGPDEICSFVIGDACGDVYNPYHEWEVAFPPVPKPTVRPLESPLEKAPTFKVLQISDTHFDPYYAEGANAECNEPLCCRASNGPALTPGGGAGRWGDYRKCDTPKRTIDHMLKHIADTHTDIDYILWTGDLPPHDVWNQTKEENLKVLQETVAQMSDMFPGVPIFPALGNHESSPVNSFPPPYISSPDQNIAWLYDELDTQWRRWLPAGVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWLVFVIITQKIFFTF

Description

Converts sphingomyelin to ceramide.

Catalytic Activity

H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine

Cofactor

Zn(2+)

Similarity

Belongs to the acid sphingomyelinase family.
Belongs to the G-protein coupled receptor 1 family.

Feature

chain  Sphingomyelin phosphodiesterase

Uniprot

A0A2H1WW48   A0A194RHF1   A0A194PN53   I4DM60   A0A212FIX9   A0A182U186   + More
A0A182XJQ6   A0A182PMW3   A0A182VGX6   A0A182L586   A0A182IIK0   A0A182Q6E2   A0A182IIK1   Q7PZJ1   A0A182Y9I9   A0A182KEX5   A0A182M166   A0A084WIG8   A0A182RXV4   A0A182JHX6   A0A182N2R8   A0A182WQP9   A0A182SBY3   A0A182RXV5   A0A182WQP8   A0A1L8DPQ0   A0A1L8DQ04   A0A1L8DPS5   A0A1S4F4J5   Q17FG9   W5JWZ2   A0A182FZW9   Q17FG8   A0A182FZW8   Q17FH0   W8BSV3   W8ATX5   A0A2M4ALK1   A0A2M4ANM1   A0A2M4BFI8   W8BG77   A0A2M4ALB3   A0A2M4ALQ8   A0A2M4BGF7   A0A2K6VB97   A0A034V391   A0A0K8UKX6   D6WVW3   A0A139WDF2   A0A0A1XFR8   A0A0A1XCZ7   A0A0K8VNE0   A0A034V153   A0A0K8U320   B0WS01   A0A0T6B856   A0A1A9ZW88   A0A1B0FF57   U5TZ69   A0A1Q3FC40   A0A1Q3FEJ9   A0A1Q3FEE2   A0A1Q3FD90   A0A1Q3FBV2   A0A1I8P9V5   A0A1I8P9N2   A0A1I8P9M7   D3TNH1   A0A1A9UKZ8   A0A1A9X4A2   A0A1B0BYE8   A0A1W4UZV4   A0A1A9YGB8   A0A1W4V1F0   A0A0J9RJW2   A0A0J9UA65   A0A0J9RKB0   A0A0J9RKG8   B4QBX0   B3NQH4   A0A336MAU4   A0A026WT08   A0A336MIZ9   A0A1B0GGU0   B4PAW9   B4H694   A0A0R1DTP2   B4MYD9   Q28WU3   N6VFZ6   A0A151WVL7   B4J4T2   A0A3B0IYW2   A0A3B0J2R2   E2C0J8   A0A3B0IZ62   J9JZU0   A0A0M4EDA7   A0A0Q9XK69   B4KMI1  

EC Number

3.1.4.12

Pubmed

26354079    22651552    22118469    20966253    12364791    25244985    + More
24438588    17510324    20920257    24495485    25348373    18362917    19820115    25830018    24324548    20353571    22517621    22936249    17994087    24508170    30249741    17550304    15632085    20798317   

EMBL

ODYU01011505    SOQ57278.1    KQ460207    KPJ16750.1    KQ459597    KPI94861.1    + More
AK402378    BAM19000.1    AGBW02008321    OWR53682.1    APCN01002429    AXCN02001087    AAAB01008986    EAA00261.3    AXCM01001841    ATLV01023931    KE525347    KFB50012.1    GFDF01005626    JAV08458.1    GFDF01005627    JAV08457.1    GFDF01005628    JAV08456.1    CH477271    EAT45275.1    ADMH02000120    ETN67704.1    EAT45276.1    EAT45277.1    GAMC01014261    JAB92294.1    GAMC01014260    JAB92295.1    GGFK01008291    MBW41612.1    GGFK01009011    MBW42332.1    GGFJ01002580    MBW51721.1    GAMC01014259    JAB92296.1    GGFK01008248    MBW41569.1    GGFK01008383    MBW41704.1    GGFJ01002747    MBW51888.1    GAKP01021948    JAC37004.1    GDHF01024977    JAI27337.1    KQ971358    EFA08230.2    KYB25998.1    GBXI01004959    JAD09333.1    GBXI01005491    JAD08801.1    GDHF01011917    JAI40397.1    GAKP01021946    JAC37006.1    GDHF01031381    JAI20933.1    DS232063    EDS33619.1    LJIG01009347    KRT83261.1    CCAG010006382    CCAG010006383    KF417890    AGZ15175.1    GFDL01009901    JAV25144.1    GFDL01009087    JAV25958.1    GFDL01009122    JAV25923.1    GFDL01009552    JAV25493.1    GFDL01010053    JAV24992.1    EZ422973    JQ308535    ADD19249.1    AFJ68090.1    JXJN01022601    CM002911    KMY96303.1    KMY96300.1    KMY96301.1    KMY96302.1    CM000362    EDX08525.1    CH954179    EDV56977.1    UFQT01000641    SSX26029.1    KK107119    QOIP01000009    EZA58816.1    RLU18737.1    SSX26028.1    AJWK01000745    AJWK01000746    AJWK01000747    CM000158    EDW92509.1    CH479213    EDW33318.1    KRK00555.1    CH963894    EDW77128.2    CM000071    EAL26573.2    ENO01975.2    KQ982699    KYQ51950.1    CH916367    EDW00628.1    OUUW01000001    SPP73394.1    SPP73393.1    GL451800    EFN78515.1    SPP73395.1    ABLF02039753    CP012524    ALC41877.1    CH933808    KRG05506.1    EDW10828.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000075902    UP000076407    UP000075885    + More
UP000075903    UP000075882    UP000075840    UP000075886    UP000007062    UP000076408    UP000075881    UP000075883    UP000030765    UP000075900    UP000075880    UP000075884    UP000075920    UP000075901    UP000008820    UP000000673    UP000069272    UP000007266    UP000002320    UP000092445    UP000092444    UP000095300    UP000078200    UP000091820    UP000092460    UP000192221    UP000092443    UP000000304    UP000008711    UP000053097    UP000279307    UP000092461    UP000002282    UP000008744    UP000007798    UP000001819    UP000075809    UP000001070    UP000268350    UP000008237    UP000007819    UP000092553    UP000009192   

Pfam

PF00149   Metallophos        + More
PF00128   Alpha-amylase
PF00001   7tm_1
PF05184   SapB_1

Interpro

IPR011001   Saposin-like        + More
IPR041805   ASMase/PPN1_MPP       
IPR029052   Metallo-depent_PP-like       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR008139   SaposinB_dom       
IPR011160   Sphingomy_PDE       
IPR017853   Glycoside_hydrolase_SF       
IPR006047   Glyco_hydro_13_cat_dom       
IPR000276   GPCR_Rhodpsn       
IPR017452   GPCR_Rhodpsn_7TM       
IPR007856   SapB_1       

SUPFAM

SSF47862   SSF47862        + More
SSF51445   SSF51445       

Gene 3D

3.60.21.10    

CDD

cd00842  MPP_ASMase

ProteinModelPortal

A0A2H1WW48   A0A194RHF1   A0A194PN53   I4DM60   A0A212FIX9   A0A182U186   + More
A0A182XJQ6   A0A182PMW3   A0A182VGX6   A0A182L586   A0A182IIK0   A0A182Q6E2   A0A182IIK1   Q7PZJ1   A0A182Y9I9   A0A182KEX5   A0A182M166   A0A084WIG8   A0A182RXV4   A0A182JHX6   A0A182N2R8   A0A182WQP9   A0A182SBY3   A0A182RXV5   A0A182WQP8   A0A1L8DPQ0   A0A1L8DQ04   A0A1L8DPS5   A0A1S4F4J5   Q17FG9   W5JWZ2   A0A182FZW9   Q17FG8   A0A182FZW8   Q17FH0   W8BSV3   W8ATX5   A0A2M4ALK1   A0A2M4ANM1   A0A2M4BFI8   W8BG77   A0A2M4ALB3   A0A2M4ALQ8   A0A2M4BGF7   A0A2K6VB97   A0A034V391   A0A0K8UKX6   D6WVW3   A0A139WDF2   A0A0A1XFR8   A0A0A1XCZ7   A0A0K8VNE0   A0A034V153   A0A0K8U320   B0WS01   A0A0T6B856   A0A1A9ZW88   A0A1B0FF57   U5TZ69   A0A1Q3FC40   A0A1Q3FEJ9   A0A1Q3FEE2   A0A1Q3FD90   A0A1Q3FBV2   A0A1I8P9V5   A0A1I8P9N2   A0A1I8P9M7   D3TNH1   A0A1A9UKZ8   A0A1A9X4A2   A0A1B0BYE8   A0A1W4UZV4   A0A1A9YGB8   A0A1W4V1F0   A0A0J9RJW2   A0A0J9UA65   A0A0J9RKB0   A0A0J9RKG8   B4QBX0   B3NQH4   A0A336MAU4   A0A026WT08   A0A336MIZ9   A0A1B0GGU0   B4PAW9   B4H694   A0A0R1DTP2   B4MYD9   Q28WU3   N6VFZ6   A0A151WVL7   B4J4T2   A0A3B0IYW2   A0A3B0J2R2   E2C0J8   A0A3B0IZ62   J9JZU0   A0A0M4EDA7   A0A0Q9XK69   B4KMI1  

PDB

5FIC     E-value=1.02475e-58,     Score=575

KEGG

101746583    K12350 sphingomyelin phosphodiesterase [EC:3.1.4.12] | (RefSeq) sphingomyelin phosphodiesterase

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004767   GO:0006685   GO:0046872   GO:0016798   GO:0016021   GO:0016787   GO:0005975   GO:0061750   GO:0005615   GO:0046513   GO:0008081   GO:0005764   GO:0004930   GO:0005634   GO:0008270   GO:0005667   GO:0005737   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

SignalP

Position:   1 - 22,         Likelihood:  0.992230

 

 

Length:

450

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.98943

Exp number, first 60 AAs:

20.93717

Total prob of N-in:

0.96377

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  450

 

 

Pi

203.396761

Theta

171.515688

Tajima's D

1.131154

CLR

0.136266

CSRT

0.695065246737663

Interpretation

Uncertain