Gene

KWMTBOMO02740

Pre Gene Modal

BGIBMGA003720

Annotation

PREDICTED:_sphingomyelin_phosphodiesterase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):9939895-9944646      View in EpiBrowser

Full name

Sphingomyelin phosphodiesterase      

Location in the cell

Mitochondrial   Reliability : 2.252

CDS

ATGAATTTGAAAGAAGCAAATCTGTTTGGATATCCGATATGGTATAAGTTGTACTCGGCCAGGTCTGCGTACCTGATGCCGGCGTTGCGACCGCAAGACTGGGACAAGTTTATTGACGACATGACCGCGAAAGAAGAAGTTTTCAATTTGTATTACAAACACTATTGGAAGAACAGTCCCCGCAGAGGTATGTGCGACAGTGAATGTCGTAAGCGATTGATTTGCGACGCGCGGTCGGGACGATCACACGACCGAAGGGCCCTCTGCGTGCACATCGAAGCACGCATCGACGGCGCCGCACCCACTCCACAGACTTGGAGAGCTTGGCTATATAATGGCTTGTCTGTTTCAGATGAACCTAGCGTACAACAAGTATAA

Protein

MNLKEANLFGYPIWYKLYSARSAYLMPALRPQDWDKFIDDMTAKEEVFNLYYKHYWKNSPRRGMCDSECRKRLICDARSGRSHDRRALCVHIEARIDGAAPTPQTWRAWLYNGLSVSDEPSVQQV

Description

Converts sphingomyelin to ceramide.

Catalytic Activity

H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine

Cofactor

Zn(2+)

Similarity

Belongs to the acid sphingomyelinase family.

Feature

chain  Sphingomyelin phosphodiesterase

Uniprot

H9J2I3   I4DNR9   A0A2H1WW48   A0A212FIX9   I4DM60   A0A194RHF1   + More
A0A0L7KM87   A0A1E1WJC8   A0A194PN53   A0A2P8Y985   A0A151JNZ1   A0A2H8TJK1   A0A1B6CHV1   A0A1B6BX76   A0A0C9R1P7   A0A2S2NPD7   A0A0M8ZR76   A0A0A1XCZ7   A0A2J7Q8U9   A0A2J7Q8T3   A0A2J7Q8T9   A0A154PI80   A0A2S2QDZ0   A0A067RKN2   J9JZU0   A0A0Q9WFK0   A0A1I8P9M7   A0A0A1XFR8   B4J4T2   A0A151JWZ9   B4LK49   A0A151WVL7   A0A195D6Z5   A0A158NFM2   A0A1A9X4A2   F4X0C3   A0A195AXW9   A0A0T6B7T0   A0A1B6F6D2   B4MYD9   A0A1A9UKZ8   A0A0Q9XK69   A0A1I8MSL3   A0A0M4EDA7   B3MDM0   T1P878   T1PA28   B4KMI1   A0A0J7L1C1   A0A1I8MSL0   A0A1B6L7T1   A0A1I8MSI9   A0A1I8P9V5   A0A3B0IYW2   A0A1I8P9N2   A0A1I8MSJ2   A0A1A9YGB8   A0A1I8MSL2   A0A0K8VNE0   A0A026WT08   A0A1B6MBG3   A0A3B0IZ62   A0A3B0J2R2   A0A336MIZ9   A0A0P8XQL7   A0A1B6FP94   A0A0P9AG89   E9IEU7   A0A1B0BYE8   W8BSV3   A0A1A9ZW88   A0A1B0FF57   B4H693   D3TNH1   E2C0J8   A0A1B6MBI5   A0A088A9Y5   A0A034V391   A0A0K8UKX6   A0A2A3E0P7   A0A0K8U320   A0A034V153   E0VT73   W8BG77   W8ATX5   A0A182KEX5   A0A182JHX6   A0A224XJK0   A0A182Q6E2   A0A182N2R8   A0A023F8R8   A0A1B0GGU0   R4G4X4   A0A1L8DPQ0   A0A1L8DPS5   B4IHE2   A0A1L8DQ04   A0A1Y1LHP2   A0A2M4BGF7  

EC Number

3.1.4.12

Pubmed

19121390    22651552    22118469    26354079    26227816    29403074    + More
25830018    24845553    17994087    21347285    21719571    25315136    24508170    30249741    21282665    24495485    20353571    22517621    20798317    25348373    20566863    25474469    28004739   

EMBL

BABH01007983    AK403101    BAM19559.1    ODYU01011505    SOQ57278.1    AGBW02008321    + More
OWR53682.1    AK402378    BAM19000.1    KQ460207    KPJ16750.1    JTDY01008749    KOB64418.1    GDQN01003935    JAT87119.1    KQ459597    KPI94861.1    PYGN01000786    PSN40825.1    KQ978791    KYN28340.1    GFXV01001653    MBW13458.1    GEDC01024328    JAS12970.1    GEDC01031406    JAS05892.1    GBYB01010059    JAG79826.1    GGMR01006395    MBY19014.1    KQ435936    KOX68326.1    GBXI01005491    JAD08801.1    NEVH01016946    PNF24993.1    PNF24992.1    PNF24994.1    KQ434924    KZC11549.1    GGMS01006698    MBY75901.1    KK852458    KDR23573.1    ABLF02039753    CH940648    KRF79525.1    GBXI01004959    JAD09333.1    CH916367    EDW00628.1    KQ981620    KYN39223.1    EDW60638.2    KQ982699    KYQ51950.1    KQ976750    KYN08647.1    ADTU01014665    ADTU01014666    ADTU01014667    GL888497    EGI60081.1    KQ976716    KYM76887.1    LJIG01009347    KRT83262.1    GECZ01024024    JAS45745.1    CH963894    EDW77128.2    CH933808    KRG05506.1    CP012524    ALC41877.1    CH902619    EDV37483.2    KA644797    AFP59426.1    KA644798    AFP59427.1    EDW10828.1    LBMM01001397    KMQ96388.1    GEBQ01020215    JAT19762.1    OUUW01000001    SPP73394.1    GDHF01011917    JAI40397.1    KK107119    QOIP01000009    EZA58816.1    RLU18737.1    GEBQ01006712    JAT33265.1    SPP73395.1    SPP73393.1    UFQT01000641    SSX26028.1    KPU76858.1    GECZ01017734    JAS52035.1    KPU76857.1    GL762722    EFZ20884.1    JXJN01022601    GAMC01014261    JAB92294.1    CCAG010006382    CCAG010006383    CH479213    EDW33317.1    EZ422973    JQ308535    ADD19249.1    AFJ68090.1    GL451800    EFN78515.1    GEBQ01006685    JAT33292.1    GAKP01021948    JAC37004.1    GDHF01024977    JAI27337.1    KZ288472    PBC25325.1    GDHF01031381    JAI20933.1    GAKP01021946    JAC37006.1    DS235760    EEB16579.1    GAMC01014259    JAB92296.1    GAMC01014260    JAB92295.1    GFTR01007786    JAW08640.1    AXCN02001087    GBBI01000925    JAC17787.1    AJWK01000745    AJWK01000746    AJWK01000747    ACPB03007771    GAHY01000995    JAA76515.1    GFDF01005626    JAV08458.1    GFDF01005628    JAV08456.1    CH480838    EDW49166.1    GFDF01005627    JAV08457.1    GEZM01055093    GEZM01055092    JAV73154.1    GGFJ01002747    MBW51888.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000053268    UP000245037    + More
UP000078492    UP000053105    UP000235965    UP000076502    UP000027135    UP000007819    UP000008792    UP000095300    UP000001070    UP000078541    UP000075809    UP000078542    UP000005205    UP000091820    UP000007755    UP000078540    UP000007798    UP000078200    UP000009192    UP000095301    UP000092553    UP000007801    UP000036403    UP000268350    UP000092443    UP000053097    UP000279307    UP000092460    UP000092445    UP000092444    UP000008744    UP000008237    UP000005203    UP000242457    UP000009046    UP000075881    UP000075880    UP000075886    UP000075884    UP000092461    UP000015103    UP000001292   

PRIDE

H9J2I3   

Pfam

PF00149   Metallophos        + More
PF05184   SapB_1

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR011160   Sphingomy_PDE       
IPR041805   ASMase/PPN1_MPP       
IPR029052   Metallo-depent_PP-like       
IPR011001   Saposin-like       
IPR008139   SaposinB_dom       
IPR007856   SapB_1       

SUPFAM

SSF47862   SSF47862       

Gene 3D

3.60.21.10    

CDD

cd00842  MPP_ASMase

ProteinModelPortal

H9J2I3   I4DNR9   A0A2H1WW48   A0A212FIX9   I4DM60   A0A194RHF1   + More
A0A0L7KM87   A0A1E1WJC8   A0A194PN53   A0A2P8Y985   A0A151JNZ1   A0A2H8TJK1   A0A1B6CHV1   A0A1B6BX76   A0A0C9R1P7   A0A2S2NPD7   A0A0M8ZR76   A0A0A1XCZ7   A0A2J7Q8U9   A0A2J7Q8T3   A0A2J7Q8T9   A0A154PI80   A0A2S2QDZ0   A0A067RKN2   J9JZU0   A0A0Q9WFK0   A0A1I8P9M7   A0A0A1XFR8   B4J4T2   A0A151JWZ9   B4LK49   A0A151WVL7   A0A195D6Z5   A0A158NFM2   A0A1A9X4A2   F4X0C3   A0A195AXW9   A0A0T6B7T0   A0A1B6F6D2   B4MYD9   A0A1A9UKZ8   A0A0Q9XK69   A0A1I8MSL3   A0A0M4EDA7   B3MDM0   T1P878   T1PA28   B4KMI1   A0A0J7L1C1   A0A1I8MSL0   A0A1B6L7T1   A0A1I8MSI9   A0A1I8P9V5   A0A3B0IYW2   A0A1I8P9N2   A0A1I8MSJ2   A0A1A9YGB8   A0A1I8MSL2   A0A0K8VNE0   A0A026WT08   A0A1B6MBG3   A0A3B0IZ62   A0A3B0J2R2   A0A336MIZ9   A0A0P8XQL7   A0A1B6FP94   A0A0P9AG89   E9IEU7   A0A1B0BYE8   W8BSV3   A0A1A9ZW88   A0A1B0FF57   B4H693   D3TNH1   E2C0J8   A0A1B6MBI5   A0A088A9Y5   A0A034V391   A0A0K8UKX6   A0A2A3E0P7   A0A0K8U320   A0A034V153   E0VT73   W8BG77   W8ATX5   A0A182KEX5   A0A182JHX6   A0A224XJK0   A0A182Q6E2   A0A182N2R8   A0A023F8R8   A0A1B0GGU0   R4G4X4   A0A1L8DPQ0   A0A1L8DPS5   B4IHE2   A0A1L8DQ04   A0A1Y1LHP2   A0A2M4BGF7  

PDB

5FIC     E-value=7.19436e-09,     Score=137

KEGG

101746583    K12350 sphingomyelin phosphodiesterase [EC:3.1.4.12] | (RefSeq) sphingomyelin phosphodiesterase

GO

GO:0016798   GO:0046872   GO:0006685   GO:0004767   GO:0016021   GO:0016787  

Length:

125

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08899

Exp number, first 60 AAs:

0.08899

Total prob of N-in:

0.08587

outside

1  -  125

 

 

Pi

243.560594

Theta

177.252798

Tajima's D

1.202218

CLR

0.041257

CSRT

0.711614419279036

Interpretation

Uncertain