Gene

KWMTBOMO02693  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003742

Annotation

PREDICTED:_phospholipid_scramblase_2_isoform_X1_[Papilio_xuthus]

Location

Bomo_Chr5(-):8970738-8980874      View in EpiBrowser

Full name

Phospholipid scramblase       + More
Phospholipid scramblase 2      

Alternative Name

Ca(2+)-dependent phospholipid scramblase 2

Location in the cell

Extracellular   Reliability : 1.802 Nuclear   Reliability : 1.623

CDS

ATGTCACATAAACCAACACCATACTCACCAAATTTCCCTGCAAGTCATGGATATGTACCTCCACCAGAAGGAGAAAAGCCAAATGAAAGTTACCCCATGCATCCTCAAAGCGGCTATCCTGGCCCACCACCCACTCCTATGCCACACCCCGGCCTACATCCTGGGGCACAACCCCTTCCGGGCATGCAGCATGGGTTCCAGCCAGGATTTCAACCTGGCTATCAACCAGGATTTGCTCCTGGATATCCTCAGCCTAGTGGATATCCGGTACCAGTGATGCAACAACCAGGTCCACAAGCTCCAGGTGGTTGGATGAATATGCCGCAAGGCCTCAGCAACTGCCCTCGAGGTTTGGAATACCTTTCCATGATTGACCAACTGATAATGCATCAGAAAGTTGAATTATTAGAAGCTTTTGTTGGGTTCGAGACAAACAACAAATACACAGTTATGAACAGTGTTGGTCAAAAAGTTTATTATGCGATTGAGGATAATGATTGCTGCACAAGAAACTGCTGCGGACCTTTACGTCCTTTCGATATGAAAATTATGGACAACTTCAATAATGAGGTGTATTCGAAGGATGGAGAAACGAAAGTTGGCAAAATCACGAAGTCGTGGTCTGGATTTGCACGCGAAGCCTTCACCGATGCCGACAATTTTGGGATAAGTTTCCCGATGGACCTGGACGTCAAAATCAAAGCTGTACTCCTTGGAGCATGTTTTCTCATAGATTTTATGTTCTTTGAAAAAGGCAACAACAATCGCAACTGA

Protein

MSHKPTPYSPNFPASHGYVPPPEGEKPNESYPMHPQSGYPGPPPTPMPHPGLHPGAQPLPGMQHGFQPGFQPGYQPGFAPGYPQPSGYPVPVMQQPGPQAPGGWMNMPQGLSNCPRGLEYLSMIDQLIMHQKVELLEAFVGFETNNKYTVMNSVGQKVYYAIEDNDCCTRNCCGPLRPFDMKIMDNFNNEVYSKDGETKVGKITKSWSGFAREAFTDADNFGISFPMDLDVKIKAVLLGACFLIDFMFFEKGNNNRN

Description

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system (By similarity).

Cofactor

Ca(2+)

Similarity

Belongs to the phospholipid scramblase family.

Keywords

Calcium   Complete proteome   Lipoprotein   Membrane   Metal-binding   Palmitate   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Phospholipid scramblase 2

Uniprot

H9J2K5   A0A194RH99   A0A2A4JBK1   A0A194PPA5   A0A2H1W112   A0A2U4B9Y0   + More
A0A164K3H3   I4DRJ1   S7PKU0   A0A2Y9FAX0   A0A182UQK5   A0A182XIL7   A7UTQ0   A0A182HM28   A0A336LIQ1   A0A0L8HP27   A0A3Q0CG14   A0A182NLZ8   A0A023EP48   W8BMU4   H0XGL6   A0A034V5I4   Q3ZBG9   L8IBI8   A0A1L8DKT2   A0A0A1WZG5   A0A1S4FR97   Q16S90   A0A1Q3FYP9   A0A1Q3G488   A0A0M3QWA3   A0A2U3V139   A0A341DDA9   A0A1Q3G455   A0A1Q3G454   A0A1Q3G442   A0A2Y9NZM1   A0A2Y9P824   A0A182H417  

Pubmed

19121390    26354079    22651552    12364791    14747013    17210077    + More
24945155    24495485    25348373    22751099    25830018    17510324    26483478   

EMBL

BABH01008122    BABH01008123    KQ460207    KPJ16695.1    NWSH01002038    PCG69341.1    + More
KQ459597    KPI94813.1    ODYU01005650    SOQ46717.1    LRGB01003375    KZS02914.1    AK405142    BAM20531.1    KE163298    EPQ11468.1    AAAB01008960    EDO63672.1    APCN01004327    APCN01004328    APCN01004329    UFQS01000007    UFQT01000007    SSW97099.1    SSX17485.1    KQ417640    KOF90957.1    GAPW01002366    JAC11232.1    GAMC01008227    GAMC01008224    JAB98328.1    AAQR03063136    AAQR03063137    GAKP01020406    GAKP01020404    JAC38546.1    BC103299    JH881519    ELR53830.1    GFDF01007001    JAV07083.1    GBXI01010514    JAD03778.1    CH477680    EAT37325.1    GFDL01002387    JAV32658.1    GFDL01000466    JAV34579.1    CP012525    ALC43799.1    GFDL01000464    JAV34581.1    GFDL01000462    JAV34583.1    GFDL01000463    JAV34582.1    JXUM01108608    KQ565247    KXJ71181.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000245320    UP000076858    + More
UP000075903    UP000076407    UP000007062    UP000075840    UP000053454    UP000189706    UP000075884    UP000005225    UP000009136    UP000008820    UP000092553    UP000252040    UP000248483    UP000069940    UP000249989   

PRIDE

H9J2K5    Q3ZBG9   

Pfam

PF03803   Scramblase

Interpro

IPR005552   Scramblase        + More
IPR025659   Tubby-like_C       

SUPFAM

SSF54518   SSF54518       

ProteinModelPortal

H9J2K5   A0A194RH99   A0A2A4JBK1   A0A194PPA5   A0A2H1W112   A0A2U4B9Y0   + More
A0A164K3H3   I4DRJ1   S7PKU0   A0A2Y9FAX0   A0A182UQK5   A0A182XIL7   A7UTQ0   A0A182HM28   A0A336LIQ1   A0A0L8HP27   A0A3Q0CG14   A0A182NLZ8   A0A023EP48   W8BMU4   H0XGL6   A0A034V5I4   Q3ZBG9   L8IBI8   A0A1L8DKT2   A0A0A1WZG5   A0A1S4FR97   Q16S90   A0A1Q3FYP9   A0A1Q3G488   A0A0M3QWA3   A0A2U3V139   A0A341DDA9   A0A1Q3G455   A0A1Q3G454   A0A1Q3G442   A0A2Y9NZM1   A0A2Y9P824   A0A182H417  

KEGG

101738538    no KO assigned | (RefSeq) phospholipid scramblase 1

GO

GO:0016021   GO:0005509   GO:0019899   GO:0006915   GO:0051607   GO:2000373   GO:0042609   GO:0005154   GO:0005887   GO:0045071   GO:0062023   GO:0035456   GO:0048471   GO:0017124   GO:0017128   GO:0005829   GO:0045089   GO:0045121   GO:0005794   GO:0001228   GO:0005730   GO:0017121   GO:0046872   GO:0005886  

PANTHER

PTHR23248  

Subcellular location

Membrane  

Length:

257

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.28974

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04291

outside

1  -  257

 

 

Pi

220.77178

Theta

180.956179

Tajima's D

1.022205

CLR

0.318766

CSRT

0.669566521673916

Interpretation

Uncertain