Gene

KWMTBOMO02650

Pre Gene Modal

BGIBMGA002650

Annotation

hydroxymethylglutaryl-CoA_lyase_[Bombyx_mori]

Location

Bomo_Chr5(-):7922488-7936768      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 1.293

CDS

ATGAATAATGTTACAAAAACTTGCGTTCTTAATATACTCCGTTCTAATAACTTCTTGCAACGTAGTCTTAGTACAGTAGCCCCTGAAATCAGAATTTATGAAGTAGGACCGAGAGATGGCCTTCAAAATGAATCTAAGTTTGTTCCAACAGACATTAAAGTTGAACTCATTAGTAAAATCGTTGCTGCAGGTATAAAAAATGTAGAATCTGCAAGTTTTGTCAGTCCAAAATGGGTTAAACAAATGAGTGACAGTGTTGATGTTATGAAAAATATTCAAAGAGTGCCTGGAGTGAATTACCCTGTACTTGTTCCAAATTTGAAAGGATATGAAACAGCTAAACAATGCAACGTAGAAGAAATTGCTATATTTCCTGCTGGTTCGGAAGGATTTTCACAAAAAAATCTAAATTGCTCGGTGGAAGAAGGTCTTAGAAGATTTAAACAGGTCGCGGACGAGGCCGTTCGTGACGGCTTGCGAGTAAGGGGATATATTTCATGTGTTGTTGGTTGTCCCTACGATGGACCGATTCACCCGAAAAATATTGCTAAGATAACAGAACAATTGATTGCGATGGGCTGTTATGAAGTATCGCTTGGTGATACGATTGGAGTAGGCACGGCCGGCTCCGTCCGCCGACTTCTTCATGAAATCCTCACTGTCGCAAAACCGGAACAACTAGCCCTTCACTTCCATGACACATACGGACAAGGACTTTCCAATTTACTAGCTGGCCTCGAATTTGGTATTAAAACAGTAGATTCTTCCATCTCCGGACTCGGCGGATGCCCGTATGCACGCGGCGCGAGCGGTAACCTTGCCACCGAAGACCTAGTCTATTTCCTGTATGGCCTGGGAGTCAACACTGACGTAGACCTAGTAAAGATTATAGAAGCAGGTCGATACATTTCCAACTTCCTTGGAAAACCTACCGAATCCAAAGTTAACAGGGTCATTAGTGATAGATTTACTAATTACAGAGATATTGTCAAACTAGCGTCTTGTAATTGTTCATAG

Protein

MNNVTKTCVLNILRSNNFLQRSLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQMSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGDTIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYGQGLSNLLAGLEFGIKTVDSSISGLGGCPYARGASGNLATEDLVYFLYGLGVNTDVDLVKIIEAGRYISNFLGKPTESKVNRVISDRFTNYRDIVKLASCNCS

Uniprot

Q2F685   A0A068FML6   A0A2A4K7D1   A0A1V0M858   A0A0P0EW22   A0A194RL07   + More
A0A212FAD4   A0A1Z2RRL3   A0A194PMX4   A0A2W1BL34   I4DKT7   S4PXV1   A0A2S2Q9R4   A0A0L7LIZ6   A0A2H8TDC4   J9JNQ5   A0A2S2N8W0   A0A0M4E097   A0A1B6E3A3   A0A1B6EG21   A0A1I8MLQ1   B4KJT9   T1PAG6   A0A034W4I4   A0A1L8E0E1   A0A1I8P856   B3N673   A0A1L8E0J2   A0A2H0DC66   A0A0T6AYB1   U5EV24   A0A0K8VS82   Q29JX1   B4GJ06   A0A1I8P835   B3MKS8   B4NZY2   A0A0L0BQD7   B4LRF1   A0A1D1USM0   A0A0P4WEF2   B4HY09   A0A0J9QY70   A0A2J7RQL9   Q9VM58   A0A3B0JH82   Q4V3J3   A0A2A4URF2   A0A1W0A6I7   D2VQL9   A0A2A4TL94   A0A0P5LGC6   A0A084VMH8   A0A3B0RD10   A0A0N8APU4   A0A154VJN6   W8AYA2   A0A2U1WQV7   A0A2W4LWR3   A0A2J7RQP2   A0A1V9ZE25   A0A182P6E9   A0A1X7ULZ5   A0A1W4UBN6   A0A0P5MSL3   A0A2T8I799   A0A2A5CKY2   A0A1J1HS28   J3JX73   A0A369TC19   A0A2U1VHB5   F7BBT8   A0A1W3JEL8   A0A1W6CIJ1   A0A024UQZ2   A0A3N1KVD1   A0A0P5DZG9   A0A1G4SPC9   A0A3B0RPT1   E9H2A9   A0A3L6PLN2   A0A1Y1KSU5   H2XSN3   K3XAW7   A0A1Y1XX93   A0A1B0BLP4   A0A2S3IC76   A0A1A9URL7   A0A182K9C7   D3TP72   A0A0K8TKP7   T0QEW1   B4JPT0   A0A067CPT5   A0A0U5G0Y4   Q6INN1   A0A1L8GTJ9   A0A328E5J7   A0A2W5HJC7  

Pubmed

26385554    28349297    26445454    26354079    22118469    28605547    + More
28756777    22651552    23622113    26227816    25315136    17994087    25348373    15632085    17550304    26108605    27649274    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    29099490    25527045    20211133    24438588    24495485    22516182    12481130    15114417    21292972    30683860    28004739    20353571    26369729    23785293    27762356   

EMBL

DQ311187    ABD36132.1    KJ622053    AID66661.1    NWSH01000078    PCG79838.1    + More
KU755470    ARD71180.1    KT261688    ALJ30228.1    KQ460207    KPJ16661.1    AGBW02009501    OWR50679.1    KY938839    ASA46480.1    KQ459597    KPI94781.1    KZ150098    PZC73566.1    AK401905    BAM18527.1    GAIX01004398    JAA88162.1    GGMS01005087    MBY74290.1    JTDY01000927    KOB75405.1    GFXV01000284    MBW12089.1    ABLF02031568    GGMR01001044    MBY13663.1    CP012523    ALC38478.1    GEDC01004886    JAS32412.1    GEDC01000420    JAS36878.1    CH933807    EDW12542.2    KA644918    AFP59547.1    GAKP01009907    GAKP01009905    GAKP01009903    GAKP01009901    JAC49045.1    GFDF01001886    JAV12198.1    CH954177    EDV59160.1    GFDF01001885    JAV12199.1    PCTP01000224    PIP79200.1    LJIG01022578    KRT79829.1    GANO01002070    JAB57801.1    GDHF01010578    JAI41736.1    CH379062    EAL32840.1    CH479184    EDW37320.1    CH902620    EDV31609.1    CM000157    EDW87809.1    JRES01001533    KNC22226.1    CH940649    EDW64621.1    BDGG01000001    GAU90227.1    GDRN01069555    JAI64027.1    CH480818    EDW51939.1    CM002910    KMY88664.1    NEVH01000641    PNF43139.1    AE014134    BT031041    AAF52467.2    ABV82423.1    OUUW01000006    SPP81545.1    BT023363    AAY55779.1    NVTJ01000046    PCI47767.1    JNBS01000405    OQS05902.1    GG738889    EFC40971.1    NVTE01000001    PCI34396.1    GDIQ01171872    GDIP01111506    JAK79853.1    JAL92208.1    ATLV01014596    KE524975    KFB39172.1    UOED01000063    VAV90960.1    GDIQ01254707    JAJ97017.1    LPXN01000156    KZD01552.1    GAMC01016734    GAMC01016732    JAB89823.1    LGQZ01000028    PWC54342.1    QGUL01000021    PZN05860.1    PNF43138.1    JNBR01000154    OQR96080.1    GDIQ01159682    JAK92043.1    CM008053    PVH33551.1    NVVY01000002    PCJ44539.1    CVRI01000020    CRK90888.1    BT127841    AEE62803.1    QPMH01000004    RDD62891.1    LGRA01000021    PWC33413.1    EAAA01002742    CP015848    ARJ64666.1    KI913953    ETW08719.1    RJKX01000016    ROP83924.1    GDIP01154853    JAJ68549.1    FMTS01000005    SCW71013.1    UOEJ01000053    VAV93899.1    GL732585    EFX74176.1    PQIB02000017    RLM58199.1    GEZM01074931    JAV64404.1    GL376565    MCFE01000384    ORX90360.1    JXJN01016527    PAN41166.1    CCAG010006129    EZ423224    ADD19500.1    GDAI01002895    JAI14708.1    JH767160    EQC33281.1    CH916372    EDV98910.1    KK583198    KDO31235.1    LN997848    CUW41810.1    BC072247    AAH72247.1    CM004471    OCT87141.1    NQVE01000046    RAL51908.1    QFOK01000277    PZP57650.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    UP000007819    + More
UP000092553    UP000095301    UP000009192    UP000095300    UP000008711    UP000001819    UP000008744    UP000007801    UP000002282    UP000037069    UP000008792    UP000186922    UP000001292    UP000235965    UP000000803    UP000268350    UP000243217    UP000006671    UP000030765    UP000076400    UP000245126    UP000243579    UP000075885    UP000007879    UP000192221    UP000243499    UP000183832    UP000253941    UP000245184    UP000008144    UP000193515    UP000024375    UP000278222    UP000199150    UP000000305    UP000275267    UP000193498    UP000092460    UP000078200    UP000075881    UP000092444    UP000030762    UP000001070    UP000030745    UP000063191    UP000186698    UP000248728   

PRIDE

Q2F685    Q9VM58    Q4V3J3   

Pfam

PF00682   HMGL-like        + More
PF03102   NeuB

Interpro

IPR000891   PYR_CT        + More
IPR027167   HMG-CoA_lyase       
IPR013785   Aldolase_TIM       
IPR000138   HMG_CoA_lyase_AS       
IPR013132   Neu5Ac_N       
IPR030020   HL_mitochondrial       

Gene 3D

3.20.20.70    

ProteinModelPortal

Q2F685   A0A068FML6   A0A2A4K7D1   A0A1V0M858   A0A0P0EW22   A0A194RL07   + More
A0A212FAD4   A0A1Z2RRL3   A0A194PMX4   A0A2W1BL34   I4DKT7   S4PXV1   A0A2S2Q9R4   A0A0L7LIZ6   A0A2H8TDC4   J9JNQ5   A0A2S2N8W0   A0A0M4E097   A0A1B6E3A3   A0A1B6EG21   A0A1I8MLQ1   B4KJT9   T1PAG6   A0A034W4I4   A0A1L8E0E1   A0A1I8P856   B3N673   A0A1L8E0J2   A0A2H0DC66   A0A0T6AYB1   U5EV24   A0A0K8VS82   Q29JX1   B4GJ06   A0A1I8P835   B3MKS8   B4NZY2   A0A0L0BQD7   B4LRF1   A0A1D1USM0   A0A0P4WEF2   B4HY09   A0A0J9QY70   A0A2J7RQL9   Q9VM58   A0A3B0JH82   Q4V3J3   A0A2A4URF2   A0A1W0A6I7   D2VQL9   A0A2A4TL94   A0A0P5LGC6   A0A084VMH8   A0A3B0RD10   A0A0N8APU4   A0A154VJN6   W8AYA2   A0A2U1WQV7   A0A2W4LWR3   A0A2J7RQP2   A0A1V9ZE25   A0A182P6E9   A0A1X7ULZ5   A0A1W4UBN6   A0A0P5MSL3   A0A2T8I799   A0A2A5CKY2   A0A1J1HS28   J3JX73   A0A369TC19   A0A2U1VHB5   F7BBT8   A0A1W3JEL8   A0A1W6CIJ1   A0A024UQZ2   A0A3N1KVD1   A0A0P5DZG9   A0A1G4SPC9   A0A3B0RPT1   E9H2A9   A0A3L6PLN2   A0A1Y1KSU5   H2XSN3   K3XAW7   A0A1Y1XX93   A0A1B0BLP4   A0A2S3IC76   A0A1A9URL7   A0A182K9C7   D3TP72   A0A0K8TKP7   T0QEW1   B4JPT0   A0A067CPT5   A0A0U5G0Y4   Q6INN1   A0A1L8GTJ9   A0A328E5J7   A0A2W5HJC7  

PDB

3MP3     E-value=2.7136e-92,     Score=863

KEGG

692821    K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] | (RefSeq) Hmgc; hydroxymethylglutaryl-CoA lyase

PATHWAY

00072    Synthesis and degradation of ketone bodies - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00650    Butanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0005829   GO:0004419   GO:0016051   GO:0006551   GO:0005777   GO:0005759   GO:0003824   GO:0016021   GO:0016829   GO:0046951   GO:0006629   GO:0006552   GO:0005739   GO:0008270   GO:0006812   GO:0015299   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

PANTHER

PTHR42738:SF4   PTHR42738:SF12  

Length:

338

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0355599999999999

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.05851

outside

1  -  338

 

 

Pi

215.444753

Theta

172.263189

Tajima's D

0.272499

CLR

1.480107

CSRT

0.445077746112694

Interpretation

Possibly Positive selection