Gene
KWMTBOMO02645
Pre Gene Modal
BGIBMGA002656
Annotation
PREDICTED:_histone-lysine_N-methyltransferase?_H3_lysine-79_specific_isoform_X7_[Bombyx_mori]
Full name
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Alternative Name
Histone H3-K79 methyltransferase
Location in the cell
Nuclear Reliability : 4.093
Sequence
CDS
ATGGCTTTGGATTTACGCCTGCATTCTCCTGCGGGCGCGGAACCTGTTGTTTATACATGGCCCCTCACTTCAGGTCATGGCTCGGACAAACACGATGGAGCTTTGGAAATAGTAGAAACTATAAGATGGGTTTGCGACGATTTACCCGAGATGAAGGCCGCTTTGGAGTACAACATACTTTGCGATTACGATACTCATTCATACGAAAGTATGCGAGCCCTTTGCGACCGTTTCAACCGAGCCATCGATTCTGTAGTTGCTTTGGAAAAAGGTACGTCCTTACCAGCACAACGGTTAAACAAGTATCCTTCAAGAGGCTTACTGAAGCACATATTACAACAAACCTACAATCAAGCCGTAGCGGATCCCGAAAAATTAAATCAATACGAACCCTTTTCTCCCGAGGTGTACGGTGAGACTTCTTACGAGTTAGTTTGTCAAATGATAGATCAAATAGAAATATCAGCTGACGATGTATTTGTGGACTTGGGCTCAGGTGTGGGACAGGTTGTACTACAAATGGCAGCTGCAACACCGTGTCGCATCTGCCTCGGTGTTGAAAAGGCAGAAGTTCCTAGTAAATATGCTGAGAACATGGATTTGCATTTTAGGATGTGGATGAAATGGTATGGCAAAAAGTATGGAGAGTATAAATTAATAAAAGGCGACTTTTTGTTGGATGAGCATCGGGAAAAAATAAATGCTGCTACAATTGTTTTTGTCAATAACTTTGCATTTGGACCACACGTTGATCACCAGCTAAAAGAAAGATTTGCAGATTTAAAAGATGGTGCGAAAATAGTGTCATCAAAAAGCTTTTGTCCATTAAATTTTCGAATAACGGACAGGAATCTGAGTGATATTGGAACCATTATGCACGTAAGCGAGATGACGCCACTGAAAGGCTCCGTTTCTTGGACGGGGAAACCAGTATCATATTATTTGCATATAATAGATAGGACCAAATTGGAGAGATATTTTCAAAGACTGAAAAATCCGAAACTCAAGGTCAGCAAAAGGGGTTCACATAACGGGTGTGAAGATGGAGAAGGAAGCGGTAAACGAAACCTCAGTGCCCCTCCAACAAGACAGCCTACGCCTGATCTACTCAACGGCAACAGCAATCACAGCACGGGCTCACTGCCAGAGCGCAGACGGAAGGTAGCACGCCCTAGGACTGTCAGGGGTGACAATGGGCGCACACGTCGTGCTGCGGCCGCCAAGAGACGCGTGGCACGGCGCTCCAGTGACGAGAGCGACGAGGAGTCTAGCGGCACAGACGACGCACCGCCTGGACCAGAACCTGCGCCCAGGGAGTGGGGCGCTCCTTGGGCCTCATCGTCCGACTCCAACCGTAGCCGTCGAGCGACGAGTAAGCGCGTGGCGTCGGGCGGAGGCGCGCGGCGGCGAGCGGCCCGCGCCAAGCGACGCCGCACCACGCCCGCCGCCATCGCCGGCCTGGACTTGCTGCACTCCACCACGCTCGAGTCCACCATACACAACGGCTCCGTGACGGCCCCGCCGCCGGGCTGCGTGGGGCAGCGGCTGTCGGCGCTGGGCGTGCAGCTGCAGCCCGCCGAGCGCCTGCACTCCGAGCTCGACATCCCGCGCTCGCCGCACACCCCCTACAGCCTCCAGCTACTGCTCGATATGTTCCGGGACCAGTACCTCGCTTTCATCCAGCGCATGAATACGCCTGAATACGCCAATGAAATACGAAACCAAATAGAGAAAGAAAAGGAAAAAAATCATAAATTGAAATCGAGAGCATCTCAATTGGACAAACAAATTAACGTCTTAATAAGTGACAGTGTAGCACTTCTCAAAGCCCGCATGAGCGAGCTTGGCATCCACGCCAACAACACCGTTGACCTCTTAGCGAAAGCGAAAGAAATCGTCGGAAGACACAAAGAACTGCAAAGTAAAGCGAGTAAATTACAAGCCCAGGTGAATAGTATAGAAGCTGAACAGGCAGTGCTAGTAAAACAACGGACGTTTGAAATTACTGAAAAGTATCGGCAGCTCGGACACGTACCACATGATGCTGAAGTTACTCAAAGCATAGCTCAAGAGTGTATTTTAAAAGAAATTTCGGCCACTTTAGCCCACAGGAAAAGATTACACGCTCAAGTGGGTCATTTACAAAATGAAATCACGCAGATGGAAAGGGCTAGCGAACAGAAACCGACCACTTCCTCCGTTCCCGTCACTCCCGTCAAGATGCACGCGGTTAACGCGAAACCGAGAAAGAGAGAACAGCGTTCGCGATCACAAGAATGGCCCGAGGTTCCGGATATTGGCAAAATAGAAGAGCAGAACCCGGAACTCCTCGCTCAGAAGATACTCGAGACGGGACGACAGATCGAAGCCGGAAAGGTCACCAAACCTAACGTCATAGTCAACGGATACACGAGAGAATCCGAACGACTCGACAGGTACCCAAAATCGACCACTCCGAACCCTAGGCCCCAGACGCAACGCCCGTCTCTCGCTCATAGGCATTCGCCTGTAAAATCCCAGAAACCACTTAACGTTATCGGTAAAGTTCAAGAATCACCGAAAGTGATCAATTTCGAAGACAGGCTGAAGAGTATAATAACTTCGGTGTTGAACGAAGACCAAGAACAGAGGAAAGCTTCTCGGCAGGTGACACCGAGCAGTCCGTACAGTAACGGGTACGTGACGGGCCGACCCACCGCCGCCTTCCCGCCGCGCCGCGACCTGCGCCGGGAGAGGTTCCCCTTCGAGCGCCACCACCACCCCCACCAGCCCCACCAGCCGGACTACACGCAGGTAACTTCACTACCGATACACATTCATTACATATTTACTAATGCCGAGAGCCTTGACGTCATCTTTCGCATTCCGCATATCATCAAATCTAAACTATTATAA
Protein
MALDLRLHSPAGAEPVVYTWPLTSGHGSDKHDGALEIVETIRWVCDDLPEMKAALEYNILCDYDTHSYESMRALCDRFNRAIDSVVALEKGTSLPAQRLNKYPSRGLLKHILQQTYNQAVADPEKLNQYEPFSPEVYGETSYELVCQMIDQIEISADDVFVDLGSGVGQVVLQMAAATPCRICLGVEKAEVPSKYAENMDLHFRMWMKWYGKKYGEYKLIKGDFLLDEHREKINAATIVFVNNFAFGPHVDHQLKERFADLKDGAKIVSSKSFCPLNFRITDRNLSDIGTIMHVSEMTPLKGSVSWTGKPVSYYLHIIDRTKLERYFQRLKNPKLKVSKRGSHNGCEDGEGSGKRNLSAPPTRQPTPDLLNGNSNHSTGSLPERRRKVARPRTVRGDNGRTRRAAAAKRRVARRSSDESDEESSGTDDAPPGPEPAPREWGAPWASSSDSNRSRRATSKRVASGGGARRRAARAKRRRTTPAAIAGLDLLHSTTLESTIHNGSVTAPPPGCVGQRLSALGVQLQPAERLHSELDIPRSPHTPYSLQLLLDMFRDQYLAFIQRMNTPEYANEIRNQIEKEKEKNHKLKSRASQLDKQINVLISDSVALLKARMSELGIHANNTVDLLAKAKEIVGRHKELQSKASKLQAQVNSIEAEQAVLVKQRTFEITEKYRQLGHVPHDAEVTQSIAQECILKEISATLAHRKRLHAQVGHLQNEITQMERASEQKPTTSSVPVTPVKMHAVNAKPRKREQRSRSQEWPEVPDIGKIEEQNPELLAQKILETGRQIEAGKVTKPNVIVNGYTRESERLDRYPKSTTPNPRPQTQRPSLAHRHSPVKSQKPLNVIGKVQESPKVINFEDRLKSIITSVLNEDQEQRKASRQVTPSSPYSNGYVTGRPTAAFPPRRDLRRERFPFERHHHPHQPHQPDYTQVTSLPIHIHYIFTNAESLDVIFRIPHIIKSKLL
Summary
Catalytic Activity
L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Miscellaneous
In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Uniprot
EC Number
2.1.1.43
EMBL
Proteomes
PRIDE
Pfam
PF08123 DOT1
SUPFAM
SSF53335
SSF53335
ProteinModelPortal
PDB
4WVL
E-value=6.93142e-132,
Score=1209
Ontologies
GO
PANTHER
Topology
Subcellular location
Nucleus
Length:
964
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00353
Exp number, first 60 AAs:
0.0002
Total prob of N-in:
0.00003
outside
1 - 964
Population Genetic Test Statistics
Pi
236.179701
Theta
162.261531
Tajima's D
0.277175
CLR
1.796653
CSRT
0.449527523623819
Interpretation
Uncertain
