Silkworm Genome Informatics Database

Gene

KWMTBOMO02644

Annotation

PREDICTED:_histone-lysine_N-methyltransferase?_H3_lysine-79_specific_isoform_X5_[Bombyx_mori]

Location

Bomo_Chr5(-):7794252-7795898 View in EpiBrowser

Full name

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Alternative Name

Histone H3-K79 methyltransferase

Location in the cell

Nuclear Reliability : 3.621

CDS

ATGCGTATTTCGGTTTCCCCGGCTAAGCTGGCGTTGCGGCGACACCTGTCGCAGGAGCGGCTCGCGGCGCCGGCGCGCACCATCGGCGACCTCGTCAACGGCGAGATCGAGCGCACCCTCGAGATCTCCAACCAGAGCATCATCAACGCGGCCGTCAACATGAGCGCGCGCTATCACGACGCCAACGGGACGCCGGCCCCGCATCAACCGCTAGAAGGGCTAGCGGCTTGCTTACAAGCCCGTGTTTTGGCTTCTGAGTACTGGCGCGGACGGAACGGCGTCAACGGAGGTTCTAATACTCCGAACGGCAGCGTTTCGGGCGACCTGGAGGATTCCCGTCCTCGGTCTCCGCCGCCCGATCCTCATTCGAACACGTCTACCCCTCTGGTCGATGAATCACCGGACGGTGGAAGGATACCCGAAGTAGAAGGTTGCGAGGAAGTAGACGAAAGTAAATGGCAAGATCGCATAGCTTTTCGTTTTGATCAAATAATATCGTTCGCGTCGACGGCGATCGAGGACAAGCGGCGGCGCTCGGACGAGGCGTGCAACACGTCGCCCGACTCCGGCATCGGGCACGGCGAGGCGGCGGCCGTGGCGGCGGCGGCGGCGGGCGGCGCGCGCGGCGACACGGCGCTGCAGCACTTCCCGCCGCACCACTTCAAGAAGCGGCTGTACCGGCGGTCGCGCTGGGGAGCCGCCGACTGGGAGCGCCCGCCGATGTGA

Protein

MRISVSPAKLALRRHLSQERLAAPARTIGDLVNGEIERTLEISNQSIINAAVNMSARYHDANGTPAPHQPLEGLAACLQARVLASEYWRGRNGVNGGSNTPNGSVSGDLEDSRPRSPPPDPHSNTSTPLVDESPDGGRIPEVEGCEEVDESKWQDRIAFRFDQIISFASTAIEDKRRRSDEACNTSPDSGIGHGEAAAVAAAAAGGARGDTALQHFPPHHFKKRLYRRSRWGAADWERPPM

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

Uniprot

H9IZH1 A0A212FJU6 A0A2H1VS65 A0A194PMW4 A0A194RGT5 A0A1B6D0N3 + More
A0A1L8DWJ1 A0A1S3DV74 A0A1B6FNA8 A0A146MAN7 A0A2S2N8X2 A0A0A9X222 A0A0K8T0W5 A0A2S2QCP4 A0A2H8TUL3

EC Number

2.1.1.43

Pubmed

19121390 22118469 26354079 26823975 25401762

EMBL

BABH01014123 BABH01014124 AGBW02008206 OWR54013.1 ODYU01004121 SOQ43660.1 + More
KQ459597 KPI94771.1 KQ460207 KPJ16654.1 GEDC01018078 JAS19220.1 GFDF01003300 JAV10784.1 GECZ01018109 JAS51660.1 GDHC01002130 JAQ16499.1 GGMR01000929 MBY13548.1 GBHO01029893 JAG13711.1 GBRD01006648 JAG59173.1 GGMS01006087 MBY75290.1 GFXV01005834 MBW17639.1

Proteomes

UP000005204 UP000007151 UP000053268 UP000053240 UP000079169

PRIDE

H9IZH1

Pfam

PF08123 DOT1

Interpro

IPR025789   DOT1_dom        + More
IPR029063   SAM-dependent_MTases
IPR030445   H3-K79_meTrfase

SUPFAM

SSF53335 SSF53335

ProteinModelPortal

H9IZH1 A0A212FJU6 A0A2H1VS65 A0A194PMW4 A0A194RGT5 A0A1B6D0N3 + More
A0A1L8DWJ1 A0A1S3DV74 A0A1B6FNA8 A0A146MAN7 A0A2S2N8X2 A0A0A9X222 A0A0K8T0W5 A0A2S2QCP4 A0A2H8TUL3

KEGG

101736339 K11427 histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43] | (RefSeq) histone-ly

GO

GO:0031151 GO:0051726 GO:0005634

PANTHER

PTHR21451

Subcellular location

Nucleus

Length:

241

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00096

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04330

outside

1 - 241

Pi

255.894377

Theta

204.328674

Tajima's D

0.685696

CLR

0.809248

CSRT

0.566971651417429

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics