Gene

KWMTBOMO02640

Pre Gene Modal

BGIBMGA002645

Annotation

PREDICTED:_A_disintegrin_and_metalloproteinase_with_thrombospondin_motifs_14-like_[Bombyx_mori]

Location

Bomo_Chr5(+):7703008-7727517      View in EpiBrowser

Full name

Histone-lysine N-methyltransferase, H3 lysine-79 specific      

Alternative Name

Histone H3-K79 methyltransferase

Location in the cell

Extracellular   Reliability : 1.851 Nuclear   Reliability : 1.308

CDS

ATGGCGTATCGAAATTTCCAGGAGCTTCTGCCAACATTTGGGTGGTGGCAGGAGGAGGGGCGTGGTGAGCGGGGTCACGGCGCAGACGTACAAGTAGTGTACTTGCCAGCGTTGTTGCCGCGGGAAGCACAGTCCTCCGTGGACGGTAGCAATGATGACGTTCCTTTACCGTACAACTTTGATGCGTTCGGTCGTAACTTCGATCTTCAGCTGGTGCCAAACCGTCGACTGGTGTCTCCAGAGTTCCGCGTGTGGACCGAACGTGGGGAAGAGAAACCCTTGTCCAGCGTGGATGCCTCTTGCCATTTCCTGCATGCTAGTCCTAACGCAGTAGCTGCCTTCTCGGCTTGCAAAGATCATGCACTACACGGACTAATCGTCGTCGATAACTCTACATATGAGGTCCGCCCGTTGCCTTCTGGTGTTGGCCGTGCTGAGAACAGCTATGGTCGTACTGCACACGTAATTCGAAGAGCATCTCCTCCTTCACCGCCCGTCGATGATGCCAGAGTCCTAAGACCGCGGCCGCGGCGCCGTCCGCGAAACCACACTCCTCCAGTGAAGAAAGGCCCGGCCAGCTATACCATAGAAATAGCACTGTTTCTCGACGAAGCTGCATATAAAATTTTTCATCCATTTTTTCATTACAATGAAGCTGATTTGCGTGATATGTTGCTGGCTTATATAAATGGGGTACAGGCGCTATATCAACATTCTTCCCTTGGTACTCATATCCAGTTGTCACTAGTGAGGTTAACGTTATTAAGGTCTCAGCCAACTGATCTTTCAGCGCATGCCGAACGTGGCAAACTCCTAGACTCTTTCTGTGCATATCAAAGATCACTAAACGTTGAAGATGATGAAGATCCCGAACATTGGGATATGGCCTTACTGTTATCTGGATTAGATTTTTATTCAGAAGAAAATGGTCGGCGGAACGGCGTCACTATGGGCCTAGCGCCCGTGGGTGGGGTGTGCTTGCCGGCGCACGCATGCGTGGTGTCGGAGTTCGGTGCCACGGACGTGCTCGGCCGTCCCTACCCGTCAGCAGGCTTCACTTCCGTCTACATACTGGCGCACGAGATCGGACACAACTTGGGTATGCATCACGACGGTACCGGGAACACGTGCGCCCGCGACGGTTACATAATGTCGCCGTCTCGAGGAACCAATGGAGAGGCTTCCTGGTCATCCTGCAGTGCTAGAGTCGTTGCCGACCTCAAATGGGCTACTTGCCTGTTGGATGGTGACGACGGCGAGGAAGACATCCCAAATGAGCTTCAGCATGAACGATTTAGCGGAGCGCCTGGTGCTATATGGAGCGCAAAGAAACAGTGTGAGGTTTTGTTGCGTGACGCGGACGCAGCGCCTTGGTCGGGCGGCGGAGACCAGCGGGGGCAATGCGCCCAGCTCGCGTGCCGCACCCCGCACCGCGCCGGCTTCTTCTACGCCGGCCCCGCGCTGCCCGGCACTGCTTGTGGCAATAAAATGTGGTGTCAAGGTGGGGAGTGTGTGCCTTCGAACTCCGTACCGACATCCAGCACGCGCGTTCCGCCATCGGCCGGTATGGCGGAGGGCGAGTCTGGCGGCTGGACCGTATGGAGAGAAGGCGCGTGTCGGTCCGGCTGCTCAGCCAAGTCGCGGGGCTTTAGAGAACGTAGACGGGAATGCGCTACGACCACCACCTGCCAAGGATCCGCTTACGATGTCGTACTGTGTGATGATACCAAGGTTTGCGGCAAGAAGAGCCGAGTGAGTGCCAATGAGCTTGCTTCCCGCAAGTGCAGCGAGTACGCGGCGCGCGTGCCGTCGCTGGACGCGCGCGCCGGCGGGCTGCAGGCCCCGCATGATCCTACTCGCATGTGGATGGGGTGCGCAATATTCTGCAGGCGAGCTTCCGGCGGTGGGTTTTACGCTCCTCGGGTGGAACTCAACGCGGCAGGTCTCGATCCCTATCTGCCTGACGGTACCTGGTGCCACAACGATGGGAAACATGACTATTACTGCATGCAACATCATTGTCTGCCAGAGAATTTCAAGATGTCAACGCAATACCACATTTGGGAGTTGCCATCTCAGGACATTGGCGGGTCGTTTAACGCTCGTGCTTTGACCACTCCTGATGATGAAGCCGCCGAGGCGGCTGTACGAGAATATTTATCTTTAGACAGCCATGGAGTGCCTCTTACGAGAGGCGCATTCCCTCCAAGTTTACCCGATGAACCTGAAGACAACTGGGAGGTAGTCGACTACGTGGAAATTCATAGAAATGACCCCTCTTAA

Protein

MAYRNFQELLPTFGWWQEEGRGERGHGADVQVVYLPALLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSPPVDDARVLRPRPRRRPRNHTPPVKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGECVPSNSVPTSSTRVPPSAGMAEGESGGWTVWREGACRSGCSAKSRGFRERRRECATTTTCQGSAYDVVLCDDTKVCGKKSRVSANELASRKCSEYAARVPSLDARAGGLQAPHDPTRMWMGCAIFCRRASGGGFYAPRVELNAAGLDPYLPDGTWCHNDGKHDYYCMQHHCLPENFKMSTQYHIWELPSQDIGGSFNARALTTPDDEAAEAAVREYLSLDSHGVPLTRGAFPPSLPDEPEDNWEVVDYVEIHRNDPS

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

Uniprot

H9IZG0   A0A2A4K869   A0A2W1BL44   A0A2H1VZM7   A0A212FJY1   A0A194PMV9   + More
A0A194RH49   A0A0L7LV37   D6WRL2   A0A2J7RCF5   A0A2A3EIQ2   A0A0C9QT06   A0A088A5V6   A0A0M8ZTR7   A0A0L7R1T7   A0A1B0EVJ6   A0A195BAH8   A0A158NUV5   A0A151K0J4   E2A767   F4WE17   A0A3L8D6J8   U4UQG6   A0A151IV55   A0A026WD85   A0A151I6G1   B0W448   A0A232F4Y4   A0A151WP70   A0A182W8K3   A0A084WQ39   A0A182PM95   J9HSG8   A0A182XHA8   A0A1J1ISI4   A0A182R1R9   A0A182HR27   A0A182KH83   A0A182FN59   A0A182Q2D9   A0A154P3M5   A0A182NNU2   K7JNF7   A0A2S2NN49   N6U222   J9JKB5   E0VIC6   A0A182GXZ2   A0A2S2Q9Q2   A0A0N8CFH1   A0A0P5ND54   A0A0N8B5Q9   A0A0P5ZV18   A0A164NEH7   A0A0P5XRH6   A0A0P5XLF5   A0A0N8C3N1   A0A0N8B670   E9GBH0   A0A0P5D8W7   A0A0P6GPU8   A0A0P5ZV22   A0A0P6IMI2   A0A0P5SGW4   A0A0P5ZVI0   A0A0P5D981   A0A0P5K7C4   A0A0N8A4C8   A0A0N8DJ19   A0A0P6HRV6   A0A0P5LTZ7   A0A0P5RDW6   A0A0N8DHU4   A0A182M5L6   A0A0P4Z4M5   A0A0P5B1N8   A0A0N8AGF6   A0A0P6CYJ7   A0A087SYI7   A0A182Y641   A0A164NDJ1   A0A0K2TDM0  

EC Number

2.1.1.43

Pubmed

19121390    28756777    22118469    26354079    26227816    18362917    + More
19820115    21347285    20798317    21719571    30249741    23537049    24508170    28648823    24438588    17510324    20075255    20566863    26483478    21292972    25244985   

EMBL

BABH01014132    NWSH01000078    PCG79860.1    KZ150098    PZC73576.1    ODYU01005438    + More
SOQ46289.1    AGBW02008206    OWR54019.1    KQ459597    KPI94766.1    KQ460207    KPJ16650.1    JTDY01000024    KOB79368.1    KQ971354    EFA07053.2    NEVH01005885    PNF38508.1    KZ288229    PBC31683.1    GBYB01006864    JAG76631.1    KQ435848    KOX70980.1    KQ414667    KOC64827.1    AJWK01020279    KQ976532    KYM81548.1    ADTU01026691    ADTU01026692    KQ981296    KYN43095.1    GL437267    EFN70723.1    GL888102    EGI67455.1    QOIP01000012    RLU15801.1    KB632319    ERL92285.1    KQ980926    KYN11392.1    KK107261    EZA53928.1    KQ978473    KYM93694.1    DS231834    EDS32641.1    NNAY01000969    OXU25672.1    KQ982905    KYQ49495.1    ATLV01025174    ATLV01025175    KE525371    KFB52333.1    CH477320    EJY57558.1    CVRI01000057    CRL02070.1    APCN01001634    AXCN02001984    KQ434809    KZC06516.1    GGMR01005994    MBY18613.1    APGK01045628    APGK01045629    APGK01045630    KB741037    ENN74671.1    ABLF02025829    ABLF02025830    DS235191    EEB13132.1    JXUM01020696    JXUM01020697    KQ560579    KXJ81822.1    GGMS01005265    MBY74468.1    GDIP01136879    JAL66835.1    GDIQ01166508    JAK85217.1    GDIQ01210187    JAK41538.1    GDIP01038649    JAM65066.1    LRGB01002860    KZS05887.1    GDIP01070392    JAM33323.1    GDIP01070393    JAM33322.1    GDIQ01118011    JAL33715.1    GDIQ01208899    JAK42826.1    GL732538    EFX83156.1    GDIP01159285    JAJ64117.1    GDIQ01030662    JAN64075.1    GDIP01039101    JAM64614.1    GDIQ01019418    JAN75319.1    GDIP01139870    JAL63844.1    GDIP01051437    JAM52278.1    GDIP01161082    JAJ62320.1    GDIQ01188393    JAK63332.1    GDIP01183713    JAJ39689.1    GDIP01028895    JAM74820.1    GDIQ01015899    JAN78838.1    GDIQ01165615    JAK86110.1    GDIQ01102775    JAL48951.1    GDIP01032295    JAM71420.1    AXCM01000626    GDIP01218616    JAJ04786.1    GDIP01191128    JAJ32274.1    GDIP01149889    JAJ73513.1    GDIQ01087935    JAN06802.1    KK112544    KFM57926.1    KZS05860.1    HACA01006752    CDW24113.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000007266    UP000235965    UP000242457    UP000005203    UP000053105    UP000053825    UP000092461    UP000078540    UP000005205    UP000078541    UP000000311    UP000007755    UP000279307    UP000030742    UP000078492    UP000053097    UP000078542    UP000002320    UP000215335    UP000075809    UP000075920    UP000030765    UP000075885    UP000008820    UP000076407    UP000183832    UP000075900    UP000075840    UP000075881    UP000069272    UP000075886    UP000076502    UP000075884    UP000002358    UP000019118    UP000007819    UP000009046    UP000069940    UP000249989    UP000076858    UP000000305    UP000075883    UP000054359    UP000076408   

PRIDE

H9IZG0   

Pfam

PF01562   Pep_M12B_propep        + More
PF17771   ADAM_CR_2
PF01421   Reprolysin
PF08123   DOT1

Interpro

IPR002870   Peptidase_M12B_N        + More
IPR041645   ADAM_CR_2       
IPR024079   MetalloPept_cat_dom_sf       
IPR001590   Peptidase_M12B       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR025789   DOT1_dom       
IPR029063   SAM-dependent_MTases       
IPR030445   H3-K79_meTrfase       
IPR001969   Aspartic_peptidase_AS       

SUPFAM

SSF53335   SSF53335        + More
SSF82895   SSF82895       

Gene 3D

3.40.390.10     2.20.100.10    

ProteinModelPortal

H9IZG0   A0A2A4K869   A0A2W1BL44   A0A2H1VZM7   A0A212FJY1   A0A194PMV9   + More
A0A194RH49   A0A0L7LV37   D6WRL2   A0A2J7RCF5   A0A2A3EIQ2   A0A0C9QT06   A0A088A5V6   A0A0M8ZTR7   A0A0L7R1T7   A0A1B0EVJ6   A0A195BAH8   A0A158NUV5   A0A151K0J4   E2A767   F4WE17   A0A3L8D6J8   U4UQG6   A0A151IV55   A0A026WD85   A0A151I6G1   B0W448   A0A232F4Y4   A0A151WP70   A0A182W8K3   A0A084WQ39   A0A182PM95   J9HSG8   A0A182XHA8   A0A1J1ISI4   A0A182R1R9   A0A182HR27   A0A182KH83   A0A182FN59   A0A182Q2D9   A0A154P3M5   A0A182NNU2   K7JNF7   A0A2S2NN49   N6U222   J9JKB5   E0VIC6   A0A182GXZ2   A0A2S2Q9Q2   A0A0N8CFH1   A0A0P5ND54   A0A0N8B5Q9   A0A0P5ZV18   A0A164NEH7   A0A0P5XRH6   A0A0P5XLF5   A0A0N8C3N1   A0A0N8B670   E9GBH0   A0A0P5D8W7   A0A0P6GPU8   A0A0P5ZV22   A0A0P6IMI2   A0A0P5SGW4   A0A0P5ZVI0   A0A0P5D981   A0A0P5K7C4   A0A0N8A4C8   A0A0N8DJ19   A0A0P6HRV6   A0A0P5LTZ7   A0A0P5RDW6   A0A0N8DHU4   A0A182M5L6   A0A0P4Z4M5   A0A0P5B1N8   A0A0N8AGF6   A0A0P6CYJ7   A0A087SYI7   A0A182Y641   A0A164NDJ1   A0A0K2TDM0  

PDB

3B2Z     E-value=6.21248e-23,     Score=269

KEGG

101736461    no KO assigned | (RefSeq) A disintegrin and metalloproteinase with thrombospondin motifs 14-like

GO

GO:0004222   GO:0007229   GO:0031151   GO:0051726   GO:0005634   GO:0004190   GO:0006508   GO:0008237   GO:0016021   GO:0006812   GO:0015299   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

PANTHER

PTHR21451  

Subcellular location

Nucleus  

Length:

760

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00714

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00034

outside

1  -  760

 

 

Pi

255.73108

Theta

165.426708

Tajima's D

1.269775

CLR

0.224186

CSRT

0.728063596820159

Interpretation

Uncertain