Gene

KWMTBOMO02630  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002640

Annotation

PREDICTED:_ubiquitin_carboxyl-terminal_hydrolase_[Bombyx_mori]

Location

Bomo_Chr5(+):7578718-7579596      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase      

Alternative Name

Ubiquitin thioesterase

Location in the cell

Cytoplasmic   Reliability : 2.948

CDS

ATGGCGACCGAAACTTTAGTCCCTCTTGAATCCAATCCCGATGTCCTGAACAAGTTTTTGCAAAAGCTCGGCGTACCAAACAAATGGAATATTGTAGATGTCATGGGACTTGATCCTGAAACGCTTTCGTGGGTACCTCGCCCTGTGCTTTCTGTAATGCTACTTTTCCCAATTTCTGATGCTTACGAAAATCACAAAAAAACTGAAGAAAATGAGATTCTGTCCAAAGGGCAAGAAGTTTCTGGAAATATTTTCTATATGAAACAAAATATCAGCAATGCATGTGGGACTATAGCTCTTGTACATAGTGTGGCCAACAATACGGACATAATTGAATTATCTGATGGTCATATGCAGAAATTTTTAAATGAAGCTAAAGGACTTGATGCTACTGCTCGTGGTAAATTGTTGGAAAAGTCTGAAGGCATCATTAATGCTCACAAGGAATTGGCTCAAGAAGGCCAAACAAATACACCAAGTGCTGAAGATCCCGTCAACCATCATTTTATCAGCTTTGTCCAGAAAGATGGAGCATTGTATGAGTTAGATGGCCGTAAAGCTTTTCCTGTCAATCATGGCCCAACTTCACAGGAAACTTTGTTGGAAGATGCAGCAAAAATTTGCAAAGAATTTATGGCTCGCGATCCGAATGAAGTACGCTTTACAGTAATTGCTCTAGTAGCATCTGATTAA

Protein

MATETLVPLESNPDVLNKFLQKLGVPNKWNIVDVMGLDPETLSWVPRPVLSVMLLFPISDAYENHKKTEENEILSKGQEVSGNIFYMKQNISNACGTIALVHSVANNTDIIELSDGHMQKFLNEAKGLDATARGKLLEKSEGIINAHKELAQEGQTNTPSAEDPVNHHFISFVQKDGALYELDGRKAFPVNHGPTSQETLLEDAAKICKEFMARDPNEVRFTVIALVASD

Description

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C12 family.

Keywords

Complete proteome   Hydrolase   Protease   Reference proteome   Thiol protease   Ubl conjugation pathway  

Feature

chain  Ubiquitin carboxyl-terminal hydrolase

Uniprot

E5EVW1   I4DKT6   A0A2W1BL54   A0A2A4JUX1   A0A194RGS0   A0A2H1VVL3   + More
S4NNT0   A0A0L7KLJ4   A0A212FJW0   R4V3Z4   A0A2J7PH84   A0A2J7PH73   A0A1B6L6K8   A0A1B6GNB3   E2B4G1   A0A1B6DXJ4   A0A158NQ48   A0A1Y1KU92   A0A2J7PH70   A0A2H1VCW9   A0A2A4K064   D6WF38   A0A1B0EWD8   H3ATA4   A0A2B4RRN0   A0A088ADV0   A0A1B6JRV9   A0A195BIZ1   A0A2A3E091   A0A1L8ED88   A0A151J061   A0A1B6LCB9   A0A212F4P9   A0A0V0G373   A0A1I8P8K9   A0A0C9QR99   A0A1B6FL35   J3JZJ6   A0A195FNM5   N6TNY7   A0A195CVR3   A0A1I8MWE8   W8BY65   A0A224XX86   A0A069DQC6   E2A1T2   A7S784   C3XWK4   A6YPQ5   U5EVC7   A0A0P4VYK6   R4G8N5   F4WMS1   E2J7E7   A0A1W4W4Z9   A0A3Q0J064   A0A3Q0J573   A0A067QU01   V9KNH4   A0A3M6TFU9   A0A0K8TT99   W5N056   Q5XHE2   A0A0A9YB44   K7J625   A0A0P4WK80   A0A194R1S8   A0A232F2K9   B4MVT2   A0A026WJW2   M9MRD0   P35122   R4WRB2   B3MJB3   D3TNH8   A0A1A9ZF47   C1K736   C4WTW9   A0A1A9UNR7   A0A1W5LJR1   A0A1B0C1N6   Q28GY5   A0A194Q7N1   A0A1W4V6Y9   E0V9V0   B4Q7N8   A0A1A9YIS3   A0A1B0FQ50   L5KKF6   A0A2Y9DBF8   A0A1A9W0Q2   A0A1U7STR8   A0A287CXP1   A0A2U3V1L6   A0A340WHQ4   A0A2Y9NCS4   A0A384AG15   G1LY51   G3SEB1   A0A2I3GN22  

EC Number

3.4.19.12

Pubmed

19121390    21457781    22651552    26354079    28756777    23622113    + More
26227816    22118469    20798317    21347285    28004739    18362917    19820115    9215903    22516182    23537049    25315136    24495485    26334808    17615350    18563158    18207082    27129103    21719571    24845553    24402279    30382153    26369729    27762356    25401762    26823975    20075255    28648823    17994087    24508170    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1426603    7683284    10731138    23691247    20353571    20431018    20566863    22936249    23258410    20010809    22398555   

EMBL

BABH01014146    HM012805    ADQ89804.1    AK401904    KQ459589    BAM18526.1    + More
KPI97514.1    KZ150098    PZC73586.1    NWSH01000598    PCG75424.1    KQ460207    KPJ16639.1    ODYU01004695    SOQ44853.1    GAIX01013816    JAA78744.1    JTDY01009043    KOB64167.1    AGBW02008206    OWR54028.1    KC740719    AGM32543.1    NEVH01025149    PNF15688.1    PNF15687.1    GEBQ01020650    JAT19327.1    GECZ01005831    JAS63938.1    GL445556    EFN89422.1    GEDC01006894    JAS30404.1    ADTU01022963    GEZM01075307    JAV64148.1    PNF15686.1    ODYU01001855    SOQ38636.1    NWSH01000333    PCG77318.1    KQ971327    EFA00904.1    AJWK01005593    AFYH01085089    AFYH01085090    AFYH01085091    AFYH01085092    AFYH01085093    AFYH01085094    AFYH01085095    AFYH01085096    AFYH01085097    LSMT01000359    PFX19459.1    GECU01005742    JAT01965.1    KQ976464    KYM84411.1    KZ288497    PBC25180.1    GFDG01002111    JAV16688.1    KQ980658    KYN14774.1    GEBQ01018650    JAT21327.1    AGBW02010334    OWR48703.1    GECL01003685    JAP02439.1    GBYB01003182    JAG72949.1    GECZ01018880    JAS50889.1    BT128678    KB632033    AEE63635.1    ERL88179.1    KQ981382    KYN42155.1    APGK01057490    KB741280    ENN70950.1    KQ977279    KYN04249.1    GAMC01008305    GAMC01008304    JAB98251.1    GFTR01003815    JAW12611.1    GBGD01002789    JAC86100.1    GL435798    EFN72604.1    DS469591    EDO40453.1    GG666471    EEN67738.1    EF639066    GEMB01003922    ABR27951.1    JAR99334.1    GANO01001091    JAB58780.1    GDKW01000892    JAI55703.1    ACPB03023923    GAHY01000662    JAA76848.1    GL888218    EGI64548.1    HP429365    ADN29865.1    KK853018    KDR12443.1    JW867635    AFP00153.1    RCHS01003667    RMX40276.1    GDAI01000463    JAI17140.1    AHAT01035001    BC084116    CM004468    AAH84116.1    OCT95509.1    GBHO01014210    GBRD01006179    GBRD01006178    GBRD01006177    GDHC01020228    JAG29394.1    JAG59642.1    JAP98400.1    GDRN01048972    JAI66623.1    KQ461073    KPJ09806.1    NNAY01001211    OXU24718.1    CH963857    EDW75802.1    KK107167    EZA56253.1    AE014134    ADV36932.1    S60346    X69678    X69679    AF145600    AK417212    BAN20427.1    CH902620    EDV31323.1    CCAG010011564    EZ422980    ADD19256.1    FJ800570    ACO36738.1    ABLF02030392    AK340802    BAH71339.1    KX091173    ANI85922.1    JXJN01024138    AAMC01006658    AAMC01006659    AAMC01006660    BC135703    CR761162    AAI35704.1    CAJ83746.1    KQ459324    KPJ01547.1    DS234996    EEB10156.1    CM000361    CM002910    EDX03418.1    KMY87606.1    CCAG010006700    KB030714    ELK11018.1    AGTP01036544    AGTP01036545    AGTP01036546    ACTA01180065    CABD030089848    CABD030089849    ADFV01174587   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000037510    UP000007151    + More
UP000235965    UP000008237    UP000005205    UP000007266    UP000092461    UP000008672    UP000225706    UP000005203    UP000078540    UP000242457    UP000078492    UP000095300    UP000030742    UP000078541    UP000019118    UP000078542    UP000095301    UP000000311    UP000001593    UP000001554    UP000015103    UP000007755    UP000192223    UP000079169    UP000027135    UP000275408    UP000018468    UP000186698    UP000002358    UP000215335    UP000007798    UP000053097    UP000000803    UP000007801    UP000092444    UP000092445    UP000007819    UP000078200    UP000092460    UP000008143    UP000192221    UP000009046    UP000000304    UP000092443    UP000010552    UP000248480    UP000091820    UP000189704    UP000005215    UP000245320    UP000265300    UP000248483    UP000261681    UP000008912    UP000001519    UP000001073   

PRIDE

E5EVW1    M9MRD0    P35122   

Pfam

PF01088   Peptidase_C12

Interpro

IPR038765   Papain-like_cys_pep_sf        + More
IPR036959   Peptidase_C12_UCH_sf       
IPR001578   Peptidase_C12_UCH       

SUPFAM

SSF54001   SSF54001       

Gene 3D

3.40.532.10    

ProteinModelPortal

E5EVW1   I4DKT6   A0A2W1BL54   A0A2A4JUX1   A0A194RGS0   A0A2H1VVL3   + More
S4NNT0   A0A0L7KLJ4   A0A212FJW0   R4V3Z4   A0A2J7PH84   A0A2J7PH73   A0A1B6L6K8   A0A1B6GNB3   E2B4G1   A0A1B6DXJ4   A0A158NQ48   A0A1Y1KU92   A0A2J7PH70   A0A2H1VCW9   A0A2A4K064   D6WF38   A0A1B0EWD8   H3ATA4   A0A2B4RRN0   A0A088ADV0   A0A1B6JRV9   A0A195BIZ1   A0A2A3E091   A0A1L8ED88   A0A151J061   A0A1B6LCB9   A0A212F4P9   A0A0V0G373   A0A1I8P8K9   A0A0C9QR99   A0A1B6FL35   J3JZJ6   A0A195FNM5   N6TNY7   A0A195CVR3   A0A1I8MWE8   W8BY65   A0A224XX86   A0A069DQC6   E2A1T2   A7S784   C3XWK4   A6YPQ5   U5EVC7   A0A0P4VYK6   R4G8N5   F4WMS1   E2J7E7   A0A1W4W4Z9   A0A3Q0J064   A0A3Q0J573   A0A067QU01   V9KNH4   A0A3M6TFU9   A0A0K8TT99   W5N056   Q5XHE2   A0A0A9YB44   K7J625   A0A0P4WK80   A0A194R1S8   A0A232F2K9   B4MVT2   A0A026WJW2   M9MRD0   P35122   R4WRB2   B3MJB3   D3TNH8   A0A1A9ZF47   C1K736   C4WTW9   A0A1A9UNR7   A0A1W5LJR1   A0A1B0C1N6   Q28GY5   A0A194Q7N1   A0A1W4V6Y9   E0V9V0   B4Q7N8   A0A1A9YIS3   A0A1B0FQ50   L5KKF6   A0A2Y9DBF8   A0A1A9W0Q2   A0A1U7STR8   A0A287CXP1   A0A2U3V1L6   A0A340WHQ4   A0A2Y9NCS4   A0A384AG15   G1LY51   G3SEB1   A0A2I3GN22  

PDB

6ISU     E-value=1.04563e-65,     Score=632

KEGG

101746072    K05609 ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-termina

GO

GO:0006511   GO:0004843   GO:0016021   GO:0005737   GO:0016579   GO:1904888   GO:0007219   GO:0036459   GO:0005829   GO:0043130   GO:0005634   GO:0005622   GO:0006812   GO:0015299   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

PANTHER

PTHR10589  

Length:

230

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01534

Exp number, first 60 AAs:

0.01189

Total prob of N-in:

0.01848

outside

1  -  230

 

 

Pi

138.520051

Theta

137.720306

Tajima's D

0.018246

CLR

52.368979

CSRT

0.373131343432828

Interpretation

Uncertain