Gene

KWMTBOMO02604

Pre Gene Modal

BGIBMGA002665

Annotation

PREDICTED:_adenylate_cyclase_type_7-like_[Papilio_machaon]

Location

Bomo_Chr5(-):6558240-6594237      View in EpiBrowser

Full name

Adenylate cyclase       + More
Guanylate cyclase      
Adenylyl cyclase X E      

Location in the cell

PlasmaMembrane   Reliability : 3.889

CDS

ATGGGCTCTGTGGTGCTTCAAGTAGGCGCCTTAGAGCTCTTAGCAAGGTATTCAACGAACTCTGGGAGAGCGACCAGCGTTCTCTCATCATTACATGAATTCAGAACACAAGAAGTTGAATTGGCTGGTGGGAAACAGTGGAATTGGAAGTATTTAAGGGATCAATTTGATCAAAAAGATTTAGAAGGACTCTACAGAAAATACGATGACAAACTGAGAGATGTATTAATTCATATTTATGTATCTCTTCTAGTATTCTTTACGACTGTACACATCGTTTTAGTTGTGATATCTACATTTTCAGAGCAAATACAGTCAGAGTCAACATACTTAACAATGGGAATGTACGTTTTGCGTATTGCAATACCAGCTCTATCACTTTGCAAGAAGGTATATGAGCCCTTGAAGAAGAAGTGCAATTGGATGCCGATATTTATTACATTTTTTGTTACTTTGCACTTAGTTTTAACAGATATCGCTGTGTGCATCTACAGTTCGTTCGAGGGGATATCGTTGAGACCAGCATACGCAACGATGGCTTTGCTGTCTATTTACATATTTTTACCTATGAGAAACAATTTCCTGGTAATAATACTGGGTGTTTTGGTCAGCGCTATCTATGTACTGATCTTTGCTTTCTTCACTTATCGGCAGAACCCACAGATCGGTGTTGTCGTAGCATCAGATATAATTTATCTGATCGGCGTAAATCTAATGGGCGTGTACTTTAGGCTAATGAACGAAATAATTACAAGACGGTCCTTTTTGGACAGAAGAGCCTGTGTGGAGAGTACGTTAAGATTGAAATTCGTTAAGGATCAAGAAGAACGGCTGATGATGAGTATTTTACCAGAGCACATCGTATCCAAAGTAAGACAGGACATTAGAAATATGTTTTTGGGACTACACACTCGCGACTTAAGTTACACTATGAGATCATTCAATCAGTTATACGTCGAAGAACACGAAAATGTCAGTATTCTTTATGCGGATGTCGTTAATTACACAATGATATCAACAAGTTTATCTCCCATGAGAATGGTGGAATTACTGAACGAGCTTTTCGGAAGATTTGACGAGGCTTCAGAGGAATACGATGTACTACGGATAAAATTCCTTGGTGACTGTTACTACTGCGTCAGTGGGATTCCAAAGCCTTCTGTTTATCATGCGAAAAACTGCGTTGATTTAGGACTGGAAATGATTCATATCATCAAAGATGTCAGAGAAAAACGCTCCTTAAACATAGATATGAGGATAGGTGTACATTCCGGGAGAATTCTGAGTGGCTTGATAGGTATCAGAAAATGGCAATACGATGTTTGGTCAAAAGACGTTACCATAGCAAACAAAATGGAATCCACCGGAAAAGCTGGAAAAGTTCACGTAACCAAGCAAACGCTAGAACTCCTTATAGATTTTGCAAGAGAATATATTATTGAACCAAATTTTGAATCTCAAAATGATCCTTTCATCACAAAAAATAAACTGGAAACCTTTCTTCTGTCACGACCAGCCAGGCCTCCAGAATACAAACCCTTCCGTAGAGCATCCGTTGGATTTAACAAGATAATTACAACTAAAACTTCAACATCTAGACGATCGGATAACAGAAATTCAACGAGACGAACAACAACGTTCATGGATGAGAACTTGGTGGAATACCAGCAAATGTTGAAAGCTGCTGACGCGCAGATGGCAAAGGAGATCGAAGAAATGACAAAGGGAAAAGAATTTTTCAAGAAAGAGTCAAACTTGAACCGTTGTTCGCTAATGTTCAAAGACTTCCGTCTTGAAAAGATGTTCCTTTTGCTGTCGGATCCACTATTTAAATATTACATAACATGCTGTCTTATTATTTTATGCTTGATTTTATTGATCAATGGACTAACTACAAATTGGCTTTATGACTTCCATTGGATTACTTGGCTGCTTTTTGGATTCCTTGTTATCGGACTAATTATAATGCAACCCTTCACGTGGTTCCACTTTTTATGGACAAAATACAAAGGAATCGATGAACCGAAAAACAAATATTTGCGATATATATATGACATTTCTTCAAATATAATAAGATCTGCTAAAATAAGAACAATAATGTATTTATTGATAAGTCTAGGTCTGGCTGCGACTTCAGTAATTACAGTTGTTGGATGTTCTGTTGTAGAAGTAGAATTAGTGGATGCTGAATCAGTATTATCCAATTGTGTATCGTCATGGCACGTCACACAATGTTGGGGGCTGGCGCTCCTTTTGAATTTCCTATTCAGCAGAGTTTTTTTCATATTTAAGTGGATCGTTGCCGGTGGAATGACAGTGTTCTACCTATGGGTTGTTTGGAAAATAAAAACTTCTCTTTTTGCTGAAGATGCAACATGGAATGTTGGAACAACTGAACACAGAAACCGATTAGACCATTTATGGCAATTGCAACTAAGTGAGGAGCAACAAGAAGCTGAAACTATGCTTAAAGTTAATAATATGCTTTTGGAGAATATTTTACCTGCTCATGTAGTTCAGGTGTACTTAAATTTGAATAGGTCAATAGATGAGTTGTATTATGAAAAGTATGACAATGTGGCCGTAATGTTCGCCTCCCTCACTGACTACAAACTGGGCCTAGAAGGTGACGCAGATATGAGTGATAAATTTGTGTTAAGCATATTAGATGAAGTAATTTCAGATTTCGACCGGTTGCTCCTAACAGGAACATCGGCTCATAGAGTTGAAAAAATTAAAATGGCAGGTTGGACTTATATGGCTGCATGCGGATTAGATCCAAATAGACGCGAATCACCCGATGCTATGTCTCATACATCTAACAGTCCAAATAACAGTCCATATAGTAAATCCGTTGTATTAACCATGGTTGAATTCGCTGCAGCTATGATGATGCAACTTCAAAATTTTAATCGAGGGTCATTTCAAAGCTTTGAAGGACTCAATTTAAGAATAGGTATCTCACACGGCGAAGTAGCAGCGGGCGTGGTGGGGTCTTTAAAGCCGCTTTATGATATTTGGGGACATGCAGTAAACATGGCTTCAAGAATGGATTCGACTGGACAAACTGGTAAAATTCAAGTTACCGAAAATACAGCAATATTACTGGACGAATGTGACATTCTTACGACTTACCGAGGAGAGACTTTCGTCAAGGGAGCAGGATACATCAAAACATATTATGTTCCACTTGATGAAAATTTCAATTTAATAAAAAAGGATCAAAGTCTACATTACTATAGATTAGAAGATAGGAATCGTTATTATAACCTTAGGAATACGAACTTTGAAGAACCTTATTCAGATAATGACAATATTGAATCAGAAACTTACGATTCTACTTTTAGTGTTAGAGATCTTAGTATTCTTAGTGACAATTCTAGTCTATACGTCGAAGAACACGAAAATGTCAGCATTCTTTATGCGGATGTCGTTAATTACACAATGATATCAACAAGTTTGTCTCCCATGAGAATGGTGGAATTACTGAACGAGCTTTTCGTAAGATTTGACGAGGCTTCAGAGGAATACGATGTACTACAAATAAAATTCCTTGGCGACTGTTACTACTGCGTCAGTGGGATTCCAAAGCCTTCTGTTTATCATGCGAAAAACTGCGTTGATTTAGGACTGGAAATGATTCATATCATCAAAGATGTCAGAGAAAAACGCTCCTTAAACATAGATATGAGGATAGGTGTACATTCCGGGAGAATTCTGAGTGGCTTAATAGGTATCAGAAAATGGCAATACGATGTTTGGTCAAAAGACGTTACCATAGCAAACAAAATGGAATCCACCGGAAAAGCTGGAAAAGTTCACGTAACCAAGCAAACGCTAGAACTCCTTATAGATTTTGCAAGAGAATATATTATTGAACCAAATTTTGAATCTCAAAATGATCCTTTCATCACAAAAAATAAATTGGAAACCTTTCTTCTGTCACGACCAGCCAGACCTCCAGAATACAAACCCTTCCGTAGAGCATCCGTTGGATTTAACAAGATAATTACAACTAAAACTTCAACGTCTAGACGATCGGATAACAGAAATTCAACGAGACGAACAACAACGTTCATGGACGAGAACTTGGTGGAATATCAGCAAATGTTGAAGGCTGCTGACGCGCAGATGGCGAAGGAGATCGAAGAAATGACAAAGGGAAAAGAATTTTTCAAGAAAGAATCAAACTTGAACCGATGTTCGCTAATGTTCAAAGACTTCCGTCTTGAAAAAATGTTCCTTTTGCTGTCGGACCCTCTATTTAAATATTACATAACATGCTGTCTTATTATTTTATGCTTGATTTTATTGATCAATGGATTAACTACAAATTGGCTTTATGATTTCCATTGGGTGTACTTAAATTTGAATAGGTCAATAGACGAGTTGTATTATGAAAAGTATGACAATGTGGCAGTAATGTTCGCCTCCCTCACTGACTACAAACTGGGCCTAGAAGGTGACGCAGATATGAGTGATAAATTTGTGTTAAGCATATTAGATGAAGTAATTTCAGATTTCGACCGGTTGCTCCTAACAGGAACATCGGCTCATAGAGTTGAAAAAATTAAAATGGCAGGTTGGACTTATATGGCTGCATGCGGATTAGATCCAAATAGACGCGAATCACCAGATGCTATGTCTCGTAACCATGGTTGA

Protein

MGSVVLQVGALELLARYSTNSGRATSVLSSLHEFRTQEVELAGGKQWNWKYLRDQFDQKDLEGLYRKYDDKLRDVLIHIYVSLLVFFTTVHIVLVVISTFSEQIQSESTYLTMGMYVLRIAIPALSLCKKVYEPLKKKCNWMPIFITFFVTLHLVLTDIAVCIYSSFEGISLRPAYATMALLSIYIFLPMRNNFLVIILGVLVSAIYVLIFAFFTYRQNPQIGVVVASDIIYLIGVNLMGVYFRLMNEIITRRSFLDRRACVESTLRLKFVKDQEERLMMSILPEHIVSKVRQDIRNMFLGLHTRDLSYTMRSFNQLYVEEHENVSILYADVVNYTMISTSLSPMRMVELLNELFGRFDEASEEYDVLRIKFLGDCYYCVSGIPKPSVYHAKNCVDLGLEMIHIIKDVREKRSLNIDMRIGVHSGRILSGLIGIRKWQYDVWSKDVTIANKMESTGKAGKVHVTKQTLELLIDFAREYIIEPNFESQNDPFITKNKLETFLLSRPARPPEYKPFRRASVGFNKIITTKTSTSRRSDNRNSTRRTTTFMDENLVEYQQMLKAADAQMAKEIEEMTKGKEFFKKESNLNRCSLMFKDFRLEKMFLLLSDPLFKYYITCCLIILCLILLINGLTTNWLYDFHWITWLLFGFLVIGLIIMQPFTWFHFLWTKYKGIDEPKNKYLRYIYDISSNIIRSAKIRTIMYLLISLGLAATSVITVVGCSVVEVELVDAESVLSNCVSSWHVTQCWGLALLLNFLFSRVFFIFKWIVAGGMTVFYLWVVWKIKTSLFAEDATWNVGTTEHRNRLDHLWQLQLSEEQQEAETMLKVNNMLLENILPAHVVQVYLNLNRSIDELYYEKYDNVAVMFASLTDYKLGLEGDADMSDKFVLSILDEVISDFDRLLLTGTSAHRVEKIKMAGWTYMAACGLDPNRRESPDAMSHTSNSPNNSPYSKSVVLTMVEFAAAMMMQLQNFNRGSFQSFEGLNLRIGISHGEVAAGVVGSLKPLYDIWGHAVNMASRMDSTGQTGKIQVTENTAILLDECDILTTYRGETFVKGAGYIKTYYVPLDENFNLIKKDQSLHYYRLEDRNRYYNLRNTNFEEPYSDNDNIESETYDSTFSVRDLSILSDNSSLYVEEHENVSILYADVVNYTMISTSLSPMRMVELLNELFVRFDEASEEYDVLQIKFLGDCYYCVSGIPKPSVYHAKNCVDLGLEMIHIIKDVREKRSLNIDMRIGVHSGRILSGLIGIRKWQYDVWSKDVTIANKMESTGKAGKVHVTKQTLELLIDFAREYIIEPNFESQNDPFITKNKLETFLLSRPARPPEYKPFRRASVGFNKIITTKTSTSRRSDNRNSTRRTTTFMDENLVEYQQMLKAADAQMAKEIEEMTKGKEFFKKESNLNRCSLMFKDFRLEKMFLLLSDPLFKYYITCCLIILCLILLINGLTTNWLYDFHWVYLNLNRSIDELYYEKYDNVAVMFASLTDYKLGLEGDADMSDKFVLSILDEVISDFDRLLLTGTSAHRVEKIKMAGWTYMAACGLDPNRRESPDAMSRNHG

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate
GTP = 3',5'-cyclic GMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

ATP-binding   Complete proteome   Lyase   Magnesium   Membrane   Metal-binding   Nucleotide-binding   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Adenylyl cyclase X E

Uniprot

A0A2A4JWP0   A0A1A9VJ86   E2C8S2   A0A088A9P4   A0A158NDG4   A0A151I8P7   + More
A0A0L7QXT2   A0A151WG64   A0A195DJ43   A0A195B1A1   E1ZWP3   K7IW63   A0A195FI12   A0A026WVL9   A0A232F4A6   Q17AS9   A0A1Q3FH84   A0A182QY05   B0W3P0   A0A182JM26   A0A182NHL1   A0A182X6E4   A0A182WIR8   A0A182JNX9   A0A182P3J4   A0A182KRT2   A0A182VBB7   A0A1Q3FH75   W5JPE3   A0A182XZ95   A0A182FFX0   Q7QJS0   A0A1B0D5W6   A0A182I3Q0   A0A182RFN9   A0A0A1XK61   A0A1L8E010   A0A0K8VG24   A0A0K8VJ34   A0A1I8P6M3   W8BSK9   A0A1L8DZR4   A0A1I8P6L0   A0A1I8MAK7   A0A1B0BR96   A0A1A9XV14   A0A1A9X0W6   A0A084VFC6   A0A1B0G1W6   A0A0M4EKS3   A0A1W4W4V1   B3M753   Q9W038   Q8IGU9   Q9NJ99   B3NBF6   B4PEC4   A0A0J9RMB5   A0A0P8XSB8   W8C4S9   A0A0R1DUK7   B4QN42   B4J0I9   A0A3B0KP39   B4H5T3   A0A0Q9WUX1   Q2LYT8   B4LBX0   A0A0M5IYV0   B3N3B7   Q9VK50   B3MNI0  

EC Number

4.6.1.1
4.6.1.2

Pubmed

20798317    21347285    20075255    24508170    28648823    17510324    + More
20966253    20920257    23761445    25244985    12364791    25830018    24495485    25315136    24438588    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    11180822    17550304    22936249    18057021    15632085    19046378   

EMBL

NWSH01000437    PCG76437.1    GL453694    EFN75639.1    ADTU01012487    ADTU01012488    + More
KQ978338    KYM95041.1    KQ414699    KOC63427.1    KQ983185    KYQ46836.1    KQ980800    KYN12900.1    KQ976690    KYM78065.1    GL434869    EFN74401.1    KQ981560    KYN39907.1    KK107083    EZA60062.1    NNAY01001046    OXU25359.1    CH477330    EAT43379.1    GFDL01008129    JAV26916.1    AXCN02000593    DS231833    EDS32187.1    GFDL01008124    JAV26921.1    ADMH02000483    ETN66262.1    AAAB01008807    EAA04045.4    AJVK01000420    APCN01000217    GBXI01002901    JAD11391.1    GFDF01002098    JAV11986.1    GDHF01014526    JAI37788.1    GDHF01013415    JAI38899.1    GAMC01004433    JAC02123.1    GFDF01002106    JAV11978.1    JXJN01019007    ATLV01012374    KE524785    KFB36670.1    CCAG010004392    CP012525    ALC43910.1    CH902618    EDV38714.1    AE014296    BT053678    AAF47621.2    ACK77593.1    BT001587    AAN71342.1    AF177931    AAF33110.1    CH954178    EDV50278.1    CM000159    EDW92962.1    CM002912    KMY97061.1    KMY97063.1    KPU77597.1    GAMC01002192    JAC04364.1    KRK00840.1    CM000363    EDX08924.1    CH916366    EDV96825.1    OUUW01000012    SPP87636.1    CH479212    EDW33150.1    CH940647    KRF84555.1    KRF84556.1    CH379069    EAL29772.2    EDW69770.2    ALC44268.1    CH954177    EDV58757.1    AE014134    BT126324    CH902620    EDV32088.2   

Proteomes

UP000218220    UP000078200    UP000008237    UP000005203    UP000005205    UP000078542    + More
UP000053825    UP000075809    UP000078492    UP000078540    UP000000311    UP000002358    UP000078541    UP000053097    UP000215335    UP000008820    UP000075886    UP000002320    UP000075880    UP000075884    UP000076407    UP000075920    UP000075881    UP000075885    UP000075882    UP000075903    UP000000673    UP000076408    UP000069272    UP000007062    UP000092462    UP000075840    UP000075900    UP000095300    UP000095301    UP000092460    UP000092443    UP000091820    UP000030765    UP000092444    UP000092553    UP000192221    UP000007801    UP000000803    UP000008711    UP000002282    UP000000304    UP000001070    UP000268350    UP000008744    UP000008792    UP000001819   

PRIDE

Q17AS9    Q9W038    Q8IGU9    Q9NJ99    Q9VK50   

Pfam

PF00211   Guanylate_cyc        + More
PF06327   DUF1053
PF16214   AC_N
PF13855   LRR_8
PF00053   Laminin_EGF
PF00052   Laminin_B
PF00055   Laminin_N
PF00069   Pkinase

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR009398   Adcy_conserved_dom       
IPR029787   Nucleotide_cyclase       
IPR032628   AC_N       
IPR001054   A/G_cyclase       
IPR030672   Adcy       
IPR001611   Leu-rich_rpt       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR032675   LRR_dom_sf       
IPR000742   EGF-like_dom       
IPR008211   Laminin_N       
IPR000034   Laminin_IV       
IPR002049   Laminin_EGF       
IPR038684   Laminin_N_sf       
IPR000719   Prot_kinase_dom       
IPR000014   PAS       
IPR035965   PAS-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF55073   SSF55073        + More
SSF56112   SSF56112       
SSF55785   SSF55785       

Gene 3D

3.30.70.1230     3.80.10.10     2.60.120.1490    

ProteinModelPortal

A0A2A4JWP0   A0A1A9VJ86   E2C8S2   A0A088A9P4   A0A158NDG4   A0A151I8P7   + More
A0A0L7QXT2   A0A151WG64   A0A195DJ43   A0A195B1A1   E1ZWP3   K7IW63   A0A195FI12   A0A026WVL9   A0A232F4A6   Q17AS9   A0A1Q3FH84   A0A182QY05   B0W3P0   A0A182JM26   A0A182NHL1   A0A182X6E4   A0A182WIR8   A0A182JNX9   A0A182P3J4   A0A182KRT2   A0A182VBB7   A0A1Q3FH75   W5JPE3   A0A182XZ95   A0A182FFX0   Q7QJS0   A0A1B0D5W6   A0A182I3Q0   A0A182RFN9   A0A0A1XK61   A0A1L8E010   A0A0K8VG24   A0A0K8VJ34   A0A1I8P6M3   W8BSK9   A0A1L8DZR4   A0A1I8P6L0   A0A1I8MAK7   A0A1B0BR96   A0A1A9XV14   A0A1A9X0W6   A0A084VFC6   A0A1B0G1W6   A0A0M4EKS3   A0A1W4W4V1   B3M753   Q9W038   Q8IGU9   Q9NJ99   B3NBF6   B4PEC4   A0A0J9RMB5   A0A0P8XSB8   W8C4S9   A0A0R1DUK7   B4QN42   B4J0I9   A0A3B0KP39   B4H5T3   A0A0Q9WUX1   Q2LYT8   B4LBX0   A0A0M5IYV0   B3N3B7   Q9VK50   B3MNI0  

PDB

3MAA     E-value=2.21167e-53,     Score=534

KEGG

101737125    K01768 adenylate cyclase [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 1-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0004016   GO:0016021   GO:0000166   GO:0035556   GO:0006171   GO:0005886   GO:0016849   GO:0009190   GO:0005524   GO:0046872   GO:0004672   GO:0004383   GO:0005887   GO:0007189   GO:0016020   GO:0008270   GO:0043565   GO:0005515   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

Subcellular location

Membrane  

Length:

1553

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

256.288989999999

Exp number, first 60 AAs:

0.01294

Total prob of N-in:

0.94166

inside

1  -  75

TMhelix

76  -  98

outside

99  -  107

TMhelix

108  -  127

inside

128  -  139

TMhelix

140  -  162

outside

163  -  171

TMhelix

172  -  189

inside

190  -  193

TMhelix

194  -  216

outside

217  -  220

TMhelix

221  -  243

inside

244  -  607

TMhelix

608  -  630

outside

631  -  639

TMhelix

640  -  662

inside

663  -  699

TMhelix

700  -  722

outside

723  -  736

TMhelix

737  -  756

inside

757  -  760

TMhelix

761  -  780

outside

781  -  1419

TMhelix

1420  -  1442

inside

1443  -  1553

 

 

Pi

221.331491

Theta

195.252862

Tajima's D

0.243118

CLR

0.493125

CSRT

0.44012799360032

Interpretation

Possibly Positive selection