Gene

KWMTBOMO02529  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002594

Annotation

adenylate_kinase_2_[Bombyx_mori]

Location

Bomo_Chr5(+):4899002-4904256      View in EpiBrowser

Full name

Adenylate kinase      

Alternative Name

ATP-AMP transphosphorylase
ATP:AMP phosphotransferase
Adenylate kinase cytosolic and mitochondrial
Adenylate monophosphate kinase

Location in the cell

Cytoplasmic   Reliability : 1.345 Mitochondrial   Reliability : 1.775 Nuclear   Reliability : 1.154

CDS

ATGGCACCGGCCGCTGCAGCCACGAAACTAAAACCTGATGAGGATCCTTTAGGAATAAGGGCCGTGCTACTTGGCCCTCCTGGATCCGGTAAGGGGACTCAGGCTCCTCGTCTGAAAGAAAAGTATTGTGTTTGTCACCTATCCACTGGTGACATGCTGCGTGCTGAAGTCTCATCGGGATCAGACCTGGGACGACGCCTTAAGAAGGTCATGGATGAGGGCAAACTTGTTTCCGATGAAATGGTGGTTGATATGATTGACAAGAACTTGGATCAACCTGAGTGCAAGAATGGTTTCTTACTTGATGGATTCCCTAGAACTGTACCCCAGGCTGAGAAGTTGGACGATCTATTGGCGAAGCGCAAGACTGCACTGGACGCCGTAATCGAGTTCGGAATCGAGGACAGTCTGCTCGTAAGGAGAATTACGGGCAGACTGATTCACCCACCTAGTGGTCGTAGCTATCACGAAGAGTTCCACCCGCCGAAGAAACCAATGACTGACGATGTCACCGGAGAAGCTTTGATAAAAAGGTCCGACGACAATGTCGAGGCTCTGAAGAAACGCTTAGCTACATATCATGCTCAAACGGTTCCTTTAGTAGACTATTACATGAGGAAAGGTCTACATTGGCGCGTCGATGCATCGAAAGCCGCTGACGACGTCTTCAACAAAATCGATAATATCTTTAAGAGTAGAATTTTCAGCAGAGCACGGTCTGCTTTGTAA

Protein

MAPAAAATKLKPDEDPLGIRAVLLGPPGSGKGTQAPRLKEKYCVCHLSTGDMLRAEVSSGSDLGRRLKKVMDEGKLVSDEMVVDMIDKNLDQPECKNGFLLDGFPRTVPQAEKLDDLLAKRKTALDAVIEFGIEDSLLVRRITGRLIHPPSGRSYHEEFHPPKKPMTDDVTGEALIKRSDDNVEALKKRLATYHAQTVPLVDYYMRKGLHWRVDASKAADDVFNKIDNIFKSRIFSRARSAL

Description

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.

Catalytic Activity

AMP + ATP = 2 ADP

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family. AK2 subfamily.
Belongs to the adenylate kinase family.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Kinase   Mitochondrion   Nucleotide-binding   Reference proteome   Transferase   Phosphoprotein  

Feature

chain  Adenylate kinase

Uniprot

D2Y062   I7E453   A0A194R0M3   A0A194PL28   I1XB05   S4PGE2   + More
A0A2A4IYP6   A0A0L7LIT0   A0A2H1WLV9   A0A212EGS0   D6W7C6   J3JTL3   A0A1B6F5R1   W8CEH7   N6U870   A0A182UUR3   A0A182JT33   A0A182TDG5   A0A1B0C953   A0A182X4T6   A0A182KS19   A0A182I3X5   Q7QJX9   A0A1A9ZZH7   A0A336M5Z7   A0A1B6HC04   A0A1B6M664   A0A182P4G3   A0A182IYG8   A0A2M3ZI41   A0A1A9V699   W5JSV0   B4PAR6   D3TLM5   A0A1L8EEJ1   A0A0J9RL87   B4QBH8   B4I2A8   B3NQ53   A0A034VQD5   A0A2M4AMT8   A0A0L0BQJ4   Q9U915   T1PER8   B4MQT3   A0A182MTV2   A0A182GVU5   A0A1B0BW27   A0A023EKV1   Q1HQK0   A0A1I8PDA2   A0A1W4UZE1   A0A0A1WU31   A0A1Q3EXB4   A0A182RB07   V5G5Q0   A0A084VF42   A0A1L8DXZ1   A0A2M4BY64   B0X5E3   A0A1A9WI61   A0A1Y1LBS1   A0A182NHA8   B3MCQ5   A0A182QXH5   A0A1L8DXV0   A0A182WJ02   A0A182XZA4   A0A0K8TT75   T1E828   A0A087SUP8   B4KLY1   A0A1B6CWT8   B4LP08   A0A151IBS1   B4J672   U5EXT6   A0A0L7QRZ4   A0A0P4X9D0   A0A0P5J3E6   A0A0P5J980   A0A0P6IBS3   Q290A8   A0A0P4WVG2   A0A2S2NUU7   A0A0M4EBJ7   E9GFK4   F4WV76   A0A0B4J2Q4   E9J058   A0A151WJW2   A0A0C9R051   A0A3B0JDA8   A0A026WRM3   A0A195EVX7   A0A2H8TX84   A0A1W4X547   A0A151IRE1   C4WT06   A0A1J1IRY8  

EC Number

2.7.4.3

Pubmed

19121390    26354079    23622113    26227816    22118469    18362917    + More
19820115    22516182    24495485    23537049    20966253    12364791    20920257    23761445    17994087    20353571    22936249    25348373    26108605    10786623    10731132    12537572    18327897    25315136    26483478    24945155    17204158    17510324    25830018    24438588    28004739    25244985    26369729    15632085    21292972    21719571    20075255    21282665    24508170    30249741   

EMBL

BABH01014382    BABH01014383    GU270853    ADB27115.1    JX046921    AFO83997.1    + More
KQ461103    KPJ09391.1    KQ459606    KPI91810.1    JQ801344    AFI80907.1    GAIX01003707    JAA88853.1    NWSH01004591    PCG64881.1    JTDY01000942    KOB75352.1    ODYU01009553    SOQ54060.1    AGBW02015043    OWR40670.1    KQ971307    EFA11124.1    BT126570    AEE61534.1    GECZ01024252    JAS45517.1    GAMC01000176    JAC06380.1    APGK01039127    KB740967    KB632399    ENN76846.1    ERL94665.1    AJWK01001915    AJWK01001916    APCN01000227    AAAB01008807    UFQT01000381    SSX23787.1    GECU01035489    GECU01025473    GECU01015473    JAS72217.1    JAS82233.1    JAS92233.1    GEBQ01008584    JAT31393.1    GGFM01007431    MBW28182.1    ADMH02000542    ETN65995.1    CM000158    CCAG010018993    EZ422327    ADD18603.1    GFDG01001662    JAV17137.1    CM002911    KMY96219.1    CM000362    CH480820    CH480824    CH954179    GAKP01013431    JAC45521.1    GGFK01008768    MBW42089.1    JRES01001518    KNC22281.1    AB009996    AE013599    AY069848    KA647277    AFP61906.1    CH963849    AXCM01015711    JXUM01020521    KQ560574    KXJ81847.1    JXJN01021586    GAPW01003801    JAC09797.1    DQ440444    CH477917    GBXI01012369    JAD01923.1    GFDL01015088    JAV19957.1    GALX01003061    JAB65405.1    ATLV01012360    KE524785    KFB36586.1    GFDF01002822    JAV11262.1    GGFJ01008884    MBW58025.1    DS232375    GEZM01060343    JAV71053.1    CH902619    AXCN02000894    GFDF01002850    JAV11234.1    GDAI01000252    JAI17351.1    GAMD01002562    JAA99028.1    KK112039    KFM56587.1    CH933808    GEDC01019329    JAS17969.1    CH940648    KQ978111    KYM96948.1    CH916367    GANO01000763    JAB59108.1    KQ414766    KOC61410.1    GDIP01245812    JAI77589.1    GDIQ01205224    JAK46501.1    GDIQ01203476    JAK48249.1    GDIQ01023231    JAN71506.1    CM000071    GDIP01254596    JAI68805.1    GGMR01008193    MBY20812.1    CP012524    ALC42646.1    GL732542    EFX81793.1    GL888384    EGI61842.1    GL767291    EFZ13829.1    KQ983031    KYQ48148.1    GBYB01000216    JAG69983.1    OUUW01000001    SPP73210.1    KK107128    QOIP01000006    EZA58341.1    RLU21104.1    KQ981953    KYN32420.1    GFXV01007062    MBW18867.1    KQ981129    KYN09272.1    ABLF02021004    AK340409    BAH71026.1    CVRI01000059    CRL02983.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    + More
UP000007266    UP000019118    UP000030742    UP000075903    UP000075881    UP000075902    UP000092461    UP000076407    UP000075882    UP000075840    UP000007062    UP000092445    UP000075885    UP000075880    UP000078200    UP000000673    UP000002282    UP000092444    UP000000304    UP000001292    UP000008711    UP000037069    UP000000803    UP000095301    UP000007798    UP000075883    UP000069940    UP000249989    UP000092460    UP000008820    UP000095300    UP000192221    UP000075900    UP000030765    UP000002320    UP000091820    UP000075884    UP000007801    UP000075886    UP000075920    UP000076408    UP000054359    UP000009192    UP000008792    UP000078542    UP000001070    UP000053825    UP000001819    UP000092553    UP000000305    UP000007755    UP000002358    UP000075809    UP000268350    UP000053097    UP000279307    UP000078541    UP000192223    UP000078492    UP000007819    UP000183832   

PRIDE

D2Y062    Q7QJX9    B3NQ53    Q9U915    B4MQT3    Q1HQK0    + More
B0X5E3    B3MCQ5    B4LP08    B4J672    Q290A8   

Pfam

PF05191   ADK_lid

Interpro

IPR028587   AK2        + More
IPR006259   Adenyl_kin_sub       
IPR007862   Adenylate_kinase_lid-dom       
IPR000850   Adenylat/UMP-CMP_kin       
IPR027417   P-loop_NTPase       
IPR033690   Adenylat_kinase_CS       

SUPFAM

SSF52540   SSF52540       

CDD

cd01428  ADK

ProteinModelPortal

D2Y062   I7E453   A0A194R0M3   A0A194PL28   I1XB05   S4PGE2   + More
A0A2A4IYP6   A0A0L7LIT0   A0A2H1WLV9   A0A212EGS0   D6W7C6   J3JTL3   A0A1B6F5R1   W8CEH7   N6U870   A0A182UUR3   A0A182JT33   A0A182TDG5   A0A1B0C953   A0A182X4T6   A0A182KS19   A0A182I3X5   Q7QJX9   A0A1A9ZZH7   A0A336M5Z7   A0A1B6HC04   A0A1B6M664   A0A182P4G3   A0A182IYG8   A0A2M3ZI41   A0A1A9V699   W5JSV0   B4PAR6   D3TLM5   A0A1L8EEJ1   A0A0J9RL87   B4QBH8   B4I2A8   B3NQ53   A0A034VQD5   A0A2M4AMT8   A0A0L0BQJ4   Q9U915   T1PER8   B4MQT3   A0A182MTV2   A0A182GVU5   A0A1B0BW27   A0A023EKV1   Q1HQK0   A0A1I8PDA2   A0A1W4UZE1   A0A0A1WU31   A0A1Q3EXB4   A0A182RB07   V5G5Q0   A0A084VF42   A0A1L8DXZ1   A0A2M4BY64   B0X5E3   A0A1A9WI61   A0A1Y1LBS1   A0A182NHA8   B3MCQ5   A0A182QXH5   A0A1L8DXV0   A0A182WJ02   A0A182XZA4   A0A0K8TT75   T1E828   A0A087SUP8   B4KLY1   A0A1B6CWT8   B4LP08   A0A151IBS1   B4J672   U5EXT6   A0A0L7QRZ4   A0A0P4X9D0   A0A0P5J3E6   A0A0P5J980   A0A0P6IBS3   Q290A8   A0A0P4WVG2   A0A2S2NUU7   A0A0M4EBJ7   E9GFK4   F4WV76   A0A0B4J2Q4   E9J058   A0A151WJW2   A0A0C9R051   A0A3B0JDA8   A0A026WRM3   A0A195EVX7   A0A2H8TX84   A0A1W4X547   A0A151IRE1   C4WT06   A0A1J1IRY8  

PDB

2C9Y     E-value=6.56918e-86,     Score=806

KEGG

100329147    K00939 adenylate kinase [EC:2.7.4.3] | (RefSeq) adk2; adenylate kinase 2

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046034   GO:0046033   GO:0005758   GO:0005524   GO:0006172   GO:0004017   GO:0005829   GO:0035172   GO:0016049   GO:0005739   GO:0006139   GO:0019205   GO:0016776   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

PANTHER

PTHR23359  

Subcellular location

Cytoplasm   Predominantly mitochondrial.   With evidence from 1 publications.
Cytosol   Predominantly mitochondrial.   With evidence from 1 publications.
Mitochondrion intermembrane space   Predominantly mitochondrial.   With evidence from 1 publications.

Length:

242

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06062

outside

1  -  242

 

 

Pi

175.405468

Theta

193.444821

Tajima's D

-0.389902

CLR

0.340935

CSRT

0.260836958152092

Interpretation

Uncertain