Gene

KWMTBOMO02524

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr5(-):4827377-4832241      View in EpiBrowser

Full name

Probable RNA-directed DNA polymerase from transposon X-element       + More
Probable RNA-directed DNA polymerase from transposon BS      
RNA-directed DNA polymerase from mobile element jockey      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 2.233

CDS

ATGGAGTTTTCTCCAACCAATACACTGCTCGCGGAATTCTTAAGCGAGAAATACCCGGCCCTCGAATCAGAATTTTTAGCTTACAAAGCTAAACGCGCCGTGAACTGTTCTGCCGTGCCCGCCGCGCCCGTTGTTTCCGCCACGCTTGCCGTTCCCGCGTCCCCTGCAAGCGCGCGCAAAACTCCCGCGCCGTACACCGCAGCCTCCGTCGCGCCCAGCACACCCATGTCCCCCATACTGTCGCGAAAAACTCCCGCGTCTACCGCGGCAGCTTCCATTCTACCTCAGCGATCATCTGCGGCTTCCGTCGCGTCCGCCGCTCCCGCGCCTTCCTCCTCGTCCTCTGACTCTGACTCGGATATGGAGGTTGACCTCGTTCCCGCCTCATTAACAGATGGATTCACCCTCGTGCAAAAGGGTAAGAAGCGCGCCGCGGAGTCCCGAGCTTCCGCGGCCGCTAAAATAAGCAAAGCCGCGAACGCGTCGCGCCCCCGCCCTCCGACCCCCGTCGCTCCCTGTCCCCGTGCCACGCCGTCGCCGCGCCCGGTGGCACAAACGAGAAATCAGGCCCCTCCTCCGTTGATTCTTCAAGAGAAGGCTGCTTGGGACCGTGTCTCCCTGGCCCTTAAGGCCAAGAACATAAATTTTGTCAGTGCCCGTAACCTCGCGAACGGGATACAGATAAAAGTAGCAACACCCGACGACCATAGGGCCCTCTCAAGCTACCTCCGAAAGGAGCGTATAAGTTATCATACGTATACGCTCCAGGAGGAGCGTGAGCTCCGTGCTGTCATACGTGGCATCCCCAAGGAGTTAGATGCCGAGCTCGTAAAGGCCGACCTACTCGAACAAGGCCTACCCGTAAACTCCGTGCACCGCATGCACACAGGACGCGGGAGGGAGCCATACAATATGGTTCTCGTCGCCCTCCAGTCTACCCCCGAGGGATTTTTTAACGCTTACGGTCTCGCAAATCAACGTGATCAGGTTTGTGATTTTTTGCGTGACCATCAAATTGACATCTTTTTGGTGCAGGAGACCCTGCTTAAGCCCGCGCGCTGCGACCCTAAAATCGCGAACTATAACATGGTTAGGAACGACAGGCTCACTGCTCGTGGTGGTGGTACCGTCATTTACTATAGACGAGCCCTGCACTGCGTCCCACTCGACCCCCCCGCGCTTTCTAACATCGAAGCATCAGTATGCCGAATATCACTGACGGGACACGCGCCGATCGTTATCGCGTCCGTTTATCTTCCACCGGATAAGATAGTTCTAAGCAGTGATATCGAGGCGCTGCTCGGCATGGGAAGCTCTGTCATTCTGGCGGGCGACCTAAATTGTAAACACGTCAGGTGGAACTCACACACCACAACCCCGAATGGCAGGCGACTTGACGCGTTAGTCGATGATCTCGCCTTCGATATCGTCGCTCCGCTAACCCCGACTCACTACCCGCTAAATATCGCGCATCGCCCGGATATACTCGACATAGCGTTATTAAAAAACGTAACTCTGCGCTTACACTCGATCGAAGTAGTTTCTGAGTTAGATTCAGACCACCGTCCCGTCGTTATGAAGCTCGGTCGCGCTCCCGATTCCGTTCCCGTCACGAGGACTGTGGTGGATTGGCACACGCTGGGCATCAGCCTGGCTGAATCTGATCCACCATCGCTCCCATTTAGCCCGGACTCTACCCCGTCTCCTCAGGATACCGCTGAAGCCATAGACATCTTAACGTCACACATCACCTCGACATTAGATAGGTCATCTAAGCAAGTTGTAGCGGAGGACTTCCTTCACCGCTTCAAATTGCCCGACGATATTAGGGAACTCCTTAGAGCTAAGAACGCCTCGATCCGCGCCTACGATAGGTATCCTACCGTGGATAATCGTATTCGAATGCGTGCCCTACAACGCGACGTAAAGTCTCGCATCGCCGAAGTCCGAGATGCCAGATGGTCTGATTTCTTAGAAAGTCTCGCGCCCTCCCAAAGGTCTTACTACCACTTAGCTCGTACTCTCAAATCGGATACGGTAGTAACTATGCCCCCCCTTGTAGGCCCCTCAGGCCGACTCGCGGCGTTCGATGATGATGAAAAAGCAGAGCTGCTGGCCGATACATTGCAAACCCAGTGCACGCCCAGCACTCAATCCGTGGACCCTGTTCATGTAGAATTAGTAGACAGTGAGGTAGAACGCAGAGCCTCCTTGCCACCCTCGGATGCGTTACCACCCGTCACCCCGATGGAAGTTAAAGACTTGATCAAAGACCTACGTCCTCGCAAGGCTCCCGGTTCCGACGGTATATCTAACCGCGTTATTAAGCTTCTACCCGTCCAACTCATCGTGATGTTGGCATCTATTTTCAATGCCGCTATGGCGAACTGTATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGCATACATAAACCCGGTAAACCAAAAAATCATCCGACGAGCTACCGCCCGATTAGCCTCCTCATGTCTCTAGGCAAACTGTATGAGCGTCTGCTCTACAAACGCCTCAGAGACTTCGTCTCATCCAAGGGCATTCTCATCGATGAACAATTCGGATTCCGTACAAATCACTCATGCGTTCAACAGGTGCACCGCCTCACGGAGCACATTCTTGTGGGGCTTAATCGACCAAAACCGTTATACACGGGAGCTCTCTTCTTCGACGTCGCAAAGGCGTTCGACAAAGTCTGGCACAATGGTTTGATTTTCAAACTATTCAACATGAGCGTGCCGGATAGTCTCGTGCTCATCATACGGGACTTCTTGTCGAACCGCTCTTTTCGATATCGAGTCGAGGGAACCCGCTCCTCCCCACGACCTCTCACAGCTGGAGTCCCGCAAGGCTCTGTCCTCTCACCCCTCTTATTTAGCTTATTCGTCAACGATATTCCCCGGTCGCCGCCGACCCATTTAGCTTTATTCGCCGACGACACGACTGTTTACTATTCTAGTAGAAATAAGTCCATAATCGCGAAGAAGCTTCAGAGCGCAGCTCTAGCGCTAGGACAGTGGTTCCGAAAATGGCGCATAGACATCAACCCAGCGAAAAGTACTGCGGTGCTATTTCAGAGGGGAAGCTCCACACGGATTTCCTCCCGGATTAGGAGGAGGAATCTCACACCCCCGATTACTCTCTTTAGACAACCCATACCCTGGGCTAGGAAGGTCAAGTACCTGGGCGTTACCCTGGATGCATCGATGACATTCCGCCCGCATATAAAATCAGTCCGTGACCGTGCTGCGTTTATTCTCGGTAGACTCTACCCCATGATCTGTAAGCGGAGTAAAATGTCCCTTCGGAACAAGGTGACACTTTACAAAACTTGCATAAGGCCCGTCATGACTTACGCGAGTGTGGTGTTCGCCCACGCGGCCCGCACACACATAGACACCCTCCAATCCCTACAATCCCGCTTTTGCAGGTTAGCTGTCGGGGCTCCGTGGTTCGTGAGGAACGTTGACCTACACGACGACCTGGGCCTCGAATCAATTCGGAAATACATGAAGTCAGCGTCGGAACGATACTTCGATAAGGCTATGCGTCATGATAATCGCCTTATCGTTGCCGCCGCTGACTACTCCCCGAATCCTGATCATGCAGGAGCCAGTCACCGTCGACGCCCTAGACACGTCCTTACGGATCCATCAGATCCAATAACCTTTGCATTAGATGCCTTCAGCTCTAATACTAGGGGCAGGCTTAGGGACCCCGGTAACCGTACTCGTCGAACTCGACAAAGAGGTCGACGTGCAACCTAA

Protein

MEFSPTNTLLAEFLSEKYPALESEFLAYKAKRAVNCSAVPAAPVVSATLAVPASPASARKTPAPYTAASVAPSTPMSPILSRKTPASTAAASILPQRSSAASVASAAPAPSSSSSDSDSDMEVDLVPASLTDGFTLVQKGKKRAAESRASAAAKISKAANASRPRPPTPVAPCPRATPSPRPVAQTRNQAPPPLILQEKAAWDRVSLALKAKNINFVSARNLANGIQIKVATPDDHRALSSYLRKERISYHTYTLQEERELRAVIRGIPKELDAELVKADLLEQGLPVNSVHRMHTGRGREPYNMVLVALQSTPEGFFNAYGLANQRDQVCDFLRDHQIDIFLVQETLLKPARCDPKIANYNMVRNDRLTARGGGTVIYYRRALHCVPLDPPALSNIEASVCRISLTGHAPIVIASVYLPPDKIVLSSDIEALLGMGSSVILAGDLNCKHVRWNSHTTTPNGRRLDALVDDLAFDIVAPLTPTHYPLNIAHRPDILDIALLKNVTLRLHSIEVVSELDSDHRPVVMKLGRAPDSVPVTRTVVDWHTLGISLAESDPPSLPFSPDSTPSPQDTAEAIDILTSHITSTLDRSSKQVVAEDFLHRFKLPDDIRELLRAKNASIRAYDRYPTVDNRIRMRALQRDVKSRIAEVRDARWSDFLESLAPSQRSYYHLARTLKSDTVVTMPPLVGPSGRLAAFDDDEKAELLADTLQTQCTPSTQSVDPVHVELVDSEVERRASLPPSDALPPVTPMEVKDLIKDLRPRKAPGSDGISNRVIKLLPVQLIVMLASIFNAAMANCIFPAVWKEADVIGIHKPGKPKNHPTSYRPISLLMSLGKLYERLLYKRLRDFVSSKGILIDEQFGFRTNHSCVQQVHRLTEHILVGLNRPKPLYTGALFFDVAKAFDKVWHNGLIFKLFNMSVPDSLVLIIRDFLSNRSFRYRVEGTRSSPRPLTAGVPQGSVLSPLLFSLFVNDIPRSPPTHLALFADDTTVYYSSRNKSIIAKKLQSAALALGQWFRKWRIDINPAKSTAVLFQRGSSTRISSRIRRRNLTPPITLFRQPIPWARKVKYLGVTLDASMTFRPHIKSVRDRAAFILGRLYPMICKRSKMSLRNKVTLYKTCIRPVMTYASVVFAHAARTHIDTLQSLQSRFCRLAVGAPWFVRNVDLHDDLGLESIRKYMKSASERYFDKAMRHDNRLIVAAADYSPNPDHAGASHRRRPRHVLTDPSDPITFALDAFSSNTRGRLRDPGNRTRRTRQRGRRAT

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

At least 30 copies of X-element are present in the genome and some elements are polymorphic between different strains.
Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  Probable RNA-directed DNA polymerase from transposon X-element

Uniprot

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A1Y1NA23   A0A139W8G9   + More
V5GNJ2   A0A139WA11   X1WLB2   V5GNF3   A0A2S2PPK8   A0A023EYS8   A0A2S2QEE0   A0A2S2Q383   A0A2J7R7D0   A0A224X6Q4   A0A2J7PU96   X1WZH0   A0A2J7QR37   A0A224X6S1   A0A2J7PBY3   A0A2J7QY69   A0A224XI99   A0A224X6T4   A0A2S2N814   A0A087UCW3   A0A224X6U5   A0A2S2NGV8   A0A2J7QB68   A0A087UGF5   A0A2M4BD67   A0A2S2PJG2   A0A2M4BDV6   A0A2M4CV52   A0A2J7Q6J2   J9LFC9   A0A2M4CV42   A0A224X6W2   A0A2S2R9D4   A0A2H8TF37   A0A1Y1KFR3   A0A224XJI0   A0A2S2N6Q7   A0A0A9YJ00   Q9NBX4   A0A2S2P698   A0A224XIB0   A0A2M4BD66   A0A2M4BD62   A0A2M4BDA5   A0A069DZL8   A0A0A9YU04   A0A2S2NH02   A0A2H8TKI9   A0A224X6R6   A0A2M4BD83   A0A069DX78   Q95SX7   A0A2S2NPG3   A0A1B6EGD8   A0A142LX49   A0A224XHW8   A0A2S2P6S3   A0A2J7Q0S7   A0A352X8G4   P21328   A0A142LX26   A0A2S2PHL7   A0A023F0I3   A0A2S2P7B2  

EC Number

2.7.7.49

Pubmed

10333566    10380107    28004739    18362917    19820115    25474469    + More
25401762    11405632    26334808    7753626    12537569    25527032    30148503    2463954    3040362    1714378   

EMBL

U07847    AAA17752.1    AB018558    BAA76304.1    AB055391    BAB21761.1    + More
AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ973342    KXZ75569.1    GALX01005299    JAB63167.1    KQ971729    KYB24751.1    ABLF02042518    ABLF02057746    GALX01005359    JAB63107.1    GGMR01018716    MBY31335.1    GBBI01004395    JAC14317.1    GGMS01006359    MBY75562.1    GGMS01002992    MBY72195.1    NEVH01006736    PNF36716.1    GFTR01008279    JAW08147.1    NEVH01021205    PNF19912.1    ABLF02034467    NEVH01011985    PNF31054.1    GFTR01008271    JAW08155.1    NEVH01027074    PNF13841.1    NEVH01009134    PNF33528.1    GFTR01008256    JAW08170.1    GFTR01008261    JAW08165.1    GGMR01000676    MBY13295.1    KK119261    KFM75202.1    GFTR01008251    JAW08175.1    GGMR01003407    MBY16026.1    NEVH01016302    PNF25823.1    KK119692    KFM76444.1    GGFJ01001858    MBW50999.1    GGMR01016905    MBY29524.1    GGFJ01001857    MBW50998.1    GGFL01004957    MBW69135.1    NEVH01017470    PNF24199.1    ABLF02023911    GGFL01005012    MBW69190.1    GFTR01008260    JAW08166.1    GGMS01017365    MBY86568.1    GFXV01000908    MBW12713.1    GEZM01084969    JAV60363.1    GFTR01008257    JAW08169.1    GGMR01000226    MBY12845.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    AF237761    AAF81411.1    GGMR01012305    MBY24924.1    GFTR01008246    JAW08180.1    GGFJ01001844    MBW50985.1    GGFJ01001843    MBW50984.1    GGFJ01001842    MBW50983.1    GBGD01000415    JAC88474.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    GGMR01003864    MBY16483.1    GFXV01002840    MBW14645.1    GFTR01008269    JAW08157.1    GGFJ01001822    MBW50963.1    GBGD01000389    JAC88500.1    AY060438    AAL25477.1    GGMR01006408    MBY19027.1    GEDC01000337    JAS36961.1    KU543685    AMS38375.1    GFTR01008254    JAW08172.1    GGMR01012443    MBY25062.1    NEVH01019963    PNF22185.1    DNOY01000259    HBE18313.1    M22874    M38643    KU543673    AMS38352.1    GGMR01016296    MBY28915.1    GBBI01003747    JAC14965.1    GGMR01012676    MBY25295.1   

Proteomes

UP000007266    UP000007819    UP000235965    UP000054359   

PRIDE

Q93137    Q9XXW0    Q9BPQ0    Q9NBX4    Q95SX7    P21328    + More

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF03372   Exo_endo_phos
PF07727   RVT_2

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A1Y1NA23   A0A139W8G9   + More
V5GNJ2   A0A139WA11   X1WLB2   V5GNF3   A0A2S2PPK8   A0A023EYS8   A0A2S2QEE0   A0A2S2Q383   A0A2J7R7D0   A0A224X6Q4   A0A2J7PU96   X1WZH0   A0A2J7QR37   A0A224X6S1   A0A2J7PBY3   A0A2J7QY69   A0A224XI99   A0A224X6T4   A0A2S2N814   A0A087UCW3   A0A224X6U5   A0A2S2NGV8   A0A2J7QB68   A0A087UGF5   A0A2M4BD67   A0A2S2PJG2   A0A2M4BDV6   A0A2M4CV52   A0A2J7Q6J2   J9LFC9   A0A2M4CV42   A0A224X6W2   A0A2S2R9D4   A0A2H8TF37   A0A1Y1KFR3   A0A224XJI0   A0A2S2N6Q7   A0A0A9YJ00   Q9NBX4   A0A2S2P698   A0A224XIB0   A0A2M4BD66   A0A2M4BD62   A0A2M4BDA5   A0A069DZL8   A0A0A9YU04   A0A2S2NH02   A0A2H8TKI9   A0A224X6R6   A0A2M4BD83   A0A069DX78   Q95SX7   A0A2S2NPG3   A0A1B6EGD8   A0A142LX49   A0A224XHW8   A0A2S2P6S3   A0A2J7Q0S7   A0A352X8G4   P21328   A0A142LX26   A0A2S2PHL7   A0A023F0I3   A0A2S2P7B2  

KEGG

105841788    no KO assigned | (RefSeq) predicted GPI-anchored protein 58

GO

GO:0003964   GO:0004519   GO:0006313  

Length:

1261

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.44556

Exp number, first 60 AAs:

0.07888

Total prob of N-in:

0.00375

outside

1  -  1261

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0.446329

CSRT

0

Interpretation

Uncertain