Gene

KWMTBOMO02516

Pre Gene Modal

BGIBMGA002590

Annotation

myocyte_enhancing_factor_2_isoform_B_[Bombyx_mori]

Location

Bomo_Chr5(+):4504772-4590676      View in EpiBrowser

Full name

Myocyte-specific enhancer factor 2      

Alternative Name

MADS domain transcription factor

Transcription factor

SRF

Location in the cell

Nuclear   Reliability : 4.393

CDS

ATGGGTCGGAAGAAAATACAAATATCCCGGATTACGGACGAACGGAATCGGCAGGTTACTTTCAACAAACGTAAATTCGGCGTAATGAAGAAGGCGTATGAGTTGAGCGTGCTATGCGACTGTGAGATTGCACTCATCATATTCAGCTCCAACAACAAACTGTACCAATATGCAAGCACGGACATGGACAAGGTTCTGCTGAAATACACGGAATACAATGAACCGCACGAGTCCCTTACGAACCGCAACATCATCGAGAAAGAGCACAAGAACGGAGTGATGTCGCCTGACAGCCCGGAAGCCGAACCCGAATACAACCTGACCCCCCGCACCGAAGCCAAGTACTCGAAGATCGACGAGGAATTCCAAATGATGATGCAAAGGAACCAGTTGAACGGGAGCCGCGTCGGCGTTGGCGTGACGGGAAGCAACTATAACCTACCGGTCAGCGTGCCTGTCGGGAACTACGATCAATCCTTACTCCAAGCTAGTCCACAAATGCATACCTCTATCAGTCCACGGCCATCGTCTTCGGAAACCGATTCAGTATACCCAAGCGGCGGAATGCTCGAAATGTCAAACGGATACCCAGGCTCCGCATCACCACTGGGGGCGGGATGTACCCCGTCGCCGTCCCCCGGCCCCGCTCCCTCTCCCCACCGACACCCGCACAAGTCCCATGCCCACGCTCCGCCACCGCACCACTCGCCCCGACACAACAACCTGCGCGTCGTTATACCTAGTTCAATGCCACCACCGCAAGATGACATATCATATGCAGAGACACCACTAAGCTATTCACTCACCAACTTCGGACCACAGGACTTCAGTATGACCTCGGACATGGGAATCGGACTGACGTGGGGCGCTCACCAACTGCAGACGTTACAACACAACAGTGGCAGCCTGCCGGTATTGGGTGGTGGGGGAACTCCTCCACCGGCCGCGTCACCAAGCAATGTGAAGATCAAAGCGGAACCAGTATCGCCGCCACGCGCACCAGATCACTTGCATCGCGGCCCTCCTCCTGCCAGCGTACCACAGCCCGCACATCAAATGCCAGGAGTCATTGATGGCTCAGTTTCGTCTAGTAACATGGGCTCGCCGGCAGGCCAAGACATGAGGCACTCCAACGCCGTTGCGCTTGACTACGAGCAGCCCCATACCAAGCGGCCGCGGATCGAGGGTTGGGCCACATAG

Protein

MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSNNKLYQYASTDMDKVLLKYTEYNEPHESLTNRNIIEKEHKNGVMSPDSPEAEPEYNLTPRTEAKYSKIDEEFQMMMQRNQLNGSRVGVGVTGSNYNLPVSVPVGNYDQSLLQASPQMHTSISPRPSSSETDSVYPSGGMLEMSNGYPGSASPLGAGCTPSPSPGPAPSPHRHPHKSHAHAPPPHHSPRHNNLRVVIPSSMPPPQDDISYAETPLSYSLTNFGPQDFSMTSDMGIGLTWGAHQLQTLQHNSGSLPVLGGGGTPPPAASPSNVKIKAEPVSPPRAPDHLHRGPPPASVPQPAHQMPGVIDGSVSSSNMGSPAGQDMRHSNAVALDYEQPHTKRPRIEGWAT

Description

Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers (PubMed:7839146, PubMed:8052612, PubMed:8202544). Essential for myoblast fusion and consequently muscle formation in adults (PubMed:25797154). During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription (PubMed:25797154).

Similarity

Belongs to the MEF2 family.

Keywords

Activator   Alternative splicing   Complete proteome   Developmental protein   Differentiation   DNA-binding   Myogenesis   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Myocyte-specific enhancer factor 2
splice variant  In isoform F.

Uniprot

A1E2D3   Q4LG48   A0A2A4IYR6   A0A194R0N3   A0A2H1WFP3   A0A212FCK7   + More
A0A194PL18   A0A0L7LVI2   A0A1Y1MNF3   A0A1W4X0Q5   A0A1Y1MNE1   A0A1W4WZN4   A0A1W4X0Y4   A0A1Y1MNF0   A0A1W4WPY5   A0A1Y1MNE3   D6W7M3   A0A1L8DIK5   A0A1L8DIM5   A0A1L8DIU4   A0A1L8DIX0   A0A336LL04   U5EYN0   A0A1L8DIL0   A0A0P6K0X9   Q17KU1   A0A1I8MWP6   A0A1I8MWP5   A0A1W4V0M8   A0A1W4UZC4   A0A0R3NP37   A0A1I8MWQ0   B4J5M9   A0A158NSE3   A0A0M4ETH6   A0A1I8MWP7   A0A1I8MWQ1   A0A0A1X2K1   B4LP45   B3MF35   B4GIF6   B0VZE2   A0A0K8W3G2   A0A1W4UM46   A0A1W4UZ20   N6WBY7   A0A1W4V0M3   A0A1I8MWP9   Q28Z04   A0A1I8MWP4   A0A2M4AU80   A0A0A1XT31   P40791-3   A0A1I8MWP3   A0A034W258   P40791-2   A0A0R3NNE9   A0A0A1X5B3   A0A0A9YAJ9   A0A2M4CP32   A0A2M4BJ28   A0A146KQ65   A0A0R3NTW6   A0A0K8UW66   A0A0A9YF65   A0A0K8WC81   A0A087ZQU1   B4MRI7   A0A2A3EK79   A0A0K8WLP4   A0A182XZ71   A0A0B4KFI1   A0A3L8DJI9   A0A2M4AU62   A0A0J7NPK4   A0A2J7QPN5   A0A2M4CP40   A0A2M4BJ05   P40791-4   H9ZYP5   D2WLB9   A0A182KDW2   A0A2M4CPE0  

Pubmed

16045756    26354079    22118469    26227816    28004739    18362917    + More
19820115    26999592    17510324    25315136    15632085    17994087    21347285    25830018    8202544    8052612    7605749    7839146    10731132    12537572    12537569    18327897    25797154    25348373    25401762    26823975    25244985    12537568    12537573    12537574    16110336    17569856    17569867    30249741   

EMBL

EF100967    ABL09604.1    AB121093    BAE06225.1    NWSH01004680    PCG64779.1    + More
KQ461103    KPJ09401.1    ODYU01008372    SOQ51905.1    AGBW02009170    OWR51474.1    KQ459606    KPI91800.1    JTDY01000020    KOB79389.1    GEZM01026166    GEZM01026162    GEZM01026158    JAV87191.1    GEZM01026164    GEZM01026159    GEZM01026157    JAV87193.1    GEZM01026165    GEZM01026161    GEZM01026155    JAV87203.1    GEZM01026163    GEZM01026160    JAV87194.1    KQ971307    EFA11312.2    GFDF01007802    JAV06282.1    GFDF01007803    JAV06281.1    GFDF01007804    JAV06280.1    GFDF01007800    JAV06284.1    UFQS01000040    UFQT01000040    SSW98264.1    SSX18650.1    GANO01000249    JAB59622.1    GFDF01007801    JAV06283.1    GDUN01000553    JAN95366.1    CH477221    EAT47316.1    CM000071    KRT02572.1    CH916367    EDW01805.1    ADTU01024863    CP012524    ALC40557.1    GBXI01008990    JAD05302.1    CH940648    EDW62239.2    CH902619    EDV37663.2    CH479183    EDW36276.1    DS231814    EDS31679.1    GDHF01016901    GDHF01009968    GDHF01006889    JAI35413.1    JAI42346.1    JAI45425.1    ENO01689.2    EAL25811.3    GGFK01011019    MBW44340.1    GBXI01000105    JAD14187.1    U03292    U07422    X83527    U19493    AE013599    AY061096    AY061589    AY118311    GAKP01010193    GAKP01010192    JAC48759.1    KRT02574.1    GBXI01010067    GBXI01008357    GBXI01006137    JAD04225.1    JAD05935.1    JAD08155.1    GBHO01015501    GBHO01015496    GBRD01012754    GBRD01012751    GBRD01012749    JAG28103.1    JAG28108.1    JAG53070.1    GGFL01002902    MBW67080.1    GGFJ01003919    MBW53060.1    GDHC01020440    JAP98188.1    KRT02573.1    GDHF01030477    GDHF01021714    GDHF01018096    JAI21837.1    JAI30600.1    JAI34218.1    GBHO01015504    GBHO01015499    JAG28100.1    JAG28105.1    GDHF01030567    GDHF01003573    JAI21747.1    JAI48741.1    CH963850    EDW74726.2    KZ288226    PBC31894.1    GDHF01026072    GDHF01013320    GDHF01000340    JAI26242.1    JAI38994.1    JAI51974.1    AGB93375.1    QOIP01000007    RLU20333.1    GGFK01010983    MBW44304.1    LBMM01002756    KMQ94410.1    NEVH01012088    PNF30541.1    GGFL01002885    MBW67063.1    GGFJ01003871    MBW53012.1    BT133393    AFH41852.1    GQ386849    GQ386850    ADB24036.1    ADB24037.1    GGFL01002873    MBW67051.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    UP000192223    + More
UP000007266    UP000008820    UP000095301    UP000192221    UP000001819    UP000001070    UP000005205    UP000092553    UP000008792    UP000007801    UP000008744    UP000002320    UP000000803    UP000005203    UP000007798    UP000242457    UP000076408    UP000279307    UP000036403    UP000235965    UP000075881   

PRIDE

A1E2D3    Q4LG48    P40791   

Pfam

PF12347   HJURP_C        + More
PF00319   SRF-TF

Interpro

IPR022102   HJURP_C        + More
IPR033896   MADS_MEF2-like       
IPR002100   TF_MADSbox       
IPR036879   TF_MADSbox_sf       

SUPFAM

SSF55455   SSF55455       

Gene 3D

3.40.1810.10    

CDD

cd00265  MADS_MEF2_like

ProteinModelPortal

A1E2D3   Q4LG48   A0A2A4IYR6   A0A194R0N3   A0A2H1WFP3   A0A212FCK7   + More
A0A194PL18   A0A0L7LVI2   A0A1Y1MNF3   A0A1W4X0Q5   A0A1Y1MNE1   A0A1W4WZN4   A0A1W4X0Y4   A0A1Y1MNF0   A0A1W4WPY5   A0A1Y1MNE3   D6W7M3   A0A1L8DIK5   A0A1L8DIM5   A0A1L8DIU4   A0A1L8DIX0   A0A336LL04   U5EYN0   A0A1L8DIL0   A0A0P6K0X9   Q17KU1   A0A1I8MWP6   A0A1I8MWP5   A0A1W4V0M8   A0A1W4UZC4   A0A0R3NP37   A0A1I8MWQ0   B4J5M9   A0A158NSE3   A0A0M4ETH6   A0A1I8MWP7   A0A1I8MWQ1   A0A0A1X2K1   B4LP45   B3MF35   B4GIF6   B0VZE2   A0A0K8W3G2   A0A1W4UM46   A0A1W4UZ20   N6WBY7   A0A1W4V0M3   A0A1I8MWP9   Q28Z04   A0A1I8MWP4   A0A2M4AU80   A0A0A1XT31   P40791-3   A0A1I8MWP3   A0A034W258   P40791-2   A0A0R3NNE9   A0A0A1X5B3   A0A0A9YAJ9   A0A2M4CP32   A0A2M4BJ28   A0A146KQ65   A0A0R3NTW6   A0A0K8UW66   A0A0A9YF65   A0A0K8WC81   A0A087ZQU1   B4MRI7   A0A2A3EK79   A0A0K8WLP4   A0A182XZ71   A0A0B4KFI1   A0A3L8DJI9   A0A2M4AU62   A0A0J7NPK4   A0A2J7QPN5   A0A2M4CP40   A0A2M4BJ05   P40791-4   H9ZYP5   D2WLB9   A0A182KDW2   A0A2M4CPE0  

PDB

5F28     E-value=1.5113e-40,     Score=418

KEGG

692449    K09260 MADS-box transcription enhancer factor 2A | (RefSeq) Mef2, Bmmef2; myocyte enhancing factor 2

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0045944   GO:0000977   GO:0046983   GO:0005634   GO:0003677   GO:0001228   GO:0048747   GO:0016202   GO:0007507   GO:0007519   GO:0032968   GO:0001158   GO:0019730   GO:0030707   GO:0052576   GO:0007517   GO:0019915   GO:0010468   GO:0007496   GO:0045475   GO:0007520   GO:0007498   GO:0016787   GO:0000165   GO:0006518   GO:0016020   GO:0006631   GO:0006635   GO:0006281   GO:0048384  

Subcellular location

Nucleus  

Length:

399

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.57043

Exp number, first 60 AAs:

0.49484

Total prob of N-in:

0.07191

outside

1  -  399

 

 

Pi

210.238838

Theta

176.780025

Tajima's D

0.669578

CLR

0.423471

CSRT

0.570721463926804

Interpretation

Uncertain