Gene

KWMTBOMO02472

Pre Gene Modal

BGIBMGA002718

Annotation

PREDICTED:_N-acetylgalactosamine_kinase_[Papilio_machaon]

Location

Bomo_Chr5(-):2908169-2909852      View in EpiBrowser

Full name

N-acetylgalactosamine kinase      

Alternative Name

GalNAc kinase
Galactokinase 2

Location in the cell

Cytoplasmic   Reliability : 1.508

CDS

ATGAATAATCAACGACACGACGAAATACCTATATTAAAAACAACAGCTGATACACGAATCAATCAACTAAATGAAAAATTTGAAGAGGAATTTGGGATTAAGCCGAACTTCACTGTTAAAGTGCCGGGACGTGTTAATATAATTGGAGAACATATCGACTATTGTGGATATCCAGTGCTACCGATGGCTTTAGAACAAAGTATTTTGATTGCGGTTGGATTGATTAATGAAAAAGATTTAAGAATACGGAATACGAATTCTAAATACTGTAAATTTCAGATGGATATTTCGAAGCCAGAAGACTTTGACATAAAACCAGACGAAGATGGAAAACCGTTCTGGTACAATTACGTACTTTGTGGAGTAAAGGGTGGATTAGAATTTCTGAATAGAAAAATCAGAGGCGGTGTAATTTTTCTGATAGATGGAAATATTCCACCGGCTTCCGGACTATCAAGTTCGTCTGCCTTAGTAAGCGCTTCTTGTCTTGCTTTCTTACATGCTCAGAATGCTAAAATAAGTAAATTAAAAATAGCTTCTTTATGTGCCAAAAGCGAACGTTATATTGGCACTCAGGGTGGTGGAATGGATCAGGCTATTGCTTTTCTGGCGGAAAAATCTAGCGCTCAGTATATTACTTGGAATCCACTGAATGCTACGCCAGTATCCCTTCCTGAAAATGCTACCTTCGTTGTTGCACATAGTTTAGCTGAAGCAAACAAAGCTGCGACTAACGATTTTAACACAAGAGTCATAGAATGCAGACTGGCAGCCAAGATACTAGCTGCTCGTTCGGGTATTGAAGTTACGAAAGAAATTATTTCACTGAGCGAACTTCAAAAAAAGCTACAAAAATCATTAAACGAAATGCTAGAACTTGTAACCGAACATTTGGCTAAAGACCTGTATTTAAAAAGCGATATTTGTGAATTGCTGAATATACCAGAGGACGAATTGAACAGGTTCTATTTGACCCCGAACACTAGACATTTGACCGAATTTAAATTAAAACAACGTGCCATTCACGTTTACGAAGAAGCCAAGCGAGTTGATAGCTTCCGTTACTTGTGTCAGCATTCGACTTTCAAAAATGAATTATCGACAAACAGCAATAACGGTGATTTGCTCTATGAGAATGGCGTTGAAAAGATAAGCAATTTAATTGAAAATCTAGGAGTATTGATGTTGGAGAGCCATGAAAGTCTAAAGACACACTACGAATGCTCCCACGACAATCTGGATCGTTTGGTGGACTTATCGAGAAAGATGAACGTTTACGCCCGGTTAACAGGCGCGGGTTGGGGTGGATGCATTGTAGCGTTATGTCCAAAAGAAAATGTTACAAAATACATAGAAACGTTAATCGATAATTTTTATGTTGAACATTGCAATTTAGACAGGGTCAGTGCACGTTCACATGTTTTCGCAACGACGCCTAATCGCGGTGCTGTTATTTACAATTTTACATGA

Protein

MNNQRHDEIPILKTTADTRINQLNEKFEEEFGIKPNFTVKVPGRVNIIGEHIDYCGYPVLPMALEQSILIAVGLINEKDLRIRNTNSKYCKFQMDISKPEDFDIKPDEDGKPFWYNYVLCGVKGGLEFLNRKIRGGVIFLIDGNIPPASGLSSSSALVSASCLAFLHAQNAKISKLKIASLCAKSERYIGTQGGGMDQAIAFLAEKSSAQYITWNPLNATPVSLPENATFVVAHSLAEANKAATNDFNTRVIECRLAAKILAARSGIEVTKEIISLSELQKKLQKSLNEMLELVTEHLAKDLYLKSDICELLNIPEDELNRFYLTPNTRHLTEFKLKQRAIHVYEEAKRVDSFRYLCQHSTFKNELSTNSNNGDLLYENGVEKISNLIENLGVLMLESHESLKTHYECSHDNLDRLVDLSRKMNVYARLTGAGWGGCIVALCPKENVTKYIETLIDNFYVEHCNLDRVSARSHVFATTPNRGAVIYNFT

Description

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity).

Catalytic Activity

ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate

Subunit

Monomer.

Similarity

Belongs to the eIF-2B alpha/beta/delta subunits family.
Belongs to the GHMP kinase family. GalK subfamily.

Keywords

ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Reference proteome   Transferase  

Feature

chain  N-acetylgalactosamine kinase

Uniprot

H9IZN3   A0A2W1BK90   A0A2A4J0W9   A0A194QA02   A0A0L7KWY0   A0A212ERH4   + More
A0A2H1WF89   A0A194QVU5   A0A1I8MLS2   A0A182PWR6   A0A182Q9W8   B0VZ29   Q7Q7U8   Q16EZ4   Q7PPJ0   A0A084WDS6   A0A182WM67   A0A1S4G3N9   A0A182ILR1   A0A1Q3FLU2   A0A336LBR4   A0A182PWY1   A0A2M4BKS2   A0A2M4BNX3   A0A2M4BN19   A0A2J7RKA5   A0A0K8TKS2   A0A0K8U6U9   A0A023ESR4   W5J318   A0A0L0CIA0   A0A182HE50   A0A067RJ52   A0A0K8WFG4   D6WIM7   A0A2M4AQJ2   A0A1Y1JUU6   W8BHD5   A0A1W4XPT1   A0A1Q3FMJ7   B4HAZ8   Q29F49   B4J155   B3M5W2   A0A1B0CB30   G3MRA9   A0A336MUF7   B4QMN8   Q95U34   A0A195CU31   B4KVP1   A0A1E1X8T5   A0A3B4Z4A6   A0A182RUU9   A0A0G2JTQ5   Q5XIG6   A0A1J1IU32   B3NFR0   E9J4D0   E1ZVT5   G1SR20   J3JWH0   B4LEV3   A0A195FQR0   A0A336LF07   E0VT04   A0A131YXT8   B4PFG0   E2RDA6   A0A154PA83   F1MFK7   L8ISC0   A0A224YWS5   A0A1A9W4J9   A0A091SJY1   A0A0M4EI82   A0A151WLJ7   L7M8J8   M3W563   A0A2I2TZX8   A0A3B0JTC7   A0A158P498   A0A1Z5KXI2   Q32KT8   A0A2R5LEZ2   A0A195B4G4   U6CS95   A0A091FVJ8   G1L3S2   W5QIM0   G1PNK0   A0A2U3VNM5   A0A293MUJ2   E2B9N8   A0A2U3VNC3   A0A131XAD6   D2H732   A0A3B3Q1J2   A0A1W4V0H7   I3JNU8  

EC Number

2.7.1.157

Pubmed

19121390    28756777    26354079    26227816    22118469    25315136    + More
12364791    14747013    17210077    17510324    24438588    26369729    24945155    20920257    23761445    26108605    26483478    24845553    18362917    19820115    28004739    24495485    17994087    15632085    23185243    18057021    22216098    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28503490    15057822    15489334    21282665    20798317    21993624    22516182    20566863    26830274    17550304    16341006    19393038    22751099    28797301    25576852    17975172    21347285    28528879    20010809    20809919    28049606    29240929    25186727   

EMBL

BABH01014533    KZ150070    PZC74064.1    NWSH01004519    PCG65023.1    KQ459465    + More
KPJ00256.1    JTDY01004885    KOB67630.1    AGBW02013039    OWR44054.1    ODYU01008294    SOQ51748.1    KQ461103    KPJ09439.1    AXCN02000969    DS231813    EDS25751.1    AAAB01008948    EAA10363.4    CH478541    EAT32808.1    EAA10347.5    ATLV01023057    KE525340    KFB48370.1    GFDL01006455    JAV28590.1    UFQS01003147    UFQT01003147    SSX15266.1    SSX34641.1    GGFJ01004422    MBW53563.1    GGFJ01005337    MBW54478.1    GGFJ01005336    MBW54477.1    NEVH01002981    PNF41267.1    GDAI01002684    JAI14919.1    GDHF01029930    JAI22384.1    GAPW01001268    JAC12330.1    ADMH02002156    ETN58226.1    JRES01000356    KNC31970.1    JXUM01035067    KQ561046    KXJ79906.1    KK852476    KDR23048.1    GDHF01002555    JAI49759.1    KQ971321    EFA00753.1    GGFK01009547    MBW42868.1    GEZM01103077    GEZM01103076    JAV51570.1    GAMC01013912    GAMC01013910    GAMC01013909    JAB92646.1    GFDL01006339    JAV28706.1    CH479246    EDW37792.1    CH379068    EAL31223.2    KRT07466.1    CH916366    EDV96910.1    CH902618    EDV39652.1    KPU78130.1    AJWK01004785    AJWK01004786    AJWK01004787    JO844410    AEO36027.1    UFQS01002390    UFQT01002390    SSX13936.1    SSX33355.1    CM000363    CM002912    EDX09792.1    KMY98530.1    AE014296    AY058337    AAF50337.2    AAF50338.2    AAL13566.1    AAN11980.1    ADV37511.1    KQ977279    KYN04155.1    CH933809    EDW19512.1    KRG06664.1    KRG06665.1    KRG06666.1    GFAC01003762    JAT95426.1    AABR07053641    AABR07072922    AC139594    BC083716    CVRI01000059    CRL03771.1    CH954178    EDV50602.1    KQS43383.1    KQS43385.1    KQS43386.1    GL768095    EFZ12324.1    GL434637    EFN74700.1    AAGW02024721    BT127588    AEE62550.1    CH940647    EDW70210.1    KRF84786.1    KRF84787.1    KQ981382    KYN42244.1    UFQS01003193    UFQT01003193    SSX15347.1    SSX34719.1    DS235759    EEB16510.1    GEDV01005247    JAP83310.1    CM000159    EDW93086.1    KRK00938.1    KRK00939.1    AAEX03016114    AAEX03016115    KQ434846    KZC08294.1    JH880779    ELR58958.1    GFPF01007895    MAA19041.1    KK822348    KFQ40595.1    CP012525    ALC43526.1    KQ982959    KYQ48690.1    GACK01004852    JAA60182.1    AANG04001761    OUUW01000009    SPP85365.1    ADTU01008758    GFJQ02007138    JAV99831.1    BC109933    AAI09934.1    GGLE01003892    MBY08018.1    KQ976618    KYM79170.1    HAAF01000622    CCP72448.1    KL447415    KFO73219.1    ACTA01010264    ACTA01018264    ACTA01026264    ACTA01034264    ACTA01042263    ACTA01050263    ACTA01058263    AMGL01103643    AMGL01103644    AMGL01103645    AMGL01103646    AMGL01103647    AMGL01103648    AMGL01103649    AMGL01103650    AAPE02011683    AAPE02011684    AAPE02011685    AAPE02011686    AAPE02011687    AAPE02011688    AAPE02011689    GFWV01019756    MAA44484.1    GL446584    EFN87572.1    GEFH01003977    JAP64604.1    GL192544    EFB29910.1    AERX01010891   

Proteomes

UP000005204    UP000218220    UP000053268    UP000037510    UP000007151    UP000053240    + More
UP000095301    UP000075885    UP000075886    UP000002320    UP000007062    UP000008820    UP000030765    UP000075920    UP000075880    UP000235965    UP000000673    UP000037069    UP000069940    UP000249989    UP000027135    UP000007266    UP000192223    UP000008744    UP000001819    UP000001070    UP000007801    UP000092461    UP000000304    UP000000803    UP000078542    UP000009192    UP000261400    UP000075900    UP000002494    UP000183832    UP000008711    UP000000311    UP000001811    UP000008792    UP000078541    UP000009046    UP000002282    UP000002254    UP000076502    UP000009136    UP000091820    UP000092553    UP000075809    UP000011712    UP000268350    UP000005205    UP000078540    UP000053760    UP000008912    UP000002356    UP000001074    UP000245340    UP000008237    UP000261540    UP000192221    UP000005207   

PRIDE

H9IZN3    Q95U34    Q5XIG6    E2RDA6   

Pfam

PF08544   GHMP_kinases_C        + More
PF10509   GalKase_gal_bdg
PF00288   GHMP_kinases_N
PF01008   IF-2B

Interpro

IPR019741   Galactokinase_CS        + More
IPR036554   GHMP_kinase_C_sf       
IPR006204   GHMP_kinase_N_dom       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR006203   GHMP_knse_ATP-bd_CS       
IPR006206   Mevalonate/galactokinase       
IPR013750   GHMP_kinase_C_dom       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR000705   Galactokinase       
IPR019539   GalKase_gal-bd       
IPR000649   IF-2B-related       
IPR037171   NagB/RpiA_transferase-like       

SUPFAM

SSF55060   SSF55060        + More
SSF54211   SSF54211       
SSF100950   SSF100950       

Gene 3D

3.30.230.10    

ProteinModelPortal

H9IZN3   A0A2W1BK90   A0A2A4J0W9   A0A194QA02   A0A0L7KWY0   A0A212ERH4   + More
A0A2H1WF89   A0A194QVU5   A0A1I8MLS2   A0A182PWR6   A0A182Q9W8   B0VZ29   Q7Q7U8   Q16EZ4   Q7PPJ0   A0A084WDS6   A0A182WM67   A0A1S4G3N9   A0A182ILR1   A0A1Q3FLU2   A0A336LBR4   A0A182PWY1   A0A2M4BKS2   A0A2M4BNX3   A0A2M4BN19   A0A2J7RKA5   A0A0K8TKS2   A0A0K8U6U9   A0A023ESR4   W5J318   A0A0L0CIA0   A0A182HE50   A0A067RJ52   A0A0K8WFG4   D6WIM7   A0A2M4AQJ2   A0A1Y1JUU6   W8BHD5   A0A1W4XPT1   A0A1Q3FMJ7   B4HAZ8   Q29F49   B4J155   B3M5W2   A0A1B0CB30   G3MRA9   A0A336MUF7   B4QMN8   Q95U34   A0A195CU31   B4KVP1   A0A1E1X8T5   A0A3B4Z4A6   A0A182RUU9   A0A0G2JTQ5   Q5XIG6   A0A1J1IU32   B3NFR0   E9J4D0   E1ZVT5   G1SR20   J3JWH0   B4LEV3   A0A195FQR0   A0A336LF07   E0VT04   A0A131YXT8   B4PFG0   E2RDA6   A0A154PA83   F1MFK7   L8ISC0   A0A224YWS5   A0A1A9W4J9   A0A091SJY1   A0A0M4EI82   A0A151WLJ7   L7M8J8   M3W563   A0A2I2TZX8   A0A3B0JTC7   A0A158P498   A0A1Z5KXI2   Q32KT8   A0A2R5LEZ2   A0A195B4G4   U6CS95   A0A091FVJ8   G1L3S2   W5QIM0   G1PNK0   A0A2U3VNM5   A0A293MUJ2   E2B9N8   A0A2U3VNC3   A0A131XAD6   D2H732   A0A3B3Q1J2   A0A1W4V0H7   I3JNU8  

PDB

2A2D     E-value=4.09074e-92,     Score=863

KEGG

101745110    K18674 N-acetylgalactosamine kinase [EC:2.7.1.157] | (RefSeq) N-acetylgalactosamine kinase

GO

GO:0005524   GO:0004335   GO:0005534   GO:0005737   GO:0006012   GO:0033499   GO:0005829   GO:0070062   GO:0016020   GO:0033858   GO:0046835   GO:0008152   GO:0016301   GO:0016773   GO:0006281   GO:0048384  

Length:

489

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.43073

Exp number, first 60 AAs:

0.05106

Total prob of N-in:

0.01693

outside

1  -  489

 

 

Pi

211.089531

Theta

173.265257

Tajima's D

0.107941

CLR

304.455797

CSRT

0.403929803509824

Interpretation

Uncertain