Gene

KWMTBOMO02470  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002570

Annotation

Dolichyl-diphosphooligosaccharide--protein_glycosyltransferase_subunit_1_[Operophtera_brumata]

Location

Bomo_Chr5(+):2880723-2882255      View in EpiBrowser

Full name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1      

Location in the cell

PlasmaMembrane   Reliability : 2.255

CDS

ATGAGATTACCGGCAATGGCGAAGTTACAATTTACGCTTTTTTTCGTATTGTTTCTGACGATACAAACCCTTAGTGCAAGCGTGGACACAATATCTAGTGATATAAAGTTAAAAAATGTCGATCGCACAGTAGATATATCGACCCAACTCGTAAAAGTAGTATCAAAAATAGTCTTGGAGAACAGTGGCAAATCGTCAGTAAAACATTTTCTTTTTGCGGTTGAAGAAGCTGCGAAGAATAATCTAGCGTTTATTGGAGCTAAAGACAGCAATAGTAAAGATCTTCGTCTCGCTGAAACCACTGTGAAAGGTTATGACTATGTTAAATTTTGGCGTGTGGAGCTCAAGGAACCCCTAAACGCCGGTGCCACAGTAAATGTTGTTGTCGAAACTGTGTTCACCAAAGCTTTACAACCATATCCGACAGCTATAACTCAGCAAGAAGACCAGTTTGTGAAATATGTTGGCAATTTGTATACATACTCCCCGTACTATACCTCCACACAAAAAACCAGCGTAATTCTAAATACAAAGACTGTTGAATCATTTACCAAGGTGAAGCCTTTCTCACAAGTTGATGGAACAATTATTTATGGACCGTACGCTAATGTTGGGCCTTTCACTGAAAAGGAGCTCAGCATTCACTACAAAAACAATTCACCATTTTTGACTGTTACTCGCGTCGAAAGATTGATAGAAGTATCACATTGGGGTAATATTGCCATTGAAGAGGTAATTGAAATTGAGCATACAGGAGCCAAGCTCAAAGGTCCGTTTTCTAGGTATGACTATCAACAAGATCATCACAGTGGTCCTGCTAGTGTACGTGCCTACAAGACCCTCCTTCCAGCTTCCGCATCAGACGTATACTATAGAGATACGAATGGTAACATCTCCACATCCAATATGAAGGTGAAAAAAGATTCAGTGGAGTTGGATCTCAGACCTAGATATCCTTTGTTTGGAGGCTGGAGAACACATTACACACTTGGTTACAATGTCCCTAGCTATGAGTATTTATATCACTCTGGTAATGAATACTTGCTGAAAATGAGGTCTATTGATCATATTTTTGATGATATGCAAGTGGATGAATTGGTTACAAAGATCATCTTGCCAGAGGGTTCTACAGGGATCAAGTTAAACATACCTTATAGTGTCACAAGATTGCCAGACAGTCTGCACTTCACATACTTAGATACTAAAGGTCGTCCAGTAATCTCGTTTATAAAGAAAAACATTGTGGAGAACCATATCCAAGATTTTCAAATCCGTTATACATTCCCACGTCTGCTGATGTTGCAGGAACCACTTTTAGTTGTTGGCTTCTTATATACATTGTTTTTGTGTGTTATTATTTATGTAAGATTAGATTTTTCAATTCACAAGTCTGAACATAAAGATTAA

Protein

MRLPAMAKLQFTLFFVLFLTIQTLSASVDTISSDIKLKNVDRTVDISTQLVKVVSKIVLENSGKSSVKHFLFAVEEAAKNNLAFIGAKDSNSKDLRLAETTVKGYDYVKFWRVELKEPLNAGATVNVVVETVFTKALQPYPTAITQQEDQFVKYVGNLYTYSPYYTSTQKTSVILNTKTVESFTKVKPFSQVDGTIIYGPYANVGPFTEKELSIHYKNNSPFLTVTRVERLIEVSHWGNIAIEEVIEIEHTGAKLKGPFSRYDYQQDHHSGPASVRAYKTLLPASASDVYYRDTNGNISTSNMKVKKDSVELDLRPRYPLFGGWRTHYTLGYNVPSYEYLYHSGNEYLLKMRSIDHIFDDMQVDELVTKIILPEGSTGIKLNIPYSVTRLPDSLHFTYLDTKGRPVISFIKKNIVENHIQDFQIRYTFPRLLMLQEPLLVVGFLYTLFLCVIIYVRLDFSIHKSEHKD

Description

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

Subunit

Component of the oligosaccharyltransferase (OST) complex.

Similarity

Belongs to the OST1 family.

Feature

chain  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Uniprot

H9IZ85   A0A2A4J0F2   A0A2H1WUP9   M4M4L9   A0A2W1BNG9   A0A194QWV6   + More
A0A0L7L025   S4NS98   A0A212ERF2   A0A1B6MNY6   A0A1B0DGC7   A0A0A9YE32   Q1HQN9   Q16K94   A0A182GHD5   A0A023EUS8   A0A0V0G2R6   A0A1B6I7Z6   A0A067RA37   A0A1L8E285   A0A182TKM9   A0A182JHT3   A0A182JWB6   U5EUI5   A0A182T0P0   A0A182URK0   A0A224X9L2   R4FP91   A0A182QA06   A0A182XB20   A0A2R7WX54   A0A182I0L6   A0A182KJN1   Q7Q0T4   A0A171AF01   A0A084VQ08   A0A182N8M8   A0A1Q3FC91   A0A182P2B9   A0A336LXT2   B0W726   A0A182R7S3   A0A182WA74   A0A2M4A0S2   A0A2M4A0R1   A0A2M4A135   T1JMK6   A0A182MMF3   A0A182YRQ0   A0A1J1IUI7   A0A1B6D3Z8   A0A2M3Z058   W5JEA2   A0A2M4BME7   A0A310SPA5   K7J1Y5   A0A2T7NTC6   A0A0L7RAC9   A0A0J7KVM3   A0A210PHZ0   E9IHB6   A0A195EWC4   A0A151ICP8   A0A154PQV6   F4WVA4   A0A0N0BE65   A0A226DDL0   R7TCG8   A0A151IWU4   A0A1Y1MSJ9   A0A2A3ERQ0   A0A195BRY9   A0A158NNV6   A0A0B6ZBE4   A0A1S3GYD0   E2A8B3   A0A2P8Z9E7   K1QWZ6   I3KWY2   A0A1A8IPJ4   A0A1A8FE16   A0A1A8S2N5   A0A1A8M988   A0A1A8DRZ5   A0A1A8A5Q3   D6W7G4   A0A1A7XPU8   A0A3B4H0D4   A0A3P9PWW6   A0A026WQQ0   V3Z1F4   A0A1E1X980   A0A2I4BC18   A0A023FPR2   A0A3B4H0E4   A0A3P9BXA8   A0A0S7HUS8   A0A0C9RYB8   A0A3B3V5G4  

Pubmed

19121390    28756777    26354079    26227816    23622113    22118469    + More
25401762    26823975    17204158    17510324    26483478    24945155    24845553    20966253    12364791    14747013    17210077    24438588    25244985    20920257    23761445    20075255    28812685    21282665    21719571    23254933    28004739    21347285    20798317    29403074    22992520    25186727    18362917    19820115    24508170    30249741    28503490    26131772   

EMBL

BABH01014536    NWSH01004519    PCG65004.1    ODYU01011208    SOQ56799.1    JQ747499    + More
AGG36456.1    KZ149951    PZC76599.1    KQ461103    KPJ09440.1    JTDY01004081    KOB68629.1    GAIX01014202    JAA78358.1    AGBW02013039    OWR44055.1    GEBQ01002310    JAT37667.1    AJVK01059514    GBHO01015849    GDHC01015925    JAG27755.1    JAQ02704.1    DQ440405    ABF18438.1    CH477971    EAT34721.1    JXUM01063440    JXUM01063441    KQ562250    KXJ76306.1    GAPW01001374    JAC12224.1    GECL01003761    JAP02363.1    GECU01024648    JAS83058.1    KK852597    KDR20590.1    GFDF01001318    JAV12766.1    GANO01003864    JAB56007.1    GFTR01007379    JAW09047.1    ACPB03003015    GAHY01000999    JAA76511.1    AXCN02001856    KK855831    PTY24031.1    APCN01005219    AAAB01008980    EAA13877.4    GEMB01001151    JAS01997.1    ATLV01015102    KE525002    KFB40052.1    GFDL01009850    JAV25195.1    UFQS01000281    UFQT01000281    SSX02370.1    SSX22745.1    DS231851    EDS37300.1    GGFK01001030    MBW34351.1    GGFK01001020    MBW34341.1    GGFK01001027    MBW34348.1    JH431584    AXCM01000013    CVRI01000059    CRL03236.1    GEDC01016993    JAS20305.1    GGFM01001156    MBW21907.1    ADMH02001634    ETN61673.1    GGFJ01005116    MBW54257.1    KQ762207    OAD56059.1    PZQS01000009    PVD24403.1    KQ414618    KOC67815.1    LBMM01002789    KMQ94361.1    NEDP02076678    OWF36091.1    GL763196    EFZ20044.1    KQ981953    KYN32451.1    KQ978062    KYM97708.1    KQ435007    KZC13648.1    GL888384    EGI61870.1    KQ435845    KOX71198.1    LNIX01000021    OXA43685.1    AMQN01013822    KB310521    ELT91404.1    KQ980843    KYN12295.1    GEZM01023178    JAV88559.1    KZ288193    PBC34184.1    KQ976417    KYM89780.1    ADTU01021806    HACG01018386    CEK65251.1    GL437526    EFN70326.1    PYGN01000138    PSN53126.1    JH817786    EKC26046.1    AERX01008647    HAED01012804    HAEE01006999    SBQ99208.1    HAEB01009837    HAEC01009078    SBQ56364.1    HAEI01011010    SBS12217.1    HAEF01011714    HAEG01001932    SBR52869.1    HADZ01014382    HAEA01007858    SBQ36338.1    HADY01011528    HAEJ01001522    SBP50013.1    KQ971307    EFA11223.1    HADW01018440    HADX01008053    SBP19840.1    KK107128    QOIP01000006    EZA58372.1    RLU21877.1    KB203534    ESO84348.1    GFAC01003612    JAT95576.1    GBBK01001652    JAC22830.1    GBYX01436713    JAO44628.1    GBZX01000009    JAG92731.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000007151    UP000092462    + More
UP000008820    UP000069940    UP000249989    UP000027135    UP000075902    UP000075880    UP000075881    UP000075901    UP000075903    UP000015103    UP000075886    UP000076407    UP000075840    UP000075882    UP000007062    UP000030765    UP000075884    UP000075885    UP000002320    UP000075900    UP000075920    UP000075883    UP000076408    UP000183832    UP000000673    UP000002358    UP000245119    UP000053825    UP000036403    UP000242188    UP000078541    UP000078542    UP000076502    UP000007755    UP000053105    UP000198287    UP000014760    UP000078492    UP000242457    UP000078540    UP000005205    UP000085678    UP000000311    UP000245037    UP000005408    UP000005207    UP000007266    UP000261460    UP000242638    UP000053097    UP000279307    UP000030746    UP000192220    UP000265160    UP000261500   

PRIDE

H9IZ85    I3KWY2   

Pfam

PF04597   Ribophorin_I        + More
PF14966   DNA_repr_REX1B

Interpro

IPR007676   Ribophorin_I        + More
IPR039491   REX1-B       

ProteinModelPortal

H9IZ85   A0A2A4J0F2   A0A2H1WUP9   M4M4L9   A0A2W1BNG9   A0A194QWV6   + More
A0A0L7L025   S4NS98   A0A212ERF2   A0A1B6MNY6   A0A1B0DGC7   A0A0A9YE32   Q1HQN9   Q16K94   A0A182GHD5   A0A023EUS8   A0A0V0G2R6   A0A1B6I7Z6   A0A067RA37   A0A1L8E285   A0A182TKM9   A0A182JHT3   A0A182JWB6   U5EUI5   A0A182T0P0   A0A182URK0   A0A224X9L2   R4FP91   A0A182QA06   A0A182XB20   A0A2R7WX54   A0A182I0L6   A0A182KJN1   Q7Q0T4   A0A171AF01   A0A084VQ08   A0A182N8M8   A0A1Q3FC91   A0A182P2B9   A0A336LXT2   B0W726   A0A182R7S3   A0A182WA74   A0A2M4A0S2   A0A2M4A0R1   A0A2M4A135   T1JMK6   A0A182MMF3   A0A182YRQ0   A0A1J1IUI7   A0A1B6D3Z8   A0A2M3Z058   W5JEA2   A0A2M4BME7   A0A310SPA5   K7J1Y5   A0A2T7NTC6   A0A0L7RAC9   A0A0J7KVM3   A0A210PHZ0   E9IHB6   A0A195EWC4   A0A151ICP8   A0A154PQV6   F4WVA4   A0A0N0BE65   A0A226DDL0   R7TCG8   A0A151IWU4   A0A1Y1MSJ9   A0A2A3ERQ0   A0A195BRY9   A0A158NNV6   A0A0B6ZBE4   A0A1S3GYD0   E2A8B3   A0A2P8Z9E7   K1QWZ6   I3KWY2   A0A1A8IPJ4   A0A1A8FE16   A0A1A8S2N5   A0A1A8M988   A0A1A8DRZ5   A0A1A8A5Q3   D6W7G4   A0A1A7XPU8   A0A3B4H0D4   A0A3P9PWW6   A0A026WQQ0   V3Z1F4   A0A1E1X980   A0A2I4BC18   A0A023FPR2   A0A3B4H0E4   A0A3P9BXA8   A0A0S7HUS8   A0A0C9RYB8   A0A3B3V5G4  

PDB

6EZN     E-value=4.76636e-29,     Score=319

KEGG

101745402    K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I) | (RefSeq) dolichyl-diphosphoo

PATHWAY

00510    N-Glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0006486   GO:0004579   GO:0005789   GO:0016021   GO:0018279   GO:0005783   GO:0031122   GO:0003924   GO:0005525   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR21049  

Subcellular location

Endoplasmic reticulum membrane  

SignalP

Position:   1 - 25,         Likelihood:  0.975462

 

 

Length:

468

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

31.96234

Exp number, first 60 AAs:

10.78114

Total prob of N-in:

0.52263

POSSIBLE N-term signal

sequence

outside

1  -  437

TMhelix

438  -  457

inside

458  -  468

 

 

Pi

179.823103

Theta

229.244127

Tajima's D

-0.686954

CLR

1011.379785

CSRT

0.20133993300335

Interpretation

Uncertain