Gene

KWMTBOMO02467

Pre Gene Modal

BGIBMGA002721

Annotation

PREDICTED:_putative_deoxynucleoside_kinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):2861591-2864282      View in EpiBrowser

Full name

Deoxynucleoside kinase      

Alternative Name

Deoxyribonucleoside kinase
Multispecific deoxynucleoside kinase

Location in the cell

Nuclear   Reliability : 2.812

CDS

ATGTTCAGACATCCGTTTATTCGGATGCTTTGTTCAAAAGGATTGAATTTATCACATTTGACAGTTGCCTCTAACATCTCTAAAATGAGTGCCAACAATGTTAAACCATTCACCGTGTTCGTGGAAGGTAACATAGGTAGCGGTAAAACAACATTTCTGGAACATTTTCGTCAGTTTGAGGATATCACTTTGTTGACGGAGCCCGTTGAAATGTGGCGAGATCTTAAAGGTTGCAATCTTTTGGAACTCATGTACAAAGATCCGGAAAAATGGGCGATGACATTCCAGTCATACGTTTCCTTGACGATGTTGGACATGCACCGGAGACCTGCTCCAACTCCAGTAAAGCTAATGGAGCGATCATTATTCAGTGCGAGATACTGCTTCGTTGAACACATGATGAGAAATAATACACTCCATCCAGCACAGTTTGCAGTTCTTGATGAGTGGTTCCGATTCATCCAACACAACATTCCCATTGATGCTGATTTGATAGTATATCTAAAGACATCACCTTCAATAGTGTACCAAAGAATCAAAAAGAGAGCTCGTTCAGAAGAGCAGTGTGTGCCCCTGTCATACATTGAGGAACTGCATAGGTTGCATGAGGACTGGCTAATCAACAGGATACATGCTGAATGTCCCGCACCAGTATTAGTGTTAGATGCTGATTTAGACCTCTCTCAGATAACCGATGAATACAAGAGAAGTGAGCATCAAATTTTAAGAAAGGCTGTTAATGTAGTTATGAGTTCACCAAACAAGCATAGCCCAAAGAAACCAATATCAACAACACCAATCAAGATCACACCTCACATGAGGATCTTATAA

Protein

MFRHPFIRMLCSKGLNLSHLTVASNISKMSANNVKPFTVFVEGNIGSGKTTFLEHFRQFEDITLLTEPVEMWRDLKGCNLLELMYKDPEKWAMTFQSYVSLTMLDMHRRPAPTPVKLMERSLFSARYCFVEHMMRNNTLHPAQFAVLDEWFRFIQHNIPIDADLIVYLKTSPSIVYQRIKKRARSEEQCVPLSYIEELHRLHEDWLINRIHAECPAPVLVLDADLDLSQITDEYKRSEHQILRKAVNVVMSSPNKHSPKKPISTTPIKITPHMRIL

Description

Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.

Catalytic Activity

a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)

Biophysicochemical Properties

0.9 uM for thymidine
1 uM for deoxycytidine
109 uM for deoxyadenosine
654 uM for deoxyguanosine

Subunit

Monomer.

Similarity

Belongs to the DCK/DGK family.

Keywords

3D-structure   ATP-binding   Complete proteome   DNA synthesis   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Deoxynucleoside kinase

Uniprot

H9IZN6   Q9BKL3   A0A2A4IZE2   A0A2A4J006   A0A2W1BSH9   A0A1E1WHI4   + More
A0A1E1WL25   S4PCU4   A0A2H1V7L8   A0A194Q3Z2   A0A194QV82   A0A0L7LS85   A0A212ERF0   A0A1Q3F2G7   A0A1Q3F2C7   A0A1Q3F2Q4   A0A1Q3F2G4   A0A1Q3F2D3   A0A2M4ARZ5   W5JIH9   A0A2M4BVW7   A0A182F7K6   A0A182VZ93   Q16HE5   A0A182MB57   A0A1W7R8A7   Q16HE4   A0A182R649   B0W8G8   A0A1A9WMC8   A0A182QQL0   A0A182NS71   A0A084WSR2   A0A182YAM8   A0A182UV92   A0A182TT07   A0A182WSF0   Q86LB8   A0A182HLA1   U5EUB5   F5HMK6   A0A182K2S6   A0A182L9M9   A0A1I8PES5   A0A0K8TT68   A0A182PGR5   A0A0L0C989   A0A1I8M996   Q540Z9   Q9XZT6   A0A1I8M992   A0A1W4UN77   A0A034WFX4   A0A034WL34   B3MSS5   A0A1J1IJP4   B4QTW8   B4IME5   B3P388   A0A1J1IG94   A0A3B0KC97   A0A3B0K976   Q8T5K4   B4G3N4   A0A3B0K3U4   A0A1B0FQH7   A0A0A1X1D0   Q298E1   A0A1B0AGW7   A0A1I8PEZ2   A0A0R3NM75   A0A1I8PF23   A0A0K8V759   A0A0K8U7P9   B4PMQ1   B4N8I2   A0A1A9W713   B4K9B9   A0A1B0GKV6   A0A0M4EIP9   B4M0I1   A0A1B6ETS7   A0A1B0DDI7   A0A0Q9WGW9   A0A336LI23   A0A1A9XZA8   B4JV40   A0A067RDT0   W8BZ45   W8C7H4   A0A2J7RHG6   A0A1L8DXR6   A0A1A9VEQ5   A0A1A9ZXM4   D3TRF8   A0A1A9VXT8   A0A1B6KQ01   A0A182PKX0   A0A1B6C1H1  

EC Number

2.7.1.145

Pubmed

19121390    28756777    23622113    26354079    26227816    22118469    + More
20920257    23761445    17510324    24438588    25244985    12364791    12626708    14747013    17210077    20966253    26369729    26108605    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10446143    10692477    9461577    17372656    18327897    12741827    16008571    18384378    25348373    17994087    12060762    25830018    15632085    17550304    24845553    24495485    20353571   

EMBL

BABH01014537    BABH01014538    AF226281    AAK28318.1    NWSH01004519    PCG65009.1    + More
PCG65008.1    KZ149951    PZC76604.1    GDQN01004600    JAT86454.1    GDQN01003331    JAT87723.1    GAIX01003966    JAA88594.1    ODYU01001093    SOQ36843.1    KQ459465    KPJ00262.1    KQ461103    KPJ09443.1    JTDY01000216    KOB78244.1    AGBW02013039    OWR44057.1    GFDL01013304    JAV21741.1    GFDL01013358    JAV21687.1    GFDL01013211    JAV21834.1    GFDL01013299    JAV21746.1    GFDL01013325    JAV21720.1    GGFK01010255    MBW43576.1    ADMH02001150    ETN63906.1    GGFJ01008085    MBW57226.1    CH478180    EAT33669.1    AXCM01006747    GEHC01000275    JAV47370.1    EAT33668.1    DS231859    EDS39018.1    AXCN02000267    ATLV01026696    KE525417    KFB53256.1    AF488801    AAAB01008987    AAO49462.1    EAA01224.2    EGK97528.1    EGK97530.1    APCN01000888    GANO01002395    JAB57476.1    EGK97529.1    GDAI01000255    JAI17348.1    JRES01000835    KNC27974.1    AY102689    AE014297    AAM27518.1    AGB96102.1    AF045610    AF185268    Y18048    GAKP01004466    JAC54486.1    GAKP01004464    JAC54488.1    CH902623    EDV30315.2    CVRI01000050    CRK99278.1    CM000364    EDX12391.1    CH480980    EDW45841.1    CH954181    EDV48540.1    CRK99279.1    OUUW01000007    SPP82631.1    SPP82629.1    AJ439060    CAD27756.1    CH479179    EDW24355.1    SPP82630.1    CCAG010004809    GBXI01009717    JAD04575.1    CM000070    EAL28014.2    KRT00381.1    GDHF01017721    JAI34593.1    GDHF01029701    GDHF01012326    GDHF01001672    JAI22613.1    JAI39988.1    JAI50642.1    CM000160    EDW95971.2    CH964232    EDW81433.2    CH933806    EDW15551.2    AJWK01033751    AJWK01033752    CP012526    ALC46608.1    CH940650    EDW68360.2    GECZ01028491    JAS41278.1    AJVK01031994    AJVK01031995    AJVK01031996    KRF83801.1    UFQT01000014    SSX17662.1    CH916374    EDV91360.1    KK852527    KDR22026.1    GAMC01007999    JAB98556.1    GAMC01008001    JAB98554.1    NEVH01003743    PNF40270.1    GFDF01002827    JAV11257.1    CCAG010019856    EZ424010    ADD20286.1    GEBQ01026448    JAT13529.1    GEDC01029935    JAS07363.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000007151    + More
UP000000673    UP000069272    UP000075920    UP000008820    UP000075883    UP000075900    UP000002320    UP000091820    UP000075886    UP000075884    UP000030765    UP000076408    UP000075903    UP000075902    UP000076407    UP000007062    UP000075840    UP000075881    UP000075882    UP000095300    UP000075885    UP000037069    UP000095301    UP000000803    UP000192221    UP000007801    UP000183832    UP000000304    UP000001292    UP000008711    UP000268350    UP000008744    UP000092444    UP000001819    UP000092445    UP000002282    UP000007798    UP000009192    UP000092461    UP000092553    UP000008792    UP000092462    UP000092443    UP000001070    UP000027135    UP000235965    UP000078200   

PRIDE

H9IZN6    Q9BKL3    Q540Z9    Q9XZT6   

Pfam

PF01712   dNK

Interpro

IPR002624   DCK/DGK        + More
IPR031314   DNK_dom       
IPR027417   P-loop_NTPase       

SUPFAM

SSF52540   SSF52540       

CDD

cd01673  dNK

ProteinModelPortal

H9IZN6   Q9BKL3   A0A2A4IZE2   A0A2A4J006   A0A2W1BSH9   A0A1E1WHI4   + More
A0A1E1WL25   S4PCU4   A0A2H1V7L8   A0A194Q3Z2   A0A194QV82   A0A0L7LS85   A0A212ERF0   A0A1Q3F2G7   A0A1Q3F2C7   A0A1Q3F2Q4   A0A1Q3F2G4   A0A1Q3F2D3   A0A2M4ARZ5   W5JIH9   A0A2M4BVW7   A0A182F7K6   A0A182VZ93   Q16HE5   A0A182MB57   A0A1W7R8A7   Q16HE4   A0A182R649   B0W8G8   A0A1A9WMC8   A0A182QQL0   A0A182NS71   A0A084WSR2   A0A182YAM8   A0A182UV92   A0A182TT07   A0A182WSF0   Q86LB8   A0A182HLA1   U5EUB5   F5HMK6   A0A182K2S6   A0A182L9M9   A0A1I8PES5   A0A0K8TT68   A0A182PGR5   A0A0L0C989   A0A1I8M996   Q540Z9   Q9XZT6   A0A1I8M992   A0A1W4UN77   A0A034WFX4   A0A034WL34   B3MSS5   A0A1J1IJP4   B4QTW8   B4IME5   B3P388   A0A1J1IG94   A0A3B0KC97   A0A3B0K976   Q8T5K4   B4G3N4   A0A3B0K3U4   A0A1B0FQH7   A0A0A1X1D0   Q298E1   A0A1B0AGW7   A0A1I8PEZ2   A0A0R3NM75   A0A1I8PF23   A0A0K8V759   A0A0K8U7P9   B4PMQ1   B4N8I2   A0A1A9W713   B4K9B9   A0A1B0GKV6   A0A0M4EIP9   B4M0I1   A0A1B6ETS7   A0A1B0DDI7   A0A0Q9WGW9   A0A336LI23   A0A1A9XZA8   B4JV40   A0A067RDT0   W8BZ45   W8C7H4   A0A2J7RHG6   A0A1L8DXR6   A0A1A9VEQ5   A0A1A9ZXM4   D3TRF8   A0A1A9VXT8   A0A1B6KQ01   A0A182PKX0   A0A1B6C1H1  

PDB

2VP0     E-value=8.03688e-67,     Score=642

KEGG

692569    K05961 deoxynucleoside kinase [EC:2.7.1.145] | (RefSeq) deoxynucleoside kinase-like

GO

GO:0005524   GO:0019206   GO:0019136   GO:0005737   GO:0005739   GO:0004797   GO:0046939   GO:0016301   GO:0006165   GO:0006230   GO:0071897   GO:0016310   GO:0006139  

Length:

276

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00553

Exp number, first 60 AAs:

0.00132

Total prob of N-in:

0.01550

outside

1  -  276

 

 

Pi

130.11188

Theta

138.609124

Tajima's D

-0.333693

CLR

48.899051

CSRT

0.274586270686466

Interpretation

Uncertain