Gene

KWMTBOMO02433  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013510

Annotation

ribonucleoside_diphosphate_reductase_small_subunit_[Bombyx_mori]

Location

Bomo_Chr5(-):1849049-1856937      View in EpiBrowser

Full name

Ribonucleoside-diphosphate reductase subunit M2      

Alternative Name

Ribonucleotide reductase small subunit

Location in the cell

Cytoplasmic   Reliability : 3.694

CDS

ATGGCTCCTACTGTTGATAAAGAGAATCTTCATAGCGGAATCAACGGTGAAAACCGTGTGCAAACGAAGTCGCCCATGAAAAATAGTGTATTGGCTACGAAAAATGACAATTTGACTGAGGAAATGGACCTCGATAAAAATTTCGAAGAGTTCGACCCACAAAAGGAACCTCTGCTGCGGGAGAACCCGCGGCGCTTTGTCATCTTCCCTATTCAATACCCCGATATATGGCAAATGTACAAGAAAGCTGAAGCTTCGTTTTGGACCGTCGAGGAAGTCGATTTGTCCAAGGATTTATCAGACTGGGAAACCTTAAAAGATAGTGAGAGACATTTCATCAAGCATGTCCTTGCTTTCTTTGCGGCTTCAGATGGCATTGTAAATGAAAACTTGGTTGAGAGATTTTCACAAGAAGTTCAAGTCACTGAGGCAAGATGTTTCTATGGCTTCCAGATAGCCATGGAAAATGTTCATTCTGAAATGTATTCCCTGCTTATAGATACCTACATCAGAGATCCGAAGGAGAGAGATTTTCTGTTTAATGCGGTTGAGACTCTTCCCTGTGTAAAGAAGAAAGCAGATTGGGCTCTACAGTGGATTGCAAGCAAGACTGCAACATTTGGTGAAAGGATTGTTGCCTTTGCAGCTGTAGAAGGAATCTTTTTCTCAGGCAGTTTTGCTTCCATCTTCTGGCTCAAAAAGCGGGGCCTTATGCCGGGACTTACATTCAGTAATGAACTTATTTCCAGGGATGAGGGTCTGCATACAGATTTTGCTTGTCTGATGTTCCAACACTTAGTTCAAAAGCCAACTAAGGAATGTGTCCTGCATATTATAAAAGATGCAGTAGTCATTGAACAAGAGTTTCTCACAGATGCGCTCCCTGTAAGACTGCTCGGTATGAACTGCGAACTAATGTCTCAGTACATAGAGTTTGTTGCAGATAGATTACTTGTTGATCTAATTGGAGAAAAGCATTACAACACAAAGAACCCCTTCGACTTCATGAATCTAATATCGCTGGAAGGTAAGACAAACTTTTTTGAGAAGAAAGTTGGAGAATACCAAAAATGCGGTGTGATGGCCAATCGCCTTGACAATGTGTTCACACTAGATGCAGACTTCTAG

Protein

MAPTVDKENLHSGINGENRVQTKSPMKNSVLATKNDNLTEEMDLDKNFEEFDPQKEPLLRENPRRFVIFPIQYPDIWQMYKKAEASFWTVEEVDLSKDLSDWETLKDSERHFIKHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENVHSEMYSLLIDTYIRDPKERDFLFNAVETLPCVKKKADWALQWIASKTATFGERIVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLMFQHLVQKPTKECVLHIIKDAVVIEQEFLTDALPVRLLGMNCELMSQYIEFVADRLLVDLIGEKHYNTKNPFDFMNLISLEGKTNFFEKKVGEYQKCGVMANRLDNVFTLDADF

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Cofactor

Fe cation

Subunit

Heterodimer of a large and a small subunit.

Similarity

Belongs to the ribonucleoside diphosphate reductase small chain family.

Keywords

Complete proteome   Cytoplasm   DNA replication   Iron   Metal-binding   Oxidoreductase   Phosphoprotein   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase subunit M2

Uniprot

H9JVE7   A0A2W1BFZ9   S4PCX5   A0A2H1W8N5   A0A212FIQ5   A0A194QA43   + More
A0A2A4JLF6   A0A0N1PGL6   A0A1Q3EVM7   A0A1Q3EVM0   A0A084WMU1   B0W5M2   W5J0Z2   A0A2M4CHV7   A0A182WMC5   A0A336MZI6   T1DRH5   A0A336MYY3   A0A182UUW7   A0A182JMA7   Q7QIF4   A0A182TWD5   A0A182X294   A0A182I6F5   A0A182L3Y8   A0A2M4ASK8   A0A182RUY6   A0A182Y867   A0A182PIU1   A0A182FFL1   A0A182K769   A0A2N9QUY7   A0A182N7E0   A0A182QMW6   A0A182G6S5   U5EUN8   B4KSE1   A0A023ER92   Q95VP8   A0A224XE08   A0A1J1I877   A0A1S4FRC9   A0A182M2M3   A0A0V0G9Z6   A0A0N8EBF9   B4MYM2   A0A1B0DF67   A0A069DTU9   A0A1B0D9Z5   A0A2J7PQX2   A0A1W4UAG9   B4P5R3   A0A1B0CVJ9   P48592   A0A067R6N6   A0A0M4EI71   B3NSA3   B4MDW7   Q9XYN8   B4HNW0   A0A0K8TMM2   B4QC59   A0A1L8DXZ6   B4J3U5   A0A2J7PQU7   A0A0A9YYL1   A0A1L8DYE8   A0A0P4VTN5   R4FNP1   W8C5P1   B3MG46   A0A3B0JXC4   U4U9Y1   A0A1B6INQ1   A0A0A1WUM8   A0A1I8ND20   A0A0L0CM40   T1P9U4   A0A1L8ED14   Q28YK7   B4H8I0   A0A1B6F8Z5   A0A131XZD3   A0A0K8WK40   A0A034WVA6   D4N2H4   A0A293MTR3   A0A0K8RE98   B7PCI3   A0A1A8BEP0   A0A1A8M193   I3KRC2   I3KRC9   A0A1A8RKN0   A0A060VW63   A0A1A8V2T2   A0A1Z5LDN9   A0A1S3S7L8   A0A1A8F5J7   A0A1A7ZYZ6  

EC Number

1.17.4.1

Pubmed

19121390    24081323    24773378    28756777    23622113    22118469    + More
26354079    24438588    20920257    23761445    12364791    14747013    17210077    20966253    25244985    26483478    17994087    24945155    12213240    16530987    17510324    26334808    17550304    10731132    12537572    12537569    8050359    18327897    24845553    10620053    26369729    22936249    25401762    27129103    24495485    23537049    25830018    25315136    26108605    15632085    25348373    20167051    25186727    24755649    28528879   

EMBL

BABH01036043    BABH01036044    BABH01036045    BABH01036046    AB703263    BAL72672.1    + More
KZ150213    PZC72157.1    GAIX01003906    JAA88654.1    ODYU01007043    SOQ49459.1    AGBW02008342    OWR53617.1    KQ459465    KPJ00301.1    NWSH01001095    PCG72649.1    KQ460796    KPJ12174.1    GFDL01015692    JAV19353.1    GFDL01015690    JAV19355.1    ATLV01024512    KE525352    KFB51535.1    DS231843    EDS35505.1    ADMH02002207    ETN57812.1    GGFL01000736    MBW64914.1    UFQT01004223    SSX35580.1    GAMD01000630    JAB00961.1    UFQT01003338    SSX34885.1    AAAB01008807    EAA04227.4    APCN01003635    GGFK01010436    MBW43757.1    KY434117    AUS94194.1    AXCN02000568    JXUM01045442    JXUM01045443    JXUM01045444    KQ561439    KXJ78586.1    GANO01002239    JAB57632.1    CH933808    EDW08423.1    GAPW01001925    JAC11673.1    AF411297    DQ250745    CH477682    AAL05057.1    ABB77235.1    EAT37295.1    GFTR01005720    JAW10706.1    CVRI01000043    CRK96419.1    AXCM01010982    GECL01001917    JAP04207.1    GDIQ01043196    JAN51541.1    CH963894    EDW77211.1    AJVK01058575    GBGD01001777    JAC87112.1    AJVK01028672    NEVH01022635    PNF18706.1    CM000158    EDW90860.1    AJWK01030689    AJWK01030690    AJWK01030691    AE013599    AY051936    U09370    KK852851    KDR15057.1    CP012524    ALC40730.1    CH954179    EDV56405.1    CH940662    EDW58732.1    AF117061    AAD30422.1    CH480816    EDW47475.1    GDAI01002180    JAI15423.1    CM000362    CM002911    EDX06690.1    KMY93069.1    GFDF01002798    JAV11286.1    CH916367    EDW01528.1    PNF18705.1    GBHO01041104    GBHO01006889    GBHO01006888    GBRD01017302    JAG02500.1    JAG36715.1    JAG36716.1    JAG48525.1    GFDF01002799    JAV11285.1    GDKW01000714    JAI55881.1    ACPB03004191    GAHY01000503    JAA77007.1    GAMC01001627    JAC04929.1    CH902619    EDV36741.2    OUUW01000001    SPP75738.1    KB632256    ERL90749.1    GECU01019154    JAS88552.1    GBXI01013641    GBXI01012144    JAD00651.1    JAD02148.1    JRES01000204    KNC33312.1    KA644935    AFP59564.1    GFDG01002182    JAV16617.1    CM000071    EAL25959.2    CH479223    EDW35015.1    GECZ01023061    JAS46708.1    GEFM01003192    JAP72604.1    GDHF01000857    JAI51457.1    GAKP01000695    JAC58257.1    GQ202541    ADD73846.1    GFWV01019168    MAA43896.1    GADI01004645    JAA69163.1    ABJB010321211    ABJB010630527    ABJB010716067    ABJB010862553    ABJB011098517    DS684069    EEC04305.1    HADZ01001437    SBP65378.1    HAEF01010541    SBR50577.1    AERX01016619    AERX01016620    HAEI01008732    HAEH01022016    SBS05829.1    FR904319    CDQ59208.1    HAEJ01013420    SBS53877.1    GFJQ02001560    JAW05410.1    HAEB01007850    SBQ54377.1    HADY01008715    SBP47200.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000218220    UP000053240    UP000030765    + More
UP000002320    UP000000673    UP000075920    UP000075903    UP000075880    UP000007062    UP000075902    UP000076407    UP000075840    UP000075882    UP000075900    UP000076408    UP000075885    UP000069272    UP000075881    UP000075884    UP000075886    UP000069940    UP000249989    UP000009192    UP000008820    UP000183832    UP000075883    UP000007798    UP000092462    UP000235965    UP000192221    UP000002282    UP000092461    UP000000803    UP000027135    UP000092553    UP000008711    UP000008792    UP000001292    UP000000304    UP000001070    UP000015103    UP000007801    UP000268350    UP000030742    UP000095301    UP000037069    UP000001819    UP000008744    UP000203822    UP000001555    UP000005207    UP000193380    UP000087266   

PRIDE

H9JVE7    P48592   

Pfam

PF00268   Ribonuc_red_sm

Interpro

IPR012348   RNR-like        + More
IPR033909   RNR_small       
IPR000358   RNR_small_fam       
IPR030475   RNR_small_AS       
IPR009078   Ferritin-like_SF       

SUPFAM

SSF47240   SSF47240       

Gene 3D

1.10.620.20    

CDD

cd01049  RNRR2

ProteinModelPortal

H9JVE7   A0A2W1BFZ9   S4PCX5   A0A2H1W8N5   A0A212FIQ5   A0A194QA43   + More
A0A2A4JLF6   A0A0N1PGL6   A0A1Q3EVM7   A0A1Q3EVM0   A0A084WMU1   B0W5M2   W5J0Z2   A0A2M4CHV7   A0A182WMC5   A0A336MZI6   T1DRH5   A0A336MYY3   A0A182UUW7   A0A182JMA7   Q7QIF4   A0A182TWD5   A0A182X294   A0A182I6F5   A0A182L3Y8   A0A2M4ASK8   A0A182RUY6   A0A182Y867   A0A182PIU1   A0A182FFL1   A0A182K769   A0A2N9QUY7   A0A182N7E0   A0A182QMW6   A0A182G6S5   U5EUN8   B4KSE1   A0A023ER92   Q95VP8   A0A224XE08   A0A1J1I877   A0A1S4FRC9   A0A182M2M3   A0A0V0G9Z6   A0A0N8EBF9   B4MYM2   A0A1B0DF67   A0A069DTU9   A0A1B0D9Z5   A0A2J7PQX2   A0A1W4UAG9   B4P5R3   A0A1B0CVJ9   P48592   A0A067R6N6   A0A0M4EI71   B3NSA3   B4MDW7   Q9XYN8   B4HNW0   A0A0K8TMM2   B4QC59   A0A1L8DXZ6   B4J3U5   A0A2J7PQU7   A0A0A9YYL1   A0A1L8DYE8   A0A0P4VTN5   R4FNP1   W8C5P1   B3MG46   A0A3B0JXC4   U4U9Y1   A0A1B6INQ1   A0A0A1WUM8   A0A1I8ND20   A0A0L0CM40   T1P9U4   A0A1L8ED14   Q28YK7   B4H8I0   A0A1B6F8Z5   A0A131XZD3   A0A0K8WK40   A0A034WVA6   D4N2H4   A0A293MTR3   A0A0K8RE98   B7PCI3   A0A1A8BEP0   A0A1A8M193   I3KRC2   I3KRC9   A0A1A8RKN0   A0A060VW63   A0A1A8V2T2   A0A1Z5LDN9   A0A1S3S7L8   A0A1A8F5J7   A0A1A7ZYZ6  

PDB

1XSM     E-value=3.81446e-145,     Score=1319

KEGG

100873153    K10808 ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] | (RefSeq) RnrS, BmRNRS; ribonu

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0009263   GO:0016491   GO:0016021   GO:0004748   GO:0005829   GO:0006919   GO:0046872   GO:0006260   GO:0005737   GO:0004175   GO:0005089   GO:0035023   GO:0006289   GO:0004518   GO:0006281   GO:0048384   GO:0055114  

PANTHER

PTHR23409  

Subcellular location

Cytoplasm  

Length:

375

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

16.8432699999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.56019

outside

1  -  375

 

 

Pi

192.090975

Theta

168.885687

Tajima's D

0.63312

CLR

28.49796

CSRT

0.550672466376681

Interpretation

Uncertain