Gene

KWMTBOMO02425

Pre Gene Modal

BGIBMGA013495

Annotation

PREDICTED:_proline-rich_protein_PRCC-like_[Plutella_xylostella]

Location

Bomo_Chr5(+):1776178-1778943      View in EpiBrowser

Full name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2      

Location in the cell

Nuclear   Reliability : 4.755

CDS

ATGGCATTAGTAGCGTATGAAAATAGCGATTCGAGTGATTTTGAAGATTGTGATACAGAAAGTCCTGCTGCTGTAATATCTACTGAGAAATACGCTGCATCTACTTCGACTTTGGTGCACGACACAACAGAGCCTTGCCAAAATTTATTCAATCTTTTACCCGAGCCATCCCACAAGAAACCACTGGTTGTAGAGGAAGATGATGAGTTCTTACACAAAAAAGAAAAACACATTGTAAAACCAAAGGCTAAGATATCTGTACCTTCATTACAAGATTTTAAAGACATGGAAGACAGTTTACCAAATAACAAAAATAAAATTCACAGTGGTGGAAAAAAATCTGGTCTCCTCAGCATTCTTCCCCAGCCTAAGAATGGAGTGACATTAACAAATAAATCATTTATCCCCAATATACTTGTAAAAAATCCAACCACAACTAGCATTAAGAAAAAGCAGCAAACTCAATCATCACCAAAAAAAGTTAAAAAAGAAACTCAGTCAATAATAAATGATTATTCAGATGAAAGTGACAGTGAGGAATTAGGAAATGATTTCTTTTCAATAAATAAACCTGTACTCATTGCTCCTGAAGTATTGTCTGTAGATAGTGAATTGGTACAAAATACAAACACAAGTAAGGGACTATCAAGTTTCGACTCTCACATTAATAACAATATGAATGGGTATGAAACTGGAGAGACTGATCTAAATGTCGTTGCAAGTACAGAGACGCCCGTTGATAATTCCCATGACTTAGAAATACCTGTTGAGAATCACAATCAACAACCTTCTAATAGTAATGAGGATATATTGGATGATGAAGCTATACTGAAATTAGTCGGAGCTCGTGGCAAGAGAAAACGTGAAGAAATCCAAATAGTTGATGTGAATCAGAAAGAGGTACTTGGTGACTCACGAGAATGGTTACTGAAGAGTCTAATGGATGACACCACCCGGCGAGTATCATCTAGTAAGAAAAGGGGAAATGAACCTACTAATCAACAAAAAAGGAAACATCAGATCACATACTTGGCCCATCAGGCAAAAGCAAATGAAGCAGAGCTACAGAACCAATGGGCTAACAACAGAATGTCAAGAAGACAAACACAATCCAAATATGGATTCTAG

Protein

MALVAYENSDSSDFEDCDTESPAAVISTEKYAASTSTLVHDTTEPCQNLFNLLPEPSHKKPLVVEEDDEFLHKKEKHIVKPKAKISVPSLQDFKDMEDSLPNNKNKIHSGGKKSGLLSILPQPKNGVTLTNKSFIPNILVKNPTTTSIKKKQQTQSSPKKVKKETQSIINDYSDESDSEELGNDFFSINKPVLIAPEVLSVDSELVQNTNTSKGLSSFDSHINNNMNGYETGETDLNVVASTETPVDNSHDLEIPVENHNQQPSNSNEDILDDEAILKLVGARGKRKREEIQIVDVNQKEVLGDSREWLLKSLMDDTTRRVSSSKKRGNEPTNQQKRKHQITYLAHQAKANEAELQNQWANNRMSRRQTQSKYGF

Description

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Catalytic Activity

L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine

Similarity

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

Uniprot

H9JVD2   A0A2A4JM30   A0A2A4JKM8   A0A2W1BNI1   A0A2H1VMF5   A0A0N1PIA8   + More
A0A194QA47   A0A212FIR1   A0A0L7L2R3   S4NYF3   A0A1E1VZ33   A0A067R108   A0A2P8ZHE6   A0A2J7Q699   A0A0C9PL62   H3DJH9   A0A154NWW6   Q4RLD3   A0A151WWF8   A0A232ELR3   E2AUF3   M4AKZ8   A0A0A1XBS0   A0A146VNJ4   H2UBZ0   A0A146P5S1   A0A0L7RCD8   A0A3P8PFZ8   A0A3P9DMY4   A0A1B6EDA7   A0A1B6EYH8   A0A3B5K565   A0A3B4FPC7   A0A0J7L112   A0A2L2YB88   A0A1B6L6H4   A0A3P8PG07   A0A034VNK9   A0A026WXE2   A0A3B5K7A1   A0A0V0G7G5   F4X7L0   A0A293MX50   A0A1A9X2W9   A0A2P6KC70   A0A0P4VMQ7   T1HEY0   B5X457   I3KUU8   A0A1A8H3S1   A0A195DWU6   A0A1A8IQ12   A0A060WSX9   A0A1A7YFA1   A0A3P8VEI1   A0A3Q0IRP7   A0A0S7FG56   A0A1S3M3H6   A0A2R7WMK0   B5X4C3   A0A3P8YC65   A0A060YEI2   A0A1A8K9D5   A0A1A8U2B8   A0A1A8DPZ5   E9IYK1   A0A1A8Q2E8   A0A1A8N2U8   A0A195B1V9   A0A158P0P3   A0A3B3YH76   A0A3B3U836   A0A224XQZ5   A0A2I4AIG9  

EC Number

2.5.1.108

Pubmed

19121390    28756777    26354079    22118469    26227816    23622113    + More
24845553    29403074    15496914    28648823    20798317    23542700    25830018    21551351    25186727    26561354    25348373    24508170    30249741    21719571    27129103    20433749    24755649    24487278    25069045    21282665    21347285   

EMBL

BABH01036055    NWSH01001095    PCG72634.1    PCG72635.1    KZ150118    PZC73233.1    + More
ODYU01003352    SOQ42003.1    KQ460393    KPJ15382.1    KQ459465    KPJ00306.1    AGBW02008342    OWR53623.1    JTDY01003397    KOB69621.1    GAIX01013830    JAA78730.1    GDQN01011066    JAT79988.1    KK853111    KDR11211.1    PYGN01000057    PSN55925.1    NEVH01017534    PNF24109.1    GBYB01001743    JAG71510.1    KQ434777    KZC04176.1    CAAE01015022    CAG10799.1    KQ982691    KYQ52021.1    NNAY01003522    OXU19271.1    GL442820    EFN62912.1    GBXI01006389    JAD07903.1    GCES01067270    JAR19053.1    GCES01147207    JAQ39115.1    KQ414617    KOC68401.1    GEDC01023335    GEDC01020988    GEDC01005682    GEDC01001387    JAS13963.1    JAS16310.1    JAS31616.1    JAS35911.1    GECZ01026878    JAS42891.1    LBMM01001513    KMQ96164.1    IAAA01017980    LAA05257.1    GEBQ01020717    JAT19260.1    GAKP01015577    JAC43375.1    KK107069    QOIP01000002    EZA60725.1    RLU25978.1    GECL01002081    JAP04043.1    GL888862    EGI57539.1    GFWV01019017    MAA43745.1    MWRG01016332    PRD23904.1    GDKW01000136    JAI56459.1    ACPB03020686    BT045826    ACI34088.1    AERX01028432    HAEB01009001    HAEC01009726    SBQ77942.1    KQ980199    KYN17306.1    HAED01012974    SBQ99396.1    FR904593    CDQ67695.1    HADW01020526    HADX01006383    SBP28615.1    GBYX01465792    GBYX01465791    GBYX01465788    JAO15820.1    KK855054    PTY20561.1    BT045892    ACI34154.1    FR910193    CDQ90136.1    HAEE01008234    SBR28284.1    HADY01010923    HAEJ01001060    SBS41517.1    HADZ01016589    HAEA01007133    SBQ35613.1    GL767018    EFZ14388.1    HAEH01009528    HAEI01012946    SBR87384.1    HAEF01013263    HAEG01000209    SBR63413.1    KQ976667    KYM78272.1    ADTU01005682    GFTR01005444    JAW10982.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000027135    UP000245037    UP000235965    UP000007303    UP000076502    UP000075809    UP000215335    UP000000311    UP000002852    UP000265000    UP000005226    UP000053825    UP000265100    UP000265160    UP000261460    UP000036403    UP000053097    UP000279307    UP000007755    UP000091820    UP000015103    UP000087266    UP000005207    UP000078492    UP000193380    UP000265120    UP000079169    UP000265140    UP000078540    UP000005205    UP000261480    UP000261500    UP000192220   

PRIDE

H9JVD2   

Pfam

PF10253   PRCC        + More
PF01866   Diphthamide_syn

Interpro

IPR018800   PRCC        + More
IPR042264   DPH1/DPH2_2       
IPR042265   DPH1/DPH2_3       
IPR016435   DPH1/DPH2       
IPR010014   DHP2       
IPR042263   DPH1/DPH2_1       

Gene 3D

3.40.50.11840     3.40.50.11850     3.40.50.11860    

ProteinModelPortal

H9JVD2   A0A2A4JM30   A0A2A4JKM8   A0A2W1BNI1   A0A2H1VMF5   A0A0N1PIA8   + More
A0A194QA47   A0A212FIR1   A0A0L7L2R3   S4NYF3   A0A1E1VZ33   A0A067R108   A0A2P8ZHE6   A0A2J7Q699   A0A0C9PL62   H3DJH9   A0A154NWW6   Q4RLD3   A0A151WWF8   A0A232ELR3   E2AUF3   M4AKZ8   A0A0A1XBS0   A0A146VNJ4   H2UBZ0   A0A146P5S1   A0A0L7RCD8   A0A3P8PFZ8   A0A3P9DMY4   A0A1B6EDA7   A0A1B6EYH8   A0A3B5K565   A0A3B4FPC7   A0A0J7L112   A0A2L2YB88   A0A1B6L6H4   A0A3P8PG07   A0A034VNK9   A0A026WXE2   A0A3B5K7A1   A0A0V0G7G5   F4X7L0   A0A293MX50   A0A1A9X2W9   A0A2P6KC70   A0A0P4VMQ7   T1HEY0   B5X457   I3KUU8   A0A1A8H3S1   A0A195DWU6   A0A1A8IQ12   A0A060WSX9   A0A1A7YFA1   A0A3P8VEI1   A0A3Q0IRP7   A0A0S7FG56   A0A1S3M3H6   A0A2R7WMK0   B5X4C3   A0A3P8YC65   A0A060YEI2   A0A1A8K9D5   A0A1A8U2B8   A0A1A8DPZ5   E9IYK1   A0A1A8Q2E8   A0A1A8N2U8   A0A195B1V9   A0A158P0P3   A0A3B3YH76   A0A3B3U836   A0A224XQZ5   A0A2I4AIG9  

KEGG

101740866    K13105 proline-rich protein PRCC | (RefSeq) proline-rich protein PRCC

GO

GO:0017183   GO:0016740  

PANTHER

PTHR13621   PTHR10762   PTHR10762:SF2  

Length:

375

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01225

outside

1  -  375

 

 

Pi

15.37209

Theta

15.560342

Tajima's D

-1.276414

CLR

1118.55184

CSRT

0.0909454527273636

Interpretation

Uncertain