Gene

KWMTBOMO02423

Pre Gene Modal

BGIBMGA013494

Annotation

diptheria_toxin_resistance_protein_[Bombyx_mori]

Location

Bomo_Chr5(+):1769898-1772233      View in EpiBrowser

Full name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2      

Alternative Name

Diphthamide biosynthesis protein 2
Diphtheria toxin resistance protein 2
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2

Location in the cell

Cytoplasmic   Reliability : 2.537 Nuclear   Reliability : 1.898

CDS

ATGGGGAATTTTACTACAGAAGACAAAATATGTATAACACGTGAGATAACAGTAAATAAAACTGAAGGTTATGACGATATAATCACCAATTTTGATATAAAGGAAACATGCAAATGGATCGAAAGAAAAAAGTTTGCGAAAGTGTGCTTACAATTTCCCGATGACCTGCTAGAAGTAAGTTGCAAAGTTTATAAGGAAATTAAAGATCGAATTGAAGTTGACCTGTATATTATGGGAGATACATCATATGCTAGCTGTTGTATAGATTCTGTGGCAGCTATGCATGTGCAGGCCAATGGAATTGTGCATTATGGTCACAAATGCTTTTCAAAAACTGATATACCAGTTTACATGGTATTGCCAAAAGAAAAACTGGATTTTGATGCAGCAATAAATACATTGAAAGAAAAATATGATTCTGATGACAACATGAAGTTATGCCTCTTTTATGGTGCAGAATTTGAACACTGCAATGAAAATATCACCCGAAAATGGTTTCAAAAATATCCAAAGAGTTATATATGTCACATTGAATTAGAAGATAAGCCTGAGAGATTTCTTGGAAGGATAATCAAAGACGTACAAAATGTGGAATACCCAATTCAAGCATTGAAAGATTGTATCTGCATTTATTTAGGCTCTCGGGGGCAGACAATATTCAACTACACTATATCTATTCCAGCTACCAAATGGTACTTATTAAATCCATCATCCAGTCAATTAGAACAATTGGATGAAACAATATGGTTTAAGCGCAGACGCTTCCTTATAGAGAAGTGTAAAGATGCTAATATAATTGGTATACTTATATGTAAGCTATCAGGTAAACAGACCAAAGATATCATCAGTAGAATGAAAGAACTCTGTAAAGTAAATGGAAAGAAAAGCTACATTGTGTCTGTTGGTAAACCCAATAGTGCTAAATTAGCCAATTTTCCTGAAATTGACATATATGTGATGATTGCATGTCCAGAAAATGATCTATACAGTTCGCGGGACTTTTATAGACCAATAGTTTTCCCGTACGAACTTGAAATTGCCCTCAATTCCAACAGAGAACCTTTTCCCACATACCATGTCACAGACTATGATGAACTTCTACCTGGAAGAAGACACTATGGAGATATTAAACCGATACAAGAGATCGCAGATGTTAGTCTAATAACAGGCCGAATAAGAGAAGCGAAAGTGAACCATTTAGATGGCAGTAGTCAAGAACTAGCTGAACAACAAAATTGGGCTTTAGAATCGATAGGAAAGACCCTCCAAGATAGATCTTGGAAAGGTCTAGAACAAAAACTAGGCGAAACTGAAGTAAAAAAGGTGGAAGAAGGACGTAAAGGCATAGCATTACAGTACAGCAATGAACAGGAGTGA

Protein

MGNFTTEDKICITREITVNKTEGYDDIITNFDIKETCKWIERKKFAKVCLQFPDDLLEVSCKVYKEIKDRIEVDLYIMGDTSYASCCIDSVAAMHVQANGIVHYGHKCFSKTDIPVYMVLPKEKLDFDAAINTLKEKYDSDDNMKLCLFYGAEFEHCNENITRKWFQKYPKSYICHIELEDKPERFLGRIIKDVQNVEYPIQALKDCICIYLGSRGQTIFNYTISIPATKWYLLNPSSSQLEQLDETIWFKRRRFLIEKCKDANIIGILICKLSGKQTKDIISRMKELCKVNGKKSYIVSVGKPNSAKLANFPEIDIYVMIACPENDLYSSRDFYRPIVFPYELEIALNSNREPFPTYHVTDYDELLPGRRHYGDIKPIQEIADVSLITGRIREAKVNHLDGSSQELAEQQNWALESIGKTLQDRSWKGLEQKLGETEVKKVEEGRKGIALQYSNEQE

Description

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Catalytic Activity

L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine

Similarity

Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Belongs to the DPH1/DPH2 family.

Keywords

Complete proteome   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Uniprot

H9JVD1   Q1HQ93   A0A2A4JLQ0   A0A2W1BHP6   A0A2H1VDH5   A0A194Q441   + More
A0A0N1I8I1   A0A212FIS5   I4DP23   A0A0L7L2R3   A0A2A4JKQ9   A0A3L8DSB2   A0A0M9ABI2   A0A182GK36   A0A026W7B4   E2A1X7   A0A084VIU1   A0A158NFQ3   A0A151IIN5   A0A195BCL3   A0A195DP53   A0A1S4FAI8   T1JHR2   A0A151JY61   Q17A10   A0A182QA95   A0A1Q3FCY7   A0A151WP56   F4X191   E2B5Y1   A0A2A3EIM5   A0A182NVE3   E9IGJ7   A0A336MMB7   A0A3B4CQW2   A0A087UE05   A0A336M9T5   A0A2M4CSM8   A0A2I4B6D5   A0A0Q3UTI7   A0A2M4CSW6   A0A3B5KY45   A0A1B0CN26   A0A182F3S6   A0A2M4AG44   U3JS13   A0A0K8TMD5   A0A1L8DRI1   A0A182W8D4   A0A182RIK2   A0A2M4BM60   M3ZIC7   A0A0C9Q2K4   H3CTM0   V3Z5M5   A0A3P9NVB2   A0A1S3J669   A0A3P8Q1U9   A0A3P9C0U1   A0A1S3INN0   A0A3B4G8E7   A4QN59   A0A182K789   A0A3P9KAQ8   A0A210PEJ6   H2LL62   A0A3B3WCE2   I3JBD0   A0A3M0K5Y6   A0A2P8Y8A0   A0A182J7Z6   B7P2L9   B4HE38   A0A3B3TZH4   A0A3B3CHR5   A0A3L8SPW3   Q29AH9   A0A0K8RB18   A0A2U9CWB1   A0A3B3SU56   A0A2D0RE65   A0A3B3Q2A5   A0A2I0UK78   A0A3B4TPU6   A0A023GKT2   E6ZI97   H2SH65   A0A182UYH2   A0A3B3WCY0   A0A3B4BFR3   W5KIG8   H0ZAY3   A0A087Y1G2   A0A131Y394   G1NC63   A0A182TE15   I3JBC9   A0A3P9IT33   A0A182WRA4  

EC Number

2.5.1.108

Pubmed

19121390    28756777    26354079    22118469    22651552    26227816    + More
30249741    26483478    24508170    20798317    24438588    21347285    17510324    21719571    21282665    26369729    23542700    15496914    23254933    25186727    17554307    28812685    29403074    17994087    29451363    30282656    15632085    29240929    21551351    25463417    25329095    20360741    20838655   

EMBL

BABH01036055    DQ443159    ABF51248.1    NWSH01001095    PCG72638.1    KZ150118    + More
PZC73235.1    ODYU01001972    SOQ38910.1    KQ459465    KPJ00308.1    KQ460393    KPJ15380.1    AGBW02008342    OWR53621.1    AK403257    BAM19663.1    JTDY01003397    KOB69621.1    PCG72637.1    QOIP01000005    RLU23063.1    KQ435691    KOX81155.1    JXUM01069156    KQ562538    KXJ75666.1    KK107361    EZA51997.1    GL435845    EFN72571.1    ATLV01013404    KE524855    KFB37885.1    ADTU01014527    KQ977464    KYN02549.1    KQ976514    KYM82293.1    KQ980662    KYN14695.1    JH431958    KQ981494    KYN40947.1    CH477341    EAT43096.1    AXCN02002009    GFDL01009584    JAV25461.1    KQ982893    KYQ49581.1    GL888528    EGI59763.1    GL445887    EFN88950.1    KZ288230    PBC31577.1    GL763048    EFZ20302.1    UFQT01001602    SSX31130.1    KK119395    KFM75594.1    UFQT01000731    SSX26780.1    GGFL01004178    MBW68356.1    LMAW01000958    KQK84842.1    GGFL01004177    MBW68355.1    AJWK01019707    AJWK01019708    AJWK01019709    GGFK01006371    MBW39692.1    AGTO01000846    GDAI01002290    JAI15313.1    GFDF01005008    JAV09076.1    GGFJ01004981    MBW54122.1    GBYB01008223    JAG77990.1    KB203188    ESO86068.1    BC134939    NEDP02076747    OWF34913.1    AERX01042061    QRBI01000117    RMC08579.1    PYGN01000809    PSN40491.1    ABJB010258820    ABJB011093016    DS623090    EEC00841.1    CH480815    EDW42130.1    QUSF01000010    RLW05790.1    CM000070    EAL27371.1    GADI01005446    JAA68362.1    CP026263    AWP20898.1    KZ505709    PKU46450.1    GBBM01000926    JAC34492.1    FQ310508    CBN81781.1    ABQF01031189    AYCK01007996    GEFM01003435    JAP72361.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000279307    UP000053105    UP000069940    UP000249989    UP000053097    UP000000311    UP000030765    UP000005205    UP000078542    UP000078540    UP000078492    UP000078541    UP000008820    UP000075886    UP000075809    UP000007755    UP000008237    UP000242457    UP000075884    UP000261440    UP000054359    UP000192220    UP000051836    UP000261380    UP000092461    UP000069272    UP000016665    UP000075920    UP000075900    UP000002852    UP000007303    UP000030746    UP000242638    UP000085678    UP000265100    UP000265160    UP000261460    UP000000437    UP000075881    UP000265180    UP000242188    UP000001038    UP000261480    UP000005207    UP000269221    UP000245037    UP000075880    UP000001555    UP000001292    UP000261500    UP000261560    UP000276834    UP000001819    UP000246464    UP000261540    UP000221080    UP000261420    UP000005226    UP000075903    UP000261520    UP000018467    UP000007754    UP000028760    UP000001645    UP000075902    UP000265200    UP000076407   

PRIDE

H9JVD1    Q1HQ93   

Pfam

PF01866   Diphthamide_syn        + More
PF10253   PRCC

Interpro

IPR016435   DPH1/DPH2        + More
IPR042263   DPH1/DPH2_1       
IPR010014   DHP2       
IPR042264   DPH1/DPH2_2       
IPR042265   DPH1/DPH2_3       
IPR018800   PRCC       

Gene 3D

3.40.50.11840     3.40.50.11850     3.40.50.11860    

ProteinModelPortal

H9JVD1   Q1HQ93   A0A2A4JLQ0   A0A2W1BHP6   A0A2H1VDH5   A0A194Q441   + More
A0A0N1I8I1   A0A212FIS5   I4DP23   A0A0L7L2R3   A0A2A4JKQ9   A0A3L8DSB2   A0A0M9ABI2   A0A182GK36   A0A026W7B4   E2A1X7   A0A084VIU1   A0A158NFQ3   A0A151IIN5   A0A195BCL3   A0A195DP53   A0A1S4FAI8   T1JHR2   A0A151JY61   Q17A10   A0A182QA95   A0A1Q3FCY7   A0A151WP56   F4X191   E2B5Y1   A0A2A3EIM5   A0A182NVE3   E9IGJ7   A0A336MMB7   A0A3B4CQW2   A0A087UE05   A0A336M9T5   A0A2M4CSM8   A0A2I4B6D5   A0A0Q3UTI7   A0A2M4CSW6   A0A3B5KY45   A0A1B0CN26   A0A182F3S6   A0A2M4AG44   U3JS13   A0A0K8TMD5   A0A1L8DRI1   A0A182W8D4   A0A182RIK2   A0A2M4BM60   M3ZIC7   A0A0C9Q2K4   H3CTM0   V3Z5M5   A0A3P9NVB2   A0A1S3J669   A0A3P8Q1U9   A0A3P9C0U1   A0A1S3INN0   A0A3B4G8E7   A4QN59   A0A182K789   A0A3P9KAQ8   A0A210PEJ6   H2LL62   A0A3B3WCE2   I3JBD0   A0A3M0K5Y6   A0A2P8Y8A0   A0A182J7Z6   B7P2L9   B4HE38   A0A3B3TZH4   A0A3B3CHR5   A0A3L8SPW3   Q29AH9   A0A0K8RB18   A0A2U9CWB1   A0A3B3SU56   A0A2D0RE65   A0A3B3Q2A5   A0A2I0UK78   A0A3B4TPU6   A0A023GKT2   E6ZI97   H2SH65   A0A182UYH2   A0A3B3WCY0   A0A3B4BFR3   W5KIG8   H0ZAY3   A0A087Y1G2   A0A131Y394   G1NC63   A0A182TE15   I3JBC9   A0A3P9IT33   A0A182WRA4  

PDB

6BXO     E-value=5.8737e-16,     Score=206

KEGG

732891    K17866 diphthamide biosynthesis protein 2 | (RefSeq) diptheria toxin resistance protein

GO

GO:0016740   GO:0017183   GO:0005839   GO:0051603   GO:0004175   GO:0005089   GO:0035023   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR10762   PTHR10762:SF2  

Length:

458

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00757

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00571

outside

1  -  458

 

 

Pi

234.495143

Theta

181.946872

Tajima's D

0.925104

CLR

0.002669

CSRT

0.64016799160042

Interpretation

Uncertain