Gene

KWMTBOMO02416

Pre Gene Modal

BGIBMGA013521

Annotation

PREDICTED:_WW_domain-containing_protein_tag-325_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr5(-):1596979-1625817      View in EpiBrowser

Full name

Rho GTPase-activating protein conundrum      

Location in the cell

Nuclear   Reliability : 2.994

CDS

ATGGTTGTGATTCTGAGGTTTAATTCGAAGGAGTTCACTTTTCGAACGGCAAAAGAAGGCGAGTTCGAAACGGAATGGTTGCAGGCCGCAGGGCTGGGATCCCTCGCGGCTCCGTTCCAAGCTGGTCTGGAGGTCACCGAGGCCCAGCTGGGTGAGGCGGTGCGGCCTTTACCCAGGGAACAGGCTGCAGCCGTGAGGAGACGCGTCAGGAGGCTCAACAGGACTGTGAGGAGACGTCGCGCGGCTTCCAGGGCCAGGAAGCCCGATATAAGAGATGTCTTCCGGGACTTAGAGAACTCAAGTGGTAGTGAACCGCGGTCGCGCAGCGCGACCCCCGACTCACTGGACTCTCTGCCGAGCGGCGGCTCCGGCAGCCCCCCCGCCGAGTGGGCCGACGGACCTACACCCACCGACTTCGTCGAACGGTATCCGGGTACAGGCGCGCACAGTCCGCTGGCTCGCACGCCGTCCGCACCCGCCGCCCCGCGCCGCGCCCCTGTGTCGCCCCCCCTTCCCATGCACGAACTCTTCAAGCCCAACGACCTGCACTGGGCGGACATCGCGACCAACACAGAGGGAATCGAACTGCTAGGCTATCAACGATACGGCACTGTCCAGGGGCCGAGAATAGGGAAGGAACGAATCAACGGATCTATACTGAAAGGCAATGATCCCTTCATTAACAACAAGCACGCTAGCGTATCTCGAGCGAAGAGTGTGGTCTCCGCGCAGCAGCCGCTCAGCTTTGAGCACAAATTCAACTTGGACAGACAGATGATGAGTCACGACGAGGATTGGCCGGAGGCGGACAGTAACGTGGACATAGAGAGCATAAGCGAGCCTCAACTGAAGCGCTTGCAGCCGCTACTGTGGTTGGAGCTCACGGCGATATTCGACAAGTACTCGCTGCCCTTCCAGAAGAGGAAGCCACCCAAAAAGAAGCGGAAGGAAGAGGGCTCCGTGTTCGGCGTGTCCTTGGAGACGCTGGTCCGCAAGGACATGATCCTGTGGGAGGAGACGTGCAGCGCGCCGAGCGTGCTGTGCTGCGTCACGCGCGCGCTGCGGGCTCGCGCGCACCACGAGGGGCTGCTCAGGGTCTCCGGGAACAAACAGAAGGTATCAGAGCTGAGTCAGCTGATAGAGCGGCAGTGGTACGAGGACCGCGGCGCGGTGGAGGCGGCCGTCTCGCTCGCCAAGGGACACGACCTCGCCGCCGTCTACAAGCGGCTGCTGCGGGCGCTGCCCCAGCCCCTACTCACGCAGGAGCTCATGAGGCTCTTCTACCACACTTATGCGCTGAGTGGATCGACCCGCGGGCGCGCCCTCAACCTGCTGGTGCTGCTGCTGGGTCCGGAGGCACGCGCCACGCTGCGGGAGCTGCTGCGGCTCGCCAACGACATCGTCGCGCACGCGCACGCCAACAAGATGAACGAGCACAACGTCGCCATGATCATCGCGCCCACGCTCTTCCCGCCCAGCCTTCTGATCAAGCAATCAGACAGCCTGGAGACGCAGCTCGCGACCGCCGCCAACAGCTGTCACGTTACGGAAGCCATGATGCGGCACTCCGAACAACTCTGGACCGTGCCGCCCTCCCTCCTCGCCGCTGCTCAGAGGAAGCCGCAAGCTCATCGCAGATTACAGCACACTTGA

Protein

MVVILRFNSKEFTFRTAKEGEFETEWLQAAGLGSLAAPFQAGLEVTEAQLGEAVRPLPREQAAAVRRRVRRLNRTVRRRRAASRARKPDIRDVFRDLENSSGSEPRSRSATPDSLDSLPSGGSGSPPAEWADGPTPTDFVERYPGTGAHSPLARTPSAPAAPRRAPVSPPLPMHELFKPNDLHWADIATNTEGIELLGYQRYGTVQGPRIGKERINGSILKGNDPFINNKHASVSRAKSVVSAQQPLSFEHKFNLDRQMMSHDEDWPEADSNVDIESISEPQLKRLQPLLWLELTAIFDKYSLPFQKRKPPKKKRKEEGSVFGVSLETLVRKDMILWEETCSAPSVLCCVTRALRARAHHEGLLRVSGNKQKVSELSQLIERQWYEDRGAVEAAVSLAKGHDLAAVYKRLLRALPQPLLTQELMRLFYHTYALSGSTRGRALNLLVLLLGPEARATLRELLRLANDIVAHAHANKMNEHNVAMIIAPTLFPPSLLIKQSDSLETQLATAANSCHVTEAMMRHSEQLWTVPPSLLAAAQRKPQAHRRLQHT

Description

GTPase-activating protein (GAP) for Rho1; functions with the ERM protein Moe to regulate Rho1 and control proliferation in the developing epithelium. Recruited by Moe to the cell cortex where it negatively regulates Rho1 activity. Can also promote cell proliferation independently of its GAP activity, perhaps by acting with Arf51F (Arf6) to positively regulate Rac1.

Subunit

Interacts with Moe (via FERM domain).

Keywords

Cell junction   Cell membrane   Complete proteome   Cytoplasm   GTPase activation   Membrane   Reference proteome  

Feature

chain  Rho GTPase-activating protein conundrum

Uniprot

A0A2W1BG34   A0A2H1VMF4   A0A212FIQ8   H9JVF8   A0A194Q4N9   A0A0N1IAD1   + More
A0A0L7LFN2   A0A1L8DMA6   A0A1L8DMJ8   A0A1J1I3B3   A0A158NQC2   A0A151IDW7   A0A1B0AMD8   A0A1A9Y488   K7IP81   A0A0A1XHT8   A0A1B0ABL9   W8AGN4   A0A182MNJ8   B4NZE7   Q16F46   B4HBJ6   A0A0K8ULN3   A0A151JU67   A0A151WGC8   A0A1A9UV83   A0A1Q3F2H5   A0A0L0BRX3   A0A0L7RJ03   A0A034WAA7   E9IWB2   B4NTI8   A0A0P6ISZ2   A0A1S4G3J9   A0A151JPN3   C9QP26   B3NKK6   Q8T0G4   A0A3B0KWR6   A0A0K8TNC9   B4MQU5   A0A182NUN2   B4LPF0   B4KLU1   A0A0P8YJI4   W8B2R3   B5DTJ8   A0A0K8UX92   A0A0P4VVZ8   A0A182GXI9   A0A182KFL4   Q7PWV8   A0A034W565   A0A182QJ15   A0A182Y984   A0A224X8B6   A0A1S4GZD3   A0A182F4Y5   A0A182XDH5   A0A182UUQ1   A0A2M3ZH16   A0A182I721   A0A023F076   A0A0V0GAB6   A0A2M4AGX2   A0A0K8V4L2   A0A0R1DUP4   A0A2M4ADS3   A0A2M4ADI6   A0A182J5B2   W8ASF8   A0A2M4BGR1   A0A2M4CMB0   A0A1B6FZC5   A0A1B6EID3   A0A2S2Q628   A0A0A9WXS8   W5JG67   T1HCL0   A0A146M526   F4WBB7   A0A0P9C657  

Pubmed

28756777    22118469    19121390    26354079    26227816    21347285    + More
20075255    25830018    24495485    17994087    17550304    17510324    26108605    25348373    21282665    22936249    26999592    10731132    12537572    23468526    26369729    15632085    27129103    26483478    12364791    25244985    25474469    25401762    20920257    23761445    26823975    21719571   

EMBL

KZ150118    PZC73241.1    ODYU01003354    SOQ42010.1    AGBW02008342    OWR53627.1    + More
BABH01036070    BABH01036071    BABH01036072    KQ459465    KPJ00314.1    KQ460393    KPJ15373.1    JTDY01001383    KOB74021.1    GFDF01006488    JAV07596.1    GFDF01006487    JAV07597.1    CVRI01000038    CRK94084.1    ADTU01023121    ADTU01023122    KQ977901    KYM98889.1    JXJN01000392    GBXI01003770    JAD10522.1    GAMC01019033    GAMC01019031    GAMC01019030    GAMC01019028    JAB87525.1    AXCM01000044    CM000157    EDW89860.1    KRJ98754.1    CH478512    EAT32862.1    CH479257    EDW38774.1    GDHF01024690    JAI27624.1    KQ981788    KYN35792.1    KQ983176    KYQ46903.1    GFDL01013280    JAV21765.1    JRES01001567    KNC21954.1    KQ414583    KOC70788.1    GAKP01008265    GAKP01008264    GAKP01008263    JAC50688.1    GL766483    EFZ15140.1    CH983165    CM002911    EDX15646.1    KMY91574.1    GDUN01001014    JAN94905.1    KQ978756    KYN28598.1    BT099908    ACX32979.1    CH954179    EDV54310.1    AE013599    AY069334    AAL39479.1    OUUW01000032    SPP89811.1    GDAI01002163    JAI15440.1    CH963849    EDW74484.1    CH940648    EDW61209.2    CH933808    EDW09751.2    CH902626    KPU79128.1    GAMC01019029    JAB87526.1    CH475944    EDY71227.2    GDHF01021151    JAI31163.1    GDKW01000345    JAI56250.1    JXUM01020455    JXUM01020456    KQ560572    KXJ81855.1    AAAB01008984    EAA15039.4    GAKP01008266    JAC50686.1    AXCN02000734    GFTR01007809    JAW08617.1    GGFM01006999    MBW27750.1    APCN01003346    GBBI01003800    JAC14912.1    GECL01001253    JAP04871.1    GGFK01006718    MBW40039.1    GDHF01018480    JAI33834.1    KRJ98755.1    GGFK01005531    MBW38852.1    GGFK01005525    MBW38846.1    GAMC01019032    JAB87523.1    GGFJ01003108    MBW52249.1    GGFL01002245    MBW66423.1    GECZ01014243    JAS55526.1    GECZ01032079    GECZ01020802    JAS37690.1    JAS48967.1    GGMS01003857    MBY73060.1    GBHO01031055    GBRD01010141    JAG12549.1    JAG55683.1    ADMH02001302    ETN63071.1    ACPB03002427    GDHC01004254    JAQ14375.1    GL888062    EGI68473.1    KPU79129.1   

Proteomes

UP000007151    UP000005204    UP000053268    UP000053240    UP000037510    UP000183832    + More
UP000005205    UP000078542    UP000092460    UP000092443    UP000002358    UP000092445    UP000075883    UP000002282    UP000008820    UP000008744    UP000078541    UP000075809    UP000078200    UP000037069    UP000053825    UP000000304    UP000078492    UP000008711    UP000000803    UP000268350    UP000007798    UP000075884    UP000008792    UP000009192    UP000007801    UP000001819    UP000069940    UP000249989    UP000075881    UP000007062    UP000075886    UP000076408    UP000069272    UP000076407    UP000075903    UP000075840    UP000075880    UP000000673    UP000015103    UP000007755   

PRIDE

H9JVF8    C9QP26    Q8T0G4   

Pfam

PF00620   RhoGAP

Interpro

IPR008936   Rho_GTPase_activation_prot        + More
IPR000198   RhoGAP_dom       

SUPFAM

SSF48350   SSF48350       

Gene 3D

1.10.555.10    

ProteinModelPortal

A0A2W1BG34   A0A2H1VMF4   A0A212FIQ8   H9JVF8   A0A194Q4N9   A0A0N1IAD1   + More
A0A0L7LFN2   A0A1L8DMA6   A0A1L8DMJ8   A0A1J1I3B3   A0A158NQC2   A0A151IDW7   A0A1B0AMD8   A0A1A9Y488   K7IP81   A0A0A1XHT8   A0A1B0ABL9   W8AGN4   A0A182MNJ8   B4NZE7   Q16F46   B4HBJ6   A0A0K8ULN3   A0A151JU67   A0A151WGC8   A0A1A9UV83   A0A1Q3F2H5   A0A0L0BRX3   A0A0L7RJ03   A0A034WAA7   E9IWB2   B4NTI8   A0A0P6ISZ2   A0A1S4G3J9   A0A151JPN3   C9QP26   B3NKK6   Q8T0G4   A0A3B0KWR6   A0A0K8TNC9   B4MQU5   A0A182NUN2   B4LPF0   B4KLU1   A0A0P8YJI4   W8B2R3   B5DTJ8   A0A0K8UX92   A0A0P4VVZ8   A0A182GXI9   A0A182KFL4   Q7PWV8   A0A034W565   A0A182QJ15   A0A182Y984   A0A224X8B6   A0A1S4GZD3   A0A182F4Y5   A0A182XDH5   A0A182UUQ1   A0A2M3ZH16   A0A182I721   A0A023F076   A0A0V0GAB6   A0A2M4AGX2   A0A0K8V4L2   A0A0R1DUP4   A0A2M4ADS3   A0A2M4ADI6   A0A182J5B2   W8ASF8   A0A2M4BGR1   A0A2M4CMB0   A0A1B6FZC5   A0A1B6EID3   A0A2S2Q628   A0A0A9WXS8   W5JG67   T1HCL0   A0A146M526   F4WBB7   A0A0P9C657  

PDB

3EAP     E-value=5.11687e-06,     Score=121

KEGG

101744937    K20639 Rho GTPase-activating protein 18/28/40 | (RefSeq) rho GTPase-activating protein 18

GO

GO:0007165   GO:0045179   GO:0005096   GO:0008284   GO:0034260   GO:0005886   GO:0043547   GO:0030054   GO:0051056   GO:0005737   GO:0032956   GO:0030833   GO:0016021   GO:0005839   GO:0051603   GO:0004175   GO:0005089   GO:0035023   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm   Recruited by Moe to the cell cortex. In the epithelium, predominately expressed at the apical cortex.   With evidence from 2 publications.
Cell membrane   Recruited by Moe to the cell cortex. In the epithelium, predominately expressed at the apical cortex.   With evidence from 2 publications.
Cell cortex   Recruited by Moe to the cell cortex. In the epithelium, predominately expressed at the apical cortex.   With evidence from 2 publications.
Cell junction   Recruited by Moe to the cell cortex. In the epithelium, predominately expressed at the apical cortex.   With evidence from 2 publications.

Length:

550

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01928

Exp number, first 60 AAs:

0.00101

Total prob of N-in:

0.00153

outside

1  -  550

 

 

Pi

203.139941

Theta

161.388296

Tajima's D

0.893194

CLR

0.589934

CSRT

0.625518724063797

Interpretation

Uncertain