Gene

KWMTBOMO02403  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013531

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_muscle_M-line_assembly_protein_unc-89-like_[Bombyx_mori]

Location

Bomo_Chr5(-):1203033-1282547      View in EpiBrowser

Full name

Obscurin       + More
Muscle M-line assembly protein unc-89      
Kalirin      
Triple functional domain protein      

Alternative Name

Muscle M-line assembly protein Unc-89
Obscurin
Uncoordinated protein 89
Huntingtin-associated protein-interacting protein
PAM COOH-terminal interactor protein 10
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Obscurin-RhoGEF
Obscurin-myosin light chain kinase

Location in the cell

Nuclear   Reliability : 2.45

CDS

ATGCAGCAGGTCGTTTCCCGGTACATGAAGCCCATCGACAAGGCCACCGCACCGAAACCGGTCTTCGATAATCGTGAACTGTTATTCTCCAACTTCAGGCAGATCTGCGAGTTTCATAATACCGTTCTTCTTGAAGGCATTAAGTACTATGCTGGTGAGCCTCGAATGCTAGGAAGAGCGCTTCTTCGCATGGAGCGGGAGTTCGACAAGCACGTCGCTTACTGCCGCGACGAGCCAAGAGCCCAGTATCTTCTAGCTAACGATCCAGTCGTGAAGAAATACTTTCAGAATTGGGTTTTAGTAAATGTTAACTTACAGGATCTAGCAGACAGTCTCGGCGACGATAAGGGTATAACTGAACATCTAAAGCTTCCGATACAAAGGATCAACGACTACCAGCTTCTTCTGAAGGAACTAGTGAAGTATTCGAGACGTCTCGGCGAAGACTGTAACGACCTCCAGAAGGCTCTAGAACTATTTCTTGGCGTTCCGAATCGCGCCACTGACAACAAATTCTTAGCCTCCATCGAAGGATTTAGAGGCAACATCTATAAACTAGGAAGACTTCTCACCCACGACTGGTTTACCGTCACCGACCAGGAAGGCAGGACCAAGGATCGGTATCTTTTCCTCTTCAAAGCGAGGATCTTGGTCTGCAAAGTCAAGAGGATATCTCAGGACAGATCTGTCTTCGTTCTAAAGGATATCATCAAGCTCCCCGAAGTCGAAGTGAAGGAAGTGACCGGAGAACCATTGAAGTTCGAACTTCGCCAGAAAAATCCACCGCTTGATTTGATCGTCGGTGCTCACAAGGAGCACGTGAAGAATACTTGGTTGGCTGAAATCAACAAACACGCTTCGGACATCGTTGCCCTTGCGGAACACGCAGCAGATGACCTTCAAGTTCTTCAGGCCGTAGAAACCAAAGAAACTGCGGAAGAGAAGAAGAAGAAGCGCGAACATACAGAAGAGGTTATCGTTAAAGCAGAGCAAGAGGTGAAAGAGAAACGATCCCGCACCGAAGACATTGAAGTCACCCAGGTTTCGGTTAAAGAAGAAACTTCCCAGCAAGTAAAAGTCAAAAGAAAAGCATCTGTTGAGAGCACAGTTGCTACTAAAATCTCCAAATCAGAAGTCGTAGAAGTATTCTCTCTTAACGAGAACCAGGAATCTGTCGTTAGCGCAATCGACACTGAAGTGAGAAGTGACGTCACAACTGATTTAGAAACTAAATCATCAGTGACTGTAAGCGCTCTGAACGCCGAGACTGAACCTGTTACATCACAATTGGAAAGTCAACAAACTTTGAAAACTGAGCATACAGAAGCAAAAGTAGAAGAACAAATTGTTCAAGCGTCTCAAACGACTGAAGAATATGTTGAAAAATCAATAAAAACTACTAAGCAATCATCTGTAGTTGAAACGACAGAATCATTTCAAGAGATAAGATCTCTCGAACAAGACTCTACAAAAATCTCAACAGAAGATAGAATTACAGTTCGAGAAGAAGAAGAACCAATCCACGCCATTCAAGAGTGTACAAACACACAAGAGAGATCAGACGAGTCATTTGAAACTGTTAAACAAATCCCTGAAATATCAAAAGAAACAGCGGAGAACGAAATATTAGAAACAACAAAAGAATCATCTGAAACTGTTATTCAAGTTTCAGAATCTCTTAGTGAAACTGTTTCTGAAACTGTGATAGCTGTTTCCGAAACTGAAGAAACGTTGCAAACGTTTGAACAGAAAGATTCTACAACTCCCCCAGCAGACCAGATAGCGACCGCTGTTTTAAAGCCTACTACAGCTGAGGCAATAGAAGAAAGTGTGCAAAGACAACAGACTTTGCAAGAAGTTAAATTAGAAGAACCCATTAGTGAGACTGCTTCAGCCCTAAATCAAGAAACAAAAATCATAGAAATATCTGAACAAAAATCTGAACAGACTGTCAATTTCGAGAGCGTAGCTAAAGAATCCAAAGAATTTGAACTAAACGCTACTGAAGAAGTTAAAAAATTAGTTGGAAAGGCACACGAGGAAAGCGCTTCTGCAGGCGGTCAAACTGTAACCACAGAGGAGATTGGTGACGACGAGATGTCGAGGTATAGCCGCAGTTCGCGGATATCTGGAGAGTACTCCAGCAGCGCTAGAAAATCATCTACTGGTGGACGATATGAGTCCTCTACTTATGACAGCACTGGTCTATCATCATATTCACGACGCGAGAGCGGATCACGTCTCGAAAGTGCGAGATATGAAACTGGCGGATCTACTGAAGGCGGAGTCTCCTCGCGCTACGAATCTAAGTACTCGAGCTCATCAAAGATAGAAGGAGGTTCCAAATATGGCATTGAGTCTAGCTATGAAAGCAAAGTAGACGGATCCAAATACGGAATTGATTATGATTCCAGCAGCAAACGCAATAGTATTGCTTCTAAATATGGGGTCGAAGCTGAAACGAACAGCAAAATTGATGGCATTGCATCAAAATATGCCATCGAGTCAGAAACTACAAGCAAAATTGACAGCATTGCTAATAAATACGGAATTGATACCGAAAAAGCAAGCAAGATTGATGGAACCGCATCTAAATATGGAGTAGAATCAGAAACCACAAGCAAAATTGATAGTATTGCTTCTAAATATAGGAAAGAATCCGAGGGCTCCATCAAAGTTGATATGGTTTCGTCTAAGTATGGCGTGGAATCTGAAACGTCTAGTAAAATTGACAGTATTGCATCAAAGTATGGCATTGAATCAAAATACGAAGCTGAAGGACGTTCATCTAAATATAGCTCTCAAATCAGTTATGACGGCAATAAGGTTGACGGTGTATCTACAAAGTTAGAAAGTAGTTTCGAGAGTTCTAGCAATGGAGGCTCAGTCTACGAGAGCAAATATTCTAAGCGAGCCATTTCCAACGGCGTACATTCTGAAGAGTCTGAATTACAGAGGTCTATTTCCAAGTCTGAAGCTCAGGATGGAAGACCAGTGTTCTCAAAAACTCTCGAAGGCCAAAACATCGAGCTGACGCCGGAAGAAAGAAAGCAGAGGAATGCTCTAAACGCTCCGTACTTCTTAGTAGCCTTGAAGGACACTGAGATCATGGAAAATACCTACTTGCGTTTCATGATCAGAGTCAAGGGCAATCCCAACCCAGAAGTTAAGTTCTACCGCGACGACAAAGAGATCGTGGCGAAGTCGGATACGGACCGTATCTCCATCATCACGACCCGCGCCGACCGTGGCTGCTACGAACTGGTGATCCCAGACGTGACTCCAGCCGATGCGGGCAAATACTCCTGCAGGGCTATGAATATTTACGGCGACGTCGTTTCCGAAGCTAAAGTTACCGTTGTTGATGACAAAAACATATTTGGTGAACTGCTTCCTGGTGGTGATGGTCTGCTGGCTAAAGGCGAGAAGCCAGCTTTCACGTGGAAGAAAGATGGACAGCCCTACGATCCTGAAGAACGATTCAAGGTTCTTCTTGGTGACGACGAAGACTCCCTGGCGCTGGTGTTCCAGCACGTGAAGCCGGAGGATGCTGGGTTGTACACGTGTGTGGCTAAGACCAGTACAGGAAATATATCTTGCTCAGCCGAGCTTACTGTTCAAGGTGCCGTGAACGAACTTCACCGGGAGCCAGAGAAGCCGACCCTGGTGATCGAGCATCGGGACGCTATCGTCTCGATGGGCGCCTCGGCCATGCTGGAGCTACAATGCAAGGGCTTCCCGAAGCCGAGTGTCGTGTTCAAGCATGACGGGAAGGTGGTGGAACCAGACACCAGACATAAGTTCTTGTACGAGGATGAAGAGAGCATGTCTCTTGTGATAAAGAACGTGACGTCAGCAGATGCCGGAGAGTACCAGGTGACGGCCAGCAATGAGCTCGGTGAAGACACTTCCACCATGAACCTAGTGGTGAAGGCGCCGCCGAAATTTAAGAAGAAGATCGAAAATCAAACCTGCATGGTCGGCACGACTCACACCGTCATAATAGAAGTGGAAGGAACACCTTCACCAGACCTGACATTCTACAAGGACGGAACTGAAATCAAGAGCTCTGAACGCATACAAATCGTTAAAGAGAGTGAGGAAATATACAAGATCACAATTAAAGATGCCAAGTTGACCGACACTGGATCGTATTCTGTAGTAGCTAAGAACGAAGTGAACCAATGCTCTGAGTTCTGGCAATGGCACGTGACGTCACCGCCCCGACTCGTGAAGAAGCTGGGCGGCTCCAAGGTCGTCGACGAGAAGGAGACAGTCACTTTCAGCATCGAAACCGAAGCTGAACCGGCACCGACTGTCAAATGGTTCAAGAATAAGACGGAATTGACGGAGTCGTCAACGGTGAAAATCTCATCATCCGGGTCGGCTCACTCCCTCGTGATCACGTCTGCCGCAAGGGCTGATGCTGGAGAGTATTCTTGTGAGGTCCGTAACGTGCACGGCGAGGCGAGTGACGTCAGCACATTGAACGTCCGCTGCGGTCCGGTGTTCACGGAGCGCCTGCGTGACGTCACGGCCAGCGAGGGTGACGTCAATGTCGAGTTCACGGTCGCCGTTGATGCATTCCCGCAACCCACCATTCGATGGTACTTGGGAGACGTGGAGGTCACAGAAAAGAAGTCTGTGTTCACTCGCGTGGATAGCGGCAACACGCACAAGTTGATCCTCAAGGAAGTGTCGGCTGAATATTCCGGACAGTACACATGTAAAGTTTCCAACGAACTGGGGGATGACTCCTGCCAGGCAACTTTCACTGTTAACAGAAAACCCCGGTTCACTAAGAGCCTGGTGGATATGACCGTCGACGCAGGTCAGACCCTAAAACTTGATGTGGAAGTTGAGGGCAGCCCGGAACCCAAGGTTCGCTGGTTTAAAGATGGAAAAGAAGTCACTACTGATGCCAGAATTAAAATAGAAAGAGACACTAAGAGGCTCGAAAATTATCATCTCACGGTGACATTAGTGAAGGAAGAAGACGGTGGCGAATACGAAGTTAAAGCTGAGAATGAGATGGGAAGCGTGTCATCGAAGAGTACAGTCACAGTCCACACGAGGGAAGTCCACTCGAGGATCACTAAGGAAGAAGTGGAAAGTGAAATTGATGCGAAGGCAAAACAACCTTTAGAGGAAGAAGTTGAAAGTTCAATAACGGGGGAAGTTCACTCGAAGATCACTAAGGAACAAATGCAAAGTGAAATCGATGCGAAGGCAAAACAGCCTCTTGAGGAAAAAGTTGAAAGTTCAATAGCGGTGGAAGCTCACTCGAAGATCACTAAGAAAGAAGTGCAAAGTGAAATCGATGCGAAGGCAAAACAGCCTCTAGAGGAAAAAGTTGAAAGTTCAATAGCGGTGGAAGCTCACTCGAAGATCACTAAGAAAGAAGTGCAAAATGAAATCGATGCGAAGGCAAAACAGCCTCTAGAGGAAGAAGTTCAAAGTTCAATAGCGGGGGAAGTTCACTCGAAAATCACTAAGAAAGAAGTGCAAAGTGAAATTGATGCGGAGGCAAAACAGCCTTTAGAAGAAGAAGTTGAAAAAACACAAAAACTTAGTGCAAAAAAAGAAAAATCAGCATCGGAAACAATCGAAGAAAGATCTATTTGGGAGGATGATGATGCCGAAAAAGCTAAAAAACCAATCATTGAAGAATCTGAAGTTCCCAAGCCAAGTAAGGGTCGTAAGTCGCTTTCAGAGCCGGATACAGTGGAAGAGAAATCATTTTGGGATGATGTAGGTGATGACGAAAAACCAAAGAAAGTAACATTCGAAGACACCGATAAACCTGTGAAGAAGAAAGGTAGAAAATCTATCTCAGAAGTCATAGAAGAAAAGTCTATTTGGGATGACGATCGTAAAGAGGAAAATACAAAAAATATTGTTATTGATGAAGTTGAAACTCCACGCCGTGATAAAGCAAATGAATCTGTCACAGAGCCAGAAATATCCGAAGAGAAATCTTTTTGGGATGATAGTGACAGCAAATCATCAAAGAAACCTAAAGTGGCAGAAGTAAACAGTGAAAAAGTCGACAAAGGCTCAAAATCCAGCACTCCGCTTGAAGTAGCTGAGGAAAAAAGCATTTGGGATGAAAACCACAATGAAAAGATCAAGAAACCTATCGTTGAAGAGGTGATCGTTGAAAAGAAAATCGGTGATACAAGCGTCACAAAACCTGAATCAATAGAAGAAGTACCTCTGGATGAAGAACTCAAATCATCCAAACGTAAATCTTTGAAAAAAGAGTCTGTTTCAGAAGAACCATTAAGTGCTGAAGTCGAAGGACGAGTTTTTGAAACAGTAACTACTTTCAAGAAAGGTGACGATGGATCTATCATAATGTCTAAAGTAAGCAGCAGCAGGTCTCATGGTGCTATCGTCACAGGTCCCGCTGAAACGCACACTTTACATAAAATGACATCGAGCACTGTTTATTATGAGGACGATGACGAGTTCGAAAGTAGAAAGATTATAAAACCAAATCAGCCACATACAACTTCATTGGAAGTTGAAGAAATAGCCAGCCATAGTTATATGCTGTCGGAAATGGGTCATTTTACCATACCAGATTACATCAGGCGTGGAACTTACGGCATAATTGAAGAGCCTCAAACTGATTCTGATGCGGAAAGTACGAGAGGCATTAAGAATTATAACAACAGAACTGTGTCAATTATGTCCATGTCCGAGGATGAAATGAGCTGGCACAATGAATCTTTATCACGCGAAATTTCCATTGAAGACCTTTCGAAATCTATCTTTGATATTGACGATACTAGAAAAGTTTTCAGTAAAGACTCATATGTACGTCAGTCATCTTTCAAAGAGGACTATTTCACTAATAAAGGTGATGAAGAATCCTTAATTCTCAAAGAAAAATCAGAAAAAGTATTCGAAAACGATATCACAGAGAAACTCATTCACATCTCAAAAGATTTCGACGAAAATGAATTTAAAAATATTAAAAGTAAAGTAGATGATGTTAGAAATAGACTTATTGAAGAGTTAGTCATTGGGCCTGACAGAAAATTAGATAGCTTAACAAAAGACGTAACCGAAATGACCGTAGAAAGAAAACGAAAGGGAGAGGCAAAATTGTTTAGCGTTCAGGAAGAAGCGAATGACCAACAAGTGGACGATCTGTTGAAACGAAGCCAGAGACAGAGAAGCATCCTCGATGATATTCTAAATAAGGAAGACGAAAAAGCATCACCTACCTTAAAAGACAGTTCCTTCAAGGACAAAGAGGTATACGAGTCCCTTCCACTAGTTTACACGGTTGAAGCATCCGGGACTCCTAAGCCGGCAATTCGCTGGCTTCACGACGGTAAGGAAGTAAAGCCTTGCGGCAGAGTTCACATCACCAACGAAGGAGATCTTTATAAATTGGAGATCGATAGAGTTAATTTGGATGACGCTGGACAATGGCAGTGCGAGATTAGCAATGACCTCGGCAAGAATGTACTGAAGGCCGATTTGACGGTAAAACCCGAAAGTGAGCTCCGCAAGCCAAAGTTTACGCAACCTCTAGAAGCCCAGCGCATTCTTCAACGGGAGCCCGTCAGTCTCCAAGCTGTTTGTACAGCGGACCCTCAACCACATGTGTCGTGGCTTCTTAACGGAGTAGAATTGACTCCCGACGCTACAATCGTGACGTCAGCCGATACAAAGGATATTGAACATGGTTTGAAAGAGTGCACTTTCACCCTGCAAATTCCCACTGGTCGCCATGCTGATACCGGTAACTATACCATCCAAGCTAAGAACAAATACGGTGTTGGTGAAAGTTCTGCTCGTCTCGACATTCTGCTGAGACCAGAGATCGAAGGTCTCAAGGATGTTTCTGCCGTACCTTATGAGGAGACCACCTTCGTTGCCAACGTCCGAGCTAACCCCATTGCTGAGATTCAGTGGAGTAAAGACGGATACGTTATCAAACCATCGTCTCACATCGAGATAAGCGAAGACAAAGATGCTGAGAAGTATCAGCTCACTGTTAAGAAGGTCGGAATGGACGACGCTGGTGTATACACGCTGACAGCCAAGAACGAGATCGGTGAAACCGCCCAACAAGCTAAGCTCATCATACGCACCGGCGAGCCAATCTTCACTAAGCCTTTGAAGAAGCAAACGGTGAAAGACTACGATGATTGCACGCTGAAGGTGCGCTGCGACGGCGAACCGAAACCGGAGGTGAAGTGGTACGTGAACGGCAAGGAGATAACCAACGATGACCGTCACACCGTCACCACGGAAGTCGGTGGTCAGGTTGACAGCGAGCTGGACATCAAGCACTTCAATAGTGACGATACTGGAAAGTACAAAGTTCGCGCGTTGAACTTGGCCGGTGAGGCGTCTTGCGAAGCTCAGATAACGTTAGCGCAGCTAGCCCCAGGGTTCACACACCGTCTGGACAGGCAGAAGGACGTTGACGAAGGGGAACCTCTCGAGCTGAAGGCTAAGATCGACGGCAGCCCTACTCCAACTGCCACTTGGTACAAAGACGGTGTTCCGATTCCCGCAGACGACGATCACGTGAAGCAGTCAGCTCTGGCCGAGGGCTGGGTCAAACTGAACATCGCTGAAGTGACCCCCTCCGACTGCGGAGCGTATAAACTGGTCATATCCAACCCTAACGGTGACAACTCGGCTTTGTGTGCAGTCGCTGTTAATCCTACACCAAGGAAGCCATCGTTCAGTCAAGAGCTAGAAGACGTAAAGGCAGTAGTGGGTCAGCCATTGAAACTAGAAGCCAGGGTGATGGCCTTCCCAGCGCCAGAAGTCAAGTGGTTCAAGGACGGCTTGCCGGTCCGTCCATCACAGGCGATCAACTTCATCAATCAGCCGGGCGGAGTCGTCGGTCTCAGCATCGACAACTGCAAGCCGGAAGATGCTGGAGTCTACTCACTCACCGTCACCAACAAACTCGGAGAGGTCGGTTCAAAGGCGAATGTCGACGTAACTCAAAAGGAGCGGAAACCAGCCTTCATAGCAGAACTACAACCTACCAAGGTCATTGAAGGATTCCCGGTCAGACTGGAAGTCAAGGTGCTTGGACATCCGCCACCTACTATCAAATGGACACTTGACGGTAAAGAGTTGGTTCCGGACGGCGTCCGTATTCGTGTGGTGTCACAGCCAGACGGGACACACGCGCTGCTCATCGCGGCCGCTACGCCATCCGACGCTGGACGATACGGAGTCGTCGCCAACAATGACAAGGGCGAGACCAAGTCTGAAGCAGACCTGACCGTGTCCAGTCGCCAGGACGACTCGAACCCACAAGAGCGGCCGCAGTTCATCCACGGCCTCAGGGATGTGACGGCAGCGGAGGGACAGCCTCTCTCGGTGACCGCGCCCTTCGTCGGCAACCCTGTCCCCGAGGTCACGTGGACTAAGGACGGACAACCCTTGAAGCCAGACGAGAAGATCCTGCTCACGTGCGACGGGAAACGGGTGGGTCTAGAAATAAACCCTGTGGAGCTGCCGGACGCGGGGGTGTACTCCGTGAAGCTGGTCAACCCTCTGGGTGAGGACAGCTCTGAAGGCAAGATCACCGTTAAGAAGGTTTACCAAGCACCCACCTTCTCCCAGCGGTTCACTGACCTGCAGCAGTTACCGACATTCGACGCCAAATTCCCTGCTCGCGTGTTCGGCATCCCCTTCCCCGACATCTCCTGGTACAAGGACGGAGTTCTTCTGAAGCACTCCGACAAATATAACATCAAACGCGACGGCGACGCTGCCTGTCTGTACGTCAGAGATATCGGACCGGACGACGCTGGAGTGTACAAGTGCGTCGCCAAGAACAGGGAGGGCGAAGCCGAGTGCCAGGCTAGTCTCGAAGTCGTTGATAAGATCGCCAGGCAGCAGAAGGTGGAGCCTCCGTCGTTCCTGAAGAAGATCGGAGACATCGAGGTGCTTCGCGGCATGAGCGCCAAGTTCACCGCCTGCGCCACCGGCTCCCCAGAACCCGACGTGCAATGGTATCGCAATGACGAGAAGCTGTTCCCTTCGGACCGGATCCGCATGGACAAGGAGAGCACGGGGCTGCTGCGGCTGAACCTGAGCCGCGTGGAGCCCTGCGACGTGGGCACCTACCGCTGCACCCTCACCAACCCTCACGGGGAAGCCTCCTGCACAGCACAGCTCACCTATGACAGTATGGAGCCGCACGCAAGCAAACGTCCAATCTCGGACCAGTACTCTGACTTCGATAAGATGAAGAAGACCGGCATCCCCATGCCCCTGGCTGACCGGCCCATCATCTCGCGCATGACCGATAGGCACCTCACCTTGTCCTGGAAGCCGTCCATCCCTCATGGACCTCGCTTCCCGGTCACATATCAGGTGGAGATGTGTGAGGTCCCTGACGGCGACTGGTTCACCGCCCGCACGGGGCTGCGCTCGTGTGTGTGCGACATCCGCAACCTCGAGCCCTTCCGCGACTACAAGTTCCGCATCCGCGTCGAAAACAAATACGGGGTCAGCGATCCCTCGCCCTTCGCCATCACGCACCGCGCCAAGCTGGAGCCCGACCCTCCGAAGTTCGTCCCCTACCTAGAGCCCGGCATCGACTTCCGCCCGGAGACCTCGCCTTACTTCCCTAGGGACTTCGATATCGAGCGTCCGCCCCATGACGGGTACGCTCAGGCTCCTCGCTTCCTGCGTCAGGAGCATGACTCGCAGTACGGGGTCAAGGGACACAATGTCAACCTGTTCTGGTTCGTCTACGGCTACCCGAAGCCCAAGATGACGTACTTCTTCAATGATGAACCGATCGAAATAGGCGGCAGATACGACTGGAGTTACACGAGGAACGGCCAAGCCACGCTGTTCATCAATAAGATGCTGGAACGTGATGCTGGCTGGTACGAAGCCGTCGCCACCAACGAGCACGGTCAGGCTCGACAGCGAGTCCGGCTGGAACTAGCAGAGTATCCCACCTTCATACGCAGACCTGAGGAGACAGTGGTGCTGCAGAGGAGGACCGTCCGACTGGAGGCCAGAGTCACGGGAGTGCCGTATCCTGATATTAAATGGTACAAGGATTGGCAGCCATTGGCACCGAGCTCCAGAATCAAGATACAGTTCATCGAGCCGGACACGACGGTGCTGGTGATCAAAGACGCGATCCTGAAGGACGAGGGTCTGTACTCCGTGTCCGCGAGGAACGTGGCCGGCTCTGTCAGCTCCTCGGCCATGCTGCACGTAGAGGAAGACGAATATGAATACGCTGACAGGATCCGCGAGCACCCGCCCCGCGTGAAGGCCAGCACGAAGCCGTTCGGAGACCAGTACGACCTGGGCGACGAGCTGGGCCGCGGAGTCCAGGGCGCCGTGTACCACGCGGCCGAGAGACTCACCGGACGCAACTACGCTGCGAAAATAATGCACGGTCATTCCGAACTGAAGCCATTCATGAAGAACGAGATAGACATCATGAACCTGCTCAACGACCGGCATCTGATCCGGCTGTACGGAGCGCACGAGCATGACCACACCGTGGCGCTGGTCACGGAGCTGGCGGCGGGAGGGGAGCTACTCAGGGACGGACTCCTGCGGGTTCCTTCCTATCCTGAGCGACGGGTTGCCTCTATCATCAGGCAACTGCTACTGGGACTAAGGCATATGCACGATAACAGCGTAGCGCACCTTGGACTAACGATCGGCGAACTCTTACTCTCGCACGCCGGCAGCGACGATATAAAGATATGCGACTTCGGACTATCACGCCGCATAAGACACAACGAACTGGGCGCCCTCCACTACGGGATGCCGGAGTATGTAGCTCCCGAAGTGGCCAACGGCGATGGCGTCTCCTTCCCAGCCGACATGTGGAGTGTCGGTATCATAACCTACATCCTGCTCAGCGGACACTCTCCATTCCGAGGTCAAAACGACCGCGAGACTCTGACGAGAATTAAGGAAGGCACTTGGAGCTGGCACGATGAGGAATGGTGGTCTCGCCTCAGTACGGAGTCCAGGGACTTCATTTCGAAGTTGTTGGTGTTTAACTGGCACGAGCGTATGGACGTGAGGACGGCTCTGTCGCATCCATGGCTGACGCTGGCGGATCGAATCTACCAGGAGGAGTACCAGATCTCGACTGATCGATTGAGGAACTACTACAATTTGTACAGAGACTGGACAAGTAACGCACAATGCCGCACGTGGTTCCGGCGTCGGCCGCTAGAGGGCGCCTTCCATCATCCCTCTAAGATGGTGTATCCACCCGGGGAAACGTACACACCAGAAGGAACTCCAGACCGCGACATCAGCACCCGCGACCGTAAGCCAGCAGAGTTCGATCTCAACTTCAAGCAGTGGGACCATCCCGACTGGGAGGTTTCCGCCACCTCTGAGAGCCATTACCAGAACGGCCCGGACACGTATCTGCTGCAGCTGCGGGACACCCAGTTCCCGGTGCGGCTCCGGGAGTACATGAAGGTGGCCTGTCACCGCTCGCCGGCATACAGCATCAACGCCTTCGACAACTACGACCCCAGGACCCCGATTATACGAGAACGTCGTCGCTTCACCGACATCATGGACGAGGAGATAGACGACGAGCGCCGAGATCGGATCAACGGGTACGGGAGCGAGTCCGGCACCGTGCGGAGGCTGCGACACGAGCTGGGCACGCGGCTCGACTCCTACGCCGAGGCTCAGGCCTTCATGGAGGCCAAGAAGGACGGCTGTCTGCCCTTCTTCCGCGAGAAGCCGCAGCTACTACCGGTCAGGGAAGGTGAACCCGCCAAGCTGTCCTGCTTCGCGGTCGGCGACCCCAAGCCCGTCATCCAGTGGTTCAAAAACGACATGGTCATCGCTGAAGGACAACGCATCAAGATCGTGGAAGACGAAGAGGGACGCTCTACTCTCGAGTTCAATCCTTCCATGCATCACGACATCGGATTCTACAAGGTGGTCGCCAGGAATAAAGTGGGGCAGACTGTCGCCCGCACCAGGGTTGTAGAAGCTACCACTCCTGACGCTCCTGACGTTCCCACCGCTGCGGAGGTTTCAGACACAGAAGTGTTGTTACGCTGGAAACAACCCAAGTACGACGGCAACTCGCCTGTCCTCTGCTATAGCCTGCAGTACAAGGCCGGCGACAGCGTCGAGTGGAAGGAGGTTGCCAACAACATCGACCACGAGTTCTTCGTCGTCCGAGATCTTAATCCGGACACCAGCTACCAGTTCCGCCTCTCCTCCAGAAACCGAATAGGCTGGAGCGAGAAGGGTGCTCCCACCAACCTTGTCAAGACGCGTGAGGCTGGTGCGAGCAAGATCGAAGTCACAAAAGCTATGAGGCATCTTCAACAGCTCACCGAATCCGGCCAGGAGATTGTTCTCGATGAAGAAAAGCCGCAGTTAGACTACTCGACCGAGAAGCAGCCCGTGGAATGGTACAGCGCCAATACGTTCACAGAGCGGTACAGCTTCATCTCGGAGCTGTGGCGCGGGAAGTTCTCCATTGTCGTCAAGGGAGTTGACAAGACAAACGACACTGTCGTGGTCGCCAAGATCCTCGAGAACAGACCAGAGACCGAGGTCCTGGTCCAGCGAGAGTACGAGTGTCTGCGAAGGCTGCGGCACGAGAGGATCGCAAACCTGCTCTCAGCGTACAGAGCTCCCGGCTCCCCGGTTTCCGTTCTGATCTTGGAGCGACTACAAGGGGCAGACGTGCTGACGTTCCTGGCAAGTCGCCATCAGTACTCGGAGCAGCTGGTGGCCACGGTGATCACGCAGGCGTTGGACGGACTACAGTACCTGCACTGGCGCGGGTACTGCCACCTGGACCTACAGCCAGACAACTTCGTCATGGCCTCCGTCCGCTCGGTGCAGGTCAAGCTCGTGGACTTTGGATCTGCTCATAAAGTCACCAAGCTCGGCACCAGTGTGCCGCAGGTCGGACATCTAGAATACAAAGCCCCGGAAATAATAAACGACGAGCCAGCGTATCCTCAGACGGACATCTGGTCTATCGGAGTCCTGGCCTACATCTTGCTGAGCGGAGTATCTCCCTTCAGAGGAAACGACGATAACGAGACCAAACAGAACATCTCCTTCGTCAGATACAGATTCGAGCATCTGTACAGCGAGATCACGCAGGAGGCTACCAGATTCCTGATGTTCGTCTTCAAGAAGGTTCCCCTGAAGCGTCCGACGGCCGAGGAGTGTCACGAGCACCGTTGGTTAGCGCAGTCTGACTTCATCAGCAAGAAGAGAGAACGAGCTATCTTCTCAAGCAGTAAACTTAAGGAATTCTCAGATGAATACCACGAACGTAAGGCCCATGAAGCATCGCAAGCCGACACGTTAACCGAAGCCTTCGGTCAGTTCGCACCGAGACTGCTCACCAGGTCCAACAGCATCCAAGAAGAACTGCTCACGAACCTCTCTAGCCAATAA

Protein

MQQVVSRYMKPIDKATAPKPVFDNRELLFSNFRQICEFHNTVLLEGIKYYAGEPRMLGRALLRMEREFDKHVAYCRDEPRAQYLLANDPVVKKYFQNWVLVNVNLQDLADSLGDDKGITEHLKLPIQRINDYQLLLKELVKYSRRLGEDCNDLQKALELFLGVPNRATDNKFLASIEGFRGNIYKLGRLLTHDWFTVTDQEGRTKDRYLFLFKARILVCKVKRISQDRSVFVLKDIIKLPEVEVKEVTGEPLKFELRQKNPPLDLIVGAHKEHVKNTWLAEINKHASDIVALAEHAADDLQVLQAVETKETAEEKKKKREHTEEVIVKAEQEVKEKRSRTEDIEVTQVSVKEETSQQVKVKRKASVESTVATKISKSEVVEVFSLNENQESVVSAIDTEVRSDVTTDLETKSSVTVSALNAETEPVTSQLESQQTLKTEHTEAKVEEQIVQASQTTEEYVEKSIKTTKQSSVVETTESFQEIRSLEQDSTKISTEDRITVREEEEPIHAIQECTNTQERSDESFETVKQIPEISKETAENEILETTKESSETVIQVSESLSETVSETVIAVSETEETLQTFEQKDSTTPPADQIATAVLKPTTAEAIEESVQRQQTLQEVKLEEPISETASALNQETKIIEISEQKSEQTVNFESVAKESKEFELNATEEVKKLVGKAHEESASAGGQTVTTEEIGDDEMSRYSRSSRISGEYSSSARKSSTGGRYESSTYDSTGLSSYSRRESGSRLESARYETGGSTEGGVSSRYESKYSSSSKIEGGSKYGIESSYESKVDGSKYGIDYDSSSKRNSIASKYGVEAETNSKIDGIASKYAIESETTSKIDSIANKYGIDTEKASKIDGTASKYGVESETTSKIDSIASKYRKESEGSIKVDMVSSKYGVESETSSKIDSIASKYGIESKYEAEGRSSKYSSQISYDGNKVDGVSTKLESSFESSSNGGSVYESKYSKRAISNGVHSEESELQRSISKSEAQDGRPVFSKTLEGQNIELTPEERKQRNALNAPYFLVALKDTEIMENTYLRFMIRVKGNPNPEVKFYRDDKEIVAKSDTDRISIITTRADRGCYELVIPDVTPADAGKYSCRAMNIYGDVVSEAKVTVVDDKNIFGELLPGGDGLLAKGEKPAFTWKKDGQPYDPEERFKVLLGDDEDSLALVFQHVKPEDAGLYTCVAKTSTGNISCSAELTVQGAVNELHREPEKPTLVIEHRDAIVSMGASAMLELQCKGFPKPSVVFKHDGKVVEPDTRHKFLYEDEESMSLVIKNVTSADAGEYQVTASNELGEDTSTMNLVVKAPPKFKKKIENQTCMVGTTHTVIIEVEGTPSPDLTFYKDGTEIKSSERIQIVKESEEIYKITIKDAKLTDTGSYSVVAKNEVNQCSEFWQWHVTSPPRLVKKLGGSKVVDEKETVTFSIETEAEPAPTVKWFKNKTELTESSTVKISSSGSAHSLVITSAARADAGEYSCEVRNVHGEASDVSTLNVRCGPVFTERLRDVTASEGDVNVEFTVAVDAFPQPTIRWYLGDVEVTEKKSVFTRVDSGNTHKLILKEVSAEYSGQYTCKVSNELGDDSCQATFTVNRKPRFTKSLVDMTVDAGQTLKLDVEVEGSPEPKVRWFKDGKEVTTDARIKIERDTKRLENYHLTVTLVKEEDGGEYEVKAENEMGSVSSKSTVTVHTREVHSRITKEEVESEIDAKAKQPLEEEVESSITGEVHSKITKEQMQSEIDAKAKQPLEEKVESSIAVEAHSKITKKEVQSEIDAKAKQPLEEKVESSIAVEAHSKITKKEVQNEIDAKAKQPLEEEVQSSIAGEVHSKITKKEVQSEIDAEAKQPLEEEVEKTQKLSAKKEKSASETIEERSIWEDDDAEKAKKPIIEESEVPKPSKGRKSLSEPDTVEEKSFWDDVGDDEKPKKVTFEDTDKPVKKKGRKSISEVIEEKSIWDDDRKEENTKNIVIDEVETPRRDKANESVTEPEISEEKSFWDDSDSKSSKKPKVAEVNSEKVDKGSKSSTPLEVAEEKSIWDENHNEKIKKPIVEEVIVEKKIGDTSVTKPESIEEVPLDEELKSSKRKSLKKESVSEEPLSAEVEGRVFETVTTFKKGDDGSIIMSKVSSSRSHGAIVTGPAETHTLHKMTSSTVYYEDDDEFESRKIIKPNQPHTTSLEVEEIASHSYMLSEMGHFTIPDYIRRGTYGIIEEPQTDSDAESTRGIKNYNNRTVSIMSMSEDEMSWHNESLSREISIEDLSKSIFDIDDTRKVFSKDSYVRQSSFKEDYFTNKGDEESLILKEKSEKVFENDITEKLIHISKDFDENEFKNIKSKVDDVRNRLIEELVIGPDRKLDSLTKDVTEMTVERKRKGEAKLFSVQEEANDQQVDDLLKRSQRQRSILDDILNKEDEKASPTLKDSSFKDKEVYESLPLVYTVEASGTPKPAIRWLHDGKEVKPCGRVHITNEGDLYKLEIDRVNLDDAGQWQCEISNDLGKNVLKADLTVKPESELRKPKFTQPLEAQRILQREPVSLQAVCTADPQPHVSWLLNGVELTPDATIVTSADTKDIEHGLKECTFTLQIPTGRHADTGNYTIQAKNKYGVGESSARLDILLRPEIEGLKDVSAVPYEETTFVANVRANPIAEIQWSKDGYVIKPSSHIEISEDKDAEKYQLTVKKVGMDDAGVYTLTAKNEIGETAQQAKLIIRTGEPIFTKPLKKQTVKDYDDCTLKVRCDGEPKPEVKWYVNGKEITNDDRHTVTTEVGGQVDSELDIKHFNSDDTGKYKVRALNLAGEASCEAQITLAQLAPGFTHRLDRQKDVDEGEPLELKAKIDGSPTPTATWYKDGVPIPADDDHVKQSALAEGWVKLNIAEVTPSDCGAYKLVISNPNGDNSALCAVAVNPTPRKPSFSQELEDVKAVVGQPLKLEARVMAFPAPEVKWFKDGLPVRPSQAINFINQPGGVVGLSIDNCKPEDAGVYSLTVTNKLGEVGSKANVDVTQKERKPAFIAELQPTKVIEGFPVRLEVKVLGHPPPTIKWTLDGKELVPDGVRIRVVSQPDGTHALLIAAATPSDAGRYGVVANNDKGETKSEADLTVSSRQDDSNPQERPQFIHGLRDVTAAEGQPLSVTAPFVGNPVPEVTWTKDGQPLKPDEKILLTCDGKRVGLEINPVELPDAGVYSVKLVNPLGEDSSEGKITVKKVYQAPTFSQRFTDLQQLPTFDAKFPARVFGIPFPDISWYKDGVLLKHSDKYNIKRDGDAACLYVRDIGPDDAGVYKCVAKNREGEAECQASLEVVDKIARQQKVEPPSFLKKIGDIEVLRGMSAKFTACATGSPEPDVQWYRNDEKLFPSDRIRMDKESTGLLRLNLSRVEPCDVGTYRCTLTNPHGEASCTAQLTYDSMEPHASKRPISDQYSDFDKMKKTGIPMPLADRPIISRMTDRHLTLSWKPSIPHGPRFPVTYQVEMCEVPDGDWFTARTGLRSCVCDIRNLEPFRDYKFRIRVENKYGVSDPSPFAITHRAKLEPDPPKFVPYLEPGIDFRPETSPYFPRDFDIERPPHDGYAQAPRFLRQEHDSQYGVKGHNVNLFWFVYGYPKPKMTYFFNDEPIEIGGRYDWSYTRNGQATLFINKMLERDAGWYEAVATNEHGQARQRVRLELAEYPTFIRRPEETVVLQRRTVRLEARVTGVPYPDIKWYKDWQPLAPSSRIKIQFIEPDTTVLVIKDAILKDEGLYSVSARNVAGSVSSSAMLHVEEDEYEYADRIREHPPRVKASTKPFGDQYDLGDELGRGVQGAVYHAAERLTGRNYAAKIMHGHSELKPFMKNEIDIMNLLNDRHLIRLYGAHEHDHTVALVTELAAGGELLRDGLLRVPSYPERRVASIIRQLLLGLRHMHDNSVAHLGLTIGELLLSHAGSDDIKICDFGLSRRIRHNELGALHYGMPEYVAPEVANGDGVSFPADMWSVGIITYILLSGHSPFRGQNDRETLTRIKEGTWSWHDEEWWSRLSTESRDFISKLLVFNWHERMDVRTALSHPWLTLADRIYQEEYQISTDRLRNYYNLYRDWTSNAQCRTWFRRRPLEGAFHHPSKMVYPPGETYTPEGTPDRDISTRDRKPAEFDLNFKQWDHPDWEVSATSESHYQNGPDTYLLQLRDTQFPVRLREYMKVACHRSPAYSINAFDNYDPRTPIIRERRRFTDIMDEEIDDERRDRINGYGSESGTVRRLRHELGTRLDSYAEAQAFMEAKKDGCLPFFREKPQLLPVREGEPAKLSCFAVGDPKPVIQWFKNDMVIAEGQRIKIVEDEEGRSTLEFNPSMHHDIGFYKVVARNKVGQTVARTRVVEATTPDAPDVPTAAEVSDTEVLLRWKQPKYDGNSPVLCYSLQYKAGDSVEWKEVANNIDHEFFVVRDLNPDTSYQFRLSSRNRIGWSEKGAPTNLVKTREAGASKIEVTKAMRHLQQLTESGQEIVLDEEKPQLDYSTEKQPVEWYSANTFTERYSFISELWRGKFSIVVKGVDKTNDTVVVAKILENRPETEVLVQREYECLRRLRHERIANLLSAYRAPGSPVSVLILERLQGADVLTFLASRHQYSEQLVATVITQALDGLQYLHWRGYCHLDLQPDNFVMASVRSVQVKLVDFGSAHKVTKLGTSVPQVGHLEYKAPEIINDEPAYPQTDIWSIGVLAYILLSGVSPFRGNDDNETKQNISFVRYRFEHLYSEITQEATRFLMFVFKKVPLKRPTAEECHEHRWLAQSDFISKKRERAIFSSSKLKEFSDEYHERKAHEASQADTLTEAFGQFAPRLLTRSNSIQEELLTNLSSQ

Description

Structural component of the muscle M line which is involved in assembly and organization of sarcomere (PubMed:22467859, PubMed:26251439). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:22467859, PubMed:26251439). Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable).
Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments (PubMed:15313609, PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:23283987, PubMed:27009202). The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340). Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202). By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901). Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371). The large isoforms regulate Ca(2+) signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca(2+) ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340). By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609). In contrast to obscurins in other species, unlikely to have serine/threonine kinase activity as both protein kinase domains are predicted to be catalytically inactive (Probable).
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (PubMed:23392350). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (By similarity).
Isoform 2 and isoform 3: bind phosphatidylinositol bisphosphates (PIP2s) via their PH domains and negatively regulate the PI3K/AKT/mTOR signaling pathway, thus contributing to the regulation of cardiomyocyte size and adhesion.
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662).
Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Subunit

Interacts with myosin (PubMed:22467859). May interact (via protein kinase domain 1) with ball (PubMed:26251439). May interact (via protein kinase domain 1 or 2) with mask (PubMed:26251439). May interact (via protein kinase domain 2) with Tm1/tropomyosin-1 (PubMed:26251439).
May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or C-terminus of the interkinase region) with lim-9 (via LIM zinc-binding domain) (PubMed:19244614). May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614). May interact (via SH3 domain) with unc-15 (PubMed:27009202). May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987). May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901). May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG (By similarity).
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.
Interacts (via protein kinase domain 1) with CDH2 and (via protein kinase domain 1) with ATP1B1 (PubMed:23392350). Isoform 2 is found in a complex with DSG2, DESM, GJA1, CDH2 and VCL (PubMed:28826662). Isoform 3 is found in a complex with DSG2, DESM, GJA1, CDH2, ANK3 and VCL (PubMed:28826662).
Interacts (via protein kinase domain 2) with CDH2 and (via protein kinase domain 1) with ATP1B1 (By similarity). Isoform 3 interacts with TTN/titin and calmodulin (PubMed:11448995, PubMed:11717165). Isoform 3 interacts with ANK1 isoform Mu17/ank1.5 (PubMed:12527750).

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

Similarity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Developmental protein   Disulfide bond   Immunoglobulin domain   Kinase   Magnesium   Metal-binding   Muscle protein   Nucleotide-binding   Reference proteome   Repeat   SH3 domain   Transferase   3D-structure   Alternative initiation   Cytoskeleton   Guanine-nucleotide releasing factor   Phosphoprotein   Direct protein sequencing   Polymorphism   Calmodulin-binding   Cell membrane   Differentiation   Glycoprotein   Lipid-binding   Membrane   Nucleus   Secreted   Chromosomal rearrangement  

Feature

chain  Obscurin
splice variant  In isoform H.
sequence variant  In a colorectal cancer sample; somatic mutation.

Uniprot

A8DYP0.1   O01761.3   P97924.3   A2CG49.1   O60229.2   A2AAJ9.3   + More
Q5VST9.3   Q1LUA6.1  

EC Number

2.7.11.1

Pubmed

10731132    12537572    15185077    18515368    22467859    26251439    + More
8603916    9851916    15313609    16453163    17326220    18801371    18337465    19244614    21868609    22621901    22768340    23283987    27009202    11080629    8910496    9139723    10692441    10777487    15950621    9285789    11606631    22673903    16644733    16141072    19468303    15489334    17242355    21183079    10023074    14702039    16641997    17974005    17357071    18088087    18669648    19807924    22738176    16959974    17344846    15289607    23392350    28826662    11448995    16710414    16625316    10997877    11717165    11814696    12527750    12618763    16205939    23186163    25173926    23594743   

EMBL

AE013599    DQ431841    ABD83643.1    U33058    FO080458    AY724774    + More
AY714779    U88156    U88157    AF230644    AF229255    AF232668    AF232669    AY621095    U94189    AK008844    AK081504    AK088732    AK139581    AK158544    AK159031    CT010573    AC154524    AC155257    AC165079    AC154588    BC157950    BC172101    BAB25925.1    BAC38239.1    BAC40535.1    BAE24075.1    BAE34552.1    CAM18305.1    U94190    AB011422    AK125979    AK131379    AC022336    AC069233    AC080008    AC112129    AC117401    CH471052    BC026865    BC058015    AL137629    GL456158    BC044882    BC060226    AY603754    AAT80900.1    AJ002535    AJ314896    AJ314898    AJ314900    AJ314901    AJ314903    AJ314904    AJ314905    AJ314906    AJ314907    AJ314908    AL353593    AL359510    AL670729    AM231061    AB046776    AB046859    BX957244    BX950864   

Proteomes

UP000000803    UP000001940    UP000002494    UP000000589    UP000005640    UP000000437    + More

PRIDE

A8DYP0    O01761    P97924    A2CG49    O60229    A2AAJ9    + More
Q5VST9    Q1LUA6   

Pfam

PF00621   RhoGEF        + More
PF00041   fn3
PF07679   I-set
PF00069   Pkinase
PF05177   RCSD
PF00169   PH
PF00435   Spectrin
PF00650   CRAL_TRIO
PF00018   SH3_1
PF00612   IQ

Interpro

IPR013783   Ig-like_fold        + More
IPR003599   Ig_sub       
IPR013098   Ig_I-set       
IPR036028   SH3-like_dom_sf       
IPR000219   DH-domain       
IPR011009   Kinase-like_dom_sf       
IPR001452   SH3_domain       
IPR000719   Prot_kinase_dom       
IPR035899   DBL_dom_sf       
IPR011993   PH-like_dom_sf       
IPR003961   FN3_dom       
IPR007110   Ig-like_dom       
IPR036116   FN3_sf       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       
IPR001849   PH_domain       
IPR035526   Obscurin_SH3       
IPR013106   Ig_V-set       
IPR007850   RCSD       
IPR001251   CRAL-TRIO_dom       
IPR028569   Kalirin       
IPR002017   Spectrin_repeat       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR036865   CRAL-TRIO_dom_sf       
IPR018159   Spectrin/alpha-actinin       
IPR000048   IQ_motif_EF-hand-BS       
IPR008266   Tyr_kinase_AS       
IPR028570   TRIO       

SUPFAM

SSF50044   SSF50044        + More
SSF48726   SSF48726       
SSF56112   SSF56112       
SSF49265   SSF49265       
SSF48065   SSF48065       
SSF52087   SSF52087       

Gene 3D

1.20.900.10     2.30.29.30     2.60.40.10     3.40.525.10    

CDD

cd00063  FN3
cd00160  RhoGEF
cd12025  SH3_Obscurin_like
cd00170  SEC14

ProteinModelPortal

A8DYP0.1   O01761.3   P97924.3   A2CG49.1   O60229.2   A2AAJ9.3   + More
Q5VST9.3   Q1LUA6.1  

KEGG

101746244    no KO assigned | (RefSeq) muscle M-line assembly protein unc-89-like

GO

GO:0031430   GO:0035023   GO:0036309   GO:0005524   GO:0007527   GO:0016301   GO:0006468   GO:0019901   GO:0007275   GO:0046872   GO:0005089   GO:0005523   GO:0045214   GO:0045989   GO:0004672   GO:1905905   GO:0040017   GO:0019902   GO:0017048   GO:0014722   GO:1905552   GO:0031672   GO:0030241   GO:0034613   GO:0031034   GO:0010628   GO:0090736   GO:0060298   GO:0071688   GO:0050773   GO:0098696   GO:0005856   GO:1905274   GO:0098885   GO:0019899   GO:0004674   GO:0098978   GO:0016020   GO:0048471   GO:0098793   GO:0043025   GO:0035556   GO:0099645   GO:0014069   GO:0007409   GO:0005085   GO:0043005   GO:0098989   GO:0007399   GO:0043547   GO:0035176   GO:0061003   GO:0060125   GO:0007595   GO:0042711   GO:0005829   GO:0046959   GO:0007528   GO:0007613   GO:0008344   GO:0060137   GO:0005654   GO:0007186   GO:0070062   GO:0043065   GO:0015629   GO:0051056   GO:0007165   GO:0048013   GO:0016192   GO:1902936   GO:0005615   GO:0030154   GO:0010314   GO:0042383   GO:0031432   GO:0005886   GO:0014067   GO:0005516   GO:0046777   GO:0030018   GO:0032266   GO:0005863   GO:0030017   GO:0070273   GO:0016604   GO:0043325   GO:0014704   GO:0005546   GO:0045296   GO:0030506   GO:0005547   GO:0030016   GO:0008307   GO:0005737   GO:0005515   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR22826:SF49   PTHR22826:SF104  

Subcellular location

   In the embryo, localizes across the muscles in a striped pattern and is positioned laterally to the sites at which muscles are attached to the epidermis. In the larval body wall muscles, localizes to the M line and moves away from the attachment sites. During pupal development, progressively forms broad striations at the M line which become more defined after pupal eclosion. Colocalizes with myosin thick filaments at the M line.   With evidence from 10 publications.
Cytoplasm  
Cytoskeleton  
Myofibril   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Sarcomere   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
M line   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Z line   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Cell membrane   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Sarcolemma   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Nucleus   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.
Secreted   Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma.   With evidence from 14 publications.

Length:

4810

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16118

Exp number, first 60 AAs:

0.0034

Total prob of N-in:

0.00019

outside

1  -  4810

 

 

Pi

217.418998

Theta

164.045591

Tajima's D

0.995437

CLR

0.478149

CSRT

0.658317084145793

Interpretation

Uncertain