Silkworm Genome Informatics Database

Gene

KWMTBOMO02401 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013532

Annotation

Vacuolar_protein-sorting-associated_protein_25_[Operophtera_brumata]

Location

Bomo_Chr5(-):1194780-1197397 View in EpiBrowser

Full name

Inositol-pentakisphosphate 2-kinase

Location in the cell

Cytoplasmic Reliability : 2.04 Nuclear Reliability : 1.923

CDS

ATGGAGGTGTTCGGGAAACAATGCAAATACATCAACGAAGGGAACGTCCATATCGTTCTAGAAGTTGTCGGAACTGATTATGTTCTGCGGCTCATCAAACAGGACGGGCAGCAGATAAACGTGAATGACGTCCGAGATTCAGTGAATTTCGTAAATTTAGTCATGATACCGCTGTTAAATAACAATTTTCAATGCAAAGAGGTCATTGTGACTATGGCAGAAGAGGAAGCGAGCAGATTGAGCCACGCCCTTTATCACATTCGACCCACTCACAGACACTTCAAGTCCATTCTTAGTCAGTATGCAATTAGAGCACCGAATCTTGCCCTGGTCAGTCCGCTGTGCGAGACCAACTACTGCGTCGAAATCAAACCGAAGGAAGGTTTCATATCCAAATCGCTCTGTGCTCATTCTAAATGCTACTTTTGTCTAAAACAATACTTGAAAGTAGAGACAAATAAAGTTGAGAAACACAGTTCATATTGTCCATTAGATCTGTTCTCCGGAGATAAATACAGAATGCGCGATGCTCTACTCCATCTCATAGAAAACCCTCAGAACAATTTCAAACTTTTTAAGAATGGTGTGGTCATTTATGATGATAAATCAGATTTGAAGACTTTTCATAATATAATTGAAAGAATAAATATCTTTGGCACGACTGATGGATTTTTAAATTTCATCATACAATTGTTACTGGCTGATGATTTTAGTTCAGATTTAGACCTCAAAGAAACTAAAGCTAGTGTTAAATATTTCAAAATACAAAAAAGGAATGAATGTGTCGATGATTCCATTTTGACTTCCAACACATTCCTGTACAAACTGCTAGAGCTTCAGAAGCTTGGGGACAGTGTTAATTTTGACGTAACAAATTATTTGAAACATGAAGATGGAGGATATGTCTCGATGATAATAGAAAATGCTGCTAATCTGAATCTCGGTGAAGCCAAAGACAAAGAGCACTTCTTTAAAAATTTGGAGCCTGTACATAGGGCATTGATAGCTGCCGTGGCAAGAGACTGCTCTATAATGATCAGCTTTTCTCCAAACTATGTGGAGAACATTCCGTGTGTCCAAAAGAAGGAACACAAGATAATGTACAGAGTTTCTGTGACAGATCTGGAACCAAAATCTATTAAAAACTTAGTTAAACGAAAAGAGACTGAAAGTGAAATGATTGAGATATACCAGAGAATCCAACCGCACACTGAGACAAGATCTAAACAACTAGAAGCATGGGAACAATTAATAACAGATTATTTGAAGGCAACAAAACAATCTACAATAGATATCAGGGAGGCATCAAACACACCGCTTTTCAATAACATAGAAATTAATAGAAAATTGTCTCAGGAAGCTATTTTAACAATATTGGAGGACATGGCTAAGGCTGGCAAGGCCGCTCCCATTGACAAGAGCAAAAACGTGTGGGAGGTATATTGGCACTCGCTGGATGAGTGGGGAAATATGATTTACAACTGGGCATGTAATAATGGGTTTAATAATTCAGTTTGTACACTGTTTGAGCTGAGAGAAGGAGATAATACCGCTGACCAAGAATTTCATAACCTTGATATGAATGTCCTGGTCAAAGCATTAAAGTCACTGGAAGCCAAAGGTCGATGCGAACTCATGGAATTTGATGACAACCAGGGTGTAAAGTTCTTTTAA

Protein

MEVFGKQCKYINEGNVHIVLEVVGTDYVLRLIKQDGQQINVNDVRDSVNFVNLVMIPLLNNNFQCKEVIVTMAEEEASRLSHALYHIRPTHRHFKSILSQYAIRAPNLALVSPLCETNYCVEIKPKEGFISKSLCAHSKCYFCLKQYLKVETNKVEKHSSYCPLDLFSGDKYRMRDALLHLIENPQNNFKLFKNGVVIYDDKSDLKTFHNIIERINIFGTTDGFLNFIIQLLLADDFSSDLDLKETKASVKYFKIQKRNECVDDSILTSNTFLYKLLELQKLGDSVNFDVTNYLKHEDGGYVSMIIENAANLNLGEAKDKEHFFKNLEPVHRALIAAVARDCSIMISFSPNYVENIPCVQKKEHKIMYRVSVTDLEPKSIKNLVKRKETESEMIEIYQRIQPHTETRSKQLEAWEQLITDYLKATKQSTIDIREASNTPLFNNIEINRKLSQEAILTILEDMAKAGKAAPIDKSKNVWEVYWHSLDEWGNMIYNWACNNGFNNSVCTLFELREGDNTADQEFHNLDMNVLVKALKSLEAKGRCELMEFDDNQGVKFF

Description

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).

Catalytic Activity

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)

Uniprot

H9JVG9 A0A0L7L8D5 A0A2H1VI58 A0A2W1BG79 A0A1E1W9X0

EC Number

2.7.1.158

Pubmed

19121390 26227816 28756777

EMBL

BABH01036148 JTDY01002376 KOB71546.1 ODYU01002690 SOQ40520.1 KZ150114 + More
PZC73291.1 GDQN01007315 JAT83739.1

Proteomes

UP000005204 UP000037510

PRIDE

H9JVG9

Pfam

PF05871 ESCRT-II + More
PF06090 Ins_P5_2-kin

Interpro

IPR008570   ESCRT-II_cplx_Vps25-sub        + More
IPR036390   WH_DNA-bd_sf
IPR036388   WH-like_DNA-bd_sf
IPR014041   ESCRT-II_cplx_Vps25-sub_N
IPR009286   Ins_P5_2-kin

SUPFAM

SSF46785 SSF46785

Gene 3D

1.10.10.10 1.10.10.570

ProteinModelPortal

H9JVG9 A0A0L7L8D5 A0A2H1VI58 A0A2W1BG79 A0A1E1W9X0

PDB

3CUQ E-value=2.62189e-36, Score=383

KEGG

101743173 K12189 ESCRT-II complex subunit VPS25 | (RefSeq) vacuolar protein-sorting-associated protein 25

PATHWAY

04144 Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0005524 GO:0071985 GO:0035299 GO:0000814 GO:0006810 GO:0016020 GO:0007165 GO:0005488 GO:0006289 GO:0004518 GO:0006281 GO:0048384

PANTHER

PTHR14456 PTHR13149

Length:

557

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.22435

Exp number, first 60 AAs:

0.00809

Total prob of N-in:

0.01308

outside

1 - 557

Pi

206.257738

Theta

199.925797

Tajima's D

0.221811

CLR

0.229309

CSRT

0.435478226088696

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics