Gene

KWMTBOMO02392  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013537

Annotation

PREDICTED:_ubiquitin-like_modifier-activating_enzyme_5_[Bombyx_mori]

Location

Bomo_Chr5(-):1008265-1014513      View in EpiBrowser

Full name

Ubiquitin-like modifier-activating enzyme 5      

Alternative Name

UFM1-activating enzyme
Ubiquitin-activating enzyme E1 domain-containing protein 1
Ubiquitin activating enzyme-like protein

Location in the cell

Cytoplasmic   Reliability : 2.232

CDS

ATGGCTTCAGTGGATGAATTGCAGAAGAAAATAAAAGAGCTTGAGGCTAAATTAGCCGCAGTTGAAGCAAAAGGAGGTCCAATGCGGCAGAAAATTGAAGTTATGTCGTCCGAAGTAGTGGATTCTAATCCCTACAGTCGTTTAATGGCTCTCAAAAGGATGGGCATTGTAAACAACTATGAACAGATCCGTGAGAAGACTGTAGCTGTAGTTGGTGTGGGAGGTGTCGGTAGTGTGACTGCTGAAATGCTGACTAGATGTGGAATTGGGAAGCTTATCCTCTTTGACTACGACAAAGTAGAACTTGCCAACATGAACCGGCTGTTCTTCCAGCCTCACCAAGCAGGGCTCAGCAAGGTGGATGCAGCTGCTGCCACATTACAGAACATTAACCCTGATGTCACCATTGATGCTTACAACTATAATATCACAACTGTTGATAACTTTCAAAAGTTCTGCGATACAATTAGTAAGGGTAGTTTAACCGGTGGCACCGTTGACCTAGTCCTTAGCTGCGTGGACAACTTCGAAGCTCGCATGGCCATCAATACAGCTTGCAATGAACTCGATCAGAAGTGGTTTGAGTCTGGTGTTAGTGAGAATGCTGTCTCTGGACACATACAATTCATTTCACCTGGGGAGTCGGCTTGTTTCGCCTGCGCTCCTCCGCTGGTGGTGGCCACTAAAGTAGACGAACGCACGCTGAAGCGGGAGGGAGTGTGTGCGGCCAGTCTACCGACCACCATGGGGATCGTCGCGGGATTCCTTGTACAAAACACTCTGAAGTATCTATTGGAGTTCGGTAATGTCACCCACTACCTGGGATACAGCGCGCTCACCGATTTCTTCCCCACGATGAGTTTGAAGCCCAACCCCACGTGCGACGACGCGTCGTGCCGCGCGCGCCAGGAGCAGCGCCGCCTGCAGCCGCGTGTGGAGCTCGCCGCCGAGGTCACCGAGGACTGCGGACCAGTGCACCAGGACAACGACTGGGGGATAAGCGTACTCGAGGAGAACAGTCCCGCGGACGAGGACTGCCCGGGGCTGAAGCTTGTGGACGGAGTCCAGGTGGCGTACAGTATCCCGGTGGATAGCAGCACCCCGGAGTCCAGCACGGGCGGCGCCGTGGCCGCCTCGGAGCTGTCGCTGGAGGACCTCATGCAGCAGATGAAGACGATGTAG

Protein

MASVDELQKKIKELEAKLAAVEAKGGPMRQKIEVMSSEVVDSNPYSRLMALKRMGIVNNYEQIREKTVAVVGVGGVGSVTAEMLTRCGIGKLILFDYDKVELANMNRLFFQPHQAGLSKVDAAAATLQNINPDVTIDAYNYNITTVDNFQKFCDTISKGSLTGGTVDLVLSCVDNFEARMAINTACNELDQKWFESGVSENAVSGHIQFISPGESACFACAPPLVVATKVDERTLKREGVCAASLPTTMGIVAGFLVQNTLKYLLEFGNVTHYLGYSALTDFFPTMSLKPNPTCDDASCRARQEQRRLQPRVELAAEVTEDCGPVHQDNDWGISVLEENSPADEDCPGLKLVDGVQVAYSIPVDSSTPESSTGGAVAASELSLEDLMQQMKTM

Description

E1-like enzyme which activates UFM1.
E1-like enzyme which activates ufm1 and sumo2.
E1-like enzyme which activates UFM1 and SUMO2.

Subunit

Interacts (via C-terminus) with Ufc1. Interacts with Ufm1.
Interacts (via C-terminus) with UFC1. Interacts with UFM1.

Similarity

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

Keywords

ATP-binding   Complete proteome   Metal-binding   Nucleotide-binding   Reference proteome   Ubl conjugation pathway   Zinc   Cytoplasm   Golgi apparatus   Nucleus   Phosphoprotein  

Feature

chain  Ubiquitin-like modifier-activating enzyme 5

Uniprot

B9VJ80   A0A2A4JGG2   A0A2W1BDJ8   A0A2H1WFS0   A0A212FI82   A0A2R5L8U2   + More
A0A1Z5LFL6   A0A1Y1NG58   A0A131YTP3   A0A2J7QRN6   A0A293MZ07   A0A1W4WR94   A0A131XCQ9   A0A1B6BXP6   A0A2J7QRN8   A0A195C3A7   A0A067QI20   A0A1E1XL24   E9J5G4   A0A1V9Y2U1   A0A026VYA9   K7IV77   D6WKS6   A0A1S3INX2   A0A195FKV5   A0A1B6I7H0   F4WR27   A0A154PT40   A0A0P5SK26   A0A0P5ZB52   L7MMT7   A0A0L7QV80   E2AW18   A0A151X0M9   A0A0J7KZM2   A0A0L0CKB9   A0A151J306   A0A158NVG3   A0A0K2U0U6   A0A151I5T7   A0A2P6KIU6   D3PG49   A0A0N0BJK9   A0A0P5U0H8   T1GUJ0   A0A0T6AYR9   B7Q170   J3JUA5   A0A0K8R4T7   T1W131   Q9VYY3   B4IK21   A0A1I8N788   A0A0P4XI14   A0A0P6IBH0   T1P928   U5EN16   N6U5D2   A0A1W4V0P3   A0A1L8FRL4   Q3KQ23   Q6GLG7   A0A0P4ZCR0   A0A0N8DI43   B4PYA4   B4R345   A0A1Q3F6C7   H0VFQ1   A0A182W5Z9   A0A0L8HX07   A0A2K5JRH3   C3YZ51   K1PEM0   A0A2L2YD03   A0A1I8PMA3   G3MIC6   K7E652   A0A034WHQ9   A0A0C9RAW1   A0A2J7QRM0   H3AKD1   A0A3B3YNE5   A0A2K6SHS0   A0A3P9NVI9   F6YEN3   A0A2J8U3K2   Q5R8X4   L8HXD8   A7MAZ3   A0A091QZG3   A0A0R3NZL0   Q29HT0   A0A0A1WHZ7   Q6IVA4   A0A1B6KIH1   A0A2K6JXW3   A0A2K6NFR6   A0A2I4BM92   A0A194Q470   A0A3B3V8X4  

Pubmed

28756777    22118469    28528879    28004739    26830274    28049606    + More
24845553    29209593    21282665    28327890    24508170    20075255    18362917    19820115    21719571    25576852    20798317    26108605    21347285    22516182    23537049    18477586    19126864    10731132    12537572    12537569    26872069    17994087    25315136    27762356    21993624    18563158    22992520    26561354    22216098    17495919    25348373    9215903    22751099    15632085    25830018    25362486    26354079   

EMBL

FJ556993    NWSH01001581    PCG70798.1    KZ150114    PZC73282.1    ODYU01008277    + More
SOQ51722.1    AGBW02008417    OWR53445.1    GGLE01001795    MBY05921.1    GFJQ02001166    JAW05804.1    GEZM01003863    JAV96518.1    GEDV01006635    JAP81922.1    NEVH01011890    PNF31235.1    GFWV01020440    MAA45168.1    GEFH01003628    JAP64953.1    GEDC01031231    GEDC01020473    GEDC01008905    GEDC01000591    JAS06067.1    JAS16825.1    JAS28393.1    JAS36707.1    PNF31236.1    KQ978350    KYM94676.1    KK853332    KDR08388.1    GFAA01003387    JAU00048.1    GL768155    EFZ11940.1    MNPL01000409    OQR80049.1    KK107591    EZA48625.1    AAZX01005089    KQ971342    EFA02985.1    KQ981512    KYN40892.1    GECU01024847    GECU01006392    JAS82859.1    JAT01315.1    GL888284    EGI63254.1    KQ435078    KZC14428.1    GDIQ01103303    JAL48423.1    GDIP01047174    LRGB01002384    JAM56541.1    KZS07933.1    GACK01000190    JAA64844.1    KQ414727    KOC62557.1    GL443213    EFN62440.1    KQ982617    KYQ53780.1    LBMM01001750    KMQ95816.1    JRES01000290    KNC32705.1    KQ980313    KYN16711.1    ADTU01027146    ADTU01027147    HACA01013920    CDW31281.1    KQ976415    KYM90153.1    MWRG01010909    PRD26248.1    BT120605    ADD24245.1    KQ435713    KOX79292.1    GDIP01119502    JAL84212.1    CAQQ02161154    LJIG01022509    KRT80202.1    ABJB010293854    ABJB010502834    ABJB010613006    DS835908    EEC12592.1    BT126818    KB632399    AEE61780.1    ERL94703.1    GADI01007646    JAA66162.1    BT150207    AGT97039.1    AM999161    AM999162    AM999163    AM999164    AM999165    AM999166    AM999167    AM999168    AM999169    AM999170    FM246273    FM246274    FM246275    FM246276    FM246277    FM246278    FM246279    FM246280    FM246281    FM246282    FM246283    FM246284    AE014298    AY071429    CH480851    GDIP01240894    JAI82507.1    GDIQ01006937    JAN87800.1    KA645207    AFP59836.1    GANO01000773    JAB59098.1    APGK01039098    KB740967    ENN76810.1    CM004477    OCT74237.1    BC106418    CR760171    BC074525    GDIP01214996    JAJ08406.1    GDIP01031503    JAM72212.1    CM000162    AM999171    CM000366    GFDL01011925    JAV23120.1    AAKN02013012    KQ417100    KOF93721.1    GG666565    JH816106    EKC20013.1    IAAA01012791    IAAA01012792    LAA05240.1    JO841627    AEO33244.1    GAKP01004763    JAC54189.1    GBYB01003991    JAG73758.1    PNF31234.1    AFYH01119763    AFYH01119764    AFYH01119765    AFYH01119766    ABGA01305521    ABGA01305522    NDHI03003471    PNJ39840.1    PNJ39843.1    CR859624    CAH91786.1    JH882702    ELR48506.1    BC151254    KK806704    KFQ32618.1    CH379064    KRT06456.1    GBXI01015628    JAC98663.1    AY620963    GEBQ01032089    GEBQ01028726    JAT07888.1    JAT11251.1    KQ459465    KPJ00338.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000235965    UP000192223    UP000078542    + More
UP000027135    UP000192247    UP000053097    UP000002358    UP000007266    UP000085678    UP000078541    UP000007755    UP000076502    UP000076858    UP000053825    UP000000311    UP000075809    UP000036403    UP000037069    UP000078492    UP000005205    UP000078540    UP000053105    UP000015102    UP000001555    UP000030742    UP000000803    UP000001292    UP000095301    UP000019118    UP000192221    UP000186698    UP000008143    UP000002282    UP000000304    UP000005447    UP000075920    UP000053454    UP000233080    UP000001554    UP000005408    UP000095300    UP000002280    UP000008672    UP000261480    UP000233220    UP000242638    UP000001595    UP000009136    UP000001819    UP000000539    UP000233180    UP000233200    UP000192220    UP000053268    UP000261500   

PRIDE

B9VJ80    T1W131    Q9VYY3    B4IK21    B4PYA4    B4R345    + More
C3YZ51    A7MAZ3    Q29HT0    Q6IVA4   

Pfam

PF00899   ThiF

Interpro

IPR029752   D-isomer_DH_CS1        + More
IPR000594   ThiF_NAD_FAD-bd       
IPR035985   Ubiquitin-activating_enz       

SUPFAM

SSF69572   SSF69572       

ProteinModelPortal

B9VJ80   A0A2A4JGG2   A0A2W1BDJ8   A0A2H1WFS0   A0A212FI82   A0A2R5L8U2   + More
A0A1Z5LFL6   A0A1Y1NG58   A0A131YTP3   A0A2J7QRN6   A0A293MZ07   A0A1W4WR94   A0A131XCQ9   A0A1B6BXP6   A0A2J7QRN8   A0A195C3A7   A0A067QI20   A0A1E1XL24   E9J5G4   A0A1V9Y2U1   A0A026VYA9   K7IV77   D6WKS6   A0A1S3INX2   A0A195FKV5   A0A1B6I7H0   F4WR27   A0A154PT40   A0A0P5SK26   A0A0P5ZB52   L7MMT7   A0A0L7QV80   E2AW18   A0A151X0M9   A0A0J7KZM2   A0A0L0CKB9   A0A151J306   A0A158NVG3   A0A0K2U0U6   A0A151I5T7   A0A2P6KIU6   D3PG49   A0A0N0BJK9   A0A0P5U0H8   T1GUJ0   A0A0T6AYR9   B7Q170   J3JUA5   A0A0K8R4T7   T1W131   Q9VYY3   B4IK21   A0A1I8N788   A0A0P4XI14   A0A0P6IBH0   T1P928   U5EN16   N6U5D2   A0A1W4V0P3   A0A1L8FRL4   Q3KQ23   Q6GLG7   A0A0P4ZCR0   A0A0N8DI43   B4PYA4   B4R345   A0A1Q3F6C7   H0VFQ1   A0A182W5Z9   A0A0L8HX07   A0A2K5JRH3   C3YZ51   K1PEM0   A0A2L2YD03   A0A1I8PMA3   G3MIC6   K7E652   A0A034WHQ9   A0A0C9RAW1   A0A2J7QRM0   H3AKD1   A0A3B3YNE5   A0A2K6SHS0   A0A3P9NVI9   F6YEN3   A0A2J8U3K2   Q5R8X4   L8HXD8   A7MAZ3   A0A091QZG3   A0A0R3NZL0   Q29HT0   A0A0A1WHZ7   Q6IVA4   A0A1B6KIH1   A0A2K6JXW3   A0A2K6NFR6   A0A2I4BM92   A0A194Q470   A0A3B3V8X4  

PDB

6H77     E-value=1.37498e-121,     Score=1116

KEGG

101746661    K12164 ubiquitin-like modifier-activating enzyme 5 | (RefSeq) ubiquitin-like modifier-activating enz

GO

GO:0005524   GO:0008641   GO:0046872   GO:0032446   GO:0071569   GO:0005737   GO:0005829   GO:0071566   GO:0005794   GO:0005634   GO:0019008   GO:0050905   GO:1990592   GO:0043231   GO:0034976   GO:0033146   GO:0006298   GO:0030983   GO:0004674   GO:0007165   GO:0005488   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm  
Nucleus  
Golgi apparatus  

Length:

393

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.81763

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.15802

outside

1  -  393

 

 

Pi

155.592491

Theta

157.14132

Tajima's D

-1.320345

CLR

102.59541

CSRT

0.087695615219239

Interpretation

Uncertain