Gene

KWMTBOMO02386

Pre Gene Modal

BGIBMGA013538

Annotation

PREDICTED:_bromodomain-containing_protein_7_[Bombyx_mori]

Location

Bomo_Chr5(-):820225-829333      View in EpiBrowser

Full name

Serine hydroxymethyltransferase      

Location in the cell

Nuclear   Reliability : 4.288

CDS

ATGGATGACATAGAAAAGCTGAGTTGCAGAGAAGAGATTTTAGAAATGAGTGATCTGGAGCACTCTGCAACCGACGATTTTAGAGAAACGGAAGGAAAATCAAAAAAGAAGAAAAGAAGACGCCGCGAAATAGATATGAACTCAGGGAAGCATATTTTTAAAAAGATAAAGCTGTCAGATGACGATGAGACAGATGATGAGATTATGATGAAAAAAATGATGCGGAACTTCAGCCCCGGACCTAACTCACCAGCTTCTCACAGAGAACCACGGACTTGTGTCCTGAAGGCTAGTCAAAAACGTCGTCCACTCTCCCGTTTGCTTGAACAGCTACTACGGAACTTAGAGAAAAGAGACCCACACCAGTTCTTTGCTTGGCCCGTCAATGATAACTTTGCTCCAGGCTACTCTACCATCATCAAGAAACCCATGGATTTCTCTACTATGAAGCAGAAGATTGATGATAATGAATACAAATCCCTTAATTGTTTTATTAGCGACTTCAAACTGATGTGCAACAATGCCATGAAGTACAACAAACCAGGCACCGTGTACCACAAGGCAGCCCGGAGACTCTTGCACGCCGGTCTCAAGCAGCTCACTCCGCAGAAACTGAGGCCGCTGGGAGACATCCTCACCTATATGTACGAGATACCCATTAGAGAGCTAGGATTCGACATGGGGAAAATGGATGTGCAGAGGGTGCTCAAACGGAACAGCCCCGTGAAGAGCGGGGGCTCCGAGCCCGAGGGCCCCGGGGACCCGGACTCCGTCAAGATACACATGGAAGCCGCGCGCGAGCAGCACCGCCGGAGACTCGCCAAGAAAGCCTTTCCGAGAATGGACGCGGAAGGGAAGACAACATTGTGCCTGGTCACCAACACGGTTGAGGGGAACGGTGAAGACAAACCCATGACCCTCGGAAAACTCATCGGGAAACTGAATCAGGGGACAGGAACTTTACACACTCCACGCGAAGACCGTCGCAACGTGGCGAAGGGTGTGAAGCCCTTGAACTACGGCCCCTTCAGCTCGTACGCGCCCTCCTACGACGGGACCTTCGCCACCCTCACCAAGGAGGAGTCGCACCTCATCTATCACACGCTACCATCAGAAACGGGACTAGGAAACGAGGAGATGCTGCGGTTCGCGCCGGACTCGCCCTGGGCCCTGCTCTACGACATGGAGGCGCTGTTCCCGGACAAGAAGCACGCGGCTGAGACCGCCCCCCCGCCTCACGACAACGAGCTGTCTAAAGTGAAGATAGACCTGGAGGAGTTGCGCTCGCTGTCGGCGCTGGGCGTGGACGTGGAGTTCGTGGCGGAGGCGGAGCGGGCCGCGCGCGACCTGGGGCTCGGGCCCGCGCTCGCGCACACCGCGCAGCTCTTGCAGCGGTTGCAGCACGAGCAGCACCAGCGGTAA

Protein

MDDIEKLSCREEILEMSDLEHSATDDFRETEGKSKKKKRRRREIDMNSGKHIFKKIKLSDDDETDDEIMMKKMMRNFSPGPNSPASHREPRTCVLKASQKRRPLSRLLEQLLRNLEKRDPHQFFAWPVNDNFAPGYSTIIKKPMDFSTMKQKIDDNEYKSLNCFISDFKLMCNNAMKYNKPGTVYHKAARRLLHAGLKQLTPQKLRPLGDILTYMYEIPIRELGFDMGKMDVQRVLKRNSPVKSGGSEPEGPGDPDSVKIHMEAAREQHRRRLAKKAFPRMDAEGKTTLCLVTNTVEGNGEDKPMTLGKLIGKLNQGTGTLHTPREDRRNVAKGVKPLNYGPFSSYAPSYDGTFATLTKEESHLIYHTLPSETGLGNEEMLRFAPDSPWALLYDMEALFPDKKHAAETAPPPHDNELSKVKIDLEELRSLSALGVDVEFVAEAERAARDLGLGPALAHTAQLLQRLQHEQHQR

Description

Interconversion of serine and glycine.

Catalytic Activity

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the SHMT family.

Uniprot

H9JVH5   A0A2H1VPZ8   A0A2W1BF18   S4PDX7   A0A212FH88   A0A194Q5R4   + More
A0A0N1IPM5   A0A0L7L4J8   A0A0C9RUM2   A0A0C9RDX9   E2BEL8   A0A151WUU2   F4WAC0   A0A195CSG6   A0A158NKY0   A0A195FSA4   A0A195E454   E0VMG6   A0A154P2U9   A0A088A0B3   A0A2A3ES74   E9IZ18   A0A0J7L877   D2A3W1   A0A2J7RIK3   E2AL99   A0A067RX80   A0A026WME5   U5EPR5   A0A182HCX5   A0A1B0DRE2   A0A1B0DFM0   A0A0L7R1P3   A0A1Q3F2B7   A0A0A9Z2Y2   A0A0M9A3N5   A0A0K8SQJ5   A0A0A9Z6V7   A0A1B6DLS8   A0A182RAW2   A0A1Q3F3E8   A0A182Q0T5   A0A182P9G8   T1HMJ5   A0A182MZ24   A0A084W1X9   B0W8Y1   Q17J04   A0A1S4F196   A0A023EZU8   A0A0V0G908   W5J5K1   A0A069DXD8   A0A224XJV3   A0A182F637   A0A0T6B9V3   A0A1B6JIT1   A0A336KJ03   E9FUK4   A0A336MWP5   A0A1B0CUP8   A0A1L8DGC2   A0A1W4WME0   A0A1W4WCB4   A0A1B6GUL2   A0A182J920   A0A1L8DHG5   A0A2R7W5A6   A0A1I8NXM4   A0A1Y1NBJ8   A0A0A1XCZ8   A0A034VL94   W8BJF4   A0A0M4E8W2   A0A0K8U5N0   A0A1B6KX48   B4HYA3   A0A0J9QXY7   B4Q5T4   B4NZG9   B4KIM6   Q9VLX2   B3MV21   A0A1I8MSX1   B3N6N7   A0A2H8TDC1   A0A1W4W747   B4N0U7   B4JQD2   A0A0P5PWY6   A0A0P5K0M7  

EC Number

2.1.2.1

Pubmed

19121390    28756777    23622113    22118469    26354079    26227816    + More
20798317    21719571    21347285    20566863    21282665    18362917    19820115    24845553    24508170    30249741    26483478    25401762    26823975    24438588    17510324    25474469    20920257    23761445    26334808    21292972    28004739    25830018    25348373    24495485    17994087    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136   

EMBL

BABH01036188    ODYU01003736    SOQ42890.1    KZ150200    PZC72284.1    GAIX01003451    + More
JAA89109.1    AGBW02008531    OWR53073.1    KQ459465    KPJ00345.1    KQ460401    KPJ14947.1    JTDY01003078    KOB70189.1    GBYB01011301    JAG81068.1    GBYB01011302    JAG81069.1    GL447829    EFN85852.1    KQ982718    KYQ51690.1    GL888048    EGI68803.1    KQ977306    KYN03653.1    ADTU01019014    ADTU01019015    KQ981281    KYN43321.1    KQ979701    KYN19687.1    DS235307    EEB14572.1    KQ434809    KZC06269.1    KZ288194    PBC33979.1    GL767078    EFZ14212.1    LBMM01000273    KMR02200.1    KQ971348    EFA04877.1    NEVH01003500    PNF40662.1    GL440553    EFN65795.1    KK852408    KDR24499.1    KK107152    QOIP01000007    EZA57195.1    RLU20067.1    GANO01003610    JAB56261.1    JXUM01033714    KQ560999    KXJ80081.1    AJVK01019958    AJVK01058828    KQ414667    KOC64785.1    GFDL01013368    JAV21677.1    GBHO01004012    GDHC01003561    JAG39592.1    JAQ15068.1    KQ435767    KOX75303.1    GBRD01010724    JAG55100.1    GBHO01004013    GDHC01017149    JAG39591.1    JAQ01480.1    GEDC01010669    JAS26629.1    GFDL01012988    JAV22057.1    AXCN02000792    ACPB03020506    ACPB03020507    ATLV01019471    KE525272    KFB44223.1    DS231860    EDS39259.1    CH477236    EAT46588.1    GBBI01003939    JAC14773.1    GECL01001521    JAP04603.1    ADMH02002094    ETN59266.1    GBGD01000547    JAC88342.1    GFTR01008003    JAW08423.1    LJIG01009051    KRT83853.1    GECU01008500    JAS99206.1    UFQS01000502    UFQT01000502    SSX04459.1    SSX24823.1    GL732525    EFX88744.1    UFQS01003099    UFQT01003099    SSX15195.1    SSX34570.1    AJWK01029522    AJWK01029523    AJWK01029524    AJWK01029525    AJWK01029526    AJWK01029527    AJWK01029528    AJWK01029529    AJWK01029530    GFDF01008581    JAV05503.1    GECZ01003647    JAS66122.1    GFDF01008257    JAV05827.1    KK854228    PTY13395.1    GEZM01007551    JAV95099.1    GBXI01005467    JAD08825.1    GAKP01014866    JAC44086.1    GAMC01007678    JAB98877.1    CP012523    ALC39440.1    GDHF01030347    JAI21967.1    GEBQ01023987    JAT15990.1    CH480818    EDW52033.1    CM002910    KMY88851.1    CM000361    EDX04130.1    KMY88850.1    CM000157    EDW87718.1    CH933807    EDW11369.1    AE014134    AY069504    AAF52557.1    AAL39649.1    CH902624    EDV33086.1    CH954177    EDV59253.1    GFXV01000302    MBW12107.1    CH963920    EDW77710.1    CH916372    EDV99112.1    GDIQ01132580    JAL19146.1    GDIQ01190894    JAK60831.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000037510    UP000008237    + More
UP000075809    UP000007755    UP000078542    UP000005205    UP000078541    UP000078492    UP000009046    UP000076502    UP000005203    UP000242457    UP000036403    UP000007266    UP000235965    UP000000311    UP000027135    UP000053097    UP000279307    UP000069940    UP000249989    UP000092462    UP000053825    UP000053105    UP000075900    UP000075886    UP000075885    UP000015103    UP000075884    UP000030765    UP000002320    UP000008820    UP000000673    UP000069272    UP000000305    UP000092461    UP000192223    UP000075880    UP000095300    UP000092553    UP000001292    UP000000304    UP000002282    UP000009192    UP000000803    UP000007801    UP000095301    UP000008711    UP000192221    UP000007798    UP000001070   

PRIDE

H9JVH5    Q9VLX2   

Pfam

PF00439   Bromodomain        + More
PF12024   DUF3512
PF00089   Trypsin
PF00464   SHMT
PF00651   BTB

Interpro

IPR036427   Bromodomain-like_sf        + More
IPR021900   DUF3512       
IPR001487   Bromodomain       
IPR011990   TPR-like_helical_dom_sf       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       
IPR018114   TRYPSIN_HIS       
IPR000210   BTB/POZ_dom       
IPR001085   Ser_HO-MeTrfase       
IPR019798   Ser_HO-MeTrfase_PLP_BS       
IPR011333   SKP1/BTB/POZ_sf       
IPR036236   Znf_C2H2_sf       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR013087   Znf_C2H2_type       
IPR039429   SHMT-like_dom       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR015424   PyrdxlP-dep_Trfase       

SUPFAM

SSF47370   SSF47370        + More
SSF50494   SSF50494       
SSF54695   SSF54695       
SSF57667   SSF57667       
SSF53383   SSF53383       

Gene 3D

1.20.920.10     1.25.40.10     3.40.640.10     3.90.1150.10    

CDD

cd00190  Tryp_SPc
cd00378  SHMT

ProteinModelPortal

H9JVH5   A0A2H1VPZ8   A0A2W1BF18   S4PDX7   A0A212FH88   A0A194Q5R4   + More
A0A0N1IPM5   A0A0L7L4J8   A0A0C9RUM2   A0A0C9RDX9   E2BEL8   A0A151WUU2   F4WAC0   A0A195CSG6   A0A158NKY0   A0A195FSA4   A0A195E454   E0VMG6   A0A154P2U9   A0A088A0B3   A0A2A3ES74   E9IZ18   A0A0J7L877   D2A3W1   A0A2J7RIK3   E2AL99   A0A067RX80   A0A026WME5   U5EPR5   A0A182HCX5   A0A1B0DRE2   A0A1B0DFM0   A0A0L7R1P3   A0A1Q3F2B7   A0A0A9Z2Y2   A0A0M9A3N5   A0A0K8SQJ5   A0A0A9Z6V7   A0A1B6DLS8   A0A182RAW2   A0A1Q3F3E8   A0A182Q0T5   A0A182P9G8   T1HMJ5   A0A182MZ24   A0A084W1X9   B0W8Y1   Q17J04   A0A1S4F196   A0A023EZU8   A0A0V0G908   W5J5K1   A0A069DXD8   A0A224XJV3   A0A182F637   A0A0T6B9V3   A0A1B6JIT1   A0A336KJ03   E9FUK4   A0A336MWP5   A0A1B0CUP8   A0A1L8DGC2   A0A1W4WME0   A0A1W4WCB4   A0A1B6GUL2   A0A182J920   A0A1L8DHG5   A0A2R7W5A6   A0A1I8NXM4   A0A1Y1NBJ8   A0A0A1XCZ8   A0A034VL94   W8BJF4   A0A0M4E8W2   A0A0K8U5N0   A0A1B6KX48   B4HYA3   A0A0J9QXY7   B4Q5T4   B4NZG9   B4KIM6   Q9VLX2   B3MV21   A0A1I8MSX1   B3N6N7   A0A2H8TDC1   A0A1W4W747   B4N0U7   B4JQD2   A0A0P5PWY6   A0A0P5K0M7  

PDB

6HM0     E-value=1.29445e-26,     Score=298

KEGG

101744221    K11723 bromodomain-containing protein 7 | (RefSeq) bromodomain-containing protein 7

GO

GO:0004252   GO:0004372   GO:0003676   GO:0035999   GO:0030170   GO:0019264   GO:0005515   GO:0006355   GO:0046983   GO:0004674   GO:0007165   GO:0005488   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR11680  

Length:

473

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00382

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00705

outside

1  -  473

 

 

Pi

255.960538

Theta

187.855058

Tajima's D

1.27364

CLR

0.451407

CSRT

0.728763561821909

Interpretation

Uncertain