Gene

KWMTBOMO02358

Pre Gene Modal

BGIBMGA014415

Annotation

hypothetical_protein_KGM_11568_[Danaus_plexippus]

Location

Bomo_Chr5(-):125527-132625      View in EpiBrowser

Full name

Integrator complex subunit 9      

Location in the cell

PlasmaMembrane   Reliability : 1.192

CDS

ATGAAGCTTTATTGTTTAAGCAATGATGCAGCGAAGCCTTGCTTTGTGTTGTCTTTCAAAGAGCTCCTCATAATGTTGGATTGTGGGCTGTCATCCCACTCTGTGCTCAACTTCCTACCGCTGCCTCCAGTGCCTAGCACTCGACTCGCATCCCTGCCTAATTACACACCACCACATCACAATGATCCACTCTTGGAAGGGGAACTAAAGGAGTGTTGCGGCAGAGTGTTTGTTGATAGCATGCCTGAGTTTTGTCCGCCTCTCGATAAAGTAGTCGATTTTTCTCAGCTAGATGTAATTTTAATCTCAAATTACACTTGCATGCTGGCCCTGCCTTTTATAACAGAAGATACAGGTTTCAAGGGCCAAGTGTATGCCACTGAACCTACTCTACAAATAGGAAGGTTCTACCTGGAGGAGCTGTCGGAGTGGGTGTGCTCAAGCGGGTCGGGGTCGGGCTCGGCCAAGCGTTGGAAGGAGGCGGTGCACGTGCTGCCCGCCCCCCTCGCCGACGTGGTGCGGCCCCGCGCGTGGCGCCGCCTGCTCGCCCCGCACCACGTCGCCCGCGCCCTCGCGCGCGTCCGCGTGGTCGGCTACGACGAGAAGGTCGACCTGTACGGCGCGCTCGACGCCACCGCCGTCAGCTCCGGCTTCTGTCTGGGCTCCGCCAACTGGGTGCTGCGCTCCGCCCACGAGAAGGTCGCCTACGTGAGCGGCTCCAGCACGCTCACCACGCACCCGCGCCCCATCAACCAGGCGGCTCTGCGGGGCGCCGACCTGCTGGTGCTGGCCGCGCTCACGCAGACGCCGGCGCACAACCCGGACCACATGCTGGGCGACCTGTGCGTGCACGCCACCGTCACGCTGCGCGCCGGCGGCTCCGTGCTGTGCCCCGTGTACCCCAGCGGCGTGCTGTACGACCTGCTGGAGTGCCTGTCGGCGCACCTGGACACGGCGGGGCTGGCGCACGTGCCGCTGTACGTGGTGTCGCCGGCGGCCGAGGCGTCGCTGGCCTACAGCAACATCCTGGCGGAGTGGGTGTCGGCGGGCAAGCAGGCGCGCGTGTACCTGCCCGAGGAGCCGTTCCCGCACGCGGCGCTGGTGCGCGCGGGGCGGCTGCGGCACGCGCGGGACCTGCACGACGACTCCTTCAGCGCAGACTTCCGCCAGCCCTGCGTCGTCTTCTGCGGACACCCCAGCCTGCGCTTCGGCGCCGCCGTGCACCTCGTCGAGCTGTGGGCCTGCAACCCGCTGCACGCCATCATATTCACAGAACCGGACTTCCCGTACACGGAGGCGCTGGCCCCCTTCCAGCCGCTGAGCATGAAGGCCTTCCACTGTCCCATCGACACGTCGCTCAACTACTCGCAGGCCAACAAGCTGGTGCGCGAGCTGCGGCCGCGCGAGCTCGCCCTGCCCGAGCAGTACGCCGCGCCCGGGCCCGCCGCCGCCGCCGCGCGCCCGCACATCGCCGCCGACGTGCCCACCGTGGTGGTGCGGCGCGGCACGGCGCGGCGCGTAGGCGGCCGCCGCACGCTGGCCCGCGGCACGCTCAGCGGCAGCCTGGCCGCCCGCCTGGCGCCGCGCGACCTCCGCGCCGGCCTGCGCGCCGCGCCCCTCCGCGCCGCGCTGTCGCTGCGGGACAGCCGCCTGCACGTGCACTCGCCGCCGCCGGGCGCGGGCGGGGCGGGGGGCGCGGAGGCGGGCGGGCGCGTGGAGTGCGGCGCGCCGGACGTGGAGGCGCTGGTGCGGGAGCTGCGGCGCGCGGGCGCGGAGGAGGCGCGGGTGGAGCGCGGCGCGGACGGCTGCATCGTGCACCTGCCGCGCCACGACACGCTGGTGCACGTGGACGCGCACGCCACGCACGTGTTCTGCGAGGCGGGCGCCGACCTGCGCCTGGCGCTGCGGCAGGCGCTGGCGCTCACCGTGCCCACCATATAG

Protein

MKLYCLSNDAAKPCFVLSFKELLIMLDCGLSSHSVLNFLPLPPVPSTRLASLPNYTPPHHNDPLLEGELKECCGRVFVDSMPEFCPPLDKVVDFSQLDVILISNYTCMLALPFITEDTGFKGQVYATEPTLQIGRFYLEELSEWVCSSGSGSGSAKRWKEAVHVLPAPLADVVRPRAWRRLLAPHHVARALARVRVVGYDEKVDLYGALDATAVSSGFCLGSANWVLRSAHEKVAYVSGSSTLTTHPRPINQAALRGADLLVLAALTQTPAHNPDHMLGDLCVHATVTLRAGGSVLCPVYPSGVLYDLLECLSAHLDTAGLAHVPLYVVSPAAEASLAYSNILAEWVSAGKQARVYLPEEPFPHAALVRAGRLRHARDLHDDSFSADFRQPCVVFCGHPSLRFGAAVHLVELWACNPLHAIIFTEPDFPYTEALAPFQPLSMKAFHCPIDTSLNYSQANKLVRELRPRELALPEQYAAPGPAAAAARPHIAADVPTVVVRRGTARRVGGRRTLARGTLSGSLAARLAPRDLRAGLRAAPLRAALSLRDSRLHVHSPPPGAGGAGGAEAGGRVECGAPDVEALVRELRRAGAEEARVERGADGCIVHLPRHDTLVHVDAHATHVFCEAGADLRLALRQALALTVPTI

Description

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).

Subunit

Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS1 and IntS12 (PubMed:23288851).

Similarity

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.

Keywords

Complete proteome   Nucleus   Reference proteome  

Feature

chain  Integrator complex subunit 9

Uniprot

A0A212FAR7   A0A2H1WHU2   A0A1B0CCX2   A0A158NMG2   A0A1B0DLC8   A0A2A3E498   + More
A0A195AZU5   A0A0A9WMH2   A0A146MIB4   E1ZZ51   A0A067R0E3   A0A151JVH0   E9IEH4   A0A336LRJ7   A0A232FG09   A0A151IZB9   A0A026WFT8   A0A2J7QAJ9   A0A0P4VQE7   A0A224XLD7   A0A1I8MGS8   A0A1B0FG36   A0A1A9YAD1   A0A1B0BYS9   A0A2J7QAJ4   A0A1A9V6T6   A0A1B0A7K7   A0A1B6MCP8   A0A1A9W7Y4   E0W4E8   A0A1B6EVY1   A0A1I8P3J3   A0A1B6CJW2   A0A0M9A8K5   A0A1B6C2X2   B4LGR3   A0A0L0BPY2   B4N6W2   B4L0Z5   B4IU55   B3M623   A0A0A1X174   B4QLU2   A0A034VDY7   A0A3B0JR90   W8B1J1   Q2M110   B4GQT9   B4PD31   A0A1B6D531   Q95TS5   A0A1W4UW20   A0A0M4EYI1   A0A0K8VLA1   B4HJ16   B4IX86   A0A1B6ED24   B3NDS0   B0WES8   U5EXK7   A0A2M4BGI2   A0A2M4BGG2   W5J541   A0A182G0G0   A0A1Q3F5E0   A0A2M4AKL5   Q16S93   A0A182IP84   A0A182IIB6   A0A182NZ52   A0A182R0V6   A0A182M956   A0A182WQM8   A0A182XUS1   A0A182S595   A0A182V860   A0A2M3Z7M5   A0A182TFD6   Q5TRM5   A0A182Y0W7   A0A182SJY4   A0A182KCW4   A0A182H3E1   A0A2M4AL55   D6WXY0   U4U926   N6TWZ0   A0A1W4WJ43   J9JZY8  

Pubmed

22118469    21347285    25401762    26823975    20798317    24845553    + More
21282665    28648823    24508170    27129103    25315136    20566863    17994087    26108605    17550304    25830018    22936249    25348373    24495485    15632085    10731132    12537572    12537569    21078872    23288851    23097424    20920257    23761445    17510324    12364791    25244985    26483478    18362917    19820115    23537049   

EMBL

AGBW02009439    OWR50813.1    ODYU01008432    SOQ52034.1    AJWK01007165    ADTU01020462    + More
AJVK01071209    KZ288381    PBC26520.1    KQ976697    KYM77562.1    GBHO01033962    GDHC01021386    JAG09642.1    JAP97242.1    GDHC01000219    JAQ18410.1    GL435293    EFN73542.1    KK852804    KDR16196.1    KQ981692    KYN37884.1    GL762591    EFZ21058.1    UFQS01000134    UFQT01000134    SSX00254.1    SSX20634.1    NNAY01000298    OXU29369.1    KQ980710    KYN14439.1    KK107238    EZA54798.1    NEVH01016330    PNF25607.1    GDKW01001372    JAI55223.1    GFTR01007587    JAW08839.1    CCAG010021081    JXJN01022812    PNF25606.1    GEBQ01006280    JAT33697.1    DS235886    EEB20504.1    GECZ01027719    JAS42050.1    GEDC01023524    GEDC01011800    JAS13774.1    JAS25498.1    KQ435726    KOX78143.1    GEDC01029436    GEDC01000904    JAS07862.1    JAS36394.1    CH940647    EDW70528.1    JRES01001546    KNC22117.1    CH964168    EDW80101.1    CH933809    EDW18152.1    CH891783    EDW99918.1    CH902618    EDV40739.2    GBXI01009646    JAD04646.1    CM000363    CM002912    EDX10641.1    KMY99935.1    GAKP01017416    GAKP01017413    GAKP01017412    GAKP01017407    JAC41536.1    OUUW01000009    SPP84645.1    GAMC01011607    GAMC01011605    JAB94950.1    CH379069    EAL30766.1    CH479188    EDW40124.1    CM000159    EDW94963.1    GEDC01016494    GEDC01001174    JAS20804.1    JAS36124.1    AE014296    AY058574    AAL13803.1    CP012525    ALC43245.1    GDHF01012660    JAI39654.1    CH480815    EDW41672.1    CH916366    EDV97418.1    GEDC01001465    JAS35833.1    CH954178    EDV52203.1    DS231911    EDS45841.1    GANO01002495    JAB57376.1    GGFJ01003003    MBW52144.1    GGFJ01003004    MBW52145.1    ADMH02002072    ETN59597.1    GFDL01012322    JAV22723.1    GGFK01008000    MBW41321.1    CH477680    EAT37322.1    APCN01004330    AXCN02000941    AXCM01010195    GGFM01003763    MBW24514.1    AAAB01008960    EAL39840.2    JXUM01107231    JXUM01107232    JXUM01107233    JXUM01107234    JXUM01107235    KQ565125    KXJ71306.1    GGFK01008198    MBW41519.1    KQ971362    EFA08915.1    KB632233    ERL90409.1    APGK01057866    KB741282    ENN70832.1    ABLF02025907   

Proteomes

UP000007151    UP000092461    UP000005205    UP000092462    UP000242457    UP000078540    + More
UP000000311    UP000027135    UP000078541    UP000215335    UP000078492    UP000053097    UP000235965    UP000095301    UP000092444    UP000092443    UP000092460    UP000078200    UP000092445    UP000091820    UP000009046    UP000095300    UP000053105    UP000008792    UP000037069    UP000007798    UP000009192    UP000002282    UP000007801    UP000000304    UP000268350    UP000001819    UP000008744    UP000000803    UP000192221    UP000092553    UP000001292    UP000001070    UP000008711    UP000002320    UP000000673    UP000069272    UP000008820    UP000075880    UP000075840    UP000075884    UP000075886    UP000075883    UP000075920    UP000076407    UP000075900    UP000075903    UP000075902    UP000007062    UP000076408    UP000075901    UP000075881    UP000069940    UP000249989    UP000007266    UP000030742    UP000019118    UP000192223    UP000007819   

PRIDE

Q95TS5   

Pfam

PF10996   Beta-Casp        + More
PF16661   Lactamase_B_6

Interpro

IPR022712   Beta_Casp        + More
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR027074   Integrator_9su       
IPR001279   Metallo-B-lactamas       

SUPFAM

SSF56281   SSF56281       

Gene 3D

3.60.15.10    

ProteinModelPortal

A0A212FAR7   A0A2H1WHU2   A0A1B0CCX2   A0A158NMG2   A0A1B0DLC8   A0A2A3E498   + More
A0A195AZU5   A0A0A9WMH2   A0A146MIB4   E1ZZ51   A0A067R0E3   A0A151JVH0   E9IEH4   A0A336LRJ7   A0A232FG09   A0A151IZB9   A0A026WFT8   A0A2J7QAJ9   A0A0P4VQE7   A0A224XLD7   A0A1I8MGS8   A0A1B0FG36   A0A1A9YAD1   A0A1B0BYS9   A0A2J7QAJ4   A0A1A9V6T6   A0A1B0A7K7   A0A1B6MCP8   A0A1A9W7Y4   E0W4E8   A0A1B6EVY1   A0A1I8P3J3   A0A1B6CJW2   A0A0M9A8K5   A0A1B6C2X2   B4LGR3   A0A0L0BPY2   B4N6W2   B4L0Z5   B4IU55   B3M623   A0A0A1X174   B4QLU2   A0A034VDY7   A0A3B0JR90   W8B1J1   Q2M110   B4GQT9   B4PD31   A0A1B6D531   Q95TS5   A0A1W4UW20   A0A0M4EYI1   A0A0K8VLA1   B4HJ16   B4IX86   A0A1B6ED24   B3NDS0   B0WES8   U5EXK7   A0A2M4BGI2   A0A2M4BGG2   W5J541   A0A182G0G0   A0A1Q3F5E0   A0A2M4AKL5   Q16S93   A0A182IP84   A0A182IIB6   A0A182NZ52   A0A182R0V6   A0A182M956   A0A182WQM8   A0A182XUS1   A0A182S595   A0A182V860   A0A2M3Z7M5   A0A182TFD6   Q5TRM5   A0A182Y0W7   A0A182SJY4   A0A182KCW4   A0A182H3E1   A0A2M4AL55   D6WXY0   U4U926   N6TWZ0   A0A1W4WJ43   J9JZY8  

PDB

6I1D     E-value=4.72827e-08,     Score=140

KEGG

101744797    K13146 integrator complex subunit 9 | (RefSeq) integrator complex subunit 9

GO

GO:0032039   GO:0016180   GO:0034472   GO:0006378   GO:0005634   GO:0005847   GO:0016021  

PANTHER

PTHR46094  

Subcellular location

Nucleus  

Length:

646

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13981

Exp number, first 60 AAs:

0.08951

Total prob of N-in:

0.00673

outside

1  -  646

 

 

Pi

193.273925

Theta

185.336735

Tajima's D

0.795772

CLR

1.62199

CSRT

0.602769861506925

Interpretation

Uncertain