Gene

KWMTBOMO02357  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014414

Annotation

PREDICTED:_leucine_carboxyl_methyltransferase_1_[Bombyx_mori]

Location

Bomo_Chr5(+):119956-122303      View in EpiBrowser

Full name

Leucine carboxyl methyltransferase 1      

Location in the cell

Cytoplasmic   Reliability : 2.288

CDS

ATGGATAATAGGATATGGTCTGCGGAAGAGGAGGCGATAATCGCGACGAACACGGAGGCTACCGAGTGCAAGCGATGTGCCGTCGAATTAGGCTACTGGAAGGATGATTACATTGGATACTTCGCTAAACATGTTGACCGAAAAGCACCAGAGATCAATCGGGGATACTACGCCAGGGTCAAGGGGGTCGAGATGTTCATACATCAATTCTTGGAGAGATGTGATACTAAATGCCAGATTATAAATCTTGGCTGTGGATTCGACACTCTTTACTGGAGACTGAAGGACACGACCCAAGCAGTTGGCAATTTTATAGAGTTGGATTTTCCAGCTGTTACTGCAAAGAAGGCTCATATCATCAAGCGCAACAAAGCACTACTGGAAAAGATTTGTAATGAAGACGGCGAAGTGGTAATTCGCGAGGGCGACTTGCACTCGGACGGTTACCACCTGGTGGGGTGCGACCTGCGCTGCCTCACCGACGTGAAGCGCAAGCTGAGCGTCGCCGCCGCGGGCGCGCCCACGCTGGTGCTGGCGGAGTGCGTGCTGGTGTACCTGCGCTCCGACGCGGCCGACGCGCTGCTGCGCCACCTGGCGGCCGCGTTCCCGCGCTGCGTGCTGCTCACGTACGAGCAGTGCAGCCTGGACGACAAGTTCGGCGAGGTGATGGCGCGCAACCTGCGGGGCCGCGGCGTGGCGGCGCCGGGGCGCTCGCACGCGCTGGGCCCGGCGGACGGCGCGGCGCGGCTGCAGACGCTGGGCTGGGGGCGCGCGCGCGCGTGGGACATGGTGGCGGTGTGGCGCGCGCTGCCGGACGAGGACCGCGCGCGCGTGGAGCGCCTGGAGATGCTGGACGAGCGCGAGCTGTTGACGCAGCTCAACTCGCACTACGCGCTGGCCGTGGCGACCACCTGCGACCTGTTCGCCGACATGGACCTCAACGCGTGGTGTCGCAGTCGATTGTTTCAGACAATTGCAAAAATGGATTATTACAACTATATGACTGCATGA

Protein

MDNRIWSAEEEAIIATNTEATECKRCAVELGYWKDDYIGYFAKHVDRKAPEINRGYYARVKGVEMFIHQFLERCDTKCQIINLGCGFDTLYWRLKDTTQAVGNFIELDFPAVTAKKAHIIKRNKALLEKICNEDGEVVIREGDLHSDGYHLVGCDLRCLTDVKRKLSVAAAGAPTLVLAECVLVYLRSDAADALLRHLAAAFPRCVLLTYEQCSLDDKFGEVMARNLRGRGVAAPGRSHALGPADGAARLQTLGWGRARAWDMVAVWRALPDEDRARVERLEMLDERELLTQLNSHYALAVATTCDLFADMDLNAWCRSRLFQTIAKMDYYNYMTA

Description

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Catalytic Activity

[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine

Similarity

Belongs to the methyltransferase superfamily. LCMT family.

Uniprot

H9JXZ6   A0A194QAC6   A0A2H1WG20   A0A212FAP9   W8C495   A0A0A1WLD7   + More
A0A034WMN9   A0A1A9ZQJ4   A0A1A9VMA8   A0A1I8PAE9   A0A023EQZ0   A0A1I8PA94   D3TNA3   A0A1B0GC70   A0A1I8PAG3   A0A1A9YA34   A0A1B0BJI2   A0A084VMQ7   B4N025   B3ML19   A0A3B0JPW6   A0A1W4V382   A0A0P8Y2W3   Q17BX2   A0A1W4VFJ7   A0A0L0CJ00   Q29KE4   B4HBZ5   A0A0R3NUY1   A0A182J753   B4NY85   B4HXT0   B3N613   Q9V3K7   B4Q6H7   A0A182QLI7   A0A1I8MEI4   T1PHN5   A0A1Q3FAB4   M9NF32   A0A0Q5W9A9   A0A0J9R2D9   A0A1Q3FAG5   A0A182NB73   A0A182KDI8   A0A182F2S7   B0XAC7   U5ESZ3   W5J4J8   A0A2M4AW73   A0A182Y8J0   A0A1S4GZ68   A0A182VNN2   A0A182UDR8   A0A182KWM4   A0A182IB64   Q7Q871   A0A182VTL7   B4M919   A0A336LGI1   B4KKI0   A0A182MC50   A0A182RA71   A0A182X4Z6   A0A336MPH7   A0A0M4EBR7   B4JPC5   A0A3B0JNH5   A0A2P8ZNH9   A0A336LTS9   A0A2J7QAI9   A0A1B6KZP1   A0A182PUH9   A0A0T6BEK8   E0W4F0   A0A1B6F0M9   A0A1L8DU57   A0A1W4XDQ0   A0A1Y1KSG2   A0A1B6HZS0   A0A1J1ILM6   A0A1B6C1A0   A0A1B3PDN9   V5IAP5   K7JBK4   N6U9Y5   A0A310SEY6   A0A0N0BE08   A0A151I964   A0A2A3E8P7   A0A087ZUY2   V9IL04   F4WV81   A0A151IWV8   A0A195BSW1   A0A151WJT7   D6W8H8   A0A195EWA2   E2BYW0  

EC Number

2.1.1.233

Pubmed

19121390    26354079    22118469    24495485    25830018    25348373    + More
24945155    20353571    24438588    17994087    17510324    26108605    15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    25315136    20920257    23761445    25244985    12364791    20966253    29403074    20566863    28004739    20075255    23537049    21719571    18362917    19820115    20798317   

EMBL

BABH01041723    BABH01041724    KQ459465    KPJ00366.1    ODYU01008432    SOQ52035.1    + More
AGBW02009439    OWR50812.1    GAMC01002418    GAMC01002417    JAC04139.1    GBXI01014458    JAC99833.1    GAKP01002141    JAC56811.1    GAPW01002554    JAC11044.1    EZ422905    ADD19181.1    CCAG010007822    JXJN01015405    ATLV01014619    KE524975    KFB39251.1    CH963920    EDW77960.1    CH902620    EDV30677.1    OUUW01000006    SPP82432.1    KPU72984.1    CH477314    EAT43848.1    JRES01000418    KNC31444.1    CH379061    EAL33231.1    CH479272    EDW40006.1    KRT04836.1    CM000157    EDW89721.1    CH480818    EDW51860.1    CH954177    EDV58051.1    AE014134    AY051573    AAF53483.1    AAK92997.1    CM000361    CM002910    EDX05159.1    KMY90406.1    AXCN02000637    KA648194    AFP62823.1    GFDL01010534    JAV24511.1    AFH03712.1    KQS70231.1    KMY90407.1    GFDL01010479    JAV24566.1    DS232578    EDS43624.1    GANO01003010    JAB56861.1    ADMH02002211    ETN57780.1    GGFK01011725    MBW45046.1    AAAB01008944    APCN01000643    EAA10069.4    CH940654    EDW57695.1    UFQS01005157    UFQT01005157    SSX16735.1    SSX35926.1    CH933807    EDW11630.1    AXCM01004643    UFQT01001563    SSX31019.1    CP012523    ALC38935.1    CH916372    EDV98755.1    SPP82433.1    PYGN01000010    PSN58064.1    UFQT01000117    SSX20371.1    NEVH01016330    PNF25579.1    GEBQ01023060    GEBQ01016766    JAT16917.1    JAT23211.1    LJIG01001164    KRT85776.1    DS235886    EEB20506.1    GECZ01026009    JAS43760.1    GFDF01004120    JAV09964.1    GEZM01075040    JAV64323.1    GECU01027505    JAS80201.1    CVRI01000054    CRL00468.1    GEDC01030156    GEDC01030154    JAS07142.1    JAS07144.1    KU660031    AOG17829.1    GALX01000825    JAB67641.1    AAZX01018475    APGK01033702    KB740886    KB632098    ENN78505.1    ERL88790.1    KQ762207    OAD56048.1    KQ435845    KOX71188.1    KQ978303    KYM95339.1    KZ288345    PBC27652.1    JR050831    AEY61362.1    GL888384    EGI61847.1    KQ980843    KYN12316.1    KQ976417    KYM89758.1    KQ983031    KYQ48143.1    KQ971312    EEZ98354.1    KQ981953    KYN32426.1    GL451531    EFN79132.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000092445    UP000078200    UP000095300    + More
UP000092444    UP000092443    UP000092460    UP000030765    UP000007798    UP000007801    UP000268350    UP000192221    UP000008820    UP000037069    UP000001819    UP000008744    UP000075880    UP000002282    UP000001292    UP000008711    UP000000803    UP000000304    UP000075886    UP000095301    UP000075884    UP000075881    UP000069272    UP000002320    UP000000673    UP000076408    UP000075903    UP000075902    UP000075882    UP000075840    UP000007062    UP000075920    UP000008792    UP000009192    UP000075883    UP000075900    UP000076407    UP000092553    UP000001070    UP000245037    UP000235965    UP000075885    UP000009046    UP000192223    UP000183832    UP000002358    UP000019118    UP000030742    UP000053105    UP000078542    UP000242457    UP000005203    UP000007755    UP000078492    UP000078540    UP000075809    UP000007266    UP000078541    UP000008237   

PRIDE

H9JXZ6    Q9V3K7    M9NF32   

Pfam

PF04072   LCM

Interpro

IPR007213   Ppm1/Ppm2/Tcmp        + More
IPR029063   SAM-dependent_MTases       
IPR016651   PPM1       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

H9JXZ6   A0A194QAC6   A0A2H1WG20   A0A212FAP9   W8C495   A0A0A1WLD7   + More
A0A034WMN9   A0A1A9ZQJ4   A0A1A9VMA8   A0A1I8PAE9   A0A023EQZ0   A0A1I8PA94   D3TNA3   A0A1B0GC70   A0A1I8PAG3   A0A1A9YA34   A0A1B0BJI2   A0A084VMQ7   B4N025   B3ML19   A0A3B0JPW6   A0A1W4V382   A0A0P8Y2W3   Q17BX2   A0A1W4VFJ7   A0A0L0CJ00   Q29KE4   B4HBZ5   A0A0R3NUY1   A0A182J753   B4NY85   B4HXT0   B3N613   Q9V3K7   B4Q6H7   A0A182QLI7   A0A1I8MEI4   T1PHN5   A0A1Q3FAB4   M9NF32   A0A0Q5W9A9   A0A0J9R2D9   A0A1Q3FAG5   A0A182NB73   A0A182KDI8   A0A182F2S7   B0XAC7   U5ESZ3   W5J4J8   A0A2M4AW73   A0A182Y8J0   A0A1S4GZ68   A0A182VNN2   A0A182UDR8   A0A182KWM4   A0A182IB64   Q7Q871   A0A182VTL7   B4M919   A0A336LGI1   B4KKI0   A0A182MC50   A0A182RA71   A0A182X4Z6   A0A336MPH7   A0A0M4EBR7   B4JPC5   A0A3B0JNH5   A0A2P8ZNH9   A0A336LTS9   A0A2J7QAI9   A0A1B6KZP1   A0A182PUH9   A0A0T6BEK8   E0W4F0   A0A1B6F0M9   A0A1L8DU57   A0A1W4XDQ0   A0A1Y1KSG2   A0A1B6HZS0   A0A1J1ILM6   A0A1B6C1A0   A0A1B3PDN9   V5IAP5   K7JBK4   N6U9Y5   A0A310SEY6   A0A0N0BE08   A0A151I964   A0A2A3E8P7   A0A087ZUY2   V9IL04   F4WV81   A0A151IWV8   A0A195BSW1   A0A151WJT7   D6W8H8   A0A195EWA2   E2BYW0  

PDB

3P71     E-value=2.88997e-46,     Score=466

KEGG

101743540    K18203 [phosphatase 2A protein]-leucine-carboxy methyltransferase [EC:2.1.1.233] | (RefSeq) leucine

GO

GO:0018423   GO:0005829   GO:0006481   GO:0008168   GO:0032259   GO:0050660   GO:0003995   GO:0005515   GO:0005488   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR13600  

Length:

336

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.92757

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.11815

outside

1  -  336

 

 

Pi

272.932641

Theta

190.012741

Tajima's D

1.315276

CLR

0

CSRT

0.745762711864407

Interpretation

Uncertain