Gene

KWMTBOMO02297

Pre Gene Modal

BGIBMGA003778

Annotation

PREDICTED:_uncharacterized_protein_C630.12-like_[Bombyx_mori]

Location

Bomo_Chr4(+):17149041-17153582      View in EpiBrowser

Full name

DNA polymerase      

Location in the cell

PlasmaMembrane   Reliability : 3.484

CDS

ATGTATCTTAAAAGAAGTTCAACAGTGAAGTACTTCGCAGCCGCAATAATAGGATGTTTACTATATAGCGAATGGTTAATATATTCGATGCAGGCTTGGTATTGGAGAACCCTGGAGTGCGTCGAATACGACTCATCTTGCATCAAGATACTGTTCGTAGCAGATCCTCAGATACAGGGCGACATAGCGGTGCCGGCACCTTTTAGCTATCCAATTAATTGGGATAGTGATCGTTACCTTAAGTCAACATTTAGAGTTGTTATACAGCACTTCAGGCCAGATGTTATTGTGTACATGGGTGACCTCATGGATGAAGGTTCCATTTCCACCTTGAAACAATACCATAGCTATGTAAAAAGACTGTCTGATATATTTGAAGTTGATTATCCTATAGTGCAAATTTGGATACCAGGTGATAATGATATAGGTGGTGAGAATGAACCGATTAAGAAAGATAAAATTGAAGAGTTCAACGAAGTCTACCAACAACCAGAAACTGTGACATTCCGGAATATAACATTTTACAAAGCCAATGGTATAACGAACAGTTTCCCAAAGAAACTTAAGGGGAATGGCAATGAATACAGGATTGTGGTCTCACATTATCCTATTACATACAGACATGCTTTTGGTCATGAAGTGAATAATGAAATAAATCCGGATATATACTTCTGCGCTCACGAGCACGAGGCAAAATATGTCAGACAGAGTCGAAAACTGACCAATCGAGACTCACACATGCTAACCTCAGAGAGCGCCGTCCTGAACGTGTCAACCAAAGACGATCATTTGTATGAAATTTACGTTCCTACGTGTTCATATAGGATGGGCACAGATCAAATTGGTTATGGTGCTGCCATACTTGAGAACAACAATCAGAACTTGCGTTACACAGTGTTCTGGTCGTCACGAAGGTTTCCCTACTTATTCATTTATTTAGTAACCTTCATCATACTGCAGATCTACTTTGTAATATACTGCGCGGCTTGGGTCAGTTACAGGAAGCCAACGATGAACTGGGCCACTGATAAAGTGCCATTATTGGACAGAGTATAA

Protein

MYLKRSSTVKYFAAAIIGCLLYSEWLIYSMQAWYWRTLECVEYDSSCIKILFVADPQIQGDIAVPAPFSYPINWDSDRYLKSTFRVVIQHFRPDVIVYMGDLMDEGSISTLKQYHSYVKRLSDIFEVDYPIVQIWIPGDNDIGGENEPIKKDKIEEFNEVYQQPETVTFRNITFYKANGITNSFPKKLKGNGNEYRIVVSHYPITYRHAFGHEVNNEINPDIYFCAHEHEAKYVRQSRKLTNRDSHMLTSESAVLNVSTKDDHLYEIYVPTCSYRMGTDQIGYGAAILENNNQNLRYTVFWSSRRFPYLFIYLVTFIILQIYFVIYCAAWVSYRKPTMNWATDKVPLLDRV

Description

DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Similarity

Belongs to the DNA polymerase type-X family.

Uniprot

H9J2P1   H9JXP7   A0A2A4K919   A0A212EMK8   A0A194QMP4   A0A194QNK3   + More
A0A0L7LTI5   A0A0T6B8U5   A0A2A3E6L6   A0A087ZR85   A0A1L8DWE6   A0A1L8DWU5   E2BFY9   A0A2J7Q2E3   A0A067R9P4   A0A0L7QQK1   A0A195CUT9   A0A2J7Q2F7   F4WC33   E9IKB1   A0A0M9AAK4   A0A026WWD5   E2AH74   A0A154P5E5   A0A182PCI1   A0A232EPN5   A0A1B6CQ96   N6ULY0   A0A182M1I5   D6WH01   A0A195DLQ4   A0A195BKF4   A0A195FR16   A0A182WA52   A0A182QND2   A0A182YIM1   A0A182R7Q2   A0A1W4W9F7   A0A131XBC3   A0A158NAQ8   A0A310SJQ9   B0W1N3   Q7Q0U8   A0A182HQV4   A0A182UEW1   A0A182XLF4   A0A1S4J383   A0A2R5L7J8   A0A1Y1K5A4   A0A182NPW2   A0A182VB61   A0A0J7KSX3   A0A1Q3FJX7   A0A1Q3FJW6   L7LZP2   A0A2H8TRQ1   A0A182KJL0   A0A2J7Q2E5   A0A1J1J8A2   A0A084WGA6   B7PTK5   A0A131Y4D2   A0A182K4Q4   A0A147BIR5   A0A2M3ZI76   A0A2M3Z9F3   Q17D84   A0A2M4AP98   A0A182MZF0   A0A182P0G4   W5J506   A0A182VCS9   A0A182X1L7   Q7Q3D9   A0A182TSP1   A0A2S2R8C9   A0A0C9RJB1   A0A224XF19   A0A182F2Z5   A0A1Z5KWC0   A0A182L2F2   A0A182IEJ9   A0A2M4BRD8   A0A069DTD4   A0A182XZJ4   A0A1B6LVI1   A0A0V0GAL5   A0A182MNR4   A0A182RVK9   A0A1Y9IW62   A0A182K0B5   A0A084VBB7   A0A146LYP1   A0A0A9W8C8   A0A0K8SI43   J9JVZ1   A0A182JHW9   A0A1I8NB41   B0W195  

EC Number

2.7.7.7

Pubmed

19121390    22118469    26354079    26227816    20798317    24845553    + More
21719571    21282665    24508170    30249741    28648823    23537049    18362917    19820115    25244985    28049606    21347285    12364791    14747013    17210077    28004739    25576852    20966253    24438588    29652888    17510324    20920257    23761445    28528879    26334808    26823975    25401762    25315136   

EMBL

BABH01034423    BABH01034424    BABH01044827    BABH01044828    BABH01044829    NWSH01000050    + More
PCG80200.1    AGBW02013812    OWR42718.1    KQ458860    KPJ04756.1    KQ461191    KPJ07103.1    JTDY01000114    KOB78775.1    LJIG01009203    KRT83549.1    KZ288375    PBC26691.1    GFDF01003341    JAV10743.1    GFDF01003176    JAV10908.1    GL448096    EFN85391.1    NEVH01019371    PNF22752.1    KK852798    KDR16352.1    KQ414786    KOC60898.1    KQ977276    KYN04448.1    PNF22753.1    GL888070    EGI68013.1    GL763956    EFZ18992.1    KQ435699    KOX80587.1    KK107079    QOIP01000010    EZA60113.1    RLU17658.1    GL439483    EFN67191.1    KQ434820    KZC07071.1    NNAY01002921    OXU20292.1    GEDC01021611    JAS15687.1    APGK01026886    APGK01026887    KB740648    ENN79717.1    AXCM01000963    KQ971321    EFA00612.2    KQ980734    KYN13776.1    KQ976455    KYM85095.1    KQ981305    KYN42913.1    AXCN02001998    GEFH01005196    JAP63385.1    ADTU01009954    KQ765605    OAD53830.1    DS231823    EDS26584.1    AAAB01008980    EAA14002.4    APCN01001603    GGLE01001309    MBY05435.1    GEZM01092331    JAV56594.1    LBMM01003514    KMQ93438.1    GFDL01007221    JAV27824.1    GFDL01007231    JAV27814.1    GACK01007982    JAA57052.1    GFXV01005068    MBW16873.1    PNF22754.1    CVRI01000074    CRL07996.1    ATLV01023499    KE525344    KFB49250.1    ABJB010185757    ABJB010302451    ABJB010502063    ABJB010635012    ABJB010799269    ABJB011122057    DS786398    EEC09927.1    GEFM01002109    JAP73687.1    GEGO01005209    JAR90195.1    GGFM01007495    MBW28246.1    GGFM01004415    MBW25166.1    CH477298    EAT44345.1    GGFK01009279    MBW42600.1    ADMH02002186    ETN57925.1    AAAB01008964    EAA12253.4    GGMS01016419    MBY85622.1    GBYB01008295    JAG78062.1    GFTR01005351    JAW11075.1    GFJQ02007573    JAV99396.1    APCN01005204    GGFJ01006441    MBW55582.1    GBGD01001977    JAC86912.1    GEBQ01012299    JAT27678.1    GECL01001035    JAP05089.1    AXCM01006351    ATLV01006318    KE524352    KFB35261.1    GDHC01007169    JAQ11460.1    GBHO01038897    JAG04707.1    GBRD01013032    JAG52794.1    ABLF02010811    DS231821    EDS44965.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000242457    UP000005203    UP000008237    UP000235965    UP000027135    UP000053825    UP000078542    UP000007755    UP000053105    UP000053097    UP000279307    UP000000311    UP000076502    UP000075885    UP000215335    UP000019118    UP000075883    UP000007266    UP000078492    UP000078540    UP000078541    UP000075920    UP000075886    UP000076408    UP000075900    UP000192223    UP000005205    UP000002320    UP000007062    UP000075840    UP000075902    UP000076407    UP000075884    UP000075903    UP000036403    UP000075882    UP000183832    UP000030765    UP000001555    UP000075881    UP000008820    UP000000673    UP000069272    UP000007819    UP000075880    UP000095301   

PRIDE

H9J2P1    H9JXP7   

Pfam

PF00149   Metallophos        + More
PF14791   DNA_pol_B_thumb
PF14792   DNA_pol_B_palm
PF14716   HHH_8
PF10391   DNA_pol_lambd_f

Interpro

IPR029052   Metallo-depent_PP-like        + More
IPR033308   PGAP5/Cdc1/Ted1       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR003583   Hlx-hairpin-Hlx_DNA-bd_motif       
IPR019843   DNA_pol-X_BS       
IPR018944   DNA_pol_lambd_fingers_domain       
IPR037160   DNA_Pol_thumb_sf       
IPR002008   DNA_pol_X_beta-like       
IPR010996   DNA_pol_b-like_N       
IPR027421   DNA_pol_lamdba_lyase_dom_sf       
IPR002054   DNA-dir_DNA_pol_X       
IPR022312   DNA_pol_X       
IPR029398   PolB_thumb       
IPR028207   DNA_pol_B_palm_palm       

SUPFAM

SSF47802   SSF47802       

Gene 3D

3.60.21.10     1.10.150.110     3.30.210.10    

CDD

cd00141  NT_POLXc

ProteinModelPortal

H9J2P1   H9JXP7   A0A2A4K919   A0A212EMK8   A0A194QMP4   A0A194QNK3   + More
A0A0L7LTI5   A0A0T6B8U5   A0A2A3E6L6   A0A087ZR85   A0A1L8DWE6   A0A1L8DWU5   E2BFY9   A0A2J7Q2E3   A0A067R9P4   A0A0L7QQK1   A0A195CUT9   A0A2J7Q2F7   F4WC33   E9IKB1   A0A0M9AAK4   A0A026WWD5   E2AH74   A0A154P5E5   A0A182PCI1   A0A232EPN5   A0A1B6CQ96   N6ULY0   A0A182M1I5   D6WH01   A0A195DLQ4   A0A195BKF4   A0A195FR16   A0A182WA52   A0A182QND2   A0A182YIM1   A0A182R7Q2   A0A1W4W9F7   A0A131XBC3   A0A158NAQ8   A0A310SJQ9   B0W1N3   Q7Q0U8   A0A182HQV4   A0A182UEW1   A0A182XLF4   A0A1S4J383   A0A2R5L7J8   A0A1Y1K5A4   A0A182NPW2   A0A182VB61   A0A0J7KSX3   A0A1Q3FJX7   A0A1Q3FJW6   L7LZP2   A0A2H8TRQ1   A0A182KJL0   A0A2J7Q2E5   A0A1J1J8A2   A0A084WGA6   B7PTK5   A0A131Y4D2   A0A182K4Q4   A0A147BIR5   A0A2M3ZI76   A0A2M3Z9F3   Q17D84   A0A2M4AP98   A0A182MZF0   A0A182P0G4   W5J506   A0A182VCS9   A0A182X1L7   Q7Q3D9   A0A182TSP1   A0A2S2R8C9   A0A0C9RJB1   A0A224XF19   A0A182F2Z5   A0A1Z5KWC0   A0A182L2F2   A0A182IEJ9   A0A2M4BRD8   A0A069DTD4   A0A182XZJ4   A0A1B6LVI1   A0A0V0GAL5   A0A182MNR4   A0A182RVK9   A0A1Y9IW62   A0A182K0B5   A0A084VBB7   A0A146LYP1   A0A0A9W8C8   A0A0K8SI43   J9JVZ1   A0A182JHW9   A0A1I8NB41   B0W195  

KEGG

101745501    no KO assigned | (RefSeq) uncharacterized protein C630.12-like

GO

GO:0016787   GO:0016021   GO:0006506   GO:0051301   GO:0004527   GO:0005783   GO:0005634   GO:0046872   GO:0003677   GO:0003887   GO:0006281   GO:0005777   GO:0007031   GO:0003676   GO:0008017   GO:0006289   GO:0004518   GO:0048384  

PANTHER

PTHR13315  

Subcellular location

Nucleus  

Length:

351

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

43.9917099999999

Exp number, first 60 AAs:

21.07887

Total prob of N-in:

0.92813

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  34

outside

35  -  307

TMhelix

308  -  330

inside

331  -  351

 

 

Pi

139.397444

Theta

136.843833

Tajima's D

-0.340213

CLR

1.803083

CSRT

0.274386280685966

Interpretation

Uncertain