Gene

KWMTBOMO02271

Pre Gene Modal

BGIBMGA003091

Annotation

PREDICTED:_protein_spire_[Bombyx_mori]

Location

Bomo_Chr4(-):15625179-15655245      View in EpiBrowser

Full name

Protein spire      

Location in the cell

Nuclear   Reliability : 3.055

CDS

ATGTGTTTCCGTTGGTTACAGCTGGTGGTGAACCTGGCCCTCGTGATATACCATGCTCTGGACTACACACACGCGGAGGACGAGGAGAGGCTCATCTCGCCCGACCTCGAGGGGCTCATCACCGAGATGACGTCATGTGATCTAGTTGATGACGATGAAGAATGCGGCGCGCTGTCCGAGGGCTCGGAGACGTCTGAAGGTGGACGCGCCGACACCGACGACGAGGGTATAGAACGGGACTCGGAGCCGGCTCCCAGGAGACGCAGACGACGAAGACGGTTCATGCTCAAAGATGTTATAGAGAGATGCGTTTGGCATTGCGGAGGCGGCGGTCGTTGCGCCCGGGACGCGGCGGCGGCTCACTACCGCGCCGTGTGCCGGGCTCTGGTCGCGGAGGCCCTCGAACTGGCCTCGTTCCTTGCCAGGGTCAGGGTCGGAGGCGCGAGAGACATGGGCGCCGCCGAAGACTCCGCCACGCATCTCGACACGCTGCAATTCTCTGATTGGGCAAGATTTTGGATGCAAGTTATCGGCGAACTCCGAATGGGCGTGAAGTTAAAGAAAGTGAATTATTCAAGAACGCCAATTGAATATGAATTGACACCGTACGAGATCCTTATGGACGACATCAGATCGAGAAGATATACGTTGAGGAAAGTCGATGGAGCGATACCACAGAGTGTGAAGAAGGACGCCCACGCTATGATTCTCGAATTCATTAGAAGTAGACCTCCGCTGAAAAAGGCCTCAGAACGTAAATTACCCCCACCGAAACGAGAGGCAACGCCAAGGGAGAAACTCCTCGCTTCCATCCAGGTCGGCAGGCGACTGAGACCGACACCATACTCCAACAGGCTATATCCCACCCTACCCTAA

Protein

MCFRWLQLVVNLALVIYHALDYTHAEDEERLISPDLEGLITEMTSCDLVDDDEECGALSEGSETSEGGRADTDDEGIERDSEPAPRRRRRRRRFMLKDVIERCVWHCGGGGRCARDAAAAHYRAVCRALVAEALELASFLARVRVGGARDMGAAEDSATHLDTLQFSDWARFWMQVIGELRMGVKLKKVNYSRTPIEYELTPYEILMDDIRSRRYTLRKVDGAIPQSVKKDAHAMILEFIRSRPPLKKASERKLPPPKREATPREKLLASIQVGRRLRPTPYSNRLYPTLP

Description

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton.

Subunit

Interacts with bsk, Rho1, Rac1, Cdc42 and wash. Interacts with capu.

Similarity

Belongs to the spire family.

Keywords

3D-structure   Actin-binding   Alternative splicing   Cell membrane   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Cytoskeleton   Developmental protein   Membrane   Phosphoprotein   Protein transport   Reference proteome   Repeat   RNA editing   Transport  

Feature

chain  Protein spire
splice variant  In isoform C.

Uniprot

A0A2A4K886   A0A194QNP1   A0A212EJ87   A0A2H1VDK1   D6WL34   A0A0T6B177   + More
A0A023F1I2   E0VEK2   A0A1L8DKC5   A0A1B6KKK9   N6U997   A0A1L8DKB8   A0A1L8DKL4   U4UAK8   A0A1B6LTG1   A0A1B6KQR4   A0A0A9YKS1   A0A1B6DBE6   A0A1Y1KK75   A0A1B0APW5   A0A146L1U8   A0A224XK81   A0A0A9YT38   A0A0K8SDD1   A0A0A9YNP4   A0A182ILZ6   A0A1W4XLP9   A0A1A9YFM8   W8AV10   A0A2M3Z8N4   A0A1S4GXA3   A0A1S4GX95   A0A2M3Z6K7   A0A2M3Z4S3   A0A2M3Z5L7   Q7Q3Y6   A0A182L1I9   A0A1B6K544   A0A1B0FG44   A0A0K8WET9   A0A034V5V5   A0A1B6J6B1   T1PBW9   A0A0K8VIT6   A0A1B6JCF7   A0A0K8U2H9   A0A0K8W560   A0A0K8UNT8   A0A1I8NNS1   A0A0Q5VKH7   A0A1W4VKD4   Q9U1K1-4   D4G7C9   A0A034V6Y8   A0A0J9R4X4   A0A0P8XF04   A0A2M4CS86   A0A1B0AGV0   M9NFB6   A0A0R1DPV0   A0A2M4CQW5   A0A1W4VYD5   A0A0Q5VXR8   A0A0J9TRZ9   M9NDT9   B3NM24   A0A1W4VK57   A0A0P8XF93   A0A2M4BBN8   A0A1W4VKC9   A0A1I8N3Q5   A0A2M4CRA3   E1JHM3   A0A0J9R5Y0   A0A0N8NZ61   A0A0J9R571   B4IFB2   A0A0R3NZB9   A0A0R1DPL5   B3MK58   Q9U1K1-2   Q9U1K1   A0A3F2YQ69   B4PBJ7   A0A0Q9XIK0   A0A0Q9WL22   A0A0Q9XF29   A0A1I8P7S4   A0A3B0JN86   A0A3B0JLT5   A0A1W7R9I6  

Pubmed

26354079    22118469    18362917    19820115    25474469    20566863    + More
23537049    25401762    28004739    26823975    24495485    12364791    20966253    25348373    17994087    10556052    10744979    10731132    12537572    12537569    15674283    17018572    19633175    21730168    20538977    22334675    22936249    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25315136    15632085   

EMBL

NWSH01000048    PCG80216.1    KQ461191    KPJ07132.1    AGBW02014499    OWR41562.1    + More
ODYU01001794    SOQ38482.1    KQ971343    EFA04670.1    LJIG01016322    KRT80948.1    GBBI01003559    JAC15153.1    DS235093    EEB11808.1    GFDF01007178    JAV06906.1    GEBQ01027988    JAT11989.1    APGK01037113    KB740948    ENN77226.1    GFDF01007171    JAV06913.1    GFDF01007177    JAV06907.1    KB631899    ERL86995.1    GEBQ01013015    JAT26962.1    GEBQ01026207    JAT13770.1    GBHO01009952    JAG33652.1    GEDC01017970    GEDC01014285    JAS19328.1    JAS23013.1    GEZM01083788    JAV61008.1    JXJN01001596    GDHC01017422    GDHC01004675    JAQ01207.1    JAQ13954.1    GFTR01008007    JAW08419.1    GBHO01010874    JAG32730.1    GBRD01014737    JAG51089.1    GBHO01010876    JAG32728.1    GAMC01018077    JAB88478.1    GGFM01004111    MBW24862.1    AAAB01008964    GGFM01003411    MBW24162.1    GGFM01002763    MBW23514.1    GGFM01003044    MBW23795.1    EAA12347.4    GECU01002574    GECU01001141    JAT05133.1    JAT06566.1    CCAG010003667    GDHF01013721    GDHF01003707    GDHF01002631    JAI38593.1    JAI48607.1    JAI49683.1    GAKP01021430    GAKP01021426    JAC37522.1    GECU01013014    JAS94692.1    KA646262    AFP60891.1    GDHF01013547    JAI38767.1    GECU01010755    JAS96951.1    GDHF01031407    JAI20907.1    GDHF01005986    JAI46328.1    GDHF01023960    JAI28354.1    CH954179    KQS61841.1    AF184975    AF184976    AJ238876    AE014134    AY075586    AY089503    BT016094    AAF23615.1    AAF53884.2    AAL90241.1    AAV36979.1    CAB62901.1    BT122081    ADE06687.1    GAKP01021432    GAKP01021429    JAC37520.1    CM002910    KMY91148.1    CH902620    KPU73430.1    GGFL01003540    MBW67718.1    AFH03776.1    AHN54614.1    CM000158    KRJ99220.1    GGFL01003539    MBW67717.1    KQS61842.1    KMY91145.1    AFH03775.1    EDV54560.2    KPU73427.1    GGFJ01001087    MBW50228.1    GGFL01003678    MBW67856.1    ACZ94306.1    KMY91144.1    KPU73428.1    KMY91146.1    CH480833    EDW46334.1    CH379061    KRT04719.1    KRJ99223.1    EDV31476.1    EDW90511.2    KRJ99222.1    CH933807    KRG03443.1    CH940649    KRF81547.1    KRG03442.1    OUUW01000006    SPP81812.1    SPP81813.1    GFAH01000588    JAV47801.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000007266    UP000009046    UP000019118    + More
UP000030742    UP000092460    UP000075880    UP000192223    UP000092443    UP000007062    UP000075882    UP000092444    UP000095300    UP000008711    UP000192221    UP000000803    UP000007801    UP000092445    UP000002282    UP000095301    UP000001292    UP000001819    UP000069272    UP000009192    UP000008792    UP000268350   

PRIDE

Q9U1K1    E1JHM3   

Pfam

PF16474   KIND        + More
PF02205   WH2
PF00085   Thioredoxin

Interpro

IPR003124   WH2_dom        + More
IPR029901   Spire       
IPR011019   KIND_dom       
IPR011011   Znf_FYVE_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR013766   Thioredoxin_domain       
IPR017937   Thioredoxin_CS       
IPR036249   Thioredoxin-like_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF57903   SSF57903        + More
SSF52833   SSF52833       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A2A4K886   A0A194QNP1   A0A212EJ87   A0A2H1VDK1   D6WL34   A0A0T6B177   + More
A0A023F1I2   E0VEK2   A0A1L8DKC5   A0A1B6KKK9   N6U997   A0A1L8DKB8   A0A1L8DKL4   U4UAK8   A0A1B6LTG1   A0A1B6KQR4   A0A0A9YKS1   A0A1B6DBE6   A0A1Y1KK75   A0A1B0APW5   A0A146L1U8   A0A224XK81   A0A0A9YT38   A0A0K8SDD1   A0A0A9YNP4   A0A182ILZ6   A0A1W4XLP9   A0A1A9YFM8   W8AV10   A0A2M3Z8N4   A0A1S4GXA3   A0A1S4GX95   A0A2M3Z6K7   A0A2M3Z4S3   A0A2M3Z5L7   Q7Q3Y6   A0A182L1I9   A0A1B6K544   A0A1B0FG44   A0A0K8WET9   A0A034V5V5   A0A1B6J6B1   T1PBW9   A0A0K8VIT6   A0A1B6JCF7   A0A0K8U2H9   A0A0K8W560   A0A0K8UNT8   A0A1I8NNS1   A0A0Q5VKH7   A0A1W4VKD4   Q9U1K1-4   D4G7C9   A0A034V6Y8   A0A0J9R4X4   A0A0P8XF04   A0A2M4CS86   A0A1B0AGV0   M9NFB6   A0A0R1DPV0   A0A2M4CQW5   A0A1W4VYD5   A0A0Q5VXR8   A0A0J9TRZ9   M9NDT9   B3NM24   A0A1W4VK57   A0A0P8XF93   A0A2M4BBN8   A0A1W4VKC9   A0A1I8N3Q5   A0A2M4CRA3   E1JHM3   A0A0J9R5Y0   A0A0N8NZ61   A0A0J9R571   B4IFB2   A0A0R3NZB9   A0A0R1DPL5   B3MK58   Q9U1K1-2   Q9U1K1   A0A3F2YQ69   B4PBJ7   A0A0Q9XIK0   A0A0Q9WL22   A0A0Q9XF29   A0A1I8P7S4   A0A3B0JN86   A0A3B0JLT5   A0A1W7R9I6  

PDB

4EFH     E-value=2.34038e-11,     Score=164

KEGG

101738498    K02098 spire | (RefSeq) protein spire

PATHWAY

04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0003779   GO:0045010   GO:0016192   GO:0016021   GO:0016301   GO:0045454   GO:0005623   GO:0007015   GO:0005938   GO:0005856   GO:0030659   GO:0005737   GO:0030036   GO:0051639   GO:0045451   GO:0007315   GO:0030029   GO:0048477   GO:0048471   GO:0007304   GO:0005886   GO:0015031   GO:0030717   GO:0051493   GO:0008017   GO:0007316   GO:0003676   GO:0051537   GO:0016020   GO:0008121   GO:0009331   GO:0005634   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR21345  

Subcellular location

Cytoplasm   Punctate spots in perinuclear region and cytoplasm.   With evidence from 8 publications.
Cytoskeleton   Punctate spots in perinuclear region and cytoplasm.   With evidence from 8 publications.
Perinuclear region   Punctate spots in perinuclear region and cytoplasm.   With evidence from 8 publications.
Cell membrane   Punctate spots in perinuclear region and cytoplasm.   With evidence from 8 publications.
Cytoplasmic vesicle membrane   Punctate spots in perinuclear region and cytoplasm.   With evidence from 8 publications.

SignalP

Position:   1 - 25,         Likelihood:  0.908850

 

 

Length:

291

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32091

Exp number, first 60 AAs:

0.31452

Total prob of N-in:

0.03177

outside

1  -  291

 

 

Pi

250.073185

Theta

173.332044

Tajima's D

1.677282

CLR

0.655339

CSRT

0.821308934553272

Interpretation

Uncertain