Gene

KWMTBOMO02253

Pre Gene Modal

BGIBMGA003099

Annotation

PREDICTED:_calcium/calmodulin-dependent_3'?5'-cyclic_nucleotide_phosphodiesterase_1A_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr4(-):14837771-14882891      View in EpiBrowser

Full name

Phosphodiesterase       + More
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1      

Location in the cell

Cytoplasmic   Reliability : 2.299 Nuclear   Reliability : 1.788

CDS

ATGGATGGTGCACTAACTTGTCCGGAGCAAGGCGCGCTGACAATCGTCCGCCGTTCTTCAAGCCGGAGTAAGACCGAGAGCTGCTCCACTCCTACTGACGAACAACTCGATCAGCTCGATCTAGAAACTGAACACTTGCCCGCCGTCGACACGCCCGACGCTTGCGATAAGGCCGCACTGAGATTACGCTATCTATTAAGACAATTAAACCGAGGTGAAATTTCTGCAGAGACTTTACAAAAGAACCTACAGTATGCTGCAAAAGTGCTTGAAGCTGTCTACATAGATGAGACCAAACGATTAGCTGATGAAGATGACGAGCTCTCTGAGGTACAGCCTGATGCGGTGCCCCCTGAGGTTCGCGAATGGCTGGCGTCGACATTCACAAGACAGCTGGCGACAGCCAAACGGAAGTCGGACGAGAAGCCAAAGTTCCGGTCGGTGGCCCATGCGATACGTGCCGGAATATTCGTCGACAGAATCTATCGCCGGGTGACCAGTACCGCTCTTATGCAGTTTCCTCAGGATGTCGTTAGAGTATTGAAGACGCTGGATGAATGGTCTTTCGACGTGTTCACTCTGCACGAGGCGGCCAACGGGCAACCGGTCAAATACTTAGGTTACGAACTGTTGAATCGATACGGAATGATTCATAAATTTAAGGTTCCTCCGACAATCTTAGAGAACTTCCTCGGCCGGATAGAGGAGGGCTACTGCAGGTTTCATAATCCCTACCACAATAACCTGCACGCCGCTGACGTCGCGCAAACCGTGCACTACATGCTGTGCCAGACCGGCCTTATGAACTGGCTCTCGGACCTGGAGATCTTCGCGACGCTGGTAGCCGCCGTGGTCCACGACTACGAGCACACGGGCACGACTAACAACTTCCACGTGATGTCCGGCTCGGACACCGCCCTGCTCTACAACGACAGGGCCGTGCTGGAGAACCATCACATCAGCGCCGCCTTCAGGTTAATGCGCGAAGAAGAATACAATATACTCCAGAATCTATCCCGGGATGAGTTTCGCGAATTTCGTACGCTTGTGATCGATATGGTGCTGGCGACCGACATGTCCTTCCACTTCCAGCAACTGAAGAACATGAGATCGCTTCTGTCCCTCGCAGAGCCAACCATAGACAAATCGAAGGCTACATCTCTGGTGCTCCATTGCTGCGACATTTCGCACCCTGCTAAGAGATGGGATCTCCACCACCGATGGACAATGAGTCTCTTGGATGAGTTTTTCCTCCAAGGTGACAAAGAACGAGATCTTGGTCTGCCCTTTAGTCCGCTCTGCGACAGAAATAATACTCTGGTGGCGGAATCCCAAATTGGTTTCATTGAGTTCATCGTGGAGCCCAGCATGGGAGTTTGTGCAGACATGCTGGAATGCATTTTGGGGCCTCTGCACTCCGGCAATAAATCCGGAACTAATGCAGCGACTGAACCGACTATTGATGAAAATTCGGGCGCCGAGAGTGTTAACAAATTCAAGATAAGGAAACCTTGGATTACCTGTCTCAGTGACAATAAGAAGATATGGAAGGAGCAAGCTACTAAAGACGCCGAGGCCCGAGCCAACCAGGAGCAGGAGGAGAACATAGAGGTTCAGCCTCCACCAGAAGAATAA

Protein

MDGALTCPEQGALTIVRRSSSRSKTESCSTPTDEQLDQLDLETEHLPAVDTPDACDKAALRLRYLLRQLNRGEISAETLQKNLQYAAKVLEAVYIDETKRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATAKRKSDEKPKFRSVAHAIRAGIFVDRIYRRVTSTALMQFPQDVVRVLKTLDEWSFDVFTLHEAANGQPVKYLGYELLNRYGMIHKFKVPPTILENFLGRIEEGYCRFHNPYHNNLHAADVAQTVHYMLCQTGLMNWLSDLEIFATLVAAVVHDYEHTGTTNNFHVMSGSDTALLYNDRAVLENHHISAAFRLMREEEYNILQNLSRDEFREFRTLVIDMVLATDMSFHFQQLKNMRSLLSLAEPTIDKSKATSLVLHCCDISHPAKRWDLHHRWTMSLLDEFFLQGDKERDLGLPFSPLCDRNNTLVAESQIGFIEFIVEPSMGVCADMLECILGPLHSGNKSGTNAATEPTIDENSGAESVNKFKIRKPWITCLSDNKKIWKEQATKDAEARANQEQEENIEVQPPPEE

Description

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15673286). Required for male fertility and male mating behavior (PubMed:20551439).

Catalytic Activity

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)

Cofactor

a divalent metal cation

Biophysicochemical Properties

15.3 uM for cGMP
20.5 uM for cAMP

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Alternative splicing   Behavior   cAMP   cGMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
splice variant  In isoform C.

Uniprot

H9J0R2   A0A194PMC9   A0A2W1BRM0   A0A151JXU5   A0A151HZH2   A0A151IDW8   + More
E9IA42   A0A2A4J8S1   A0A154PFH1   A0A0L7RFY0   A0A151WS11   A0A146L145   A0A195EDA8   A0A1B6EBY1   K7IPZ8   A0A224XBF1   A0A1B6BYA4   A0A3L8D4P3   A0A0A9XIP6   A0A0A1WXK7   W8ASS9   A0A034VRC9   A0A067R622   A0A087ZWK2   E2A8S4   E2BBA7   A0A158NIF6   A0A310SH68   A0A026WWL0   A0A182LML7   A0A0Q9WA74   A0A0R3NU05   A0A084WQK0   A0A0R3P0H6   M9NF02   A0A0J9R105   A0A0J9R124   A0A0R1DRF1   A0A182QFA9   A0A0R1DK82   A0A182NUQ0   A0A0Q5WAP5   A0A0Q9WA77   A0A0P8XY04   A0A1B6KBN5   A0A0K8VVL3   A0A0R3NZG6   A0A182M968   B7YZV3   A0A1J1ILK9   A0A0J9R117   A0A0Q5WNW0   A0A1I8NIL7   A0A0P8XHM0   A0A182TDE4   A0A1I8PGH1   A0A0K8UGZ5   B4JR30   A0A0K8TWI6   W8B7P2   A0A0Q9WKH3   A0A0Q9WBF6   A0A0Q9WHC3   T1IN43   A0A0Q9WMH1   B4KIV6   A0A0Q9WA54   A0A0R3NTT5   A0A2S2N8D3   A0A0R3NTU7   A0A0R3NYR5   A0A0R3NTC2   A0A0R3NYG7   X1WIQ2   A0A0R3NTJ3   A0A0R3NT72   A0A0R3NZ09   B4GPR5   B4Q398   B7YZV4-2   B4MVY8   B4HX83   A0A0R3NTG6   B7YZV1   M9PDA0   A0A0R1DK37   A0A0J9R100   B7YZV2   A0A0J9TLL5   A0A0J9R0M6  

EC Number

3.1.4.-
3.1.4.17

Pubmed

19121390    26354079    28756777    21282665    26823975    20075255    + More
30249741    25401762    25830018    24495485    25348373    24845553    20798317    21347285    24508170    20966253    17994087    15632085    24438588    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    17550304    25315136    12537569    15673286    20551439   

EMBL

BABH01010227    BABH01010228    BABH01010229    BABH01010230    KQ459598    KPI94591.1    + More
KZ150000    PZC75316.1    KQ981607    KYN39385.1    KQ976695    KYM77576.1    KQ977939    KYM98535.1    GL761987    EFZ22551.1    NWSH01002627    PCG67812.1    KQ434893    KZC10585.1    KQ414599    KOC69743.1    KQ982796    KYQ50608.1    GDHC01017533    JAQ01096.1    KQ979074    KYN23081.1    GEDC01001856    JAS35442.1    GFTR01006680    JAW09746.1    GEDC01031031    JAS06267.1    QOIP01000014    RLU15111.1    GBHO01023022    JAG20582.1    GBXI01010690    JAD03602.1    GAMC01017315    GAMC01017313    GAMC01017307    JAB89242.1    GAKP01013101    JAC45851.1    KK852670    KDR18814.1    GL437663    EFN70153.1    GL446968    EFN87015.1    ADTU01016402    ADTU01016403    ADTU01016404    ADTU01016405    ADTU01016406    ADTU01016407    ADTU01016408    ADTU01016409    ADTU01016410    ADTU01016411    KQ769895    OAD52782.1    KK107083    EZA60096.1    CH940649    KRF81624.1    CH379060    KRT04412.1    ATLV01025637    KE525396    KFB52494.1    KRT04406.1    AE014134    AFH03668.1    CM002910    KMY89826.1    KMY89823.1    CM000157    KRJ97593.1    AXCN02000736    KRJ97592.1    CH954177    KQS70534.1    KRF81625.1    CH902624    KPU74341.1    GEBQ01031114    GEBQ01014034    JAT08863.1    JAT25943.1    GDHF01009400    JAI42914.1    KRT04416.1    AXCM01003796    ACL83025.2    CVRI01000054    CRL00642.1    KMY89818.1    KQS70536.1    KPU74342.1    GDHF01026375    JAI25939.1    CH916372    EDV99360.1    GDHF01033661    JAI18653.1    GAMC01017309    JAB89246.1    KRF81620.1    KRF81622.1    KRF81623.1    JH431140    KRF81621.1    CH933807    EDW12462.1    KRF81619.1    KRT04409.1    GGMR01000719    MBY13338.1    KRT04410.1    KRT04413.1    KRT04408.1    KRT04415.1    ABLF02037443    ABLF02037445    ABLF02037449    ABLF02037456    ABLF02037457    ABLF02037458    ABLF02037459    KRT04411.1    KRT04414.1    KRT04405.1    CH479187    EDW39587.1    CM000361    EDX04729.1    AY118396    AAM48425.1    CH963857    EDW75858.2    CH480818    EDW52628.1    KRT04407.1    ACL83024.1    AGB92930.1    KRJ97594.1    KMY89821.1    ACL83023.1    KMY89820.1    KMY89822.1   

Proteomes

UP000005204    UP000053268    UP000078541    UP000078540    UP000078542    UP000218220    + More
UP000076502    UP000053825    UP000075809    UP000078492    UP000002358    UP000279307    UP000027135    UP000005203    UP000000311    UP000008237    UP000005205    UP000053097    UP000075882    UP000008792    UP000001819    UP000030765    UP000000803    UP000002282    UP000075886    UP000075884    UP000008711    UP000007801    UP000075883    UP000183832    UP000095301    UP000075902    UP000095300    UP000001070    UP000009192    UP000007819    UP000008744    UP000000304    UP000007798    UP000001292   

PRIDE

H9J0R2    B7YZV4    B7YZV1   

Pfam

PF08499   PDEase_I_N        + More
PF00233   PDEase_I

Interpro

IPR023174   PDEase_CS        + More
IPR023088   PDEase       
IPR013706   PDEase_N       
IPR002073   PDEase_catalytic_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR003607   HD/PDEase_dom       

Gene 3D

1.10.1300.10    

CDD

cd00077  HDc

ProteinModelPortal

H9J0R2   A0A194PMC9   A0A2W1BRM0   A0A151JXU5   A0A151HZH2   A0A151IDW8   + More
E9IA42   A0A2A4J8S1   A0A154PFH1   A0A0L7RFY0   A0A151WS11   A0A146L145   A0A195EDA8   A0A1B6EBY1   K7IPZ8   A0A224XBF1   A0A1B6BYA4   A0A3L8D4P3   A0A0A9XIP6   A0A0A1WXK7   W8ASS9   A0A034VRC9   A0A067R622   A0A087ZWK2   E2A8S4   E2BBA7   A0A158NIF6   A0A310SH68   A0A026WWL0   A0A182LML7   A0A0Q9WA74   A0A0R3NU05   A0A084WQK0   A0A0R3P0H6   M9NF02   A0A0J9R105   A0A0J9R124   A0A0R1DRF1   A0A182QFA9   A0A0R1DK82   A0A182NUQ0   A0A0Q5WAP5   A0A0Q9WA77   A0A0P8XY04   A0A1B6KBN5   A0A0K8VVL3   A0A0R3NZG6   A0A182M968   B7YZV3   A0A1J1ILK9   A0A0J9R117   A0A0Q5WNW0   A0A1I8NIL7   A0A0P8XHM0   A0A182TDE4   A0A1I8PGH1   A0A0K8UGZ5   B4JR30   A0A0K8TWI6   W8B7P2   A0A0Q9WKH3   A0A0Q9WBF6   A0A0Q9WHC3   T1IN43   A0A0Q9WMH1   B4KIV6   A0A0Q9WA54   A0A0R3NTT5   A0A2S2N8D3   A0A0R3NTU7   A0A0R3NYR5   A0A0R3NTC2   A0A0R3NYG7   X1WIQ2   A0A0R3NTJ3   A0A0R3NT72   A0A0R3NZ09   B4GPR5   B4Q398   B7YZV4-2   B4MVY8   B4HX83   A0A0R3NTG6   B7YZV1   M9PDA0   A0A0R1DK37   A0A0J9R100   B7YZV2   A0A0J9TLL5   A0A0J9R0M6  

PDB

5W6E     E-value=1.03048e-104,     Score=972

KEGG

101736773    K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] | (RefSe

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0007165   GO:0004114   GO:0046872   GO:0016787   GO:0005516   GO:0060179   GO:0032504   GO:0004115   GO:0048101   GO:0047555   GO:0005615   GO:0046058   GO:0046068   GO:0008081   GO:0006072   GO:0009331   GO:0005634   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

Length:

544

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00549

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00087

outside

1  -  544

 

 

Pi

249.668062

Theta

169.250427

Tajima's D

1.189844

CLR

1.096175

CSRT

0.719914004299785

Interpretation

Uncertain