Gene

KWMTBOMO02247

Pre Gene Modal

BGIBMGA003105

Annotation

PREDICTED:_trypsin_beta-like_[Bombyx_mori]

Location

Bomo_Chr4(-):14708044-14708621      View in EpiBrowser

Full name

Inactive serine protease scarface      

Location in the cell

Extracellular   Reliability : 1.587 PlasmaMembrane   Reliability : 1.483

CDS

ATGAATAATCTGTTGTTATATTTATACGTTTTAACTGTCCTCGGGCCATTTGCTTTATCGAAACACACAAATGTTACTAAAGATTTGGAACCTCTGATTTACAAAGGATACGAAGTTGGAATACACGATTATTCCTACGCTTGTTTTCTGCATTTCAAAACCACCAGGCCGACTTCGTGTGGAGCTTCCCTTATAATGGTCCAAGCTGTTCTGACGGCAGCGCACTGCATGGACGATATCCGGATCAAGAGCGGCGAAATTCACGCGTTTTTCGGATCAAACGTACCAAAAGATTCTTCGGTTATCAGAAGAGTCGGGAATTATGAAATAAATCCAAAATATAATGAGGTGAATGGTAAGAACAATCTGGCAGTGGCGTTTCTGGATTATAGAGTACCACTTCGGCAGGGCATCAAGAAGATCCCGCTGTCAATCAGAGATCCAGTGCCACGAACTGATCTGTTTTCAGTGGGTTGGGGCAAACAAAGCGTAAGTAAACTATATTCTCAATTTCTACATTAG

Protein

MNNLLLYLYVLTVLGPFALSKHTNVTKDLEPLIYKGYEVGIHDYSYACFLHFKTTRPTSCGASLIMVQAVLTAAHCMDDIRIKSGEIHAFFGSNVPKDSSVIRRVGNYEINPKYNEVNGKNNLAVAFLDYRVPLRQGIKKIPLSIRDPVPRTDLFSVGWGKQSVSKLYSQFLH

Description

Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium (PubMed:28628612, PubMed:20379222). Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways (PubMed:28628612, PubMed:20379222). In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development (PubMed:20379222, PubMed:20530545, PubMed:25737837).

Similarity

Belongs to the peptidase S1 family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Reference proteome   Secreted   Serine protease homolog   Signal  

Feature

chain  Inactive serine protease scarface

Uniprot

D9HQ67   D9HQ25   A0A212FKN2   T1GDM2   R4G2C0   R4G7C9   + More
T1GQB9   B4KXH6   A0A0U5GTC1   A0A1I8MTT1   T1P882   A0A1B0BUI5   G4YJG1   B6Z1X6   A0A1Q1NPF7   W5LWA6   A0A1W4V7B4   A0A1Q1NPF4   A0A1Q1NPI1   A0A1Q1NP77   A0A1W4V5K3   A0A0K8SCH7   A0A146LZD5   A0A034VGE4   A0A0A9W4V0   A0A1A9WYS8   B4N135   A0A034VKN4   A0A3P8NRS8   A0A3P8NRG2   A0A1A9XIV4   A0A1B0FAF0   A0A2V1DTG0   A0A1I8NNQ7   A0A1A9US87   A0A182FUP8   A0A1A9ZAW2   R0JV69   B3MBQ9   A0A218UA67   B4L9R3   T1GQ14   A0A0P9C129   W5LXF7   A7DYW0   A0A310SCG7   Q0GSS5   A7DYV6   Q0GSS6   Q0GSS7   U3IJ08   A0A3P9CA61   A0A0A1XLZ0   A0A2K8JSL6   A0A0K8WBX2   I3K9X1   A0A1D5P7Y3   A7DYV9   A7DYW5   K7FZ69   Q0GST3   Q0GST5   A0A0J9R7H1   A7DYV7   A0A182FUP6   Q7K5M0   Q9VQA0   A0A0J9TTW9   L0ATN6   B4II01   A0A1B6MUX8   I3K8H2   V8NPI1   A0A336LFU1   A0A0L8HT00   A0A3M7R237   A0A182N2U4   A0A1J1I662   A7DYW3   A0A1A7XCF2   A0A3B4AJ83   A0A1A9WAU6   A0A0L7R7Y2  

Pubmed

20375075    22118469    17994087    25315136    16946064    19294452    + More
28130397    26823975    25348373    25401762    29679020    17573377    16783023    23749191    25186727    25830018    15592404    17381049    22936249    10731132    12537572    12537569    15342518    20379222    20530545    25737837    28628612    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24297900    30375419    25463417   

EMBL

HM023822    ADJ58555.1    HM023780    ADJ58513.1    AGBW02008010    OWR54307.1    + More
CAQQ02093592    GAGI01000010    JAA74559.1    GAGI01000011    JAA74558.1    CAQQ02035930    CH933809    EDW18662.2    CDMC01000006    CEN62071.1    KA644802    AFP59431.1    JXJN01020710    JH159151    EGZ29916.1    EU790599    ACJ22645.1    KX459638    AQM58389.1    KX459645    AQM58396.1    KX459663    AQM58414.1    KX459571    AQM58322.1    GBRD01015002    JAG50824.1    GDHC01005675    JAQ12954.1    GAKP01016576    JAC42376.1    GBHO01041168    JAG02436.1    CH963920    EDW78197.1    GAKP01016577    JAC42375.1    CCAG010019386    CCAG010019387    CCAG010019388    KZ805371    PVI00574.1    KB743121    EOB01127.1    CH902619    EDV38205.2    MUZQ01000559    OWK50390.1    CH933816    EDW17111.1    CAQQ02143884    KPU77319.1    AM765862    CAO78763.1    KQ764252    OAD54568.1    DQ539273    DQ539274    DQ539275    DQ539276    DQ539277    DQ539280    AM765864    ABG02794.1    ABG02795.1    ABG02796.1    ABG02797.1    ABG02798.1    ABG02801.1    CAO78765.1    AM765858    CAO78759.1    DQ539279    ABG02800.1    DQ539278    AM765863    ABG02799.1    CAO78764.1    ADON01075126    ADON01075127    ADON01075128    ADON01075129    ADON01075130    ADON01075131    GBXI01001973    JAD12319.1    KY031181    ATU82932.1    GDHF01003626    JAI48688.1    AERX01012107    AERX01012108    AADN05000689    AM765861    CAO78762.1    AM765867    CAO78768.1    AGCU01052657    DQ539271    DQ539272    AM765866    ABG02792.1    ABG02793.1    CAO78767.1    DQ539244    DQ539245    DQ539246    DQ539247    DQ539248    DQ539249    DQ539250    DQ539251    DQ539252    DQ539253    DQ539254    DQ539255    DQ539256    DQ539258    DQ539261    DQ539262    DQ539263    DQ539264    DQ539265    DQ539266    DQ539267    DQ539268    DQ539269    DQ539270    AM765857    AM765868    AM765869    AM765870    AM765871    AM765872    AM765873    AM765874    AM765875    AM765876    ABG02765.1    ABG02766.1    ABG02767.1    ABG02768.1    ABG02769.1    ABG02770.1    ABG02771.1    ABG02772.1    ABG02773.1    ABG02774.1    ABG02775.1    ABG02776.1    ABG02777.1    ABG02779.1    ABG02782.1    ABG02783.1    ABG02784.1    ABG02785.1    ABG02786.1    ABG02787.1    ABG02788.1    ABG02789.1    ABG02790.1    ABG02791.1    CAO78758.1    CAO78769.1    CAO78770.1    CAO78771.1    CAO78772.1    CAO78773.1    CAO78774.1    CAO78775.1    CAO78776.1    CAO78777.1    CM002911    KMY91639.1    AM765859    CAO78760.1    AE013599    AY047548    AAK77280.1    AE014134    AY060796    AAF51277.1    AAL28344.1    KMY91640.1    JX915894    AFZ78860.1    CH480841    EDW49527.1    GEBQ01011698    GEBQ01000257    JAT28279.1    JAT39720.1    AERX01017497    AZIM01002473    ETE63965.1    UFQS01005297    UFQT01005297    SSX16784.1    SSX35971.1    KQ417459    KOF91865.1    REGN01004409    RNA17643.1    CVRI01000038    CRK93881.1    AM765865    CAO78766.1    HADW01014130    SBP15530.1    KQ414637    KOC66990.1   

Proteomes

UP000007151    UP000015102    UP000009192    UP000054771    UP000095301    UP000092460    + More
UP000002640    UP000018468    UP000192221    UP000091820    UP000007798    UP000265100    UP000092443    UP000092444    UP000244855    UP000095300    UP000078200    UP000069272    UP000092445    UP000007801    UP000197619    UP000016666    UP000265160    UP000005207    UP000000539    UP000007267    UP000000803    UP000001292    UP000053454    UP000276133    UP000075884    UP000183832    UP000261520    UP000053825   

PRIDE

Q0GSS5    Q0GSS6    Q0GSS7    Q0GST3    Q0GST5    Q7K5M0    + More
Q9VQA0   

Pfam

PF00089   Trypsin        + More
PF18399   CLIP_SPH_Scar
PF12032   CLIP
PF15494   SRCR_2
PF01390   SEA
PF00431   CUB
PF00629   MAM
PF00057   Ldl_recept_a
PF00530   SRCR

Interpro

IPR009003   Peptidase_S1_PA        + More
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR001314   Peptidase_S1A       
IPR033116   TRYPSIN_SER       
IPR040973   CLIP_SPH_Scar       
IPR035914   Sperma_CUB_dom_sf       
IPR038565   CLIP_sf       
IPR022700   CLIP       
IPR033040   GZMM       
IPR001190   SRCR       
IPR000859   CUB_dom       
IPR013320   ConA-like_dom_sf       
IPR017448   SRCR-like_dom       
IPR000998   MAM_dom       
IPR023415   LDLR_class-A_CS       
IPR036364   SEA_dom_sf       
IPR036772   SRCR-like_dom_sf       
IPR002172   LDrepeatLR_classA_rpt       
IPR036055   LDL_receptor-like_sf       
IPR000082   SEA_dom       

SUPFAM

SSF50494   SSF50494        + More
SSF49854   SSF49854       
SSF57424   SSF57424       
SSF49899   SSF49899       
SSF82671   SSF82671       
SSF56487   SSF56487       

Gene 3D

2.60.120.290     2.20.20.90     3.10.250.10     3.30.70.960     4.10.400.10    

CDD

cd00190  Tryp_SPc
cd06263  MAM
cd00041  CUB
cd00112  LDLa

ProteinModelPortal

D9HQ67   D9HQ25   A0A212FKN2   T1GDM2   R4G2C0   R4G7C9   + More
T1GQB9   B4KXH6   A0A0U5GTC1   A0A1I8MTT1   T1P882   A0A1B0BUI5   G4YJG1   B6Z1X6   A0A1Q1NPF7   W5LWA6   A0A1W4V7B4   A0A1Q1NPF4   A0A1Q1NPI1   A0A1Q1NP77   A0A1W4V5K3   A0A0K8SCH7   A0A146LZD5   A0A034VGE4   A0A0A9W4V0   A0A1A9WYS8   B4N135   A0A034VKN4   A0A3P8NRS8   A0A3P8NRG2   A0A1A9XIV4   A0A1B0FAF0   A0A2V1DTG0   A0A1I8NNQ7   A0A1A9US87   A0A182FUP8   A0A1A9ZAW2   R0JV69   B3MBQ9   A0A218UA67   B4L9R3   T1GQ14   A0A0P9C129   W5LXF7   A7DYW0   A0A310SCG7   Q0GSS5   A7DYV6   Q0GSS6   Q0GSS7   U3IJ08   A0A3P9CA61   A0A0A1XLZ0   A0A2K8JSL6   A0A0K8WBX2   I3K9X1   A0A1D5P7Y3   A7DYV9   A7DYW5   K7FZ69   Q0GST3   Q0GST5   A0A0J9R7H1   A7DYV7   A0A182FUP6   Q7K5M0   Q9VQA0   A0A0J9TTW9   L0ATN6   B4II01   A0A1B6MUX8   I3K8H2   V8NPI1   A0A336LFU1   A0A0L8HT00   A0A3M7R237   A0A182N2U4   A0A1J1I662   A7DYW3   A0A1A7XCF2   A0A3B4AJ83   A0A1A9WAU6   A0A0L7R7Y2  

PDB

4DGJ     E-value=3.7221e-06,     Score=116

KEGG

105842305    no KO assigned | (RefSeq) trypsin beta-like

GO

GO:0004252   GO:0046658   GO:0019897   GO:0016021   GO:0008236   GO:0008219   GO:0005044   GO:0016020   GO:0048803   GO:0045197   GO:0055037   GO:0005770   GO:0007390   GO:0090099   GO:0007394   GO:0005615   GO:0016324   GO:0048802   GO:0005769   GO:0006508   GO:0007560   GO:0005737   GO:0050793   GO:0007391   GO:0005576   GO:0004368   GO:0006072   GO:0009331   GO:0005634   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR24271:SF51  

Subcellular location

Secreted  

SignalP

Position:   1 - 20,         Likelihood:  0.979522

 

 

Length:

173

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.21684

Exp number, first 60 AAs:

2.97715

Total prob of N-in:

0.12658

outside

1  -  173

 

 

Pi

134.468775

Theta

151.653333

Tajima's D

-0.35623

CLR

0

CSRT

0.28263586820659

Interpretation

Uncertain