SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO02240
Pre Gene Modal
BGIBMGA003106
Annotation
PREDICTED:_histone-lysine_N-methyltransferase_SETD2_isoform_X2_[Bombyx_mori]
Location
Bomo_Chr4(-):14500537-14514815      View in EpiBrowser
Full name
Histone-lysine N-methyltransferase      
Location in the cell
Nuclear   Reliability : 3.923
 

Sequence

CDS
ATGGCGAAGCGAAAGAAGGCTGCGACAAGGACTGTCGCGACGAGGCGCACTAGTCGGCGCGGGAAACAGACGAGTAGTGTCGCGCCTACTGAGGGCGAGCCCTCTGCGTCCGTCGAAGCCACAGCCGAAAATAACGAGCCTCCGTCTCCTCAGCCCAGTACCTCTGAGCTCCAGTCAGGATCCAATGATGACCACAATATCTCAGAATCACAACCATCAGAGATACAGGAGACAACCTCTAAACCCAACCCTGTTCCAATCATTTCATTGCACAAGAAGTTTGGCAAATACAGATGTTTGTTCAATAGTGATGATGCATTTCTTAGAAAATATGAAATTGGGAGTGATAGTGAAACCAACAGTAGTATGGAAATTAGAATAGTTGACCCATGTGCCAGCTCTGAGTCTGATTCAAATGCTGCAATAGATACACAATCAGATACAAACAGTGTTGTTTGTATCAGTCCAATGAACAGTGTTACAAATGTAGTGCAGTGTAGCTCAAGAGATATATCACCTTTGACTGTAATACATCAAGCCTCTGAAAATCATGAACGAGAGTTGGATGAGCAAAAAAATAGGGATCTGGAGTCTCCTTCAATATTAGATGATAATTCTCAAATCACTGATGATTTTGATGAAAAGATTGAGATCACAAGGAAAGAAAGCCCTGTGATGATTGAAACAGATGCTCTTTCAAAAGAAGCAATTTCATCTAAAAATCAAGATTTATGTCCACAATATAATGAAACTGATCATAGTATTCTTCTGGAGGATGACCAAGTGGACTACAATTGTGATGATGAGGAAATAATAACAGTTGTACAAATAGTTGAAGATGACAATCCAGAACTTTACTATGACATCAAAATAGATAGCCCAAAGGTTAATGCAGGAGAATTCGAACAAGAGCAAAGTAAAAAGTCTCAGGAGATAGATTTTCAGAGACATTTTCAGAATTTAAAATTGAATTCAATTGCTGAATCCACCTCTCCAATGGAATGTTCAGAAATTATTGATATTACAACACCATGTGGCACTCCAGATCTCCAACCACCCAAAGACAGTTTGAATGATCTGTTAATAAGACCAGATCCTAGTTTGACACCTAGTTCAACTCTATCAGACGATAGTAATTGTTCTCGGGCAGATCACATTCAAAACAACTCTAATGATTCAGCTGAGTCATCACCAACAGGGGTACGCAGGTCGAATCGTATAAAAACAATAAGTAATCTCAAACAAAAAACTAAAGGTTATGGTCTAGTAAAGACCCCACTGAAAAAGGCTCTGATAACTCAAACAAAGTTAAAATTAGAAGAAATTGGATCTGACAGTCAGGAGAAATTTAGTGATCAGGGTAACACAGCTCCAAATTCTCCTTCGTTTCCAGTTCCATCAGAGATGCCTGTAAAAGTAAAGTCTAGGTGGAGGCGGTCTAGTGAGTTAGAAATGGGAACAAACTCTCCTGCTAGCTCACCATTAGCTAGTCCAGGTCTGCCCCAACGTATGCCGGCTGTGAATGAAGGGAATGAAAGTGAAGAGCAGGAGTCTGTAGCTCTAAGTAAAGAAGCATATGATAAAATAATCGAAGACAGAATGAATCAGTACCAGCATTTAGATGAGAATGAGTATTTATGTGAAAGGATGATTAGTAAGGAAACTAAGAAAATGATCTGTGACTGTTTCATGACCAAAGAAGAGTTAGAACGCGGTGAACTAGCATGCGGTGAAGATTGTCTTAATAGACTACTTATGATTGAATGTAACTCCAGATGTCCTGTAGGAGATCGTTGTACAAATAGAAGGTTCCAGAAGAGAGAGAATGCTGCTATAAAAGTTTTCTATGCGGACAAAAAAGGCTGTGGAGTTGAAGCTAATGTGGACATACCAACGGGTGAATTTCTGATGGAATATGTTGGGGAAGTACTAGATTATGAACAATTCTACAAACGCGCTCAAGCGTATTCGGATGAAAATAATCTCCATCACTACTTCATGTCTCTAAAAGGTGATACGGTAATAGATGCTACGATGAAGGGGAATATATCAAGATTTATCAATCACTCGTGCGATCCTAATGCTGAGACGCAGAAGTGGACCGTGAATGGAGAGCTGAGGATTGGATTCTTCAGTAAAAGAGATATTGTAGTCGGAGAGGAGATCACATTTGATTACCAGTTCCAGAGGTTTGGGAAGGTCGCTCAGCGCTGTTATTGCGGCACCGACAACTGTCGCGGCTGGATCGGTGGCGAACCTGACTCTGACGACGAATATGATGACGAGGAGGAGGAAGATGTGTCCACGTCAAAGTCTAGTACGTCTGAAGGGGCGCAGTCCGAGTCGACGAGCGCGGAGCAGCCGCTGCCGAAGCCTCGTAAGCCGAAACGTGACCGCAAATATAAACCTAAGCCGCCCGAACTTGAACAGGACGCTGACATTGAAGAAGATTTAGAAGCATTAAATCGCACTGGCGTGAAGAATCAATCGCATACGTTGCGGCTTTCTCGTACAGTTGTCCGTGCCAAGGGACGAAAAGCGCAGATAGCTTTACTAAGACTGCTCAGAGACGCAGATCTGCCATGTCGAAGACTATTCTTGGACTACAGGGGTCTGAGATTATTGGCGCCTTGGTGTACTGATGCTCCGTTAGACTTCAAATTGGAAATGCTGCAGACAGTAGATCGGTTGCCAATCCCGAACAAGACACTGGTTCAAGAAAGCCGTTTCTTTATAATTGTGGAGCGTTGGTTGAGTACGGCGGACACTCTACCAGATAACAATGTATTCATTGATGAAGCCACCGGTTTGCCCATTGACTTACCAAATGGACCAAATCCAGAATCTGCTGTGAGTCCAGACAAGATAAAGGAAAATATGAACATCGTCGAGAAAATAAAGGATCTATCGAGCCAATTGCTTGAACGATGGTCCAGTTTAAAGGAAGTTTTTAAAATACCTAAGAAAGAGAGAATACAACAAATGAAAGAACATGAACGTCAAGCTAATGTAGAACGACGTGCTGCTGACTCGAGCGGTTCCAGAGATAGGGATAGAGAAAGAGATAGAAGAGAAGAGAGAGATAGGGAAAGAGAAAAGGAAAGGGAACGCGATAGAGAAAGGGAAAGAGAACGAGAACGTGACAGGGAACGTGAACGGGAAAAGGAGAAAGAGAGAGAAAGAGACAGACATAGGGAGAGAGAAAGAGACCGTGACAGGGATAGAGATAGAGATGACAGGGATAGAAGAAAAAGAAGAGTTAGTCCCGAGGGAAGGAGAAGTATTCGTTTAAGTGAAAGAGTACTGGCGGCCGTGCCTCCCATGTCGAAGGAGGAACGCAGACGGGCGTTCGCGGAGGCGGCCGCCGCGGCCGAGGAGACGCGCCGCCAGCGGGAGCAGCGCCCGCCGTGGCCCGGCTACTGGCCCCACGAACAGTTCTCGCCGATGTTTCCCGGTGGAATGATGGGCAATGGGAACATGATGGGCGGCATGATGCCGAACATGCCGGCCAACATGTTGGGCTGCGTGCCTGACCTCCCTCAGGACTGGATGCAGCAGCACGAGTTTCCACCGCCGGGCTTCTGTCCCCCCTTCCCGCCTGCTCAGCCCTTCTGTATGCCGCAAGCTAATATGATGGGTATGAGCGGCTTCGGTGTTGGCGGCTTCATGTACGGACAGCAGATGGCGCCGTTCCCGCAGCCACAAGAACCGCCGCTACCGAGCGCGCCGGTGCCCGCGGCGCCGCCCCCCGCGCCCCGGCCGCCGACGCTGAGCGACACGGGCGAGGTGCTGCTGCCGTCGCAGTGGCGCAGCACGGTGGACCCGCGCGGCCGCACCTACTACTACCACGTCAAGCTGCGCCAGCCGCAGTGGTACCCGCCGCCGCTGCCGCCCTCGCCGCCGCCCGGTAACTGTACTACTGCGGTTACAATACTATCTAGTCTTATGCATTTATTCACATCTTAA
Protein
MAKRKKAATRTVATRRTSRRGKQTSSVAPTEGEPSASVEATAENNEPPSPQPSTSELQSGSNDDHNISESQPSEIQETTSKPNPVPIISLHKKFGKYRCLFNSDDAFLRKYEIGSDSETNSSMEIRIVDPCASSESDSNAAIDTQSDTNSVVCISPMNSVTNVVQCSSRDISPLTVIHQASENHERELDEQKNRDLESPSILDDNSQITDDFDEKIEITRKESPVMIETDALSKEAISSKNQDLCPQYNETDHSILLEDDQVDYNCDDEEIITVVQIVEDDNPELYYDIKIDSPKVNAGEFEQEQSKKSQEIDFQRHFQNLKLNSIAESTSPMECSEIIDITTPCGTPDLQPPKDSLNDLLIRPDPSLTPSSTLSDDSNCSRADHIQNNSNDSAESSPTGVRRSNRIKTISNLKQKTKGYGLVKTPLKKALITQTKLKLEEIGSDSQEKFSDQGNTAPNSPSFPVPSEMPVKVKSRWRRSSELEMGTNSPASSPLASPGLPQRMPAVNEGNESEEQESVALSKEAYDKIIEDRMNQYQHLDENEYLCERMISKETKKMICDCFMTKEELERGELACGEDCLNRLLMIECNSRCPVGDRCTNRRFQKRENAAIKVFYADKKGCGVEANVDIPTGEFLMEYVGEVLDYEQFYKRAQAYSDENNLHHYFMSLKGDTVIDATMKGNISRFINHSCDPNAETQKWTVNGELRIGFFSKRDIVVGEEITFDYQFQRFGKVAQRCYCGTDNCRGWIGGEPDSDDEYDDEEEEDVSTSKSSTSEGAQSESTSAEQPLPKPRKPKRDRKYKPKPPELEQDADIEEDLEALNRTGVKNQSHTLRLSRTVVRAKGRKAQIALLRLLRDADLPCRRLFLDYRGLRLLAPWCTDAPLDFKLEMLQTVDRLPIPNKTLVQESRFFIIVERWLSTADTLPDNNVFIDEATGLPIDLPNGPNPESAVSPDKIKENMNIVEKIKDLSSQLLERWSSLKEVFKIPKKERIQQMKEHERQANVERRAADSSGSRDRDRERDRREERDREREKERERDRERERERERDREREREKEKERERDRHRERERDRDRDRDRDDRDRRKRRVSPEGRRSIRLSERVLAAVPPMSKEERRRAFAEAAAAAEETRRQREQRPPWPGYWPHEQFSPMFPGGMMGNGNMMGGMMPNMPANMLGCVPDLPQDWMQQHEFPPPGFCPPFPPAQPFCMPQANMMGMSGFGVGGFMYGQQMAPFPQPQEPPLPSAPVPAAPPPAPRPPTLSDTGEVLLPSQWRSTVDPRGRTYYYHVKLRQPQWYPPPLPPSPPPGNCTTAVTILSSLMHLFTS

Summary

Catalytic Activity
L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Uniprot
H9J0R9   A0A2H1V5Y0   A0A0N1ID98   A0A0L7KWA5  
EC Number
2.1.1.43
Pubmed
19121390    26354079    26227816   
EMBL
BABH01010257    BABH01010258    BABH01010259    ODYU01000860    SOQ36260.1    KQ461183    + More
KPJ07564.1    JTDY01005124    KOB67346.1   
Proteomes
UP000005204    UP000053240    UP000037510   
PRIDE
H9J0R9   
Pfam
PF00856   SET        + More
PF17907   AWS
PF08236   SRI
Interpro
IPR003616   Post-SET_dom        + More
IPR042294   SETD2       
IPR001214   SET_dom       
IPR006560   AWS_dom       
IPR013257   SRI       
IPR001202   WW_dom       
IPR038190   SRI_sf       
IPR036020   WW_dom_sf       
SUPFAM
SSF51045   SSF51045       
Gene 3D
1.10.1740.100    
CDD
cd00201  WW
ProteinModelPortal
H9J0R9   A0A2H1V5Y0   A0A0N1ID98   A0A0L7KWA5  
PDB
5V22     E-value=1.16466e-73,     Score=708

Ontologies

KEGG
101738271    K11423 histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43] | (RefSeq) histone-lysine N-methyltran
PATHWAY
00310    Lysine degradation - Bombyx mori (domestic silkworm)
GO
GO:0018024   GO:0005634   GO:0005694   GO:0006355   GO:0005515   GO:0003697   GO:0004519   GO:0006289   GO:0004518   GO:0006281   GO:0048384  
PANTHER
PTHR46711  

Topology

Subcellular location
Nucleus  
Length:
1321
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.05192
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00002
outside
1  -  1321
 
 

Population Genetic Test Statistics

Pi
26.288595
Theta
223.81727
Tajima's D
0.017586
CLR
1.804459
CSRT
0.372631368431578
Interpretation
Uncertain
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