Gene

KWMTBOMO02233

Pre Gene Modal

BGIBMGA003111

Annotation

PREDICTED:_probable_serine_carboxypeptidase_CPVL_[Bombyx_mori]

Location

Bomo_Chr4(-):14392477-14401395      View in EpiBrowser

Full name

Carboxypeptidase       + More
Venom serine carboxypeptidase      
Probable serine carboxypeptidase CPVL      

Location in the cell

Extracellular   Reliability : 1.725

CDS

ATGTTGTTCATCGACAACCCTGTCGGCGCTGGCTTCAGCTTCACAGACAGTAACGATGGCTTCGTTAAAAATATGGATGAGTGCGCTTCGGATCTGTACACAGCTTTGAAACAATTCCTGATAATATTCCCCGAATTACGCACGGCACCACTGTACATTGCCGGTGAGTCGTACGCCGGGCGATACATTCCACCTTTTGCCATGAAATTGGCGGAGCAAGACCTCAACATTGGCACCTTTGAAGTCAATCTTCAGGGAATAATAATGGGAAATCCAGTGGTGGATCGTTACAGTGTTGCCAATTATACTTCCACGTTCCAGCAGTGGGGTCTAATAGACACGCAAGGAGCTATGTCAGTTAAATCTCTCCAAGATCAATACATTAAAGCCATATTGGACGGTGACGCGAGTGCTGCTTACGATTTACGCGACCAGTTGCTGTACAAACTGACTAAAATTACATTACAAAACCAATTTTTTAATGTACTAAAAAGCAATAAAGATCTTACGCTGTCTGAATTCGCGGCTTATCTACAAAAGAGTACAGTAAAAGAGGCACTCCACGTTGGAGACACAGATTTCTCCTTCATCAACACTACTGTAGACCTCGAGTTGAAGTCAGATTTCTTAACTGATATTGGAGGTACAGTCACAAAGTTATTAGAGCATTGCAAGGTATTAATATACTGCGGACAACTTGACTTGACCGCACCATGTGTACAGAGCGCCCAATATCGCAGACGCTATTGGCAGTGGAATAAAAAAGAACTTTTTCTTAGAGCGCCCAGAAGACCCTGGTTGCACAAGAATGTAGTAGCCGGGTACACCAAAAGTGGGGGTGGTTTTACAGAAGTTTTGGTGAAAGGAGCGGGTCATCTTGTACCCATAGACAAACCAGAGGAACTATACGAATTAATCAGCTGGTTTGTGTCAAGCCGAGAATTACTGCCATCTTCCGATTTCGACTCAGCTTCAGAATATGTTCCTGATTTAGATAAATCGTATTTTAGTTCTACGTCACCATCAGCAGAATCTGCATTGGGACCACAACTCGTAGCTAGATCAGCACACGGTCAACTCAGTCTTACAAAATCGGCAGAATCCAAAGATACCCCAATGTAA

Protein

MLFIDNPVGAGFSFTDSNDGFVKNMDECASDLYTALKQFLIIFPELRTAPLYIAGESYAGRYIPPFAMKLAEQDLNIGTFEVNLQGIIMGNPVVDRYSVANYTSTFQQWGLIDTQGAMSVKSLQDQYIKAILDGDASAAYDLRDQLLYKLTKITLQNQFFNVLKSNKDLTLSEFAAYLQKSTVKEALHVGDTDFSFINTTVDLELKSDFLTDIGGTVTKLLEHCKVLIYCGQLDLTAPCVQSAQYRRRYWQWNKKELFLRAPRRPWLHKNVVAGYTKSGGGFTEVLVKGAGHLVPIDKPEELYELISWFVSSRELLPSSDFDSASEYVPDLDKSYFSSTSPSAESALGPQLVARSAHGQLSLTKSAESKDTPM

Description

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Catalytic Activity

Release of a C-terminal amino acid with broad specificity.

Similarity

Belongs to the peptidase S10 family.

Keywords

Allergen   Carboxypeptidase   Complete proteome   Glycoprotein   Hydrolase   Protease   Reference proteome   Secreted   Signal   Alternative splicing   Zymogen  

Feature

chain  Carboxypeptidase
splice variant  In isoform 2.

Uniprot

H9J0S4   A0A2H1V3Z0   A0A2A4K0D9   A0A0N1INC9   A0A194PNP2   A0A0N0P9M2   + More
A0A1E1W9R5   A0A2P8YUZ9   A0A1W4X0Q1   A0A2R7WTA9   A0A2A4K0P1   A0A2H1V3X3   A0A146L8K2   K7IV07   H9J0S3   A0A348G5Z8   A0A195D9Z9   A0A195F7F6   R4WHX6   A0A2H1V444   A0A158ND03   A0A2A4JZQ9   A0A1Y1LKF5   A0A212EN12   A0A195B917   A0A195D1V5   E2BR37   F4X0L6   A0A0K8SFQ8   A0A224XJN6   A0A0A9W0I2   D7EHX7   A0A026WJK0   A0A151WYN0   A0A146L5J6   A0A0J7KEF9   A0A0K8SL40   B3SNT4   A0A170XJP7   E9IJU5   B7PI01   A0A0A9XV56   A0A1D2MBJ2   A0A2R7WYJ8   A0A220K8I1   A0A146LT64   A0A0A9XKA6   A0A146M3S2   C9WMM5   R4FLC5   A0A1V1G5G1   C1BPZ3   A0A2A3EHH5   H9J0S5   V5GQP5   A0A067QKM7   V5IG52   A0A1Y1KBB0   V5GN57   R4V3H3   U4U2S4   A0A1B0D870   A0A1B0D2X8   A0A2J7RDU7   A0A293N260   A0A1B6K7F1   A0A1V1FIY0   A0A0M8ZQT3   A0A0L7R680   A0A0A9XQP3   A0A2J7RMM3   A0A1B0CQ02   A0A0A9W9I9   A0A0K8SQH3   A0A146M8X8   A0A146L6S5   A0A146L0Y9   A0A2R7VXV6   A0A146M0Y4   A0A0A9YIS5   Q101N9   B7PC00   T1IBR4   K7IV06   E2AY00   A0A0A9XDE9   A0A0A9XJC2   B7ZN25   A0A212FM71   K7J463   R4FLQ2   A0A336M8H4   U5EN01   A0A0A9X8H2   Q9D3S9   Q869Q8   A0A067RMV2   B3SNT5   A0A1B6G2E3  

EC Number

3.4.16.-
3.4.16.5

Pubmed

19121390    26354079    29403074    26823975    20075255    23691247    + More
21347285    28004739    22118469    20798317    21719571    25401762    18362917    19820115    24508170    30249741    24548612    21282665    27289101    28630352    17073008    28410430    25765539    24845553    23537049    15489334    16141072    19468303    12097910    15875012   

EMBL

BABH01010273    BABH01010274    ODYU01000565    SOQ35547.1    NWSH01000324    PCG77476.1    + More
KQ461183    KPJ07560.1    KQ459598    KPI94603.1    KQ459327    KPJ01438.1    GDQN01007312    JAT83742.1    PYGN01000345    PSN48057.1    KK855397    PTY22370.1    PCG77478.1    SOQ35545.1    GDHC01015187    JAQ03442.1    AAZX01001204    BABH01010267    BABH01010268    BABH01010269    BABH01010270    BABH01010271    FX985537    BBF97871.1    KQ981135    KYN09229.1    KQ981744    KYN36373.1    AK416960    BAN20175.1    SOQ35546.1    ADTU01012128    PCG77477.1    GEZM01053175    JAV74144.1    AGBW02013763    OWR42868.1    KQ976558    KYM80684.1    KQ977012    KYN06384.1    GL449898    EFN81843.1    GL888498    EGI60008.1    GBRD01013857    JAG51969.1    GFTR01006388    JAW10038.1    GBHO01045227    GBHO01045224    JAF98376.1    JAF98379.1    KQ971323    KYB28573.1    KK107213    QOIP01000007    EZA55299.1    RLU20576.1    KQ982650    KYQ52877.1    GDHC01016222    JAQ02407.1    LBMM01008690    KMQ88692.1    GBRD01011805    GBRD01011803    JAG54021.1    EF589781    ABU88379.2    GEMB01004337    JAR98936.1    GL763883    EFZ19168.1    ABJB010030144    ABJB010280903    DS716089    EEC06223.1    GBHO01022474    GBHO01022473    GBHO01022471    GBHO01003884    JAG21130.1    JAG21131.1    JAG21133.1    JAG39720.1    LJIJ01002009    ODM90366.1    KK855988    PTY24551.1    MF319693    ASJ26407.1    GDHC01008170    JAQ10459.1    GBHO01022472    JAG21132.1    GDHC01004208    JAQ14421.1    FJ765738    ACPB03001109    GAHY01001473    JAA76037.1    FX985403    BAX07416.1    BT076672    ACO11096.1    KZ288242    PBC31235.1    BABH01010276    BABH01010277    BABH01010278    BABH01010279    GANP01011728    JAB72740.1    KK853243    KDR09452.1    GANP01007292    JAB77176.1    GEZM01089787    JAV57440.1    GANP01012668    JAB71800.1    KC571839    AGM32338.1    KB631843    ERL86633.1    AJVK01027239    AJVK01023133    NEVH01005284    PNF39003.1    GFWV01022477    MAA47204.1    GECU01000337    JAT07370.1    FX985408    BAX07421.1    KQ435896    KOX69240.1    KQ414646    KOC66387.1    GBHO01022476    JAG21128.1    NEVH01002552    PNF42087.1    AJWK01022899    GBHO01039130    JAG04474.1    GBRD01010445    JAG55379.1    GDHC01002421    JAQ16208.1    GDHC01015334    JAQ03295.1    GDHC01016591    JAQ02038.1    KK854125    PTY11741.1    GDHC01005550    GDHC01000917    JAQ13079.1    JAQ17712.1    GBHO01028412    GBHO01014169    GBHO01004779    JAG15192.1    JAG29435.1    JAG38825.1    DQ104699    AAZ43093.2    ABJB010180836    ABJB010862162    ABJB010946688    ABJB011123252    DS680413    EEC04122.1    ACPB03018811    AAZX01001162    GL443740    EFN61703.1    GBHO01028515    GBHO01028514    JAG15089.1    JAG15090.1    GBHO01022777    JAG20827.1    BC144966    AAI44967.1    AGBW02007654    OWR54826.1    AAZX01003260    GAHY01002044    JAA75466.1    UFQT01000606    SSX25661.1    GANO01000788    JAB59083.1    GBHO01028516    GBHO01028513    GBRD01013050    JAG15088.1    JAG15091.1    JAG52776.1    AK017087    AC073297    AC079218    BC137839    AAFI02000012    KK852415    KDR24388.1    EF589782    ABU88380.2    GECZ01013161    JAS56608.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000245037    UP000192223    + More
UP000002358    UP000078492    UP000078541    UP000005205    UP000007151    UP000078540    UP000078542    UP000008237    UP000007755    UP000007266    UP000053097    UP000279307    UP000075809    UP000036403    UP000001555    UP000094527    UP000005203    UP000015103    UP000242457    UP000027135    UP000030742    UP000092462    UP000235965    UP000053105    UP000053825    UP000092461    UP000000311    UP000000589    UP000002195   

PRIDE

H9J0S4    H9J0S3    H9J0S5    Q9D3S9   

Pfam

PF00450   Peptidase_S10        + More
PF02990   EMP70
PF03564   DUF1759

Interpro

IPR029058   AB_hydrolase        + More
IPR033124   Ser_caboxypep_his_AS       
IPR018202   Ser_caboxypep_ser_AS       
IPR001563   Peptidase_S10       
IPR004240   EMP70       
IPR005312   DUF1759       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9J0S4   A0A2H1V3Z0   A0A2A4K0D9   A0A0N1INC9   A0A194PNP2   A0A0N0P9M2   + More
A0A1E1W9R5   A0A2P8YUZ9   A0A1W4X0Q1   A0A2R7WTA9   A0A2A4K0P1   A0A2H1V3X3   A0A146L8K2   K7IV07   H9J0S3   A0A348G5Z8   A0A195D9Z9   A0A195F7F6   R4WHX6   A0A2H1V444   A0A158ND03   A0A2A4JZQ9   A0A1Y1LKF5   A0A212EN12   A0A195B917   A0A195D1V5   E2BR37   F4X0L6   A0A0K8SFQ8   A0A224XJN6   A0A0A9W0I2   D7EHX7   A0A026WJK0   A0A151WYN0   A0A146L5J6   A0A0J7KEF9   A0A0K8SL40   B3SNT4   A0A170XJP7   E9IJU5   B7PI01   A0A0A9XV56   A0A1D2MBJ2   A0A2R7WYJ8   A0A220K8I1   A0A146LT64   A0A0A9XKA6   A0A146M3S2   C9WMM5   R4FLC5   A0A1V1G5G1   C1BPZ3   A0A2A3EHH5   H9J0S5   V5GQP5   A0A067QKM7   V5IG52   A0A1Y1KBB0   V5GN57   R4V3H3   U4U2S4   A0A1B0D870   A0A1B0D2X8   A0A2J7RDU7   A0A293N260   A0A1B6K7F1   A0A1V1FIY0   A0A0M8ZQT3   A0A0L7R680   A0A0A9XQP3   A0A2J7RMM3   A0A1B0CQ02   A0A0A9W9I9   A0A0K8SQH3   A0A146M8X8   A0A146L6S5   A0A146L0Y9   A0A2R7VXV6   A0A146M0Y4   A0A0A9YIS5   Q101N9   B7PC00   T1IBR4   K7IV06   E2AY00   A0A0A9XDE9   A0A0A9XJC2   B7ZN25   A0A212FM71   K7J463   R4FLQ2   A0A336M8H4   U5EN01   A0A0A9X8H2   Q9D3S9   Q869Q8   A0A067RMV2   B3SNT5   A0A1B6G2E3  

PDB

4MWT     E-value=2.20916e-17,     Score=218

KEGG

101738672    K09645 vitellogenic carboxypeptidase-like protein [EC:3.4.16.-] | (RefSeq) probable serine carboxype

GO

GO:0004185   GO:0016021   GO:0051603   GO:0005576   GO:0006508   GO:0016788   GO:0003697   GO:0004519   GO:0005634   GO:0006289   GO:0004518   GO:0006281   GO:0048384  

PANTHER

PTHR11802   PTHR10766  

Subcellular location

Secreted  

Length:

373

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00432999999999998

Exp number, first 60 AAs:

0.00346

Total prob of N-in:

0.00245

outside

1  -  373

 

 

Pi

293.761057

Theta

179.476664

Tajima's D

2.47918

CLR

1.353339

CSRT

0.942952852357382

Interpretation

Uncertain