Gene

KWMTBOMO02229

Pre Gene Modal

BGIBMGA003113

Annotation

PREDICTED:_suppressor_of_hairless_protein_[Papilio_polytes]

Location

Bomo_Chr4(-):14346797-14351405      View in EpiBrowser

Full name

Suppressor of hairless protein      

Alternative Name

J kappa-recombination signal-binding protein
RBP-J kappa

Transcription factor

CSL

Location in the cell

Cytoplasmic   Reliability : 1.518 Mitochondrial   Reliability : 1.077 Nuclear   Reliability : 1.228

CDS

ATGCCGCACCAGTACGGCGGCGGCGCGGGCGGTGCGTCGCCGCCAGCGCCGGTGGGCGCGTACCCTCGCTACGCCAGCGCAGCTGGTCCTGGCGCTGGCGCCTATCGTCCCGAAGAACGACGTCTCACCCGTGAGGCCATGGAGAGATATTTACGTGATCGCTCTGATATGGTAGTTGTAATTTTACATGCAAAAGTAGCACAGAAATCTTATGGAAATGAAAAACGTTTTTTTTGCCCGCCTCCATGTATATACCTCTTTGGTGATGGATGGCGCCTCCGGCGAGAACGCATGCTAAGAGAGGGAGAAACGGAACAGGCAGCTCAACTGTGTGCATTCATTGGGATTGGTAATTCAGACCAAGACATGCAACAATTGGATCTCAACAATGGTAAACAGTATTGTGCTGCAAAAACCTTGTACATATCTGATTCAGATAAACGAAAACACTTTATGCTATCTGTAAAAATGTTCTATGGAAATGGACATGATATTGGTATATTCAACAGTAAAAGAATTAAAGTAATTTCAAAGCCTTCCAAAAAGAAGCAGTCATTAAAAAATGCTGACTTATGTATAGCTAGTGGAACAAAGGTAGCTCTATTTAACAGACTAAGGTCACAGACAGTGTCAACCAGATATTTGCATGTGGAAAATGGTAATTTTCATGCATCATCTACCCAATGGGGGGCATTTACTATTCATCTACTGGATGATAATGAGAGTGAGTCTGAAGAGTTTGCAGTGAGAGATGGATATGTTCACTATGGATCTACAGTAAAACTAGTCTGTTCTGTGACTGGTATGGCTTTACCAAGGCTTATTATTAGAAAGGTAGATAAACAAATGGCTTTACTAGAGGCTGATGATCCAGTATCGCAGCTACACAAATGTGCTTTTTATATGAAGGATACGGAGAGAATGTATCTATGCCTATCCCAGGAACGAATTATACAGTTCCAGGCAACTCCATGCCCTAAAGAACCCAATAAGGAAATGATAAATGATGGAGCTTGCTGGACCATAATTTCGACTGATAAGGCTGAATACCAATTTTATGAAGGAATGGGACCCGTTAGGTCACCAGTAACACCGGTACCCTTGGTGCACTCATTAAATCTCAACGGGGGTGGCGATGTTGCCATGTTAGAATTGGCTGGAGATAATTTCACACCTTCCCTACAAGTGTGGTTTGGTGATGTTGAAGCGGAAACAATGTACAGATGTGCTGAGTCCATGCTGTGCGTAGTTCCAGATATATCACAATTCAGAGGGCAGTGGCTGTGGGTCCGGCAGCCTACGCAGGTTCCTGTATCATTAGTTCGCAACGACGGTATAATATACGCAACGGGGTTGACGTTCACGTACACGCCGGAGCCGGCGCCGCGGCCGGTGTGCCCGCCGGTCGATGACGTCATGCGGCCGGACTCCGCCTGGCACGATCACCGCCTGCCGGACAACACGCTGCAATAG

Protein

MPHQYGGGAGGASPPAPVGAYPRYASAAGPGAGAYRPEERRLTREAMERYLRDRSDMVVVILHAKVAQKSYGNEKRFFCPPPCIYLFGDGWRLRRERMLREGETEQAAQLCAFIGIGNSDQDMQQLDLNNGKQYCAAKTLYISDSDKRKHFMLSVKMFYGNGHDIGIFNSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVENGNFHASSTQWGAFTIHLLDDNESESEEFAVRDGYVHYGSTVKLVCSVTGMALPRLIIRKVDKQMALLEADDPVSQLHKCAFYMKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGPVRSPVTPVPLVHSLNLNGGGDVAMLELAGDNFTPSLQVWFGDVEAETMYRCAESMLCVVPDISQFRGQWLWVRQPTQVPVSLVRNDGIIYATGLTFTYTPEPAPRPVCPPVDDVMRPDSAWHDHRLPDNTLQ

Description

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:21262215, PubMed:1617729, PubMed:8674407, PubMed:10673509). Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:10673509). Acts as a transcriptional repressor when it is not associated with Notch proteins (PubMed:10673509). When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (PubMed:10673509). Required for transcription of Sim (PubMed:10673509). Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence (PubMed:1744127, PubMed:1617730, PubMed:1617729). Required for neurogenesis in imaginal disks (PubMed:1617730, PubMed:7813798). In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development (PubMed:21262215). Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell (PubMed:12642500).

Subunit

Interacts with activated cleaved Notch. Interacts with Hairless, this interaction preventing its DNA-binding activity. Interacts with insv (via BEN domain).

Similarity

Belongs to the Su(H) family.

Keywords

3D-structure   Activator   Complete proteome   Cytoplasm   Developmental protein   DNA-binding   Notch signaling pathway   Nucleus   Polymorphism   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation  

Feature

chain  Suppressor of hairless protein

Uniprot

H9J0S6   A0A2A4K0N9   A0A212F6E3   A0A194PME4   A0A0N0PAQ3   A0A1J1ISJ4   + More
A0A067QNE9   A0A2J7Q1M8   A0A146KUU2   A0A0T6AY12   D6WM40   A0A1Y1LNS5   A0A336LNF7   A0A1W4WHF1   A0A154P393   A0A1B6D5R7   A0A0L7QXH1   A0A2A3E9N9   A0A0M9A9N2   A0A088A316   A0A310SHL6   A0A1B6FAN1   A0A2R7VTD4   E9IN48   A0A195DUS7   A0A195CB99   A0A195EWU5   A0A158NSP0   A0A3L8D7U4   A0A224XJ53   A0A026WTB0   U4ULX5   A0A0J7K7V9   E2AKY3   N6UF37   E2BI59   A0A0C9R3C6   F4W8A2   A0A1I8PEN7   E0VVF3   A0A1I8M8I4   B4KLB9   B4LRY1   B4NYT2   B4JAX1   A0A182H557   A0A1W4WBS3   X2JAI1   B4GK80   A0A0M4ED70   B3MLC4   A0A0L0C454   B4HXL8   A0A0A1XHE1   B5DHG8   Q0IF69   P28159   A0A0K8VUN6   B3N5N4   B4Q5Z2   A0A2M4AVG5   A0A182FN68   A0A226DIF7   A0A182QKQ4   C5IX11   A0A3B0KTE6   A0A182NUT1   A0A034WE05   A0A0U5JH54   W8BB01   A0A1A9WZG9   A0A182W6B4   A0A1S4GZN9   A0A182J106   Q7PWJ9   A0A182LMQ9   A0A0A9WBJ1   A0A1A9Z986   A0A1A9UH37   A0A1A9XT59   A0A182UVE5   A0A0R3NY99   K7J8Z1   A0A1B0C9Y7   A0A2J7Q1N0   T1IKI2   A0A182Y0E3   A0A2S2QD61   A0A0K2VJ17   A0A2H8TDL7   J9JLY8   B4MZD7   A0A087U6W5   A0A2L2YKP4   A0A1B2UR51   A0A2H1V9Q9   A0A087UGD6   A0A0P5ETZ8   A0A0P5RKD8   A0A182RM08  

Pubmed

19121390    22118469    26354079    24845553    29403074    18362917    + More
19820115    28004739    21282665    21347285    30249741    24508170    23537049    20798317    21719571    20566863    25315136    17994087    17550304    26483478    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26108605    25830018    15632085    23185243    17510324    1744127    1617730    10471707    12537569    10388820    1617729    7813798    7958912    8674407    10673509    12642500    21262215    21765394    22936249    25348373    24495485    12364791    20966253    25401762    26823975    20075255    25244985    26561354   

EMBL

BABH01010280    NWSH01000324    PCG77464.1    AGBW02010058    OWR49279.1    KQ459598    + More
KPI94606.1    KQ461183    KPJ07556.1    CVRI01000055    CRL01497.1    KK853129    KDR10989.1    NEVH01019394    PNF22486.1    LN812813    PYGN01000809    CEP28037.1    PSN40492.1    LJIG01022597    KRT79733.1    KQ971343    EFA04684.1    GEZM01050950    GEZM01050949    GEZM01050948    GEZM01050947    JAV75279.1    UFQT01000030    SSX18193.1    KQ434809    KZC06405.1    GEDC01016285    JAS21013.1    KQ414704    KOC63305.1    KZ288322    PBC28194.1    KQ435719    KOX78783.1    KQ761039    OAD58360.1    GECZ01022449    JAS47320.1    KK854074    PTY10757.1    GL764272    EFZ18028.1    KQ980322    KYN16601.1    KQ978023    KYM97975.1    KQ981948    KYN32621.1    ADTU01025088    QOIP01000011    RLU16550.1    GFTR01006578    JAW09848.1    KK107111    EZA58906.1    KB632357    ERL93473.1    LBMM01011916    KMQ86548.1    GL440425    EFN65900.1    APGK01024675    APGK01024676    KB740558    ENN80360.1    GL448450    EFN84630.1    GBYB01002475    GBYB01002476    JAG72242.1    JAG72243.1    GL887898    EGI69597.1    DS235811    EEB17359.1    CH933807    EDW11780.1    CH940649    EDW63657.1    CM000157    EDW89783.1    CH916368    EDW02841.1    JXUM01110820    JXUM01110821    JXUM01110822    JXUM01110823    JXUM01110824    KQ565447    KXJ70962.1    AE014134    AHN54462.1    CH479184    EDW37046.1    CP012523    ALC39710.1    CH902620    EDV30713.1    JRES01000933    KNC27138.1    CH480818    EDW51798.1    GBXI01003891    JAD10401.1    CH379058    EDY69744.1    EDY69745.1    CH477389    EAT42017.1    S69213    X58393    M94383    AY069091    AF088255    AF088256    AF088257    AF088258    AF088259    AF088260    AF088261    AF088262    AF088263    AF088264    AF088265    AF088266    AF088267    AF088268    AF088269    AF088270    AF088271    AF088272    AF088273    AF088274    GDHF01009707    JAI42607.1    CH954177    EDV57993.1    CM000361    CM002910    EDX05095.1    KMY90322.1    GGFK01011462    MBW44783.1    LNIX01000020    OXA43976.1    AXCN02000741    FJ970036    ACR61380.1    OUUW01000046    SPP90009.1    GAKP01005176    JAC53776.1    LN881712    CUK27656.1    GAMC01012372    JAB94183.1    AAAB01008984    EAA14803.5    GBHO01037777    GBRD01000229    GDHC01018616    JAG05827.1    JAG65592.1    JAQ00013.1    KRT03494.1    AJWK01003034    PNF22490.1    JH430541    GGMS01006408    MBY75611.1    HACA01033078    CDW50439.1    GFXV01000355    MBW12160.1    ABLF02032549    ABLF02032556    CH963913    EDW77476.2    KK118493    KFM73104.1    IAAA01038844    IAAA01038845    IAAA01038846    IAAA01038847    LAA08698.1    KX369026    AOD27420.1    ODYU01001401    SOQ37526.1    KK119690    KFM76425.1    GDIQ01265016    JAJ86708.1    GDIQ01108826    JAL42900.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000183832    + More
UP000027135    UP000235965    UP000245037    UP000007266    UP000192223    UP000076502    UP000053825    UP000242457    UP000053105    UP000005203    UP000078492    UP000078542    UP000078541    UP000005205    UP000279307    UP000053097    UP000030742    UP000036403    UP000000311    UP000019118    UP000008237    UP000007755    UP000095300    UP000009046    UP000095301    UP000009192    UP000008792    UP000002282    UP000001070    UP000069940    UP000249989    UP000192221    UP000000803    UP000008744    UP000092553    UP000007801    UP000037069    UP000001292    UP000001819    UP000008820    UP000008711    UP000000304    UP000069272    UP000198287    UP000075886    UP000268350    UP000075884    UP000091820    UP000075920    UP000075880    UP000007062    UP000075882    UP000092445    UP000078200    UP000092443    UP000075903    UP000002358    UP000092461    UP000076408    UP000007819    UP000007798    UP000054359    UP000075900   

PRIDE

H9J0S6    P28159   

Pfam

PF09270   BTD        + More
PF09271   LAG1-DNAbind

Interpro

IPR013783   Ig-like_fold        + More
IPR008967   p53-like_TF_DNA-bd       
IPR015350   Beta-trefoil_DNA-bd_dom       
IPR014756   Ig_E-set       
IPR037095   RBP-J/Cbf11/Cbf12_DNA-bd_sf       
IPR038007   RBP-Jkappa_IPT       
IPR036358   BTD_sf       
IPR015351   RBP-J/Cbf11/Cbf12_DNA-bd       
IPR040159   CLS_fam       

SUPFAM

SSF110217   SSF110217        + More
SSF49417   SSF49417       
SSF81296   SSF81296       

Gene 3D

2.60.40.10     2.60.40.1450    

CDD

cd01176  IPT_RBP-Jkappa

ProteinModelPortal

H9J0S6   A0A2A4K0N9   A0A212F6E3   A0A194PME4   A0A0N0PAQ3   A0A1J1ISJ4   + More
A0A067QNE9   A0A2J7Q1M8   A0A146KUU2   A0A0T6AY12   D6WM40   A0A1Y1LNS5   A0A336LNF7   A0A1W4WHF1   A0A154P393   A0A1B6D5R7   A0A0L7QXH1   A0A2A3E9N9   A0A0M9A9N2   A0A088A316   A0A310SHL6   A0A1B6FAN1   A0A2R7VTD4   E9IN48   A0A195DUS7   A0A195CB99   A0A195EWU5   A0A158NSP0   A0A3L8D7U4   A0A224XJ53   A0A026WTB0   U4ULX5   A0A0J7K7V9   E2AKY3   N6UF37   E2BI59   A0A0C9R3C6   F4W8A2   A0A1I8PEN7   E0VVF3   A0A1I8M8I4   B4KLB9   B4LRY1   B4NYT2   B4JAX1   A0A182H557   A0A1W4WBS3   X2JAI1   B4GK80   A0A0M4ED70   B3MLC4   A0A0L0C454   B4HXL8   A0A0A1XHE1   B5DHG8   Q0IF69   P28159   A0A0K8VUN6   B3N5N4   B4Q5Z2   A0A2M4AVG5   A0A182FN68   A0A226DIF7   A0A182QKQ4   C5IX11   A0A3B0KTE6   A0A182NUT1   A0A034WE05   A0A0U5JH54   W8BB01   A0A1A9WZG9   A0A182W6B4   A0A1S4GZN9   A0A182J106   Q7PWJ9   A0A182LMQ9   A0A0A9WBJ1   A0A1A9Z986   A0A1A9UH37   A0A1A9XT59   A0A182UVE5   A0A0R3NY99   K7J8Z1   A0A1B0C9Y7   A0A2J7Q1N0   T1IKI2   A0A182Y0E3   A0A2S2QD61   A0A0K2VJ17   A0A2H8TDL7   J9JLY8   B4MZD7   A0A087U6W5   A0A2L2YKP4   A0A1B2UR51   A0A2H1V9Q9   A0A087UGD6   A0A0P5ETZ8   A0A0P5RKD8   A0A182RM08  

PDB

5E24     E-value=0,     Score=2118

KEGG

101739888    K06053 recombining binding protein suppressor of hairless | (RefSeq) suppressor of hairless protein

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0000978   GO:0001228   GO:0005634   GO:0005667   GO:0043565   GO:0090571   GO:0016360   GO:0005737   GO:1900087   GO:0000980   GO:0061629   GO:0008586   GO:1990433   GO:0048190   GO:0042688   GO:0001227   GO:0005700   GO:0007219   GO:0045746   GO:0007616   GO:0045944   GO:0030097   GO:0000977   GO:0000981   GO:0001709   GO:0000122   GO:0042683   GO:0045893   GO:0017053   GO:0032991   GO:0003677   GO:0008356   GO:0045892   GO:0006355   GO:0003700   GO:0016459   GO:0051603   GO:0008483   GO:0006418   GO:0016507   GO:0048384   GO:0006357  

PANTHER

PTHR10665  

Subcellular location

Nucleus   In imaginal disk, at the onset of differentiation of socket cell, it is also present in the cytoplasm.   With evidence from 12 publications.
Cytoplasm   In imaginal disk, at the onset of differentiation of socket cell, it is also present in the cytoplasm.   With evidence from 12 publications.

Length:

490

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05629

Exp number, first 60 AAs:

0.00386

Total prob of N-in:

0.00147

outside

1  -  490

 

 

Pi

279.184807

Theta

161.719845

Tajima's D

-2.06911

CLR

0.36174

CSRT

0.0109494525273736

Interpretation

Uncertain