Gene

KWMTBOMO02226  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003044

Annotation

PREDICTED:_myosin-VIIa_[Bombyx_mori]

Location

Bomo_Chr4(+):14274946-14322750      View in EpiBrowser

Full name

Myosin-VIIa      

Alternative Name

Protein crinkled

Location in the cell

Nuclear   Reliability : 2.178

CDS

ATGGTGATCGTGACCAGGGGCGATTACATATGGATCGAGCCGGTGTCGGGGCGGGAGTTCGACGTGGCGATCGGAGCACGTGTTCTCGCGGCCGAGGGACGTCGGATCCGGGTCCGGGACGACGACGGCAACGAGCAATGGCTTCCACCGGAGCGCCGCATCAAGGCGATGCACGCGACCTCCGTGCACGGAGTCGAGGATATGATCTCACTCGGCGATCTGCACGAGGCCGGTATACTAAGGAATCTCCTCATCCGGTACAATGAAAATCTTATTTATACATACACCGGATCGATATTAGTTGCGGTGAATCCGTATCAGATACTACCGATCTACACGGCGGACCAGATCAAACTGTACAAGGAGAGAAAAATCGGCGAGCTACCACCCCATATATTCGCGATTGGTGACAACGCGTACGCACACATGCGGAGATATAATCAGGATCAATGCATCGTTATCAGCGGGGAATCGGGTGCTGGAAAGACGGAGTCAACAAAGCTTATACTTCAATACCTTGCTGCGATTAGCGGTAAACATTCATGGATAGAACAACAGATTTTAGAAGCTAATCCAATTCTAGAAGCTTTTGGGAATGCGAAGACAGTTCGAAATGATAATTCTTCGCGATTCGGAAAATATATAGATATACATTTCAATAGCTCTGGAGTTATAGAGGGAGCTAAAATTGAACAATATCTGTTGGAGAAATCTAGGATTGTATCCCAAGGCACCGAGGAGAGGAACTATCACGTGTTTTATTGTTTACTGGCTGGATTATCCAAAGACGATAAAAAGAAATTGGAATTAGGCGACCCTTCGGAATACAGATATCTGTCTGCGGGCGGGAGTTTTTCGTGCGAGGGCAGAGATGACGCTGCAGAATTCGCAGACATTAGATCAGCAATGAAAGTGTTATTATTCACAGAATCAGAAATATGGGAAATTTTAAAATTACTGGCAGCAGTCTTACATTGTGGAAACATAAAGTACGAAGCGACTGTTGTTGATAACCTTGACGCCACTGAAATTACAGAAGAAGCGAATGTAAGAAAGGTAGCCAACTTACTTGGTGTGCCCTTACAATCTCTTATACGTGCTTTGACTAGAAAAACACTATTTGCCCACGGAGAAACTGTTATATCAACACTAAGCAGAGATCAGTCTGTTGACATTAGAGATGCATTTGTGAAAGGAATTTACGGTAGGCTATTCGTAACTATTGTCAGGAAAATCAACGCGGCCATTTACAAACCCAAGTCAACTACAAGAACTGCAATTGGTGTCCTTGACATATTTGGTTTTGAAAACTTTGATCACAACAGTTTTGAACAGTTCTGCATTAACTTCGCAAACGAGAATCTACAACAGTTTTTCGTCAGGCACATTTTCAAATTGGAACAGGAAGAATATAACCATGAAGGCATAAATTGGCAACACATCGAGTTTGTTGACAATCAGGATGCTTTGGACTTGATTGCTTTGAAACAGCTAAACATTATGGCTTTGATAGACGAAGAATCTAAGTTTCCAAAAGGGACTGACCAAACTATGCTAGCTAAACTTCATAAGACGCACGGTCTCCACAGAAATTACCTTAAGCCAAAGTCTGACATTAATACTAGTTTCGGATTAAACCATTTCGCTGGAATAGTTTTTTACGACACACGGGGATTCTTAGAGAAAAACCGAGACACATTTAGTGCTGACTTACTGCAATTAATTCACATATCGACGAATAAATTCTTACAGCAGATATTCCAAGAGGATATCGTCATGGGCTCTGAAACAAGGAAACGGACACCGACGTTGTCAACGCAGTTCAAAAAATCATTAGACTTGTTGATGAGAACGTTAGGGACTTGTCAGCCGTTCTTCATTCGCTGTATCAAACCGAATGAATTTAAAAAACCAATGCTCTTCGATCGCGGCCTTTGTTGCAGACAGCTTAGATACTCCGGAATGATGGAAACTATTCGAATCCGGAGAGCCGGCTATCCGATAAGACATAGTTTTAAGGAATTTGTCGAAAGATATAGATTTTTAATATCGGGGGTACCCCCTGCTCACAAGACGGACTGTCGATCAGCCACTGCAAAAATTTGTGCTCAAGTATTAGGGAAATCCGATTATCAGTTGGGTCATACCAAAGTGTTCCTTAAAGACGCTCACGATTTGTTCTTGGAGCAAGAAAGAGACCGAGTTTTAACGAGAAAGATATTAATACTCCAAAGATCGATACGAGGATGGGTTTATCGTAGAAGATTCTTGAAGATGAGAGCGGCAGCTGTTCTCATTCAGCGTCATTGGCGGGGTAAACTACAGAGGATAAGGTACCAGAAGATGAAGGTCGGGTACGCTAGACTCCAGGCATTGATACGAGCAAGAGTCCTCGCACACAGATTCAGACATTTGCGCGGCCATATTGTCTCTCTACAGGCTGCGGCTCGCGGGTACCTGGTGCGGAGGTCGTACGGCCACAAGATGTGGGCGATCGTGAAGATCCAGAGCCACGTGCGGCGGCTGATCGCGGTGCGGCGCTACCGGCGGCTCGCGGCCGAGGAGCGCGCGCACCGCGAGGCGCTGCGGCTGCGGCGCCAGGAGGAGCAGCGCCTGCACCACCAGGGGAACACGCGCGCCAAGGAGATCGCCGAACAAAACTACAGGGAGCGTATGTACGAATTAGAAAGGCGTGAAGCTGAATTAGCTCTGGAAGAGAAGCGACAATTGGAAGCCAAGAGGACGTTGCTGCAGGAAGCGGCCCGGAAGCAAGACGAACCTGTCGACGACAGTAAACTCGTGGAGGCCATGTTTGATTTCCTGCCCGACTCTAGCAGTGAAGCCCCAGCGCCTAAGGACACATCCATTTTCAGTGACTTGCCGCAAATGAGAGCTGATCAACAAGAAATGGTGACACCAATGCAGACCACTTCCGAAGATGAAGAGGACCTTTCAGAGTTCAAGTTCCAGAAGTTTGCCGCAACTTACTTCCAAGGAAATGTCACACATCAGTACTCTAGGAAAACACTGAAACATCCATTACTGCCTTTATTAACGCAGGGAGATCAATTGGCAGCGCAAGCGTTATGGGTCACGATTCTGCGTTTCACTGGAGACCTGGCGGAGCCTAGATATCACACAATGGATCGCGACAATACGTCGGTCATGTCCAAAGTCACGGCTACGTTGGGCAGGAACTTCATCAGGTCCAAGGAGTTTCAAGAGGCGCAGATGATGGGCGTCGACCCGGATGCTTACCTAAATAAGCAAAAACCAAGGTCGATCAGACACAAACTGGTGTCTCTAACGTTGAAGAGGAAGAATAAGCTGGGTGAAGACGTCAGAAGGAAGCTACAGGATGAGGAATATACTGCAGACAGCTATCAGTCGTGGCTGGAATCGCGTCCAACTTCGAACTTAGAAAAACTTCATTTCATAATCGGTCACGGCATTCTTCGCGCAGAGCTAAGAGACGAAATATATTGTCAAATCTGCAAACAGCTGACTAACAATCCATCGAAATCCTCTCACGCCCGAGGATGGATCCTCCTATCGTTGTGTGTTGGGTGTTTTGCACCAAGTGAGAAGTTTGTCAATTATCTCAGAGCCTTTATCAGGGAAGGCCCTCCCGGCTACGCGCCGTACTGTGAGGATCGATTGAAAAGAACATTTAATAACGGCACGAGAAACCAGCCCCCCTCGTGGTTAGAACTTCAGGCCACTAAATCTAAAAAACCCATAATGTTGCCAATAACCTTTATGGATGGCAATACAAAAACTTTATTAGCCGATTCTGCGACAACAGCCAGAGAGCTTTGTAACCAACTCTCGGACAAAATCGGCCTGAGAGATCAGTTCGGTTTTTCGCTGTACATAGCCTTGTTCGACAAGGTGAGCTCGCTCGGCAGCGGGGGCGACCACGTAATGGATGCGATATCACAGTGCGAGCAATACGCAAAAGAACAAGGCGCACAAGAAAGAAATGCGCCGTGGAGATTATTCTTTAGAAAGGAAATTTTCGCTCCCTGGCACGACCCTACCGAGGATCAAGTAGCGACGAATTTGATTTATCAGCAAGTCGTGCGAGGGGTTAAATTCGGCGAATACAGATGCGATAAAGAAGAAGACCTGGCCATGATAGCTGCCCAACAGTATTACATTGAATACGGGCAAGACATGAACGCGGAACGACTCTACACGCTGTTACCCAACTACATACCGGATTATTGTTTGACAGGAGTAGAGAAAGCCGTTGATAGATGGGGCGCACTCGTCGTGCAGGCATACAAAAAGAGTTATTACGTCAAAGAGAAAGTTCCCGCTTACAAAGTCAAAGAAGATGTTGTGAGTTACGCAAAATTCAAATGGCCCCTGTTGTTCTCTAGGTTCTACGAAGCCTACAGAAATTCCGGGCCGAATTTACCTAAAAACGATGTCATAATAGCTGTTAATTGGACCGGTGTTTATGTTGTGGACGATCAAGAACAAGTCTTGTTAGAATTGTCGTTCCCGGAGATCACAACTGTCGCAAGTCAGAAGACAAATAAAGTGTTCACTCAAACGTTCAGTTTAAATACCGTAAGAGGTGAAGAATTCACATTCCAAAGTCCGAATGCAGAGGACATACGAGATTTAGTAGTTTACTTCTTAGAGGGACTAAAGAAAAGATCAAAGTTCGTGATTGCTTTACAAGATTACAAAGCTCCAGGCGAGGGGTCCAGTTTCTTGACATTCCAAAAAGGGGATCTAATAGTGTTGGAAGAAGAAAGTACAGGTGAATCGGTCTTAAATAATGGATGGTGTATTGGTCGTTGCGAAAGGACTATGGAAAGAGGAGACTTCCCTGCGGAAACAGTATACGTGCTACCCGCTTTAACGAAGCCACCGCCAGATATACTAGCTTTGTTCTGTCAAGAAGGCGCACAACACGGTCGAAGACCCCCTACGAGTACCTTCAATGGAACTGAATCGAAAGACAAACCTCATACGCTGTTAGAATACGCTCTTGACCATTTTAGATTACCACCAAAACGCACAGCTTCCAAGGGCCTAACATTATCAACAGCCAAACGAGGGGGCTCTGAAGAACTGTGGAGGCACTCCAGAGAACCAATAAAACAACCTTTGCTCAAAAAGTTGCAAGCAAAGGAAGAGCTGGCAGAAGAGGCCTGTTTCGCGTTTACGGCCATACTAAAGTACATGAGTGACCTACCTTCCAAGCGCCCCCGTATCGGCAACGAATACACCGATCATATTTTCGATGGACCTCTGAAACATGAAATATTACGCGACGAAATTTACTGCCAAATAATGAAACAGCTCACTGATAATAGAAATAGAATGTCTGAAGAACGGGGCTGGGAATTAATGTGGTTGGCTACGGGGCTATTCGCTTGTAGTCAGGGGCTGCTTAGAGAATTAACTTTATTTCTGAGAACCAGAAGGTACCCTATTGCTCAAGACTCACTTCAAAGACTGCAAAAGACGCTCCGAAACGGACAGAGGAAGTATCCGCCGCACCAAGTGGAGGTGGAAGCTATACAACACAAGACAACTCAGATATTTCACAAGGTGTACTTCCCCGACGACACCGATGAAGCTTTCGAAGTGGACTCGTCAACTCGAGCGAAAGATTTCTGCCAAAACATCGCTCAAAGACTGAATCTCAGATCTAGTGAAGGCTTTAGTTTGTTCGTTAAGATAGCTGATAAGGTGATATCGGTGCCGGAGGGAGATTTCTTTTTCGACTTCGTGCGGCATCTGACTGATTGGATTAAGAAGGCGCGTCCTACACGCGACGGAATCATACCACAGTTTACGTATCAAGTAAGTTTGTAA

Protein

MVIVTRGDYIWIEPVSGREFDVAIGARVLAAEGRRIRVRDDDGNEQWLPPERRIKAMHATSVHGVEDMISLGDLHEAGILRNLLIRYNENLIYTYTGSILVAVNPYQILPIYTADQIKLYKERKIGELPPHIFAIGDNAYAHMRRYNQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFGNAKTVRNDNSSRFGKYIDIHFNSSGVIEGAKIEQYLLEKSRIVSQGTEERNYHVFYCLLAGLSKDDKKKLELGDPSEYRYLSAGGSFSCEGRDDAAEFADIRSAMKVLLFTESEIWEILKLLAAVLHCGNIKYEATVVDNLDATEITEEANVRKVANLLGVPLQSLIRALTRKTLFAHGETVISTLSRDQSVDIRDAFVKGIYGRLFVTIVRKINAAIYKPKSTTRTAIGVLDIFGFENFDHNSFEQFCINFANENLQQFFVRHIFKLEQEEYNHEGINWQHIEFVDNQDALDLIALKQLNIMALIDEESKFPKGTDQTMLAKLHKTHGLHRNYLKPKSDINTSFGLNHFAGIVFYDTRGFLEKNRDTFSADLLQLIHISTNKFLQQIFQEDIVMGSETRKRTPTLSTQFKKSLDLLMRTLGTCQPFFIRCIKPNEFKKPMLFDRGLCCRQLRYSGMMETIRIRRAGYPIRHSFKEFVERYRFLISGVPPAHKTDCRSATAKICAQVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLKMRAAAVLIQRHWRGKLQRIRYQKMKVGYARLQALIRARVLAHRFRHLRGHIVSLQAAARGYLVRRSYGHKMWAIVKIQSHVRRLIAVRRYRRLAAEERAHREALRLRRQEEQRLHHQGNTRAKEIAEQNYRERMYELERREAELALEEKRQLEAKRTLLQEAARKQDEPVDDSKLVEAMFDFLPDSSSEAPAPKDTSIFSDLPQMRADQQEMVTPMQTTSEDEEDLSEFKFQKFAATYFQGNVTHQYSRKTLKHPLLPLLTQGDQLAAQALWVTILRFTGDLAEPRYHTMDRDNTSVMSKVTATLGRNFIRSKEFQEAQMMGVDPDAYLNKQKPRSIRHKLVSLTLKRKNKLGEDVRRKLQDEEYTADSYQSWLESRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPSKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEDRLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKIGLRDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHDPTEDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYYIEYGQDMNAERLYTLLPNYIPDYCLTGVEKAVDRWGALVVQAYKKSYYVKEKVPAYKVKEDVVSYAKFKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITTVASQKTNKVFTQTFSLNTVRGEEFTFQSPNAEDIRDLVVYFLEGLKKRSKFVIALQDYKAPGEGSSFLTFQKGDLIVLEEESTGESVLNNGWCIGRCERTMERGDFPAETVYVLPALTKPPPDILALFCQEGAQHGRRPPTSTFNGTESKDKPHTLLEYALDHFRLPPKRTASKGLTLSTAKRGGSEELWRHSREPIKQPLLKKLQAKEELAEEACFAFTAILKYMSDLPSKRPRIGNEYTDHIFDGPLKHEILRDEIYCQIMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLRELTLFLRTRRYPIAQDSLQRLQKTLRNGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCQNIAQRLNLRSSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPTRDGIIPQFTYQVSL

Description

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter. A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability. Necessary for auditory transduction: plays a role in Johnston organ (JO) organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (By similarity).
Myosins are actin-based motor molecules with ATPase activity (PubMed:16585515). Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter (PubMed:16585515). A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments (PubMed:16585515). Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (PubMed:15579689). Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability (PubMed:15579689, PubMed:16585515). Necessary for auditory transduction: plays a role in Johnston's organ organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (PubMed:15886106, PubMed:27331610). Interaction with the myosin zip may be important for its function in scolopidial apical attachment (PubMed:27331610). During oogenesis it has Cad99c-dependent and Cad99c-independent roles in regulating the shape and spacing of the follicle cell microvilli which secrete eggshell material such as the vitelline membrane (PubMed:25236597). May be required for the normal expression of Cad99c in the follicle cell microvilli (PubMed:25236597).

Subunit

Homodimerizes in a two headed molecule through the formation of a coiled-coil rod.
Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Keywords

Actin-binding   ATP-binding   Coiled coil   Complete proteome   Cytoplasm   Motor protein   Myosin   Nucleotide-binding   Reference proteome   Repeat   SH3 domain   Cell projection   Phosphoprotein  

Feature

chain  Myosin-VIIa

Uniprot

A0A2A4JZM2   A0A194PMR5   A0A0N1PEV6   H9J0K7   A0A212F5Z6   D6WM41   + More
A0A310SDF9   A0A026WSA2   A0A2J7QBS1   A0A348G641   A0A067QNC8   A0A2J7QBR2   A0A158NSP1   A0A195EXJ5   A0A151HY88   F4W8A1   A0A195CAT1   A0A195DUL7   A0A0C9RPF2   A0A1Y1LTF3   A0A182IPQ8   A0A1S4HE37   Q17LW0   A0A2M3YZS8   A0A2M4B856   A0A182RM10   B0WB21   K7J8Z2   A0A1B6CKI8   A0A182WG81   A0A182LVW6   A0A182Y0E2   E2AKY2   A0A2M4A1G1   A0A182JZ48   A0A182XNT2   A0A182R007   A0A182I7D7   A0A182VP23   A0A2M4CM41   A0A1B6ETW6   A0A182PDV3   A0A182TFZ3   W5JPK4   E0VVF2   E9IN49   A0A151XDL4   A0A182FN67   A0A2M4CMB7   A0A232EMR2   A0A182LMR3   A0A154P506   A0A1I8N9D6   U4UK26   A0A084VL31   A0A2A3E8T4   A0A0A1XPT4   A0A0K8WG24   N6TIU3   A0A034V390   A0A1B0D0B9   A0A1A9XT55   A0A1B0C0S5   A0A1A9WZG7   B4Q5Z3   A0A0A9Z3B2   A0A1I8NXV5   B4JAX3   B4MZD8   A0A0A9WZ20   B3MLC3   B4GK81   Q29P71   A0A1W4WBQ5   A0A1A9UH35   G7H829   Q9V3Z6   B4KLB7   B4NYT1   B4HXL9   B3N5N5   A0A1J1I168   A0A1A9Z988   A0A3B0L0T4   A0A182H556   A0A2M4A185   A0A2H8TFY4   A0A2S2PTH4   A0A2S2NFR8   A0A2M4B870   J9K7H6   A0A1B0G9B5   A0A2M4CMY6   A0A2J7QBS2   A0A0P5UX11   A0A0P5BI54   A0A0P5UTG2   A0A0P5SGI0   A0A0P5QQ50   A0A0N8A3P7  

Pubmed

26354079    19121390    22118469    18362917    19820115    24508170    + More
30249741    24845553    21347285    21719571    28004739    17510324    20075255    25244985    20798317    20920257    23761445    20566863    21282665    28648823    20966253    25315136    23537049    24438588    25830018    25348373    17994087    22936249    25401762    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15579689    15886106    16585515    18327897    25236597    27331610    18057021    17550304    26483478   

EMBL

NWSH01000324    PCG77465.1    KQ459598    KPI94607.1    KQ461183    KPJ07555.1    + More
BABH01010284    BABH01010285    BABH01010286    AGBW02010107    OWR49160.1    KQ971343    EFA03361.1    KQ761039    OAD58359.1    KK107111    QOIP01000011    EZA58907.1    RLU16549.1    NEVH01016296    PNF26019.1    FX985580    BBF97914.1    KK853129    KDR10964.1    PNF26021.1    ADTU01025086    ADTU01025087    ADTU01025088    ADTU01025089    KQ981948    KYN32622.1    KQ976723    KYM76657.1    GL887898    EGI69596.1    KQ978023    KYM97974.1    KQ980322    KYN16600.1    GBYB01009046    JAG78813.1    GEZM01051100    JAV75175.1    CH477210    EAT47711.1    GGFM01000990    MBW21741.1    GGFJ01000094    MBW49235.1    DS231876    EDS41979.1    GEDC01025701    GEDC01023358    JAS11597.1    JAS13940.1    AXCM01005165    GL440425    EFN65899.1    GGFK01001239    MBW34560.1    AXCN02000794    APCN01003381    GGFL01002232    MBW66410.1    GECZ01028367    JAS41402.1    ADMH02000481    ETN66322.1    DS235811    EEB17358.1    GL764272    EFZ18040.1    KQ982275    KYQ58443.1    GGFL01002304    MBW66482.1    NNAY01003312    OXU19644.1    KQ434809    KZC06404.1    KB632357    ERL93472.1    ATLV01014402    KE524970    KFB38675.1    KZ288322    PBC28193.1    GBXI01001246    GBXI01000160    JAD13046.1    JAD14132.1    GDHF01032785    GDHF01002196    JAI19529.1    JAI50118.1    APGK01024675    KB740558    ENN80359.1    GAKP01022340    JAC36612.1    AJVK01002388    JXJN01023741    JXJN01023742    CM000361    CM002910    EDX05096.1    KMY90323.1    GBHO01029892    GBHO01003875    GBHO01003862    JAG13712.1    JAG39729.1    JAG39742.1    CH916368    EDW02843.1    CH963913    EDW77477.1    GBHO01035344    GBHO01029891    GBHO01029887    JAG08260.1    JAG13713.1    JAG13717.1    CH902620    EDV30712.1    CH479184    EDW37047.1    CH379058    EAL34422.1    BT132752    AE014134    AET07635.1    AHN54463.1    AHN54464.1    AY069438    BT011332    AAF53435.1    AAR96124.1    CH933807    EDW11778.1    KRG02912.1    KRG02913.1    CM000157    EDW89782.1    CH480818    EDW51799.1    CH954177    EDV57994.1    CVRI01000038    CRK93947.1    OUUW01000046    SPP90008.1    JXUM01110817    KQ565447    KXJ70961.1    GGFK01001253    MBW34574.1    GFXV01001199    MBW13004.1    GGMR01019527    MBY32146.1    GGMR01003153    MBY15772.1    GGFJ01000103    MBW49244.1    ABLF02026551    ABLF02026555    CCAG010021883    GGFL01002524    MBW66702.1    PNF26022.1    GDIP01108971    JAL94743.1    GDIP01199210    JAJ24192.1    GDIP01108970    JAL94744.1    GDIP01140317    LRGB01002190    JAL63397.1    KZS08627.1    GDIQ01111114    JAL40612.1    GDIP01185561    JAJ37841.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000005204    UP000007151    UP000007266    + More
UP000053097    UP000279307    UP000235965    UP000027135    UP000005205    UP000078541    UP000078540    UP000007755    UP000078542    UP000078492    UP000075880    UP000008820    UP000075900    UP000002320    UP000002358    UP000075920    UP000075883    UP000076408    UP000000311    UP000075881    UP000076407    UP000075886    UP000075840    UP000075903    UP000075885    UP000075902    UP000000673    UP000009046    UP000075809    UP000069272    UP000215335    UP000075882    UP000076502    UP000095301    UP000030742    UP000030765    UP000242457    UP000019118    UP000092462    UP000092443    UP000092460    UP000091820    UP000000304    UP000095300    UP000001070    UP000007798    UP000007801    UP000008744    UP000001819    UP000192221    UP000078200    UP000000803    UP000009192    UP000002282    UP000001292    UP000008711    UP000183832    UP000092445    UP000268350    UP000069940    UP000249989    UP000007819    UP000092444    UP000076858   

PRIDE

H9J0K7    Q17LW0    Q29P71    G7H829    Q9V3Z6   

Pfam

PF00373   FERM_M        + More
PF00612   IQ
PF00784   MyTH4
PF00063   Myosin_head
PF00018   SH3_1
PF16087   DUF4817
PF15866   DUF4729
PF07653   SH3_2
PF09379   FERM_N

Interpro

IPR035963   FERM_2        + More
IPR036106   MYSc_Myo7       
IPR041793   MyoVII_FERM_C1       
IPR008989   Myosin_S1_N       
IPR038185   MyTH4_dom_sf       
IPR019749   Band_41_domain       
IPR001452   SH3_domain       
IPR000857   MyTH4_dom       
IPR000048   IQ_motif_EF-hand-BS       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR000299   FERM_domain       
IPR041794   MyoVII_FERM_C2       
IPR027417   P-loop_NTPase       
IPR029071   Ubiquitin-like_domsf       
IPR036028   SH3-like_dom_sf       
IPR036961   Kinesin_motor_dom_sf       
IPR019748   FERM_central       
IPR011993   PH-like_dom_sf       
IPR001609   Myosin_head_motor_dom       
IPR032135   DUF4817       
IPR031732   DUF4729       
IPR018979   FERM_N       

SUPFAM

SSF54236   SSF54236        + More
SSF50044   SSF50044       
SSF47031   SSF47031       
SSF52540   SSF52540       

Gene 3D

1.20.80.10     1.25.40.530     2.30.29.30     2.30.30.360     3.40.850.10    

CDD

cd13198  FERM_C1_MyoVII
cd01381  MYSc_Myo7
cd14473  FERM_B-lobe
cd13199  FERM_C2_MyoVII

ProteinModelPortal

A0A2A4JZM2   A0A194PMR5   A0A0N1PEV6   H9J0K7   A0A212F5Z6   D6WM41   + More
A0A310SDF9   A0A026WSA2   A0A2J7QBS1   A0A348G641   A0A067QNC8   A0A2J7QBR2   A0A158NSP1   A0A195EXJ5   A0A151HY88   F4W8A1   A0A195CAT1   A0A195DUL7   A0A0C9RPF2   A0A1Y1LTF3   A0A182IPQ8   A0A1S4HE37   Q17LW0   A0A2M3YZS8   A0A2M4B856   A0A182RM10   B0WB21   K7J8Z2   A0A1B6CKI8   A0A182WG81   A0A182LVW6   A0A182Y0E2   E2AKY2   A0A2M4A1G1   A0A182JZ48   A0A182XNT2   A0A182R007   A0A182I7D7   A0A182VP23   A0A2M4CM41   A0A1B6ETW6   A0A182PDV3   A0A182TFZ3   W5JPK4   E0VVF2   E9IN49   A0A151XDL4   A0A182FN67   A0A2M4CMB7   A0A232EMR2   A0A182LMR3   A0A154P506   A0A1I8N9D6   U4UK26   A0A084VL31   A0A2A3E8T4   A0A0A1XPT4   A0A0K8WG24   N6TIU3   A0A034V390   A0A1B0D0B9   A0A1A9XT55   A0A1B0C0S5   A0A1A9WZG7   B4Q5Z3   A0A0A9Z3B2   A0A1I8NXV5   B4JAX3   B4MZD8   A0A0A9WZ20   B3MLC3   B4GK81   Q29P71   A0A1W4WBQ5   A0A1A9UH35   G7H829   Q9V3Z6   B4KLB7   B4NYT1   B4HXL9   B3N5N5   A0A1J1I168   A0A1A9Z988   A0A3B0L0T4   A0A182H556   A0A2M4A185   A0A2H8TFY4   A0A2S2PTH4   A0A2S2NFR8   A0A2M4B870   J9K7H6   A0A1B0G9B5   A0A2M4CMY6   A0A2J7QBS2   A0A0P5UX11   A0A0P5BI54   A0A0P5UTG2   A0A0P5SGI0   A0A0P5QQ50   A0A0N8A3P7  

PDB

3PVL     E-value=0,     Score=2267

KEGG

101738943    K10359 myosin VIIa | (RefSeq) myosin-VIIa

GO

GO:0005524   GO:0016459   GO:0051015   GO:0003774   GO:0003779   GO:0005737   GO:0048800   GO:0030898   GO:0008407   GO:0032027   GO:0007605   GO:0030048   GO:0035317   GO:0016021   GO:0045296   GO:0005902   GO:0008586   GO:0007015   GO:0045179   GO:0035293   GO:0031477   GO:0045180   GO:0035182   GO:0070825   GO:0032529   GO:0016887   GO:0007469   GO:0042623   GO:0007423   GO:0016461   GO:0005938   GO:0005515   GO:0005856   GO:0051603   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Cytoplasm  
Cell cortex   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.
Cell projection   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.
Microvillus   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.

Length:

1945

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8.43576999999994

Exp number, first 60 AAs:

0.00451

Total prob of N-in:

0.37085

outside

1  -  1945

 

 

Pi

219.2602

Theta

160.964018

Tajima's D

1.267199

CLR

0.340378

CSRT

0.732913354332283

Interpretation

Uncertain