Gene

KWMTBOMO02223  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003116

Annotation

aspartate_aminotransferase_[Bombyx_mori]

Location

Bomo_Chr4(-):14219020-14232191      View in EpiBrowser

Full name

Aspartate aminotransferase      

Location in the cell

Cytoplasmic   Reliability : 1.634 Mitochondrial   Reliability : 1.806 Peroxisomal   Reliability : 1.108

CDS

ATGGCTCAAGTGTTAAAGAAATTAACTACCCAGGTGCTCAAGCCTAATAATGTAGACACGATCGTTGGTTGTACAGGCCTTAGAGCCAGCAGCACCTGGTGGAACAATGTTCAGATGGGTCCGCCAGATGTAATCTTAGGCATTACAGAAGCATACAAGAAGGACACACATCCTAAAAAAGTAAATCTTGGGGTTGGAGCATATAGAGACGATGAGGGAAAACCATTTGTTTTGCCTTCTGTCAGAAAGGCAGAAGAAATTCTTCACAGTAGAGGACTCAACCATGAGTATGCTCCCATTAGTGGTGAGGCCACATATACTGATGCTGTAGCTAAACTTGCTTTTGGAGAAGACAGTCCTGTCATCAAAAATAGGAGCAACTGTACTGTACAGACATTGTCCGGCACTGGCGCACTCCGACTCGGACTCGAGTTCATAACGAAACACTACGCTAAGGCAAAGGAGATCTGGCTCCCGACGCCTACTTGGGGAAACCACCCGCAAATCTGCAACACCCTCAACTTGCCGCACAAGAAATACCGTTACTTCGATCCCAAGACCAATGGTTTCGATTTGCAGGGAGCACTCGAGGATATATCAAAAATTCCCGAAGGTTCCATTATTCTGTTGCACGCGTGCGCACACAACCCCACCGGTGTTGACCCCAAGCCCAGCGACTGGGAACAACTTTCCAAGGTGATCAAAGAAAGGAAATTATTCCCGTTCTTCGACATGGCGTATCAAGGTTTCGCCACCGGTGATGTCGACAATGACGCTTTCGCAGTCCGTCTCTTCGTCAAGGAAGGACACCAAGTCATGTTGGCGCAGAGTTTCGCTAAGAACATGGGTCTGTACGGAGAGCGCGCGGGCGCCCTGACCTTCCTGTGCGGCGACGAGGCGACGGCCGCCAAGGTGATGTCGCAGGTCAAGATCATGGTCCGCGTCATGTACTCCAACCCTCCGCTGTACGGCGCCCGCCTCGTGCAGGAGATACTCACCAACGCCGAACTCAAAAAGCAATGGCTCGGAGACGTAAAGCAGATGGCGGACCGGATCATCACGATGCGGAGCCAGCTCCGCGCCGGCATCGAGGGCGCCGGCAACCCGCACCCCTGGCAACACATCACCGACCAGATCGGCATGTTCTGCTTCACCGGACTCAAGCCCGAGCAGGTCGAGCGTCTGACGAAAGAGTTCCACGTGTACCTGACGAAAGACGGACGCATTTCCGTCGCCGGCATCTCCTCGCAAAACGTGAACTACATCGCCGAGGCCATCCACAAGGTCACCTCATAA

Protein

MAQVLKKLTTQVLKPNNVDTIVGCTGLRASSTWWNNVQMGPPDVILGITEAYKKDTHPKKVNLGVGAYRDDEGKPFVLPSVRKAEEILHSRGLNHEYAPISGEATYTDAVAKLAFGEDSPVIKNRSNCTVQTLSGTGALRLGLEFITKHYAKAKEIWLPTPTWGNHPQICNTLNLPHKKYRYFDPKTNGFDLQGALEDISKIPEGSIILLHACAHNPTGVDPKPSDWEQLSKVIKERKLFPFFDMAYQGFATGDVDNDAFAVRLFVKEGHQVMLAQSFAKNMGLYGERAGALTFLCGDEATAAKVMSQVKIMVRVMYSNPPLYGARLVQEILTNAELKKQWLGDVKQMADRIITMRSQLRAGIEGAGNPHPWQHITDQIGMFCFTGLKPEQVERLTKEFHVYLTKDGRISVAGISSQNVNYIAEAIHKVTS

Catalytic Activity

2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate

Subunit

Homodimer.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Uniprot

Q1HQC7   A0A0N1I6L0   S4NIK5   A0A194PTZ8   I4DMJ4   A0A212FDH2   + More
A0A0L8HF62   A0A346QRK7   A0A023FW96   T1D424   A0A023ES24   Q5K6H3   A0A1Z5KWT1   A0A023GM60   A0A023EUC0   G3MND0   A0A023FMK0   A0A293MXN9   A0A131XI81   L7M8A4   B0WHA4   A0A131Z1G6   A0A1Q3FI36   A0A1Q3FI61   A0A1E1XB04   A0A068CE32   A0A224YHY0   A0A182NBG9   A0A0P4WGM6   T1ELV3   A0A2R5LN70   V4ABY1   A0A182XN34   A0A182VTZ7   A0A2T7NHP2   A0A182PFJ4   A0A182VLB5   A0A182LM90   Q7PM06   A0A182HI77   A0A182U304   A0A084VXF8   R7VEL1   A0A182R3W1   A0A0U2USW7   A0A067QQX8   A0A182M173   A0A182QUS5   A0A182YFU6   A0A1B6LDY2   A0A0P4VSL5   R4G4U0   A0A210PZB0   A0A0B7AFG9   A0A0P5G423   A0A0P5K485   A0A1S3JTA5   A0A0N8AHJ2   A0A0P5GJ33   S5NFZ5   A0A2M4A4I2   A0A0P5MFN2   A0A0P5NA96   A0A182F252   K1R2Q9   W5J6A8   A0A0P6B3E8   A0A2M4A4A4   A0A232EMJ7   A0A0P5S2Y0   A0A0P4WPP3   A0A0P4X5Y2   A0A2J7QBK4   E2AHR4   A0A2M4BNR8   T1DND3   A0A182K5J8   A0A0P5SY60   A0A2M3Z217   A0A1B6IW93   A0A0P5HP03   A0A2C9K2S4   A0A023F820   A0A2M4BNN4   A0A182IP37   A0A170YUJ9   T1JUT6   A0A026VYP4   A0A3L8D4A3   A0A0P5MNK1   A0A0N8DE17   Q7ZWF5   A0A0P5G3V1   A0A0B7AET5   A0A0P5FYQ1   A0A1B6D614   A0A3B3CYX3   J3JT64   A0A0A9W0U8   F1QCD4  

EC Number

2.6.1.1

Pubmed

26354079    23622113    22651552    22118469    24330624    24945155    + More
17510324    28528879    22216098    28049606    25576852    26830274    28503490    28797301    23254933    20966253    12364791    14747013    17210077    24438588    26621068    24845553    25244985    27129103    28812685    23791183    22992520    20920257    23761445    28648823    20798317    15562597    25474469    24508170    30249741    29451363    22516182    23537049    25401762    23594743   

EMBL

DQ443125    ABF51214.1    KQ461183    KPJ07552.1    GAIX01014034    JAA78526.1    + More
KQ459598    KPI94610.1    AK402512    BAM19134.1    AGBW02009066    OWR51763.1    KQ418413    KOF87430.1    MH220515    AXR98597.1    GBBL01001189    JAC26131.1    GALA01001128    JAA93724.1    GAPW01001568    JAC12030.1    AF395206    CH477240    AAQ02892.1    EAT46448.1    GFJQ02007394    JAV99575.1    GBBM01001180    JAC34238.1    GAPW01001569    JAC12029.1    JO843381    AEO34998.1    GBBK01002544    JAC21938.1    GFWV01019960    MAA44688.1    GEFH01001738    JAP66843.1    GACK01004764    JAA60270.1    DS231934    EDS27610.1    GEDV01003293    JAP85264.1    GFDL01007837    JAV27208.1    GFDL01007805    JAV27240.1    GFAC01002887    JAT96301.1    KF773747    AID18683.1    GFPF01006131    MAA17277.1    GDRN01048331    JAI66661.1    AMQM01002880    KB095905    ESO10123.1    GGLE01006854    MBY10980.1    KB202325    ESO90816.1    PZQS01000012    PVD20691.1    AAAB01008980    EAA14551.4    APCN01005643    ATLV01018053    KE525212    KFB42652.1    AMQN01004791    KB294357    ELU14716.1    KT754869    ALS04703.1    KK853129    KDR10996.1    AXCM01000469    AXCN02000619    GEBQ01018087    JAT21890.1    GDKW01001135    JAI55460.1    ACPB03008949    GAHY01000471    JAA77039.1    NEDP02005352    OWF41825.1    HACG01032633    CEK79498.1    GDIQ01268313    LRGB01000626    JAJ83411.1    KZS17493.1    GDIQ01197458    GDIQ01189856    GDIQ01143642    JAK61869.1    GDIP01146801    JAJ76601.1    GDIQ01241782    JAK09943.1    KF021982    AGR65730.1    GGFK01002319    MBW35640.1    GDIQ01180112    JAK71613.1    GDIQ01145146    JAL06580.1    JH818674    EKC37844.1    ADMH02002076    ETN59536.1    GDIP01034349    JAM69366.1    GGFK01002323    MBW35644.1    NNAY01003371    OXU19532.1    GDIQ01097648    JAL54078.1    GDIP01254375    JAI69026.1    GDIP01254076    JAI69325.1    NEVH01016296    PNF25963.1    GL439579    EFN66993.1    GGFJ01005554    MBW54695.1    GAMD01002985    JAA98605.1    GDIP01136397    JAL67317.1    GGFM01001809    MBW22560.1    GECU01016507    JAS91199.1    GDIQ01225309    GDIQ01225308    JAK26416.1    GBBI01001324    JAC17388.1    GGFJ01005555    MBW54696.1    GEMB01002944    JAS00258.1    CAEY01000784    KK107727    EZA47979.1    QOIP01000013    RLU15337.1    GDIQ01160825    JAK90900.1    GDIP01042911    JAM60804.1    BC049435    AAH49435.1    GDIQ01246849    JAK04876.1    HACG01032634    CEK79499.1    GDIQ01248607    JAK03118.1    GEDC01016176    JAS21122.1    APGK01018933    BT126420    KB740085    KB632303    AEE61384.1    ENN81578.1    ERL91839.1    GBHO01045104    GBRD01004284    JAF98499.1    JAG61537.1    BX957362    CU633476   

Proteomes

UP000053240    UP000053268    UP000007151    UP000053454    UP000008820    UP000002320    + More
UP000075884    UP000015101    UP000030746    UP000076407    UP000075920    UP000245119    UP000075885    UP000075903    UP000075882    UP000007062    UP000075840    UP000075902    UP000030765    UP000014760    UP000075900    UP000027135    UP000075883    UP000075886    UP000076408    UP000015103    UP000242188    UP000076858    UP000085678    UP000069272    UP000005408    UP000000673    UP000215335    UP000235965    UP000000311    UP000075881    UP000076420    UP000075880    UP000015104    UP000053097    UP000279307    UP000261560    UP000019118    UP000030742    UP000000437   

PRIDE

Q1HQC7    G3MND0    L7M8A4    Q7ZWF5    F1QCD4   

Pfam

PF00155   Aminotran_1_2        + More
PF01694   Rhomboid

Interpro

IPR004839   Aminotransferase_I/II        + More
IPR015424   PyrdxlP-dep_Trfase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR004838   NHTrfase_class1_PyrdxlP-BS       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR000796   Asp_trans       
IPR035952   Rhomboid-like_sf       
IPR022764   Peptidase_S54_rhomboid_dom       

SUPFAM

SSF53383   SSF53383       

Gene 3D

3.40.640.10     3.90.1150.10     1.20.1540.10    

ProteinModelPortal

Q1HQC7   A0A0N1I6L0   S4NIK5   A0A194PTZ8   I4DMJ4   A0A212FDH2   + More
A0A0L8HF62   A0A346QRK7   A0A023FW96   T1D424   A0A023ES24   Q5K6H3   A0A1Z5KWT1   A0A023GM60   A0A023EUC0   G3MND0   A0A023FMK0   A0A293MXN9   A0A131XI81   L7M8A4   B0WHA4   A0A131Z1G6   A0A1Q3FI36   A0A1Q3FI61   A0A1E1XB04   A0A068CE32   A0A224YHY0   A0A182NBG9   A0A0P4WGM6   T1ELV3   A0A2R5LN70   V4ABY1   A0A182XN34   A0A182VTZ7   A0A2T7NHP2   A0A182PFJ4   A0A182VLB5   A0A182LM90   Q7PM06   A0A182HI77   A0A182U304   A0A084VXF8   R7VEL1   A0A182R3W1   A0A0U2USW7   A0A067QQX8   A0A182M173   A0A182QUS5   A0A182YFU6   A0A1B6LDY2   A0A0P4VSL5   R4G4U0   A0A210PZB0   A0A0B7AFG9   A0A0P5G423   A0A0P5K485   A0A1S3JTA5   A0A0N8AHJ2   A0A0P5GJ33   S5NFZ5   A0A2M4A4I2   A0A0P5MFN2   A0A0P5NA96   A0A182F252   K1R2Q9   W5J6A8   A0A0P6B3E8   A0A2M4A4A4   A0A232EMJ7   A0A0P5S2Y0   A0A0P4WPP3   A0A0P4X5Y2   A0A2J7QBK4   E2AHR4   A0A2M4BNR8   T1DND3   A0A182K5J8   A0A0P5SY60   A0A2M3Z217   A0A1B6IW93   A0A0P5HP03   A0A2C9K2S4   A0A023F820   A0A2M4BNN4   A0A182IP37   A0A170YUJ9   T1JUT6   A0A026VYP4   A0A3L8D4A3   A0A0P5MNK1   A0A0N8DE17   Q7ZWF5   A0A0P5G3V1   A0A0B7AET5   A0A0P5FYQ1   A0A1B6D614   A0A3B3CYX3   J3JT64   A0A0A9W0U8   F1QCD4  

PDB

3PDB     E-value=1.16102e-154,     Score=1402

KEGG

732869    K14455 aspartate aminotransferase, mitochondrial [EC:2.6.1.1] | (RefSeq) aspartate aminotransferase

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
00360    Phenylalanine metabolism - Bombyx mori (domestic silkworm)
00400    Phenylalanine, tyrosine and tryptophan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01210    2-Oxocarboxylic acid metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0030170   GO:0009058   GO:0006520   GO:0004069   GO:0005739   GO:0006533   GO:0016021   GO:0004252   GO:0008483   GO:0003824   GO:0051603   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR11879  

Length:

431

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00417

Exp number, first 60 AAs:

0.00206

Total prob of N-in:

0.01124

outside

1  -  431

 

 

Pi

258.471175

Theta

175.543253

Tajima's D

0.822832

CLR

0.031577

CSRT

0.610469476526174

Interpretation

Uncertain