Gene

KWMTBOMO02211  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003038

Annotation

PREDICTED:_rho-associated_protein_kinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr4(+):13952482-13974135      View in EpiBrowser

Full name

Rho-associated protein kinase      

Location in the cell

Nuclear   Reliability : 2.971

CDS

ATGAAGGATTGCCTTAGTGGCCACAGAGATCAAGAACACAACAGGATGGAAGTGAAGGATGAGGATCGCATGAGGCGTCTTCATGCGTTGGAGGAACGTTTGTGTGACCCCCGTTCCACCGGTAATGTGGACTGTCTACTGGATACCGTCACTGCGCTCGTGTCCGATTGTGACCATCCAGCTATTCGTCGCATGAAAAACGTCGAAGCCTACACTAGTAGATATGAAGAGTTTTCTTCAGAAATTATTAATCTGCGAATGAAGGCAGCTGATTTCCATTTAATTAAAGTGATTGGACGAGGGGCATTTGGTGAAGTACAACTAGTCAGACAAAAGTCTACCAACCATGTTTATGCCATGAAACTTCTTAGTAAAGTAGAAATGATTAAGAGGTCAGACTCCACATTCTTTTGGGAAGAAAGGCACATTATGGCCCATGCCAACTCGGACTGGATACTAAAATTACATTTTGCATTTCAAGATCATAAATATCTTTATATGGTTATGGATTATATGCCTGGTGGTGATCTTGTCAGTCTAATGTCGAACTATGACATACCAGAGAAATGGGCAAAATTCTACACAATGGAGATTGTTCTTGCTCTGGATGTTATTCATGGCATGGGATTTGTCCATAGAGATGTAAAACCAGACAATATGTTGATAGATAAACATGGCCATTTAAAACTAGCCGATTTTGGTACTTGTATGAGAATGGGACTGGATGGTTTAGTTCGAGCAAGCAATGCTGTGGGAACTCCTGATTATATATCTCCTGAAGTTCTGCAGTCACAAAATGGTGAAGGAGTATATGGGCGTGAGTGCGATTGGTGGGCAGTAGGAATATTTTTGTACGAAATGCTTATTGGTGACCCTCCTTTTTATGCTGATAGTTTAGTGGGCACGTATGGTAAAATTATGGATCACAGGAATTCTTTACAGTTTCCTGATGATGTTGAGATCTCAAAAGAAGCAAAGTCTCTAATTAGAGGACTTTTAACTGATAGAACTAAAAGATTAGGTAGAAACAGTGTGGATGAAATTAAACAGCATCCATTTTTTATAAATGATCAATGGAGTTTTGAAAATCTGAGGGATTCTGTACCTCCTGTGGTGCCTGAACTCTCCAGTGATGATGATACTAGGAACTTTGATGATATTGAAAAATCAGATGCACTTGATGAATCCTTTCCTGTACCAAAAGCATTTGTTGGTAATCATTTGCCATTTGTTGGTTTCACTTATAATGGTGATTACCAATTGTGCACTCGCCAAAAGAAAGCAAATGACGTAGTAGACACAATATCTAATAATCATATCAACAATGATGGATCTGAAGCCATATATCAACTAGAGAAACTGCTCGAAAGAGAAAGAGATGGCAAACGTAAACTAGAAGATACTCAAGCTGCCCTATGTGCTCAGCTCGAAGAACTATCACAGAGAGAACTACGCAATAAAAAAATAATTTCTGAAAGCGATAAAGAGGTTGCATTACTGAGACATGATCTTAAAGAAATTCAACGGATAGCTGAACTGGAAGTAGAATCTAGACGAAAGGCTGAAGCTAATCTCAATGAGGCAAAACGCCGTCTTGAAGAGGAACAAACCAAGAGAACGAAAGAAATGAGTAATTTACACATATACAACGAAAAAATTAACGCATTAGAAAAACAGCTCGAAGAATTGCGAGAGAAACTAAAACAAGAGTCTGAAGCAGCAGCCAAATCTAGGAAGCAAGCTGCCGAGCTATCGGCTGCCCAGGCCGCCGCCGCAGCTGTCAACGACGGCACGGTAACCAGCTTGCGGGCTCAACGTGATGCTCTCGAACGAGAGAGAAGTATTTTATCAGAGGAACTGAGCGAAGTTAAGGCAGCTAGACAACGTTCGGAAGCGGCGGTCACAGAGGCCACCTGCAGACTCAATGCGGCTCATGCAGAATTGGAGCGCACTTCGACACGATTATCTCAAATGATCGCTGATAACAGACAATTAACAGAACGTGTATCTTCACTAGAGAAGGAATGCACTTCATTATCTCATGAGTTAAGATCAGCGCAACATTTATATCAACAAGAGTTGCGTGCACATCAGGACACGCAACGATCTCAGCTTCTCTCTAAACAAGAAGCCAACTTGGAACTAGTCAAGACCCTGCAAACTAAGCTGAACGAAGAAAAGACTGCCAGACAACGGTCGGAATCAGCTTGTCAAGAGAAAGACCGACAGATGTCGATGCTCAGCGTTGATTACAGACAGATGCAGCAGAGACTCCAGAAACTAGAGGGCGAACATCGGCAAGAAAGCGAAAAGGTATGCGGGCTGGTCGCGTCGCTAGAGCAGGAGCGCGCGGCTCGACTGGCGGCGTCGGGCGAGGTGTCGGCGGCGGAGGCGGCGGCCCGCACCGCGCTCGCCGAGCGGGACGCGCGCGCCCGCGACCTGCACGCCGTGCGCGCCGCGCTGCACGACGCCTCCGAGAAACTAGCCGCCGCCAGCGCAGAGCGGGACATGTACTACGCCAGGAGTGAAGAGTTGCGCTCTCAGTTGGAGAATGAGCAACATTACTGCCATGTGTATAGAAGTCAGGTCAATGAGATCCGCACTCAGGTGGAGGAGAGTTCTCGCGCTGCCCGGGACCTCGAACAAGAAAGATCCAGCTTGTTGCATCAACTACAGCTCGCCATTGCTAGGGCCGACTCTGAGGCTATTGCAAGATCGATAGCGGAAGAGACAGTTGGTGAACTGGAGAAGGAGAAGACAATGAAAGAGTTAGAGATGCGGGAAGCTGTGTCCCAGCATCGCGCCGAGCTGGCGGCCCGCGACAACATGCTGCAGGGCCTGCGGGACCGGGACCACGAGAACCGCGCCACCATCGACCTGCAGCGGAAGGAGGTGGACGAGCTCCGGCGCAGCGGCACGGCGCTGGCGGAGCGCGTGGCGTCGCTGCAGCGGCTGCAGGACGAGCTGGACCGACTCAACAAGAAGCTCAACTCTGAGATCATGCTCAAGCAGCAGGCGGTCAACAAGCTCGCCGAGATCATGAACAGGAAAGACATGAACCCGACTGCGGGCAAGAACAAGAGCAAGATGTCGGTCCGGAAGGACAAGGATTACCGCAAGCTGCAGCAAGAGCTGACCCGGGAGAAGGAGAAGTTCGACCAGCACATCTCGAAGCTGCAGCGGGACCTGCAGGACTGTCAGCAGCAGTTGCTGGACGAGCAGTCCACCAGGCTTAGACTTGCCATGGAGGTTGACAGCAAAGACGCTGAGATCGAGCAGCTGAAGGAGAAGCTCGCCGCGCTCACCAGCGAGACGGCGTCGCAGTCGTCGGCCGACGCGGAGGACGGCGAGAACGAGCAGATCCTCGAAGGCTGGCTCTCGGTGCCGTTCAAGCAGAACATACGCAGGCACGGCTGGAAGAAGCAGTACGTCGTCGTTTCCTCCAAGAAGATCATCTTCTACAACTCTGAGAACGATAAACAGAATACCACAGATCCCGTCATGATCTTGGATTTGAGCAAGGTGTTCCACGTGCGCTCCGTGACGCAGGGCGACGTGATCCGCGCCGACGCGAAGGACATCCCGCGGATCTTCCAGCTGCTGTACGCGGGCGAGGGGGAGGCGCGCCGCCCCGACCAGCAGGACCAGCCGCAGGACTCCACCGACCATCAAGGCAACACGGTGCAGCACAAAGGCCACGACCTGGTGAGCATCACGTACCACATCCCGACGGCGTGCGAGGTGTGCACGCGGCCGCTGTGGCACATGTTCCGGCCGCCGCAGGCCTACGAGTGTCGCCGGTGTCGGATGAAGATCCACGCGGAGCACCTGACGGAGGGCGAGGGCGTGGCGGCGTGCAAGCTGCACGCGGACCGCGCGCGCGAGCTGCTGCTGCTGGCGCCCGCCGCGCCCGAGCAGCGCCGCTGGGTGGCCCGCCTGGCGCGCCGCGTGCAGCGACACGGCTACCGCGCCGCGCACCACAACCACGACCATCGCCTCTCGCCCAGGGACTCTATGCGCTCGAACCTGAAGTCGGCCGCGCACCTGAACGTGTCCCAGCGCAGCTCCACGCTGCCCGCCAACGCGTCCATGCAGCGGCAGTGA

Protein

MKDCLSGHRDQEHNRMEVKDEDRMRRLHALEERLCDPRSTGNVDCLLDTVTALVSDCDHPAIRRMKNVEAYTSRYEEFSSEIINLRMKAADFHLIKVIGRGAFGEVQLVRQKSTNHVYAMKLLSKVEMIKRSDSTFFWEERHIMAHANSDWILKLHFAFQDHKYLYMVMDYMPGGDLVSLMSNYDIPEKWAKFYTMEIVLALDVIHGMGFVHRDVKPDNMLIDKHGHLKLADFGTCMRMGLDGLVRASNAVGTPDYISPEVLQSQNGEGVYGRECDWWAVGIFLYEMLIGDPPFYADSLVGTYGKIMDHRNSLQFPDDVEISKEAKSLIRGLLTDRTKRLGRNSVDEIKQHPFFINDQWSFENLRDSVPPVVPELSSDDDTRNFDDIEKSDALDESFPVPKAFVGNHLPFVGFTYNGDYQLCTRQKKANDVVDTISNNHINNDGSEAIYQLEKLLERERDGKRKLEDTQAALCAQLEELSQRELRNKKIISESDKEVALLRHDLKEIQRIAELEVESRRKAEANLNEAKRRLEEEQTKRTKEMSNLHIYNEKINALEKQLEELREKLKQESEAAAKSRKQAAELSAAQAAAAAVNDGTVTSLRAQRDALERERSILSEELSEVKAARQRSEAAVTEATCRLNAAHAELERTSTRLSQMIADNRQLTERVSSLEKECTSLSHELRSAQHLYQQELRAHQDTQRSQLLSKQEANLELVKTLQTKLNEEKTARQRSESACQEKDRQMSMLSVDYRQMQQRLQKLEGEHRQESEKVCGLVASLEQERAARLAASGEVSAAEAAARTALAERDARARDLHAVRAALHDASEKLAAASAERDMYYARSEELRSQLENEQHYCHVYRSQVNEIRTQVEESSRAARDLEQERSSLLHQLQLAIARADSEAIARSIAEETVGELEKEKTMKELEMREAVSQHRAELAARDNMLQGLRDRDHENRATIDLQRKEVDELRRSGTALAERVASLQRLQDELDRLNKKLNSEIMLKQQAVNKLAEIMNRKDMNPTAGKNKSKMSVRKDKDYRKLQQELTREKEKFDQHISKLQRDLQDCQQQLLDEQSTRLRLAMEVDSKDAEIEQLKEKLAALTSETASQSSADAEDGENEQILEGWLSVPFKQNIRRHGWKKQYVVVSSKKIIFYNSENDKQNTTDPVMILDLSKVFHVRSVTQGDVIRADAKDIPRIFQLLYAGEGEARRPDQQDQPQDSTDHQGNTVQHKGHDLVSITYHIPTACEVCTRPLWHMFRPPQAYECRRCRMKIHAEHLTEGEGVAACKLHADRARELLLLAPAAPEQRRWVARLARRVQRHGYRAAHHNHDHRLSPRDSMRSNLKSAAHLNVSQRSSTLPANASMQRQ

Description

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Subunit

Homodimer.

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Uniprot

E3VQ36   A0A2A4JQS9   A0A2H1VDL0   A0A194R8N7   A0A194PPF9   A0A0L7LEM1   + More
A0A2J7PRJ7   A0A2J7PRI0   A0A151XBB6   E2B7A8   A0A154NXD5   F4WIC6   A0A088ATG8   A0A2J7PRI1   A0A195BLB5   A0A158NZV1   A0A0L7RA01   A0A3L8DV67   A0A195F385   A0A151J2D9   D6WNY9   A0A026WPN6   A0A1Y1M4Z7   E2A893   A0A232EM27   K7IV18   A0A310SKS9   A0A2A3EID4   A0A0C9QM01   A0A195CM24   A0A139WHG7   A0A0C9QED7   A0A1Y1LZZ6   E0VY20   A0A023F4N1   A0A0C9R4B6   A0A2S2NMH7   A0A2S2Q665   A0A0C9R4C1   J9JZB8   A0A067RLR3   A0A224X567   A0A146KUB8   T1HUL2   A0A1S4G7D4   A0A0K8WJ47   A0A0L0CL34   B0WWT9   W8BVK1   A0A0A1WEU6   A0A1Q3F3X3   A0A0K8TVJ8   W8AW70   A0A1L8DM40   A0A1B0BMY5   A0A1I8Q3E9   E9GLV2   A0A182H9C4   A0A1I8Q3C7   A0A1A9XY85   A0A0P5W602   A0A1I8N3J7   A0A0N8EBV9   A0A0P5B6Y5   A0A0N8D6J6   A0A1J1HSG0   A0A0P5U236   A0A0P4ZIX4   A0A0P5WU04   A0A0P5B8Z3   A0A0P5CVD0   A0A1I8Q3B7   W4VRL9   A0A1A9VDC0   A0A0T6ATL5   A0A1I8Q3C4   A0A1I8Q3E3   A0A1I8Q3E8   A0A1I8Q3C1   A0A1A9Z8L7   A0A0P5ZFX7   A0A0P6ACA1   A0A0N8DLC4   A0A0P5CUK8   A0A1B0FAA8   A0A1A9WDB5   A0A0P6B1F2   X2JC83   A0A182FJW0   Q179S5   A0A182JLX8   A0A0Q5TJ56   Q9VXE3   B3MRC3   Q961D4   Q9U779   B3NVJ7   X2JKQ8   A0A0P8XK28   A0A1W4VJ27  

EC Number

2.7.11.1

Pubmed

19121390    21040523    26354079    26227816    20798317    21719571    + More
21347285    30249741    18362917    19820115    24508170    28004739    28648823    20075255    20566863    25474469    24845553    26823975    17510324    26108605    24495485    25830018    21292972    26483478    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17994087    26109357    26109356    10570971    18057021   

EMBL

BABH01010310    BABH01010311    HQ179969    ADP21243.1    NWSH01000819    PCG74058.1    + More
ODYU01001971    SOQ38907.1    KQ460779    KPJ12236.1    KQ459598    KPI94619.1    JTDY01001388    KOB73998.1    NEVH01021962    PNF18939.1    PNF18941.1    KQ982330    KYQ57673.1    GL446154    EFN88393.1    KQ434777    KZC04287.1    GL888175    EGI66057.1    PNF18940.1    KQ976440    KYM86493.1    ADTU01005006    ADTU01005007    KQ414621    KOC67581.1    QOIP01000003    RLU24317.1    KQ981856    KYN34642.1    KQ980404    KYN16200.1    KQ971343    EFA04406.2    KK107144    EZA57596.1    GEZM01044341    JAV78297.1    GL437497    EFN70359.1    NNAY01003440    OXU19414.1    AAZX01001198    AAZX01004095    KQ761797    OAD56794.1    KZ288253    PBC30946.1    GBYB01001662    GBYB01001665    JAG71429.1    JAG71432.1    KQ977580    KYN01758.1    KYB27402.1    GBYB01001664    JAG71431.1    GEZM01044340    JAV78298.1    DS235843    EEB18276.1    GBBI01002375    JAC16337.1    GBYB01001661    JAG71428.1    GGMR01005771    MBY18390.1    GGMS01004006    MBY73209.1    GBYB01001663    GBYB01001666    JAG71430.1    JAG71433.1    ABLF02039304    KK852432    KDR23978.1    GFTR01008781    JAW07645.1    GDHC01019414    JAP99214.1    ACPB03002620    GDHF01025419    GDHF01001138    JAI26895.1    JAI51176.1    JRES01000336    KNC32174.1    DS232152    EDS36200.1    GAMC01013376    JAB93179.1    GBXI01017086    GBXI01016730    GBXI01004869    JAC97205.1    JAC97561.1    JAD09423.1    GFDL01012826    JAV22219.1    GDHF01033817    GDHF01030591    JAI18497.1    JAI21723.1    GAMC01013375    JAB93180.1    GFDF01006541    JAV07543.1    JXJN01017103    GL732551    EFX79573.1    JXUM01029960    KQ560869    KXJ80552.1    GDIP01252860    GDIP01251110    GDIP01235514    GDIP01195962    GDIP01191210    GDIP01179469    GDIP01172122    GDIP01148219    GDIP01147865    GDIP01136323    GDIP01104174    GDIP01104173    GDIP01101173    GDIP01083627    JAL99541.1    GDIQ01041996    JAN52741.1    GDIP01188611    JAJ34791.1    GDIP01212269    GDIP01181364    GDIP01166213    GDIP01122721    GDIP01120878    GDIP01087678    GDIP01086633    GDIP01085230    GDIP01079325    GDIP01072826    GDIP01063879    GDIP01058984    GDIP01058983    GDIP01039587    GDIP01038536    GDIP01037388    JAM39836.1    CVRI01000020    CRK90991.1    GDIP01118832    JAL84882.1    GDIP01216010    JAJ07392.1    GDIP01081777    JAM21938.1    GDIP01203260    JAJ20142.1    GDIP01165018    JAJ58384.1    GANO01001708    JAB58163.1    LJIG01022848    KRT78409.1    GDIP01045934    JAM57781.1    GDIP01036387    JAM67328.1    GDIP01022455    JAM81260.1    GDIP01166214    JAJ57188.1    CCAG010017193    GDIP01035245    JAM68470.1    AE014298    AHN59805.1    CH477346    EAT42995.1    CH954180    KQS29958.1    BT044181    AAF48631.1    ACH92246.1    CH902622    EDV34328.1    AY051659    AAK93083.1    AF151375    AAF03776.1    EDV46389.2    AHN59807.1    KPU75083.1    KPU75084.1    KPU75085.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510    UP000235965    + More
UP000075809    UP000008237    UP000076502    UP000007755    UP000005203    UP000078540    UP000005205    UP000053825    UP000279307    UP000078541    UP000078492    UP000007266    UP000053097    UP000000311    UP000215335    UP000002358    UP000242457    UP000078542    UP000009046    UP000007819    UP000027135    UP000015103    UP000037069    UP000002320    UP000092460    UP000095300    UP000000305    UP000069940    UP000249989    UP000092443    UP000095301    UP000183832    UP000078200    UP000092445    UP000092444    UP000091820    UP000000803    UP000069272    UP000008820    UP000075880    UP000008711    UP000007801    UP000192221   

PRIDE

E3VQ36    X2JC83    Q961D4    Q9U779    X2JKQ8   

Pfam

PF00069   Pkinase        + More
PF08912   Rho_Binding
PF00169   PH

Interpro

IPR002219   PE/DAG-bd        + More
IPR017441   Protein_kinase_ATP_BS       
IPR011993   PH-like_dom_sf       
IPR001849   PH_domain       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR029875   LET-502       
IPR000719   Prot_kinase_dom       
IPR015008   Rho-bd_dom       
IPR000961   AGC-kinase_C       
IPR020684   ROCK1/ROCK2       

SUPFAM

SSF56112   SSF56112       

Gene 3D

2.30.29.30    

CDD

cd00029  C1

ProteinModelPortal

E3VQ36   A0A2A4JQS9   A0A2H1VDL0   A0A194R8N7   A0A194PPF9   A0A0L7LEM1   + More
A0A2J7PRJ7   A0A2J7PRI0   A0A151XBB6   E2B7A8   A0A154NXD5   F4WIC6   A0A088ATG8   A0A2J7PRI1   A0A195BLB5   A0A158NZV1   A0A0L7RA01   A0A3L8DV67   A0A195F385   A0A151J2D9   D6WNY9   A0A026WPN6   A0A1Y1M4Z7   E2A893   A0A232EM27   K7IV18   A0A310SKS9   A0A2A3EID4   A0A0C9QM01   A0A195CM24   A0A139WHG7   A0A0C9QED7   A0A1Y1LZZ6   E0VY20   A0A023F4N1   A0A0C9R4B6   A0A2S2NMH7   A0A2S2Q665   A0A0C9R4C1   J9JZB8   A0A067RLR3   A0A224X567   A0A146KUB8   T1HUL2   A0A1S4G7D4   A0A0K8WJ47   A0A0L0CL34   B0WWT9   W8BVK1   A0A0A1WEU6   A0A1Q3F3X3   A0A0K8TVJ8   W8AW70   A0A1L8DM40   A0A1B0BMY5   A0A1I8Q3E9   E9GLV2   A0A182H9C4   A0A1I8Q3C7   A0A1A9XY85   A0A0P5W602   A0A1I8N3J7   A0A0N8EBV9   A0A0P5B6Y5   A0A0N8D6J6   A0A1J1HSG0   A0A0P5U236   A0A0P4ZIX4   A0A0P5WU04   A0A0P5B8Z3   A0A0P5CVD0   A0A1I8Q3B7   W4VRL9   A0A1A9VDC0   A0A0T6ATL5   A0A1I8Q3C4   A0A1I8Q3E3   A0A1I8Q3E8   A0A1I8Q3C1   A0A1A9Z8L7   A0A0P5ZFX7   A0A0P6ACA1   A0A0N8DLC4   A0A0P5CUK8   A0A1B0FAA8   A0A1A9WDB5   A0A0P6B1F2   X2JC83   A0A182FJW0   Q179S5   A0A182JLX8   A0A0Q5TJ56   Q9VXE3   B3MRC3   Q961D4   Q9U779   B3NVJ7   X2JKQ8   A0A0P8XK28   A0A1W4VJ27  

PDB

6E9W     E-value=4.81483e-171,     Score=1548

KEGG

100529202    K04514 Rho-associated protein kinase 1 [EC:2.7.11.1] | (RefSeq) rock1; Rho-associated protein kinase

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0035556   GO:0046872   GO:0004674   GO:0017048   GO:0005524   GO:0007266   GO:0018107   GO:0031032   GO:0030866   GO:0005856   GO:0072518   GO:0005737   GO:0048598   GO:0000281   GO:0017049   GO:1901888   GO:0004697   GO:0005938   GO:0000022   GO:0008335   GO:0001736   GO:0050770   GO:2000040   GO:0006468   GO:0044291   GO:0030036   GO:0032956   GO:0007309   GO:0051020   GO:0008544   GO:0007302   GO:0016331   GO:0045184   GO:0035317   GO:0001932   GO:0032065   GO:0042325   GO:1901739   GO:0090303   GO:0031532   GO:0007391   GO:0042067   GO:0035191   GO:0003384   GO:0048599   GO:0032231   GO:0008360   GO:0007300   GO:0001737   GO:1903035   GO:0051496   GO:0000278   GO:1901648   GO:0106037   GO:0106036   GO:0005829   GO:0004672   GO:0051603   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR22988:SF38  

Length:

1367

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.124

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00568

outside

1  -  1367

 

 

Pi

182.356149

Theta

173.783325

Tajima's D

0.199472

CLR

17.783966

CSRT

0.423028848557572

Interpretation

Uncertain