Gene

KWMTBOMO02206  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003035

Annotation

PREDICTED:_rab3_GTPase-activating_protein_catalytic_subunit_[Papilio_polytes]

Location

Bomo_Chr4(+):13899622-13902987      View in EpiBrowser

Full name

Rab3 GTPase-activating protein catalytic subunit      

Alternative Name

RAB3 GTPase-activating protein 130 kDa subunit
Rab3-GAP p130

Location in the cell

Cytoplasmic   Reliability : 1.837

CDS

ATGAACATCAATGCCAAAAGTCTATGTAATGTCTCTTACAAAGCTCAGAGAATTTTACATGGTGACAGTCACTCTAGCATTGCAGAAGGCACACCCAATGCGCGTACATGCTTACTTCATCAAAAACTACAACTTCTCAACTGCTGCATCAAACGTACCATAGAAGGTAACGTTAACACAACCGGTCATTCTTCTGAGGAAGAGTTCTTCGACTGCTCAGAAGGCGAAGGAGCAGAGGAGCAGCCTCCCTGGGATCGACCTGTCGGCAGACTGCATCGACTCGGTGAAGCCACACTGAAAAATGGCGCGCCGCTATATGTACCACGAACACAAGATCCAGCTCCGAAGACTGAAGATCAATTAGAAGAGGACGCCGAGTTAATGGTGCGCTTGGGAGACGACGCAAAGGCTTCCGAGCTGCGAGCTCGAATGATGAGTGCTTCACTTCTCTCGGATATGGAAGCGTTCAAAGCGGCGAACCCTGGTGCAGAATTATGCGATTTCGTTCGTTGGTATTCCCCAAGAGACTGGAAGTCTGACGATGGAGGTGCCTTAGGTGAACGAATGCTCCTGCCCGGAAATCCTTGGGTTGAAGCTTGGAACGTTGCTCGTCCGGTACCGGCCTCGCGACAGAGACGACTTTTCGATGAAACTCGGGAAGCGGAACAGATTCTACATTTTCTGCGATCCCGCACGGTGAGCGGAGTGGCAGAATTGTTACTTCCCGCGATCATACGAGCAGGAGCGCTGAGAGCTACCCAAGAAGGGGCGATAGGAAGTAGCGCGTCGGTGGGAGGTGTCGACGCGCGCCGAACGTTTGAGATAGCTGTAAGAGAGCTGTATGAGGCTGAGAAAGAAGCTTGCAGAATGCTTTGTCGACGTAAGGTGCTGGGTGGCGGTGAGGAGGGACAGGCGTTGGACGCGGCGGAGAGGGCTCGCGTGCTACGCGCGGCGGGGGGAGTGCTGCCGGCGGTGGCGCGGCGCGAGTTCACGCTGCGGGTGCGGGACGCGACGGCGCCGCAACTCATGCGCGCCGCACTGGCCGACGACATCACCATCGTCGGTGCCTTTACTGAACGTATCGTCTGCTTGTAG

Protein

MNINAKSLCNVSYKAQRILHGDSHSSIAEGTPNARTCLLHQKLQLLNCCIKRTIEGNVNTTGHSSEEEFFDCSEGEGAEEQPPWDRPVGRLHRLGEATLKNGAPLYVPRTQDPAPKTEDQLEEDAELMVRLGDDAKASELRARMMSASLLSDMEAFKAANPGAELCDFVRWYSPRDWKSDDGGALGERMLLPGNPWVEAWNVARPVPASRQRRLFDETREAEQILHFLRSRTVSGVAELLLPAIIRAGALRATQEGAIGSSASVGGVDARRTFEIAVRELYEAEKEACRMLCRRKVLGGGEEGQALDAAERARVLRAAGGVLPAVARREFTLRVRDATAPQLMRAALADDITIVGAFTERIVCL

Description

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).

Subunit

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2. Interacts with LMAN1.
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (PubMed:11809763, PubMed:9733780). Interacts with LMAN1 (By similarity).

Similarity

Belongs to the Rab3-GAP catalytic subunit family.

Keywords

Complete proteome   Cytoplasm   GTPase activation   Phosphoprotein   Reference proteome   Direct protein sequencing  

Feature

chain  Rab3 GTPase-activating protein catalytic subunit

Uniprot

H9J0J8   A0A212FF94   A0A2A4JQF7   A0A0L7K4D0   A0A2H1VS82   A0A194R4T2   + More
A0A194PPH4   A0A1Y1KQS1   A0A0L7QM09   Q16WP8   A0A182KGJ8   A0A151I854   Q175P2   A0A1S4G700   A0A069DVL6   A0A154P947   A0A182R3A6   A0A195DZ61   E2BKM0   A0A182MSU1   A0A1D2NF50   A0A182P0I2   A0A182IEL5   A0A088A2F2   A0A1B6DTG6   A0A182TVD3   A0A336M955   A0A182WTH3   A0A182L2C9   A0A182VFU1   A0A182YPN9   A0A182SX11   A0A1S4HDM1   A0A3L8DM64   A0A0A9XWU8   A0A1J1IWU8   A0A3Q0DTC4   A0A1U7T783   L8Y1T2   Q3UYK8   E9HQ35   G1SGN0   Q80UJ7   W5PN04   A0A1D5RLG3   W5PN03   A4FUE5   A0A2I3GP67   L8IEZ5   A0A2Y9SHK8   A0A0G2JXA1   F1LP59   A0A384AYG0   A0A2Y9SKM2   A0A2U4AJG1   A0A384AXU2   A0A2I0MG78   P69735   A0A337SJX5   A0A2Y9MTL8   A0A341D1E4   G1RB30   A0A337SX46   A0A0D9RV02   A0A340XXN4   A0A2Y9N7U1   A0A2Y9N1P5   A0A341CYR2   A0A2U4AJ80   A0A1D5QUM4   A0A0P6K822   A0A2J8T1Z0   A0A2U4AJ87   A0A2U3ZJX9   J9NVN6   A0A2K6AGU1   A0A2K6BW43   G5AMN2  

Pubmed

19121390    22118469    26227816    26354079    28004739    17510324    + More
26334808    20798317    27289101    20966253    25244985    30249741    25401762    23385571    10349636    11042159    11076861    11217851    12466851    16141073    21292972    21993624    15368895    16141072    15489334    15696165    21183079    20809919    19468303    19393038    22751099    15057822    23371554    9030515    9733780    11809763    17975172    17431167    16341006    21993625   

EMBL

BABH01010317    BABH01010318    AGBW02008847    OWR52399.1    NWSH01000819    PCG74049.1    + More
JTDY01011269    KOB57172.1    ODYU01004150    SOQ43713.1    KQ460779    KPJ12250.1    KQ459598    KPI94634.1    GEZM01078342    JAV62761.1    KQ414902    KOC59652.1    CH477557    EAT39019.1    KQ978390    KYM94324.1    CH477397    EAT41808.1    GBGD01000746    JAC88143.1    KQ434847    KZC08466.1    KQ980031    KYN18158.1    GL448819    EFN83718.1    AXCM01006011    LJIJ01000061    ODN03852.1    APCN01005209    GEDC01008335    JAS28963.1    UFQS01000560    UFQT01000560    SSX04961.1    SSX25323.1    QOIP01000006    RLU21497.1    GBHO01021869    GBHO01021868    JAG21735.1    JAG21736.1    CVRI01000063    CRL04576.1    KB368231    ELV10217.1    AK134604    BAE22204.1    GL732714    EFX66131.1    AAGW02005109    AAGW02005110    AAGW02005111    AAGW02005112    AK172881    AK076244    AK076399    AK080432    AK164523    BC028996    BC046297    AMGL01054158    AMGL01054159    AMGL01054160    AMGL01054161    AMGL01054162    AMGL01054163    AMGL01054164    AMGL01054165    AMGL01054166    AMGL01054167    AC163690    BC114755    AAI14756.1    ADFV01039477    ADFV01039478    ADFV01039479    ADFV01039480    ADFV01039481    JH881536    ELR53717.1    AABR07020883    AKCR02000014    PKK28682.1    AABR03085327    AABR03086784    AANG04001482    AQIB01162493    AQIB01162494    AQIB01162495    AQIB01162496    AQIB01162497    JSUE03008637    JSUE03008638    GEBF01000824    JAO02809.1    NDHI03003528    PNJ27047.1    AAEX03011909    AAEX03011910    JH166011    EHA98292.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000037510    UP000053240    UP000053268    + More
UP000053825    UP000008820    UP000075881    UP000078542    UP000076502    UP000075900    UP000078492    UP000008237    UP000075883    UP000094527    UP000075885    UP000075840    UP000005203    UP000075902    UP000076407    UP000075882    UP000075903    UP000076408    UP000075901    UP000279307    UP000183832    UP000189704    UP000011518    UP000000305    UP000001811    UP000000589    UP000002356    UP000009136    UP000001073    UP000248484    UP000002494    UP000261681    UP000245320    UP000053872    UP000011712    UP000248483    UP000252040    UP000029965    UP000265300    UP000006718    UP000245340    UP000002254    UP000233140    UP000233120    UP000006813   

PRIDE

H9J0J8    Q80UJ7    A0A1D5RLG3    F1LP59    P69735   

Pfam

PF13890   Rab3-GTPase_cat

Interpro

IPR026147   Rab3-GAP_cat_su        + More
IPR036915   Cyclin-like_sf       
IPR013763   Cyclin-like       

SUPFAM

SSF47954   SSF47954       

CDD

cd00043  CYCLIN

ProteinModelPortal

H9J0J8   A0A212FF94   A0A2A4JQF7   A0A0L7K4D0   A0A2H1VS82   A0A194R4T2   + More
A0A194PPH4   A0A1Y1KQS1   A0A0L7QM09   Q16WP8   A0A182KGJ8   A0A151I854   Q175P2   A0A1S4G700   A0A069DVL6   A0A154P947   A0A182R3A6   A0A195DZ61   E2BKM0   A0A182MSU1   A0A1D2NF50   A0A182P0I2   A0A182IEL5   A0A088A2F2   A0A1B6DTG6   A0A182TVD3   A0A336M955   A0A182WTH3   A0A182L2C9   A0A182VFU1   A0A182YPN9   A0A182SX11   A0A1S4HDM1   A0A3L8DM64   A0A0A9XWU8   A0A1J1IWU8   A0A3Q0DTC4   A0A1U7T783   L8Y1T2   Q3UYK8   E9HQ35   G1SGN0   Q80UJ7   W5PN04   A0A1D5RLG3   W5PN03   A4FUE5   A0A2I3GP67   L8IEZ5   A0A2Y9SHK8   A0A0G2JXA1   F1LP59   A0A384AYG0   A0A2Y9SKM2   A0A2U4AJG1   A0A384AXU2   A0A2I0MG78   P69735   A0A337SJX5   A0A2Y9MTL8   A0A341D1E4   G1RB30   A0A337SX46   A0A0D9RV02   A0A340XXN4   A0A2Y9N7U1   A0A2Y9N1P5   A0A341CYR2   A0A2U4AJ80   A0A1D5QUM4   A0A0P6K822   A0A2J8T1Z0   A0A2U4AJ87   A0A2U3ZJX9   J9NVN6   A0A2K6AGU1   A0A2K6BW43   G5AMN2  

KEGG

101741024    K18270 Rab3 GTPase-activating protein catalytic subunit | (RefSeq) rab3 GTPase-activating protein ca

GO

GO:0005096   GO:0016021   GO:0043547   GO:0098794   GO:0060325   GO:0017112   GO:0005811   GO:0005794   GO:0061646   GO:0034389   GO:1903061   GO:1903373   GO:0060079   GO:2000786   GO:0097051   GO:0032991   GO:0071782   GO:0010628   GO:1903233   GO:0048172   GO:0043010   GO:0021854   GO:0048489   GO:0017137   GO:0032483   GO:0050821   GO:0043087   GO:0007420   GO:0005737   GO:0010807   GO:0046982   GO:0060076   GO:0005680   GO:0030071   GO:0016020   GO:0005839   GO:0051603   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR21422  

Subcellular location

Cytoplasm   In neurons, it is enriched in the synaptic soluble fraction.   With evidence from 2 publications.

Length:

364

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01634

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03117

outside

1  -  364

 

 

Pi

241.509104

Theta

175.699404

Tajima's D

0.626423

CLR

0.016657

CSRT

0.556922153892305

Interpretation

Uncertain