Gene

KWMTBOMO02205

Pre Gene Modal

BGIBMGA003034

Annotation

Uncharacterized_protein_OBRU01_12362?_partial_[Operophtera_brumata]

Location

Bomo_Chr4(+):13866547-13868701      View in EpiBrowser

Full name

Rab3 GTPase-activating protein catalytic subunit      

Alternative Name

RAB3 GTPase-activating protein 130 kDa subunit
Rab3-GAP p130

Location in the cell

Cytoplasmic   Reliability : 1.683

CDS

ATGAATGAAGAAATAGATGAATACGACATTTACCACCAAGATTTTACTACCGTATCAGAATGGGAGGTATTTGTAGCACGAATAGAAGAGGTACTGATTGATTGGAGACTGTCTAAATCCACAATGGTTAAGCATTCTGTTGAAAATCATGCAAAAAAATGGTTTACAAAAAGCGAAGAAATAAGCTATCAAGGACAGAAATTTACTCTTTCTTATAATTATATGAACTGTAAAAGTAAACCAGAAAGCACTGAAGAATCAAGTGATAAATCATTGTTGGTCGAAATCCAAGATGGACTTTGGGAAGCCACGACTAGGTTTATGGATGACAGTGACGAGAGTCCCTTTCCTGTGTCAAACTGGTTTGGTTTAAAACAATATTTAATGTTGTATCCTAATGTAGCACTTGTTGAAGGTAGTTTAATTAAACTGGTTATGAGTAGTTTAAACATAGCATTTGCAAATGTTGATTGTGGTGTACCTTTATTTGTTAAGATAAGAGAACACTGGCAACATACTTATTTAGGATTCTATGAAGACAATGAATATAAGATAAGCTTTGACACTATTCATTTAAAGAGGATATCCAATCAGTGCTCCCACTTAACTGGCCTCGTTGGATTATTTAAGTCAAAAATTGCTTCACCAGTGGCATTGGATGCTGTTGTTGTTTCAACAAAGTTTTCATATGAATTGAAAGATTTAGATGCTTTTGCATGGGGTCAGCAAACACAGTCAAACGAGTTTTTGTCTATAGATGGTTTTGATGTAAAGAAGTTGATTGAACTGCCATTTGGCTGTGATAAGAACCCCACAAAAAGTGTATTACTTAATGCAATATGGCCAAAATTTAGAGAATGCACAATAGTGGAATCATCTACGTTTTCAGATATCGATCCATTAATGGCACCAACCTGGACTCTAACTTTAAAGATGAGAGAAAATATAAATTTCCAATTGTCAGAATTAATAGGGAAGGTGATGGAACTCTTAGATAATTCTTATCTATTAATGGACACTCTTGGCTTGAGTAAAAGTCTAGGACTAGTTAACCCATTAAACAAGATTACAGAAGCTCCTATTACTATATCCAAATTGGTGAAGGCTGCAATGGGTCATGGTCGTCATACATCTGAATTCAAGGGGCCTATATCAGATGAACTGTTAATGCCCCTTTTATACTATATATTTCCTGATGCTGTTGAAGATGGCACTCATATTTATCCTCCTGATTTGAAAATGGAATTTAAACAGGATGGTAATGGATCTAAGCTATGCAGCTATGTAAAGAGTAGCCCTGAAGATTGCCTCGTCTGGAGATTATCAGTAACTGCAGCGAAACTGCATGATGCTGGTGGTCTTTCATATTTAGCACATTTGTGGTATGAATTCATTCAAGAGCTGCAGTATAGATGGGAGATGCAAATACCAGTTCCTGGGTAA

Protein

MNEEIDEYDIYHQDFTTVSEWEVFVARIEEVLIDWRLSKSTMVKHSVENHAKKWFTKSEEISYQGQKFTLSYNYMNCKSKPESTEESSDKSLLVEIQDGLWEATTRFMDDSDESPFPVSNWFGLKQYLMLYPNVALVEGSLIKLVMSSLNIAFANVDCGVPLFVKIREHWQHTYLGFYEDNEYKISFDTIHLKRISNQCSHLTGLVGLFKSKIASPVALDAVVVSTKFSYELKDLDAFAWGQQTQSNEFLSIDGFDVKKLIELPFGCDKNPTKSVLLNAIWPKFRECTIVESSTFSDIDPLMAPTWTLTLKMRENINFQLSELIGKVMELLDNSYLLMDTLGLSKSLGLVNPLNKITEAPITISKLVKAAMGHGRHTSEFKGPISDELLMPLLYYIFPDAVEDGTHIYPPDLKMEFKQDGNGSKLCSYVKSSPEDCLVWRLSVTAAKLHDAGGLSYLAHLWYEFIQELQYRWEMQIPVPG

Description

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

Biophysicochemical Properties

75 uM for GTP-loaded RAB3A

Subunit

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3GAP150.
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (PubMed:22337587).

Similarity

Belongs to the Rab3-GAP catalytic subunit family.

Keywords

Cytoplasm   GTPase activation   Alternative splicing   Complete proteome   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Rab3 GTPase-activating protein catalytic subunit
splice variant  In isoform 3.
sequence variant  In dbSNP:rs10445686.

Uniprot

H9J0J7   A0A0L7LAD9   A0A2H1X357   A0A2A4JB34   A0A212FFC8   A0A194PPH4   + More
A0A194R3I1   A0A1E1W3U9   A0A1E1WB08   A0A1B6FGQ0   D6WL62   A0A0T6BA24   A0A1B6LTE9   A0A1W4XJK2   A0A158NK38   F4WIJ7   A0A1Y1KQS1   E2A107   E0VQA7   A0A195F493   A0A026WD15   A0A0J7NZY6   A0A232EZ14   A0A195DZ61   A0A0L7QM27   E9JCD8   A0A0A9XWU8   A0A088A2F1   A0A2P8XBJ8   A0A310SPL9   N6THU8   A0A2A3E9U2   A0A154P9F7   E2BKM2   A0A3L8DM64   K7JQL9   A0A182F603   A0A182R3A8   A0A182IYR2   A0A182GQC3   A0A1L8EVK4   Q642R9   A0A084W3W1   A0A250YM54   A0A2M4CQ80   A0A151I854   A0A1L8ENU5   A0A2M4ANB3   W5J2M7   A0A182P0I0   A0A2D0R6Z6   G1RB30   R4G9R7   A0A2D0R4U4   A0A0N8A333   Q5RF09   A0A2K5I373   A0A286X9L1   A0A2K5I2U4   H0VCU4   B9A6J2   Q15042   Q15042-3   A0A2J8T1Z3   A0A2Y9HII3   A0A2R9A751   K7BLE5   G3RGG4   A0A2R9A2X7   H2QIR5   F6QUK1   U6DJQ4   H2P7F3   A0A2J8T219   A0A2K6PQY6   W5PN04   A0A2K6MXP7   A0A2K6MXQ1   A0A2K6MXP9   G3SA53   A0A1S3GDG3   A0A2K6PQX1   A0A2U3W640   A0A2Y9L322   A0A3Q0D6G3   A0A2K6PR00   A0A2Y9L9H9   W5M0U5   W5M0S6   M3XTV7   A4FUE5   A0A2Y9HPS2   L8IEZ5   A0A0P5T9Z5   G1MDA5   A0A182MDG4   A0A2U3W615   G1MDA3   K9INK1   A0A2D4FK10  

Pubmed

19121390    26227816    22118469    26354079    18362917    19820115    + More
21347285    21719571    28004739    20798317    20566863    24508170    28648823    21282665    25401762    29403074    23537049    30249741    20075255    26483478    27762356    24438588    28087693    20920257    23761445    21993624    11181995    19077034    7584044    15815621    15489334    17974005    9030515    9852129    10859313    15696165    17081983    18669648    19690332    20068231    21269460    22337587    23186163    24275569    22722832    16136131    22398555    19892987    25362486    20809919    26319212    19393038    22751099    20010809   

EMBL

BABH01010319    JTDY01001995    KOB72375.1    ODYU01013080    SOQ59761.1    NWSH01002294    + More
PCG68640.1    AGBW02008830    OWR52430.1    KQ459598    KPI94634.1    KQ460779    KPJ12252.1    GDQN01009432    JAT81622.1    GDQN01006929    JAT84125.1    GECZ01020616    JAS49153.1    KQ971343    EFA03501.1    LJIG01002764    KRT84176.1    GEBQ01013033    JAT26944.1    ADTU01018485    GL888176    EGI65933.1    GEZM01078342    JAV62761.1    GL435626    EFN73060.1    DS235408    EEB15563.1    KQ981820    KYN35283.1    KK107282    EZA53556.1    LBMM01000615    KMQ97965.1    NNAY01001561    OXU23595.1    KQ980031    KYN18158.1    KQ414902    KOC59650.1    GL771786    EFZ09513.1    GBHO01021869    GBHO01021868    JAG21735.1    JAG21736.1    PYGN01004048    PSN29377.1    KQ761976    OAD56412.1    APGK01037626    KB740948    KB632364    ENN77388.1    ERL93608.1    KZ288311    PBC28497.1    KQ434847    KZC08463.1    GL448819    EFN83720.1    QOIP01000006    RLU21497.1    JXUM01015628    KQ560435    KXJ82431.1    CM004482    OCT63360.1    BC081089    ATLV01020162    ATLV01020163    ATLV01020164    ATLV01020165    ATLV01020166    ATLV01020167    ATLV01020168    ATLV01020169    ATLV01020170    KE525295    KFB44905.1    GFFW01000202    JAV44586.1    GGFL01003318    MBW67496.1    KQ978390    KYM94324.1    CM004483    OCT60981.1    GGFK01008777    MBW42098.1    ADMH02002182    ETN58006.1    ADFV01039477    ADFV01039478    ADFV01039479    ADFV01039480    ADFV01039481    GDIP01187273    JAJ36129.1    CR857352    CAH89648.1    AAKN02006578    AAKN02006579    AAKN02006580    AAKN02006581    AAKN02006582    AB449877    CH471058    BAH16620.1    EAX11641.1    D31886    AC017031    AC020602    BC022977    BC071602    BC146809    AL096752    NDHI03003528    PNJ27048.1    AJFE02079619    AJFE02079620    AJFE02079621    AACZ04058336    AACZ04058337    GABC01008959    GABF01008915    GABD01002029    GABE01002459    NBAG03000211    JAA02379.1    JAA13230.1    JAA31071.1    JAA42280.1    PNI85722.1    CABD030015916    CABD030015917    CABD030015918    PNI85723.1    HAAF01011002    CCP82826.1    ABGA01194984    ABGA01194985    ABGA01194986    ABGA01194987    ABGA01194988    ABGA01194989    ABGA01194990    ABGA01194991    ABGA01194992    PNJ27049.1    AMGL01054158    AMGL01054159    AMGL01054160    AMGL01054161    AMGL01054162    AMGL01054163    AMGL01054164    AMGL01054165    AMGL01054166    AMGL01054167    AHAT01011639    AEYP01083417    AEYP01083418    AEYP01083419    AEYP01083420    AEYP01083421    AEYP01083422    AEYP01083423    AEYP01083424    BC114755    AAI14756.1    JH881536    ELR53717.1    GDIP01133136    JAL70578.1    ACTA01066452    ACTA01074452    ACTA01082452    ACTA01090452    AXCM01006971    GABZ01004062    JAA49463.1    IACJ01076199    LAA47845.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000053268    UP000053240    + More
UP000007266    UP000192223    UP000005205    UP000007755    UP000000311    UP000009046    UP000078541    UP000053097    UP000036403    UP000215335    UP000078492    UP000053825    UP000005203    UP000245037    UP000019118    UP000030742    UP000242457    UP000076502    UP000008237    UP000279307    UP000002358    UP000069272    UP000075900    UP000075880    UP000069940    UP000249989    UP000186698    UP000030765    UP000078542    UP000000673    UP000075885    UP000221080    UP000001073    UP000001646    UP000233080    UP000005447    UP000005640    UP000248481    UP000240080    UP000002277    UP000001519    UP000002281    UP000001595    UP000233200    UP000002356    UP000233180    UP000081671    UP000245340    UP000248482    UP000189706    UP000018468    UP000000715    UP000009136    UP000008912    UP000075883   

PRIDE

H9J0J7    Q15042   

Pfam

PF13890   Rab3-GTPase_cat

Interpro

IPR026147   Rab3-GAP_cat_su       

ProteinModelPortal

H9J0J7   A0A0L7LAD9   A0A2H1X357   A0A2A4JB34   A0A212FFC8   A0A194PPH4   + More
A0A194R3I1   A0A1E1W3U9   A0A1E1WB08   A0A1B6FGQ0   D6WL62   A0A0T6BA24   A0A1B6LTE9   A0A1W4XJK2   A0A158NK38   F4WIJ7   A0A1Y1KQS1   E2A107   E0VQA7   A0A195F493   A0A026WD15   A0A0J7NZY6   A0A232EZ14   A0A195DZ61   A0A0L7QM27   E9JCD8   A0A0A9XWU8   A0A088A2F1   A0A2P8XBJ8   A0A310SPL9   N6THU8   A0A2A3E9U2   A0A154P9F7   E2BKM2   A0A3L8DM64   K7JQL9   A0A182F603   A0A182R3A8   A0A182IYR2   A0A182GQC3   A0A1L8EVK4   Q642R9   A0A084W3W1   A0A250YM54   A0A2M4CQ80   A0A151I854   A0A1L8ENU5   A0A2M4ANB3   W5J2M7   A0A182P0I0   A0A2D0R6Z6   G1RB30   R4G9R7   A0A2D0R4U4   A0A0N8A333   Q5RF09   A0A2K5I373   A0A286X9L1   A0A2K5I2U4   H0VCU4   B9A6J2   Q15042   Q15042-3   A0A2J8T1Z3   A0A2Y9HII3   A0A2R9A751   K7BLE5   G3RGG4   A0A2R9A2X7   H2QIR5   F6QUK1   U6DJQ4   H2P7F3   A0A2J8T219   A0A2K6PQY6   W5PN04   A0A2K6MXP7   A0A2K6MXQ1   A0A2K6MXP9   G3SA53   A0A1S3GDG3   A0A2K6PQX1   A0A2U3W640   A0A2Y9L322   A0A3Q0D6G3   A0A2K6PR00   A0A2Y9L9H9   W5M0U5   W5M0S6   M3XTV7   A4FUE5   A0A2Y9HPS2   L8IEZ5   A0A0P5T9Z5   G1MDA5   A0A182MDG4   A0A2U3W615   G1MDA3   K9INK1   A0A2D4FK10  

KEGG

101741024    K18270 Rab3 GTPase-activating protein catalytic subunit | (RefSeq) rab3 GTPase-activating protein ca

GO

GO:0005096   GO:0016021   GO:0043547   GO:0005737   GO:0060325   GO:0098794   GO:2000786   GO:0097051   GO:0071782   GO:0032991   GO:0005794   GO:1903233   GO:0010628   GO:0017112   GO:0005811   GO:0061646   GO:0034389   GO:1903373   GO:0048172   GO:1903061   GO:0021854   GO:0043010   GO:0060079   GO:0017137   GO:0070062   GO:0005085   GO:0005789   GO:0007420   GO:0043087   GO:0005829  

PANTHER

PTHR21422  

Subcellular location

Cytoplasm  

Length:

480

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14752

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00925

outside

1  -  480

 

 

Pi

231.265041

Theta

201.061511

Tajima's D

0.44482

CLR

1.053044

CSRT

0.494175291235438

Interpretation

Uncertain