Gene

KWMTBOMO02185  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003028

Annotation

proteasome_beta-subunit_[Bombyx_mori]

Location

Bomo_Chr4(+):13445027-13446166      View in EpiBrowser

Full name

Proteasome subunit alpha type      

Location in the cell

Cytoplasmic   Reliability : 3.222

CDS

ATGTCTGCCCGATATGATAGAGCCATCACAGTATTTTCTCCTGATGGACATTTATTACAAGTAGAATATGCTCAAGAAGCTGTCAGAAAGGGGTCAACAGCAGTTGGAGTTAGAGGAGTCGATGTGGTAGTCTTAGGTGTTGAGAAAAAATCGGTTGCTAAATTGCAAGAAGAACGAACTGTGAGGAAAATATGTCTTTTGGATGATCACGTCGTAATGGCATTTGCCGGATTGACAGCAGACGCTCGTATATTAATAAACCGTGCACAAATCGAATGTCAATCACACAAGTTAACAGTCGAGGATCCAGTAACATTGGAGTATATTACAAGATACATAGCAGGTCTCAAACAGAAATATACTCAGAGCAATGGTCGTCGACCATTTGGTATTTCGTGTTTGATAGGAGGATTCGACTATGATGGTTCACCACACTTGTTCCAAACTGAACCTTCTGGTATATATTATGAATGGAAAGCTAATGCAACTGGTAGATCTGCAAAGACAGTACGAGAGTTTCTAGAGAAAAATTACACCGCTGATGAAGTTGCTACAGAGAATGGAGCTGTCAAGTTGGCTATCAGAGCACTCTTGGAAGTAGTACAGTCTGGCCAAAAGAACCTAGAAATTGCTGTAATGAGAAGAGGTCAACCAATGCAGATGCTTGACTTAGACACTATAAACTCCTATGTATCTGTCATTGAAAAAGAGAAAGAAGAGGAAGCAGAGAAGAAGAAACAGAAGAAGTAA

Protein

MSARYDRAITVFSPDGHLLQVEYAQEAVRKGSTAVGVRGVDVVVLGVEKKSVAKLQEERTVRKICLLDDHVVMAFAGLTADARILINRAQIECQSHKLTVEDPVTLEYITRYIAGLKQKYTQSNGRRPFGISCLIGGFDYDGSPHLFQTEPSGIYYEWKANATGRSAKTVREFLEKNYTADEVATENGAVKLAIRALLEVVQSGQKNLEIAVMRRGQPMQMLDLDTINSYVSVIEKEKEEEAEKKKQKK

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.

Similarity

Belongs to the peptidase T1A family.

Uniprot

Q2F5X2   A0A2H1WH41   A0A212FNQ2   A0A2A4J9P8   A0A1E1WAG2   S4PAE4   + More
A0A0L7L8S2   I4DMU2   A0A194R3K0   I4DJQ9   D6WMJ9   A0A1Y1K8P6   A0A0C9RJZ7   A0A1Q3FBB7   E2AC20   E2BSL1   E9IBI4   A0A195EGZ7   A0A195CKM1   F4X112   A0A151I4S8   A0A151WJN3   A0A1B6K4S1   A0A1W4X107   A0A026WX08   B0WJ50   A0A1B6FYM9   Q178M6   J3JXY6   A0A154P3I0   A0A023EL73   A0A0M9A8S2   U5EX78   A0A2A3E8Z7   A0A088A379   A0A1B0D8Y5   A0A0K8TT84   A0A067R7H0   A0A232ELL7   K7J8Y9   A0A1L8DSW2   A0A336MM85   A0A2P8XFX4   A0A336KB86   A0A1B6ECC8   T1PC04   A0A1I8PFK3   A0A1L8EEA9   E0VVI9   A0A0L0CMM8   A0A0L7QXG4   T1E8W8   A0A2M3Z4K9   A0A2M4ACB1   A0A2M4BY47   W5JI52   A0A182FMV8   A0A023F986   A0A224XIN9   E0VVJ8   R4WRL9   A0A0V0G376   A0A1J1I8N0   A0A310SI19   T1HXI3   R4G4N1   E9GMZ8   A0A162PED7   A0A1B0AFB1   A0A0P6BJY4   A0A1A9XKJ9   A0A1B0AYK6   A0A0P5YIH5   A0A0N8EIE4   A0A0P6GNH3   A0A1A9VNI3   D3TP07   A0A084VDA1   A0A0J7KZZ2   A0A1A9WVR3   A0A182J3X2   B4MG96   B3N0U7   A0A182MNA3   B4JJY1   A0A1Y9J0G6   A0A182Y0R7   A0A2C9GTU6   A0A182TAF6   A0A182VGE5   Q7Q797   A0A182HM87   A0A0M3QZT9   A0A182NMC9   A0A182QP65   A0A240PK21   A0A182PVI8   A0A182WLU3   A0A182RC23   A0A182U4L4  

EC Number

3.4.25.1

Pubmed

19121390    22118469    23622113    26227816    22651552    26354079    + More
18362917    19820115    28004739    20798317    21282665    21719571    24508170    30249741    17510324    22516182    23537049    24945155    26483478    26369729    24845553    28648823    20075255    29403074    25315136    20566863    26108605    20920257    23761445    25474469    23691247    21292972    20353571    24438588    17994087    25244985    20966253    12364791    14747013    17210077   

EMBL

BABH01010371    DQ311301    ABD36245.1    ODYU01008559    SOQ52266.1    AGBW02005153    + More
OWR55343.1    NWSH01002503    PCG68142.1    GDQN01007119    JAT83935.1    GAIX01003299    JAA89261.1    JTDY01002271    KOB71760.1    AK402610    BAM19232.1    KQ460779    KPJ12272.1    AK401527    KQ459598    BAM18149.1    KPI94655.1    KQ971343    EFA04284.1    GEZM01094224    JAV55796.1    GBYB01013612    JAG83379.1    GFDL01010171    JAV24874.1    GL438389    EFN69038.1    GL450240    EFN81344.1    GL762111    EFZ22132.1    KQ978957    KYN27157.1    KQ977622    KYN01275.1    GL888520    EGI59872.1    KQ976456    KYM84868.1    KQ983039    KYQ48068.1    GECU01001256    JAT06451.1    KK107078    QOIP01000011    EZA60266.1    RLU16465.1    DS231955    EDS28929.1    GECZ01014518    JAS55251.1    CH477361    EAT42664.1    APGK01044617    BT128108    KB741028    KB630368    KB631513    AEE63069.1    ENN74779.1    ERL83568.1    ERL84337.1    KQ434809    KZC06407.1    JXUM01031299    JXUM01082441    GAPW01003646    KQ563313    KQ560917    JAC09952.1    KXJ74077.1    KXJ80362.1    KQ435719    KOX78786.1    GANO01001083    JAB58788.1    KZ288322    PBC28197.1    AJVK01012840    GDAI01000483    JAI17120.1    KK852655    KDR19303.1    NNAY01003549    OXU19218.1    GFDF01004634    JAV09450.1    UFQS01001192    UFQT01001192    SSX09611.1    SSX29407.1    PYGN01002287    PSN30899.1    UFQS01000226    UFQT01000226    SSX01667.1    SSX22047.1    GEDC01001751    JAS35547.1    KA646301    AFP60930.1    GFDG01001761    JAV17038.1    DS235812    EEB17395.1    JRES01000290    KNC32699.1    KQ414704    KOC63308.1    GAMD01002393    JAA99197.1    GGFM01002627    MBW23378.1    GGFK01005113    MBW38434.1    GGFJ01008710    MBW57851.1    ADMH02001476    GGFL01004538    ETN62449.1    MBW68716.1    GBBI01000772    JAC17940.1    GFTR01004079    JAW12347.1    EEB17404.1    AK417337    BAN20552.1    GECL01003603    JAP02521.1    CVRI01000044    CRK96647.1    KQ761039    OAD58363.1    ACPB03015496    GAHY01000631    JAA76879.1    GL732553    EFX79203.1    LRGB01000512    KZS18777.1    GDIP01013533    JAM90182.1    JXJN01005870    GDIP01057475    JAM46240.1    GDIQ01023716    JAN71021.1    GDIQ01041338    JAN53399.1    CCAG010006445    EZ423159    ADD19435.1    ATLV01011195    KE524650    KFB35945.1    LBMM01001650    KMQ95946.1    CH940672    EDW57419.1    CH902644    EDV34826.1    AXCM01011616    CH916370    EDV99883.1    AAAB01008960    EAA11369.3    APCN01004380    CP012528    ALC49959.1    AXCN02000934   

Proteomes

UP000005204    UP000007151    UP000218220    UP000037510    UP000053240    UP000053268    + More
UP000007266    UP000000311    UP000008237    UP000078492    UP000078542    UP000007755    UP000078540    UP000075809    UP000192223    UP000053097    UP000279307    UP000002320    UP000008820    UP000019118    UP000030742    UP000076502    UP000069940    UP000249989    UP000053105    UP000242457    UP000005203    UP000092462    UP000027135    UP000215335    UP000002358    UP000245037    UP000095301    UP000095300    UP000009046    UP000037069    UP000053825    UP000000673    UP000069272    UP000183832    UP000015103    UP000000305    UP000076858    UP000092445    UP000092443    UP000092460    UP000078200    UP000092444    UP000030765    UP000036403    UP000091820    UP000075880    UP000008792    UP000007801    UP000075883    UP000001070    UP000076407    UP000076408    UP000075882    UP000075901    UP000075903    UP000007062    UP000075840    UP000092553    UP000075884    UP000075886    UP000075881    UP000075885    UP000075920    UP000075900    UP000075902   

PRIDE

Q2F5X2   

Pfam

PF00227   Proteasome        + More
PF10584   Proteasome_A_N

Interpro

IPR023332   Proteasome_alpha-type        + More
IPR001353   Proteasome_sua/b       
IPR000426   Proteasome_asu_N       
IPR029055   Ntn_hydrolases_N       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.60.20.10    

ProteinModelPortal

Q2F5X2   A0A2H1WH41   A0A212FNQ2   A0A2A4J9P8   A0A1E1WAG2   S4PAE4   + More
A0A0L7L8S2   I4DMU2   A0A194R3K0   I4DJQ9   D6WMJ9   A0A1Y1K8P6   A0A0C9RJZ7   A0A1Q3FBB7   E2AC20   E2BSL1   E9IBI4   A0A195EGZ7   A0A195CKM1   F4X112   A0A151I4S8   A0A151WJN3   A0A1B6K4S1   A0A1W4X107   A0A026WX08   B0WJ50   A0A1B6FYM9   Q178M6   J3JXY6   A0A154P3I0   A0A023EL73   A0A0M9A8S2   U5EX78   A0A2A3E8Z7   A0A088A379   A0A1B0D8Y5   A0A0K8TT84   A0A067R7H0   A0A232ELL7   K7J8Y9   A0A1L8DSW2   A0A336MM85   A0A2P8XFX4   A0A336KB86   A0A1B6ECC8   T1PC04   A0A1I8PFK3   A0A1L8EEA9   E0VVI9   A0A0L0CMM8   A0A0L7QXG4   T1E8W8   A0A2M3Z4K9   A0A2M4ACB1   A0A2M4BY47   W5JI52   A0A182FMV8   A0A023F986   A0A224XIN9   E0VVJ8   R4WRL9   A0A0V0G376   A0A1J1I8N0   A0A310SI19   T1HXI3   R4G4N1   E9GMZ8   A0A162PED7   A0A1B0AFB1   A0A0P6BJY4   A0A1A9XKJ9   A0A1B0AYK6   A0A0P5YIH5   A0A0N8EIE4   A0A0P6GNH3   A0A1A9VNI3   D3TP07   A0A084VDA1   A0A0J7KZZ2   A0A1A9WVR3   A0A182J3X2   B4MG96   B3N0U7   A0A182MNA3   B4JJY1   A0A1Y9J0G6   A0A182Y0R7   A0A2C9GTU6   A0A182TAF6   A0A182VGE5   Q7Q797   A0A182HM87   A0A0M3QZT9   A0A182NMC9   A0A182QP65   A0A240PK21   A0A182PVI8   A0A182WLU3   A0A182RC23   A0A182U4L4  

PDB

3UNH     E-value=6.30634e-92,     Score=858

KEGG

692896    K02731 20S proteasome subunit alpha 4 [EC:3.4.25.1] | (RefSeq) proteasome beta-subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0019773   GO:0006511   GO:0004298   GO:0005737   GO:0005634   GO:0010498   GO:0004175   GO:0043161   GO:0010499   GO:0005839   GO:0016021   GO:0051603   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Cytoplasm  
Nucleus  

Length:

249

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03509

Exp number, first 60 AAs:

0.0004

Total prob of N-in:

0.38185

outside

1  -  249

 

 

Pi

202.829689

Theta

197.901174

Tajima's D

0.134964

CLR

5.157502

CSRT

0.4000799960002

Interpretation

Uncertain