Gene

KWMTBOMO02172  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003141

Annotation

PREDICTED:_probable_alpha-aspartyl_dipeptidase_[Amyelois_transitella]

Location

Bomo_Chr4(-):13176552-13177556      View in EpiBrowser

Full name

Probable alpha-aspartyl dipeptidase       + More
Fatty acyl-CoA reductase      

Alternative Name

Asp-specific dipeptidase

Location in the cell

PlasmaMembrane   Reliability : 0.835

CDS

ATGGCATCTCGTCGTCAAGCACTTTTGCTGTCATCATCCAACTGCCATGGATACAATCTTTTAGAATTTGCCAAAGCGGAAATCTCCAGTTTCCTCCAAAGGAACAATGTCAAGGATTTAATATTCATTCCTTATGCTCAAAATGACTTTGATGGCTATACTACTAAAATAAAGAATGTTATAGATCAATGGGGATTCACAGTCACTGGTCTGCACACATATCCTAAGCCAGAAACTGCTATTAGTGAATCTAAAGCTATCTTTATTGGGGGTGGAAATACTTTTTTACTTTTGAAAAGATTGTACAAAAATAACTTAGTCCAATTAATGAAAAGTAAAATTGATGATGGTAGTTTAATATACATTGGAAGCAGTGCGGGAACAAATGTAGCAACAAAAAGTATTCATACAACAAATGATATGCCAATAATTTATCCACCAAGTTTTGAAGCAATTGGCATAGTTCCATTCAACATTAATCCTCATTATATTGATAAAGTTGAAAATGAAGAACATAAAGGAGAGACAAGAGACCAAAGAATAGCTGAATATCTGGAGATGCAACATGCAGCTCCAGTGTTAGGACTGAAAGAGGGTGCAATATTGCATGTTGATGGTTCAAAACTTATCTTAAAAGGTGTAAATGGAGCAGTATTATTTAGTAGGAGTCAAAAGAAAAGTGAATATAATGTGGGAGCAGATTTATCTTTTTTATTAAATGAAATTTAA

Protein

MASRRQALLLSSSNCHGYNLLEFAKAEISSFLQRNNVKDLIFIPYAQNDFDGYTTKIKNVIDQWGFTVTGLHTYPKPETAISESKAIFIGGGNTFLLLKRLYKNNLVQLMKSKIDDGSLIYIGSSAGTNVATKSIHTTNDMPIIYPPSFEAIGIVPFNINPHYIDKVENEEHKGETRDQRIAEYLEMQHAAPVLGLKEGAILHVDGSKLILKGVNGAVLFSRSQKKSEYNVGADLSFLLNEI

Description

Hydrolyzes dipeptides containing N-terminal aspartate residues.
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.
a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the peptidase S51 family.
Belongs to the fatty acyl-CoA reductase family.

Keywords

Complete proteome   Cytoplasm   Dipeptidase   Hydrolase   Protease   Reference proteome   Serine protease  

Feature

chain  Probable alpha-aspartyl dipeptidase

Uniprot

H9J0V4   A0A194PMX3   A0A194R433   S4NGQ4   A0A2H1WLQ0   A0A212ES62   + More
A0A2A4JRF1   A0A2A4JQN5   A0A0L7LAS8   Q16FQ7   A0A182J9U8   A0A084VDN5   A0A023EL13   Q16ET3   A0A1Q3FDZ6   B0X281   A0A182H012   A0A182GW41   A0A023EN87   A0A182MZI1   A0A182Y7T3   A0A0T6AW81   A0A1Y1L5R1   A0A182QYY5   B4L622   A0A336LIB4   A0A182FMK7   A0A182KB05   A0A182PNR4   A0A182VLH4   A0A182SLH4   A0A0A1WNW6   A0A034WIC2   A0A182TJZ0   A0A2M4AQU8   A0A182XEG5   W5JQ60   A0A0K8V5B9   B4M727   B4JLY7   A0A0M4EM72   A0A1I8NA78   T1PFQ7   A0A182HGL3   N6TGL6   J3JX11   Q7QFI8   B4IGM1   A0A1I8Q5Q8   A0A1L8EFQ8   A0A1L8EG38   X2JER0   Q9VYH3   B3MS43   A0A1L8EG12   B4NUD4   A0A1W4XPS8   V5G8N2   B3NX71   A0A2L2YI25   A0A023EJT9   B4Q206   T1DPV3   W8ANQ4   A0A3B0KLB9   A0A1B6DYD8   Q29IB6   A0A1J1IXA5   A0A2P6KYE2   D6WJG1   A0A1S3KFN4   C3Z578   A0A182MKR7   A0A1B0A9T2   A0A182W4J7   A0A3B3XRY9   A0A087X443   A0A3B3UX92   A0A1B0CDZ3   A0A023EJA2   A0A1B0FL65   B4NEN4   A0A1W4VJH3   A0A1L8DTI3   A0A1B0B051   T1JMC9   U5EYH1   A0A2J7RDQ2   A0A1A9VC22   A0A3B5R6Q4   A0A0S7GK00   A0A146P492   A0A0K8R4E9   A0A067R009   A0A3P8TU73   A0A3B3ZIV7   B7PQV0   A0A1A9X544   H9G9B0   A0A0P4W6A0  

EC Number

3.4.13.21
1.2.1.84

Pubmed

19121390    26354079    23622113    22118469    26227816    17510324    + More
24438588    24945155    26483478    25244985    28004739    17994087    25830018    25348373    20920257    23761445    25315136    23537049    22516182    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    26561354    17550304    24495485    15632085    18362917    19820115    18563158    23542700    24845553    25463417    21881562   

EMBL

BABH01010389    KQ459598    KPI94667.1    KQ460779    KPJ12284.1    GAIX01014644    + More
JAA77916.1    ODYU01009145    SOQ53364.1    AGBW02012845    OWR44338.1    NWSH01000765    PCG74346.1    PCG74347.1    JTDY01001935    KOB72510.1    CH478397    EAT33071.1    ATLV01011631    KE524705    KFB36079.1    GAPW01003713    JAC09885.1    CH478591    EAT32743.1    EAT32744.1    EAT32745.1    GFDL01009259    JAV25786.1    DS232282    EDS39104.1    JXUM01100448    KQ564571    KXJ72080.1    JXUM01092375    KQ563983    KXJ72979.1    GAPW01003759    JAC09839.1    LJIG01022762    KRT78855.1    GEZM01063705    GEZM01063704    JAV69012.1    AXCN02001267    CH933812    EDW05818.1    UFQS01000015    UFQT01000015    SSW97386.1    SSX17772.1    GBXI01014092    JAD00200.1    GAKP01004524    GAKP01004523    JAC54429.1    GGFK01009828    MBW43149.1    ADMH02000428    ETN66542.1    GDHF01018187    JAI34127.1    CH940653    EDW62594.1    CH916371    EDV91748.1    CP012528    ALC48758.1    KA646738    AFP61367.1    APCN01005666    APGK01028295    KB740686    KB632224    ENN79539.1    ERL90217.1    BT127779    AEE62741.1    AAAB01008846    EAA06424.5    EGK96429.1    CH480836    EDW48971.1    GFDG01001258    JAV17541.1    GFDG01001256    JAV17543.1    AE014298    AHN59653.1    AY118855    CH902622    EDV34598.1    GFDG01001260    JAV17539.1    CH983901    EDX16581.1    GALX01002001    JAB66465.1    CH954180    EDV47243.1    IAAA01020362    IAAA01020363    LAA07782.1    GAPW01004252    JAC09346.1    CM000162    EDX01527.1    GAMD01001630    JAA99960.1    GAMC01020462    JAB86093.1    OUUW01000021    SPP89410.1    GEDC01029569    GEDC01012027    GEDC01011685    GEDC01006617    JAS07729.1    JAS25271.1    JAS25613.1    JAS30681.1    CH379063    EAL32737.3    CVRI01000063    CRL04338.1    MWRG01003648    PRD31341.1    KQ971342    EFA03678.1    GG666582    EEN52435.1    AXCM01011571    AYCK01019428    AJWK01008435    AJWK01008436    AJWK01008437    GAPW01004561    JAC09037.1    CCAG010017382    CH964239    EDW82203.1    GFDF01004321    JAV09763.1    JXJN01006562    JH431934    GANO01002004    JAB57867.1    NEVH01005285    PNF38963.1    GBYX01452042    JAO29468.1    GCES01147563    JAQ38759.1    GADI01008464    JAA65344.1    KK852840    KDR15187.1    ABJB010092262    DS767852    EEC08972.1    AAWZ02015295    GDRN01097444    JAI59114.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000218220    UP000037510    + More
UP000008820    UP000075880    UP000030765    UP000002320    UP000069940    UP000249989    UP000075884    UP000076408    UP000075886    UP000009192    UP000069272    UP000075881    UP000075885    UP000075903    UP000075901    UP000075902    UP000076407    UP000000673    UP000008792    UP000001070    UP000092553    UP000095301    UP000075840    UP000019118    UP000030742    UP000007062    UP000001292    UP000095300    UP000000803    UP000007801    UP000000304    UP000192223    UP000008711    UP000002282    UP000268350    UP000001819    UP000183832    UP000007266    UP000085678    UP000001554    UP000075883    UP000092445    UP000075920    UP000261480    UP000028760    UP000261500    UP000092461    UP000092444    UP000007798    UP000192221    UP000092460    UP000235965    UP000078200    UP000002852    UP000027135    UP000265080    UP000261520    UP000001555    UP000091820    UP000001646   

PRIDE

H9J0V4    X2JER0    Q9VYH3   

Pfam

PF03575   Peptidase_S51        + More
PF07993   NAD_binding_4
PF03015   Sterile

Interpro

IPR005320   Peptidase_S51        + More
IPR029062   Class_I_gatase-like       
IPR026055   FAR       
IPR033640   FAR_C       
IPR013120   Male_sterile_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF52317   SSF52317        + More
SSF51735   SSF51735       

Gene 3D

3.40.50.880    

CDD

cd03146  GAT1_Peptidase_E

ProteinModelPortal

H9J0V4   A0A194PMX3   A0A194R433   S4NGQ4   A0A2H1WLQ0   A0A212ES62   + More
A0A2A4JRF1   A0A2A4JQN5   A0A0L7LAS8   Q16FQ7   A0A182J9U8   A0A084VDN5   A0A023EL13   Q16ET3   A0A1Q3FDZ6   B0X281   A0A182H012   A0A182GW41   A0A023EN87   A0A182MZI1   A0A182Y7T3   A0A0T6AW81   A0A1Y1L5R1   A0A182QYY5   B4L622   A0A336LIB4   A0A182FMK7   A0A182KB05   A0A182PNR4   A0A182VLH4   A0A182SLH4   A0A0A1WNW6   A0A034WIC2   A0A182TJZ0   A0A2M4AQU8   A0A182XEG5   W5JQ60   A0A0K8V5B9   B4M727   B4JLY7   A0A0M4EM72   A0A1I8NA78   T1PFQ7   A0A182HGL3   N6TGL6   J3JX11   Q7QFI8   B4IGM1   A0A1I8Q5Q8   A0A1L8EFQ8   A0A1L8EG38   X2JER0   Q9VYH3   B3MS43   A0A1L8EG12   B4NUD4   A0A1W4XPS8   V5G8N2   B3NX71   A0A2L2YI25   A0A023EJT9   B4Q206   T1DPV3   W8ANQ4   A0A3B0KLB9   A0A1B6DYD8   Q29IB6   A0A1J1IXA5   A0A2P6KYE2   D6WJG1   A0A1S3KFN4   C3Z578   A0A182MKR7   A0A1B0A9T2   A0A182W4J7   A0A3B3XRY9   A0A087X443   A0A3B3UX92   A0A1B0CDZ3   A0A023EJA2   A0A1B0FL65   B4NEN4   A0A1W4VJH3   A0A1L8DTI3   A0A1B0B051   T1JMC9   U5EYH1   A0A2J7RDQ2   A0A1A9VC22   A0A3B5R6Q4   A0A0S7GK00   A0A146P492   A0A0K8R4E9   A0A067R009   A0A3P8TU73   A0A3B3ZIV7   B7PQV0   A0A1A9X544   H9G9B0   A0A0P4W6A0  

PDB

1FYE     E-value=7.49313e-35,     Score=366

KEGG

101745104    K05995 dipeptidase E [EC:3.4.13.21] | (RefSeq) probable alpha-aspartyl dipeptidase

GO

GO:0008236   GO:0008233   GO:0005737   GO:0016805   GO:0006629   GO:0102965   GO:0016021   GO:0080019   GO:0006508   GO:0006351   GO:0032549   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR11011  

Subcellular location

Cytoplasm  

Length:

242

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03423

Exp number, first 60 AAs:

0.00334

Total prob of N-in:

0.03968

outside

1  -  242

 

 

Pi

180.847596

Theta

211.18685

Tajima's D

-0.352541

CLR

24.452334

CSRT

0.278986050697465

Interpretation

Uncertain