Gene

KWMTBOMO02170  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003142

Annotation

PREDICTED:_pre-mRNA-splicing_factor_SYF1_[Amyelois_transitella]

Location

Bomo_Chr4(-):13163332-13166206      View in EpiBrowser

Full name

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase      

Location in the cell

Cytoplasmic   Reliability : 2.683

CDS

ATGCCTCTTCTAGACGGAAAAGAAATCGACATATTCTTCAGTGAAGAAGATCTTCCGTATGAAGAGGAAATCCTAAGAAATCCATTTTCTGTCAAACATTGGCTTAGGTACATTGAACACAAGAAAACTGCACCCAAACATGAAATTAATATGATATATGAACGAGCTTTAAAAGAATTACCAGGATCTTTTAAACTTTGGTATAACTATCTTAAATTAAGAAGAAAACAAATAAGAGGTCGCTGTATAGCTGACCCATGCTATGAAGATGTAAACAATTGCTTTGAAAGGTCTTTAGTATTTATGCACAAAATGCCTAGAATATGGATGGATTACTGTTCATTCTTAACAGATCAGTATAAAATAACTACAACAAGGAAAGCGTTTGACAGTGCTCTTAGAGCTTTACCAATAACTCAACATCATAGGATATGGCCTCTTTACTTAAATTTCTTGAAGAAACACAATATACCCGAAACAGCTGTAAGAGTGTTTCGTAGGTATCTTAAATTATGTCCTGAAGATACTGAAGAGTATATTGACTACTTAACTTCAATAGATAAATTAGATGAAGCTGCAGTCAAATTGGCTCAACTAGTTAATAATGAGAATTTTCAATCAAAACATGGAAAGTCAAATCATCAACTTTGGAATGAATTATGTGAATTGATATCAAAGAATCCTGATCAAATTCATTCTCTGAATGTCGACGCTATTATCAGAGGGGGATTAAGACGTTACACTGATCAGCTAGGCCACCTGTGGAACTCTCTTGCAGACTATTATGTTCGAAGTGGTCTTTTTGAAAGAGCCAGAGACATTTATGAAGAAGCTATACAAACTGTGACTACAGTGAGGGATTTTACACAAATATTTGATGCTTATGCACAATTTGAGGAATTAAGTCTTAGTAAAAAAATGGAAGAAGTTGCCAAGAAAACTAATCCAAGTGAAGATGATGATATTGATTTAGAATTGAGACTTGCCAGATTTGAGTATCTTATGGAAAGAAGGCTGTTACTGCTTAATTCAGTTCTACTTAGACAAAATCCACATAATGTGGCTGAATGGCATAAAAGAGTCAAATTATATGAAGGTAAACCCCATGAAATAATAGATACATATACTGAAGCAGTGCAAACTGTAGACCCTAAATTAGCTGTTGGTAAACTTTTCACACTGTGGGTTGGATTTGCAAAATTTTATGAAAACAATGACCAAATTGAAGATGCCAGATTAATTTTTGAAAAAGCTACACAGGTAGCATATGTTAAAGTAGACGATTTAGCTTCAGTTTGGTGTGAATGGGCTGAAATGGAAATCAGACATGAAAATTATGAGCAAGCCCTAAAATTAATGCAAAGAGCCACTGTTTTACCAAGCAGAAAAGTAGCATATCATGATGATTCTGAAACTGTGCAAATGAGGTTGTATAAATCACTAAAGGTTTGGTCCATGTATGCTGACTTAGAAGAGAGTTTTGGTACATTCAAATCTTGCAAAGCTGTGTATGATCATATTATAGATTTAAAAATTGCTACTCCACAAATTATTATCAATTATGGATTATTTTTAGAAGAGCATAATTACTTTGAAGAAGCTTTTAGAGCATATGAAAAGGGTATTGCCTTATTCAAGTGGCCTAATGTGTATGATATTTGGAATACATATCTAACAAAATTTTTAAAAAGATATGGTGGTTCAAAACTTGAAAGAGCAAGAGATTTATTTGAGCAATGTCTTGAGCATTGTCCCAATGAATTTGCAAAGTCTATTTTCTTATTATATGCAAAATTGGAAGAAGAGCATGGTTTAGCTAGACATGCAATGTCTGTATATGAGAGAGCTACTACTGCCGTTCTACCTGAAGAAATGTTTGAAATGTTCAATATTTATATTAAAAAAGCTGCTGAAATTTATGGAGTTCCTAAAACACGACAGATTTATGAAAAGGCTATTGAGACTCTTCCTGAAGAGAAGGCTAGGGAAATGTGTGTTCGCTTCTCAGAAATGGAAACTCGCCTAGGTGAAATTGATAGAGCTCGGGCAATATATGCACACTGTAGTCAAATGTGTGATCCTAGAATTACAGCTGATTTTTGGAACACTTGGAAAGAATTTGAAGTTAGGCATGGTAATGAAGATACAATGAGAGAAATGTTAAGAATTAAAAGAAGTGTGCAAGCCACATATAATACACAGGTGAATATGATGTCTGCACAAATGTTGAGTTCTGCAGCACAGGCAGCTGGTACTATATCAGATTTAGCACCAGGTATGAAAGATGGAATGAGAATGCTTGAAGCCAAAGCAGCTGAAATGGCAGTACAGAGTAAAGGCAACATTCTATTTGTGAGAGGAGAAACCCAAGGACTTAAAGAGAGTTCTGACAAAGTAGTGAATCCTGATGAAATATCAATTGATGAAGAATCCGATCACAGTGATGATGATGCTGAAGAGGATCCAATCCAAAAGAAAGATGTACCAACTGCTGTTTTTGGAGGACTTGTCAAGGATAATGAAGACTAG

Protein

MPLLDGKEIDIFFSEEDLPYEEEILRNPFSVKHWLRYIEHKKTAPKHEINMIYERALKELPGSFKLWYNYLKLRRKQIRGRCIADPCYEDVNNCFERSLVFMHKMPRIWMDYCSFLTDQYKITTTRKAFDSALRALPITQHHRIWPLYLNFLKKHNIPETAVRVFRRYLKLCPEDTEEYIDYLTSIDKLDEAAVKLAQLVNNENFQSKHGKSNHQLWNELCELISKNPDQIHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFERARDIYEEAIQTVTTVRDFTQIFDAYAQFEELSLSKKMEEVAKKTNPSEDDDIDLELRLARFEYLMERRLLLLNSVLLRQNPHNVAEWHKRVKLYEGKPHEIIDTYTEAVQTVDPKLAVGKLFTLWVGFAKFYENNDQIEDARLIFEKATQVAYVKVDDLASVWCEWAEMEIRHENYEQALKLMQRATVLPSRKVAYHDDSETVQMRLYKSLKVWSMYADLEESFGTFKSCKAVYDHIIDLKIATPQIIINYGLFLEEHNYFEEAFRAYEKGIALFKWPNVYDIWNTYLTKFLKRYGGSKLERARDLFEQCLEHCPNEFAKSIFLLYAKLEEEHGLARHAMSVYERATTAVLPEEMFEMFNIYIKKAAEIYGVPKTRQIYEKAIETLPEEKAREMCVRFSEMETRLGEIDRARAIYAHCSQMCDPRITADFWNTWKEFEVRHGNEDTMREMLRIKRSVQATYNTQVNMMSAQMLSSAAQAAGTISDLAPGMKDGMRMLEAKAAEMAVQSKGNILFVRGETQGLKESSDKVVNPDEISIDEESDHSDDDAEEDPIQKKDVPTAVFGGLVKDNED

Description

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.

Catalytic Activity

1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

Similarity

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Uniprot

A0A2A4JSG9   A0A2H1X083   A0A194R8T7   A0A0L7LAI7   A0A0T6AUW5   A0A1B6IRL5   + More
A0A1B6FH82   A0A1B6EF93   A0A139WHY2   A0A1W4XJW9   A0A1Y1KE62   A0A2P8YV29   A0A194PPK9   A0A0V0GBT5   A0A224XI61   U4U5G6   A0A1Z1JN50   A0A023F523   A0A0A9YW84   E0W262   A0A336L7F2   A0A146M6Y8   A0A1Q3F323   A0A182HEP4   A0A0P6JS97   B0WG76   A0A3F2ZDB5   W5JW10   A0A182M0M5   A0A182K1T5   A0A2M4BDH7   A0A182WF07   A0A182PJE5   A0A2M4ADB8   A0A2M4ADJ7   A0A182SJS6   A0A182VAQ8   A0A182HQA3   A0A182Y1K4   A0A182FBA0   A0A182WZQ9   A0A182RFE8   A0A182UBZ1   A0A0L0C9Z1   A0A182U7F8   A0A182IQ88   A0A084WID7   A0A182QL07   A0A1I8M786   T1P7U2   A0A182MYS4   A0A088A6E8   W8AU96   W8AIC9   A0A2A3E4R4   A0A0A1WZ47   A0A158NWF4   A0A158NWF3   F4X2X5   A0A151IL47   A0A1I8P6J3   A0A0N0U379   A0A0K8V661   A0A151X5K2   A0A151I1C6   A0A195FTY9   A0A3L8DR97   A0A034V1V1   A0A1A9XHC1   A0A1B0B806   A0A1A9ZPK2   A0A1A9VFG1   A0A1B0G5D0   T1JEU9   A0A1A9WIW5   A0A131XKB0   B4LKJ6   A1Z9G2   A0A0J9RC34   B3MHD2   C3KGI3   K7J3H5   A0A0P5QR11   A0A0N8BZ98   A0A0P5PSF9   A0A0N8C690   A0A0P5IMP1   A0A0P5MCM0   A0A0P6EG57   A0A0P5HG42   A0A131Z7U9   L7M4U9   A0A0P5PY38   A0A0P6EYM5   A0A224Z6G3   A0A0P6ASL6   A0A0P5FKN6   A0A0P5MLM5   A0A0P5FSK1   A0A232FE96  

EC Number

2.7.4.21
2.7.4.24

Pubmed

26354079    26227816    18362917    19820115    28004739    29403074    + More
23537049    28572631    25474469    25401762    20566863    26823975    26483478    26999592    20920257    23761445    25244985    26108605    24438588    25315136    24495485    25830018    21347285    21719571    30249741    25348373    28049606    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    20075255    26830274    25576852    28797301    28648823   

EMBL

NWSH01000765    PCG74350.1    ODYU01012454    SOQ58770.1    KQ460779    KPJ12286.1    + More
JTDY01001935    KOB72508.1    LJIG01022762    KRT78854.1    GECU01018169    JAS89537.1    GECZ01020285    JAS49484.1    GEDC01000700    JAS36598.1    KQ971342    KYB27504.1    GEZM01086114    JAV59772.1    PYGN01000343    PSN48111.1    KQ459598    KPI94669.1    GECL01001319    JAP04805.1    GFTR01008164    JAW08262.1    KB631977    ERL87578.1    KY705396    ARW29622.1    GBBI01002564    JAC16148.1    GBHO01009784    JAG33820.1    DS235874    EEB19718.1    UFQS01001856    UFQT01000766    UFQT01001856    SSX12583.1    SSX27067.1    GDHC01004309    JAQ14320.1    GFDL01013094    JAV21951.1    JXUM01132274    KQ567821    KXJ69263.1    GDUN01000596    JAN95323.1    DS231923    EDS26772.1    AJWK01013176    AJWK01013177    ADMH02000120    ETN67683.1    AXCM01000340    GGFJ01001926    MBW51067.1    GGFK01005448    MBW38769.1    GGFK01005499    MBW38820.1    APCN01003303    JRES01000803    KNC28264.1    ATLV01023929    KE525347    KFB49981.1    AXCN02001027    KA644584    AFP59213.1    GAMC01018277    JAB88278.1    GAMC01018280    JAB88275.1    KZ288405    PBC26159.1    GBXI01009993    JAD04299.1    ADTU01027930    ADTU01027931    ADTU01027932    ADTU01027933    GL888600    EGI59196.1    KQ977133    KYN05476.1    KQ435922    KOX68551.1    GDHF01017897    JAI34417.1    KQ982498    KYQ55652.1    KQ976573    KYM80381.1    KQ981280    KYN43354.1    QOIP01000005    RLU22318.1    GAKP01023420    JAC35538.1    JXJN01009796    CCAG010020791    JH432130    GEFH01002455    JAP66126.1    CH940648    EDW60717.1    AE013599    BT133178    AAF58348.1    AEZ68806.1    CM002911    KMY93546.1    CH902619    EDV37932.1    BT082048    ACO95726.1    GDIQ01110740    JAL40986.1    GDIQ01244032    GDIQ01219641    GDIQ01218201    GDIQ01193594    GDIQ01181503    GDIQ01178341    GDIQ01176798    GDIQ01162716    GDIQ01148728    GDIQ01130275    GDIQ01116283    GDIQ01115027    GDIQ01113743    GDIQ01097277    GDIQ01075300    GDIQ01064149    GDIQ01062597    GDIQ01060647    GDIQ01058346    GDIQ01049708    GDIQ01044855    GDIQ01042456    JAL21451.1    GDIQ01235985    GDIQ01234940    GDIQ01233692    GDIQ01230177    GDIQ01215950    GDIQ01211884    GDIQ01197096    GDIQ01172346    GDIQ01158667    GDIQ01156659    GDIQ01151215    GDIQ01142816    GDIQ01139075    GDIQ01128970    GDIQ01127575    GDIQ01125975    GDIQ01124225    GDIQ01101676    GDIQ01098735    GDIQ01091131    GDIQ01081841    GDIQ01079851    GDIQ01048208    GDIQ01032906    GDIQ01031214    JAL27501.1    GDIQ01110739    JAL40987.1    GDIQ01235984    GDIQ01235983    GDIQ01234939    GDIQ01234938    GDIQ01233693    GDIQ01233691    GDIQ01215949    GDIQ01197095    GDIQ01158666    GDIQ01156658    GDIQ01142817    GDIQ01141070    GDIQ01128969    GDIQ01128968    GDIQ01127574    GDIQ01127573    GDIQ01125977    GDIQ01125976    GDIQ01116284    GDIQ01098734    GDIQ01095520    GDIQ01081840    GDIQ01079852    GDIQ01049709    GDIQ01048209    GDIQ01039761    GDIQ01036896    JAK15741.1    GDIQ01219640    GDIQ01181502    JAK70223.1    GDIQ01244031    GDIQ01218200    GDIQ01179795    GDIQ01179794    GDIQ01176797    GDIQ01176796    GDIQ01162715    GDIQ01148727    GDIQ01144272    GDIQ01130274    GDIQ01115026    GDIQ01113744    GDIQ01108828    GDIQ01106526    GDIQ01097276    GDIQ01065546    GDIQ01065545    GDIQ01064151    GDIQ01064150    GDIQ01062598    GDIQ01060646    GDIQ01044856    GDIQ01044854    GDIQ01029458    JAN30586.1    GDIQ01230176    JAK21549.1    GEDV01002316    JAP86241.1    GACK01006866    JAA58168.1    GDIQ01121820    JAL29906.1    GDIQ01055705    JAN39032.1    GFPF01010754    MAA21900.1    GDIP01038985    LRGB01000512    JAM64730.1    KZS18453.1    GDIQ01253974    GDIQ01245375    GDIQ01165610    JAJ97750.1    GDIQ01154717    JAK97008.1    GDIQ01253975    GDIQ01245376    JAJ97749.1    NNAY01000337    OXU29104.1   

Proteomes

UP000218220    UP000053240    UP000037510    UP000007266    UP000192223    UP000245037    + More
UP000053268    UP000030742    UP000009046    UP000069940    UP000249989    UP000002320    UP000092461    UP000000673    UP000075883    UP000075881    UP000075920    UP000075885    UP000075901    UP000075903    UP000075840    UP000076408    UP000069272    UP000076407    UP000075900    UP000075902    UP000037069    UP000075880    UP000030765    UP000075886    UP000095301    UP000075884    UP000005203    UP000242457    UP000005205    UP000007755    UP000078542    UP000095300    UP000053105    UP000075809    UP000078540    UP000078541    UP000279307    UP000092443    UP000092460    UP000092445    UP000078200    UP000092444    UP000091820    UP000008792    UP000000803    UP000007801    UP000002358    UP000076858    UP000215335   

PRIDE

A1Z9G2    C3KGI3   

Pfam

PF13181   TPR_8        + More
PF05843   Suf
PF00328   His_Phos_2
PF18086   PPIP5K2_N

Interpro

IPR011990   TPR-like_helical_dom_sf        + More
IPR003107   HAT       
IPR019734   TPR_repeat       
IPR013026   TPR-contain_dom       
IPR008847   Suf       
IPR033379   Acid_Pase_AS       
IPR000560   His_Pase_clade-2       
IPR037446   His_Pase_VIP1       
IPR029033   His_PPase_superfam       
IPR040557   VIP1_N       
IPR029062   Class_I_gatase-like       

SUPFAM

SSF48452   SSF48452        + More
SSF53254   SSF53254       
SSF52317   SSF52317       

Gene 3D

1.25.40.10     3.40.50.880    

CDD

cd07061  HP_HAP_like

ProteinModelPortal

A0A2A4JSG9   A0A2H1X083   A0A194R8T7   A0A0L7LAI7   A0A0T6AUW5   A0A1B6IRL5   + More
A0A1B6FH82   A0A1B6EF93   A0A139WHY2   A0A1W4XJW9   A0A1Y1KE62   A0A2P8YV29   A0A194PPK9   A0A0V0GBT5   A0A224XI61   U4U5G6   A0A1Z1JN50   A0A023F523   A0A0A9YW84   E0W262   A0A336L7F2   A0A146M6Y8   A0A1Q3F323   A0A182HEP4   A0A0P6JS97   B0WG76   A0A3F2ZDB5   W5JW10   A0A182M0M5   A0A182K1T5   A0A2M4BDH7   A0A182WF07   A0A182PJE5   A0A2M4ADB8   A0A2M4ADJ7   A0A182SJS6   A0A182VAQ8   A0A182HQA3   A0A182Y1K4   A0A182FBA0   A0A182WZQ9   A0A182RFE8   A0A182UBZ1   A0A0L0C9Z1   A0A182U7F8   A0A182IQ88   A0A084WID7   A0A182QL07   A0A1I8M786   T1P7U2   A0A182MYS4   A0A088A6E8   W8AU96   W8AIC9   A0A2A3E4R4   A0A0A1WZ47   A0A158NWF4   A0A158NWF3   F4X2X5   A0A151IL47   A0A1I8P6J3   A0A0N0U379   A0A0K8V661   A0A151X5K2   A0A151I1C6   A0A195FTY9   A0A3L8DR97   A0A034V1V1   A0A1A9XHC1   A0A1B0B806   A0A1A9ZPK2   A0A1A9VFG1   A0A1B0G5D0   T1JEU9   A0A1A9WIW5   A0A131XKB0   B4LKJ6   A1Z9G2   A0A0J9RC34   B3MHD2   C3KGI3   K7J3H5   A0A0P5QR11   A0A0N8BZ98   A0A0P5PSF9   A0A0N8C690   A0A0P5IMP1   A0A0P5MCM0   A0A0P6EG57   A0A0P5HG42   A0A131Z7U9   L7M4U9   A0A0P5PY38   A0A0P6EYM5   A0A224Z6G3   A0A0P6ASL6   A0A0P5FKN6   A0A0P5MLM5   A0A0P5FSK1   A0A232FE96  

PDB

6QDV     E-value=0,     Score=2743

KEGG

101740068    K12867 pre-mRNA-splicing factor SYF1 | (RefSeq) pre-mRNA-splicing factor SYF1

PATHWAY

03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0006396   GO:0000974   GO:0071007   GO:0000398   GO:0071014   GO:0071013   GO:0000349   GO:0006397   GO:0005634   GO:0033857   GO:0005524   GO:0000832   GO:0052724   GO:0052723   GO:0005829   GO:0102092   GO:0000829   GO:0008380   GO:0007443   GO:0007510   GO:0002009   GO:0071011   GO:0000381   GO:0005515   GO:0006351   GO:0032549   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR12750  

Subcellular location

  

Length:

842

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00142

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00001

outside

1  -  842

 

 

Pi

137.370103

Theta

140.940953

Tajima's D

-0.741957

CLR

115.878467

CSRT

0.189040547972601

Interpretation

Uncertain