Gene

KWMTBOMO02169

Pre Gene Modal

BGIBMGA003022

Annotation

PREDICTED:_F-box_only_protein_42_[Amyelois_transitella]

Location

Bomo_Chr4(+):13161017-13163272      View in EpiBrowser

Full name

F-box only protein 42      

Alternative Name

Just one F-box and Kelch domain-containing protein

Location in the cell

Nuclear   Reliability : 2.387

CDS

ATGGAAATCATTCATAAATCTTTACAAGAACAGACTTTGCGAAGTACAATTGAAGACCTTCCTGATGAAGTACTGGAGTTTATTTTAAGTTTTTTGCCTCCCTACAGAGACTTAGAGAACTGTGGTGGTGTCTGTAGGAGATGGTATGCGTGTGCCCAAAATGTTCTACACAAAACCTCTATAAAACTTGTAAAAGCAATTGGAGAATTTAAAATTTTGTGGAAAAACCTTTCTCCAACAAATATGTTTCCTGTTATAACAAAACGATTTTCACATGCAGCATGTATACTTGAAAATAGTATGTACATATTTGGGGGATGCACAACTAATTCTACATCATTTAATGATCTTTGGAAATTTGATTTATCAACTAGAAAATGGGTAAGACCATTAGCAACTGGCACTTATCCTGTACCTAAGGCCTATACTACAATGGTACATTACAAGAATTATTTAATAGTCTTTGGTGGTTGGACTTATCCATCTCTTTCACAGTACTATCAAAATGTCACAATGTTCAATGAAATTCATTTTTATTGCTTAGAAACAAATAAATGGATATTGATCAATGCATCCAATAGCCCACCACCAATGGCTGGACATTCGGCTTGTGTGAGGGATGATGAAATGGTTGTGTTTGGAGGGTTAGTACTGTCAACAGCAAATAGTCATCAAATTCAATGTTCGAATGATGTCTGGGTACTAGATATACCTTCCCTCACTTGGAGAAAACAACCAACAACAAAACCAAGACCTTCACCACGCTATGCTCAATCTCTTTTGGAACTGGATTGTGGAAGGTTGATGCTGTTAGGAGGTGTGCAAACATTGCATAATCGATTTGTGTATAGTGATTGTTGGGTGTTAACTATGAAAGGATCTACTTGGACATGGAAAGAACTTGCTGTCAAAAATAAGGAATGGGCTGCAGCTAATATTTGGTGTAATCCAGCTTGCAAAGTTGGTGATAAAGTTGTGAGTTTGAGTAGAAGCAGAAATGGATGGAATAGTGCTAAACCATTAGTAACATCAGCTGTGCGTTTGTCAGCTTTAAGTAGACCTGAAGGGGCTCCAGTTTCTGTAAGAGTTCAGCAAAGTTTGCAAAGGCCTTTAGATAGAGATCAAAATATAAATGGTAGAAGAGGAGAACTACCTAGAAGGCCATCAAATCCTTTGAAGTGTGAGCAGAATGATTCAAATGTAGAACCTGTTGCTGGACCTAGTAATGCCCAAATTAGTCCTAGAAAAGTGACTATTGAACCACAAAATGACATTAACGTTAATATAGATGATTCTGGTTTAAGTTCAGACAATAAGCTATCTAGTAATAACTTAGACTGTGCAAAAAAAGATTTGGCGATAAAGAGGAACAAAAATAAGAATAAAGGATTAAAAATAGTAAGACAACTACAAGAAGCTAACAAATACAGAATGGCAGCATTTGCTTGTGACTCGTCTATAAACAATTCTGCTCCAGAAAATGATCTCATTAATCAAAGGCAGATTGCTCATCTGGAACATCGAAGGGAACTTCCTCCACAAGACATTGCCCAGCAAAGACAACCAGCTGTAAAAAAAATTAAGCGAAACACATTAAGTATTGCTAAACTGTGCATCAATAATTAA

Protein

MEIIHKSLQEQTLRSTIEDLPDEVLEFILSFLPPYRDLENCGGVCRRWYACAQNVLHKTSIKLVKAIGEFKILWKNLSPTNMFPVITKRFSHAACILENSMYIFGGCTTNSTSFNDLWKFDLSTRKWVRPLATGTYPVPKAYTTMVHYKNYLIVFGGWTYPSLSQYYQNVTMFNEIHFYCLETNKWILINASNSPPPMAGHSACVRDDEMVVFGGLVLSTANSHQIQCSNDVWVLDIPSLTWRKQPTTKPRPSPRYAQSLLELDCGRLMLLGGVQTLHNRFVYSDCWVLTMKGSTWTWKELAVKNKEWAAANIWCNPACKVGDKVVSLSRSRNGWNSAKPLVTSAVRLSALSRPEGAPVSVRVQQSLQRPLDRDQNINGRRGELPRRPSNPLKCEQNDSNVEPVAGPSNAQISPRKVTIEPQNDINVNIDDSGLSSDNKLSSNNLDCAKKDLAIKRNKNKNKGLKIVRQLQEANKYRMAAFACDSSINNSAPENDLINQRQIAHLEHRRELPPQDIAQQRQPAVKKIKRNTLSIAKLCINN

Description

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity).
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Subunit

Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct (By similarity).
Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.

Keywords

Complete proteome   Kelch repeat   Phosphoprotein   Reference proteome   Repeat   Ubl conjugation pathway   Polymorphism  

Feature

chain  F-box only protein 42
sequence variant  In dbSNP:rs12069239.

Uniprot

A0A2H1X0A5   A0A2A4JSH6   A0A194PU57   S4P9T6   A0A194R3L6   A0A212ESC4   + More
A0A0L7LBA5   A0A1Y1KPV2   A0A195BD88   A0A195FT29   A0A195DI98   A0A195C311   A0A151WNR2   F4WBU6   A0A232FE77   A0A023EXH6   A0A0A9YZ53   A0A2A3E384   E2AR77   A0A154PJ48   A0A1B6LAL1   T1JLR5   E2BK30   A0A3L8DR07   E0W278   A0A1B6FR62   J3JWR2   U4U9L6   A0A1B6DFU0   G5BRU7   A0A099YX92   J9PBL7   A0A091U4B5   A0A087U2J6   U6CVW6   A0A2Y9KLX1   A0A093HZI3   Q5RDA9   A0A2U3Y227   D2HGZ9   A0A2U3VPQ8   A0A384CDI4   M3YXW8   A0A2Y9GKV9   A0A2R9B1R0   K7BHJ8   G1R8I2   H2N8X3   A0A024QZB0   Q6P3S6   H2PY50   A0A2K6T2G6   A0A2K5PX86   A0A091WL62   G3RF74   G7NU98   F7ETH8   A0A0B8RSX9   F1SUS5   I0FSS1   A0A2K6B8E3   A0A2K5LBK2   H0WRB2   A0A2K5CIU2   A0A2K5ZU41   A0A2K6GHP2   G3W8W5   F7EA52   A0A2K6L7D4   A0A0P5LR56   A0A096NFK8   A0A2K5WBP3  

Pubmed

26354079    23622113    22118469    26227816    28004739    21719571    + More
28648823    25474469    25401762    26823975    20798317    30249741    20566863    22516182    23537049    21993625    16341006    20010809    24813606    22722832    11181995    14702039    16710414    15489334    10718198    17974005    18669648    19509332    19690332    20068231    23186163    16136131    22398555    22002653    17431167    25319552    30723633    21709235    25243066   

EMBL

ODYU01012454    SOQ58769.1    NWSH01000765    PCG74352.1    KQ459598    KPI94670.1    + More
GAIX01003589    JAA88971.1    KQ460779    KPJ12287.1    AGBW02012845    OWR44341.1    JTDY01001935    KOB72506.1    GEZM01077018    JAV63459.1    KQ976511    KYM82523.1    KQ981280    KYN43457.1    KQ980824    KYN12566.1    KQ978317    KYM95227.1    KQ982911    KYQ49325.1    GL888066    EGI68374.1    NNAY01000337    OXU29094.1    GBBI01004825    JAC13887.1    GBHO01006703    GBRD01004151    GDHC01013769    JAG36901.1    JAG61670.1    JAQ04860.1    KZ288405    PBC26158.1    GL441909    EFN64059.1    KQ434936    KZC11911.1    GEBQ01019230    JAT20747.1    JH431578    GL448740    EFN83938.1    QOIP01000005    RLU22319.1    DS235874    EEB19734.1    GECZ01017140    JAS52629.1    APGK01028302    BT127680    KB740686    AEE62642.1    ENN79542.1    KB631930    ERL87301.1    GEDC01012806    JAS24492.1    JH171561    GEBF01003438    EHB12009.1    JAO00195.1    KL886156    KGL73543.1    AAEX03001852    AAEX03001853    AAEX03001854    KK413614    KFQ84695.1    KK117848    KFM71585.1    HAAF01002608    CCP74434.1    KK638634    KFV59868.1    CR858005    ACTA01036341    ACTA01044340    ACTA01052340    ACTA01060340    ACTA01068340    GL192825    EFB21809.1    AEYP01008478    AEYP01008479    AEYP01008480    AEYP01008481    AEYP01008482    AEYP01008483    AEYP01008484    AEYP01008485    AEYP01008486    AEYP01008487    AJFE02017018    AJFE02017019    AJFE02017020    AJFE02017021    AJFE02017022    AJFE02017023    AJFE02017024    AJFE02017025    AJFE02017026    AJFE02017027    GABC01008663    GABF01002482    GABD01009344    NBAG03000427    JAA02675.1    JAA19663.1    JAA23756.1    PNI25821.1    ADFV01118720    ADFV01118721    ADFV01118722    ADFV01118723    ADFV01118724    ADFV01118725    ADFV01118726    ADFV01118727    ADFV01118728    ADFV01118729    ABGA01168083    ABGA01168084    ABGA01168085    ABGA01168086    ABGA01168087    ABGA01168088    ABGA01168089    ABGA01334877    ABGA01334878    ABGA01334879    NDHI03003598    PNJ17297.1    CH471167    EAW51775.1    AK055598    AL109627    AL358794    BC006174    BC032439    BC043410    BC063864    AB037753    AL833874    AACZ04046882    AACZ04046883    GABE01010631    JAA34108.1    KK735891    KFR16362.1    CABD030001180    CABD030001181    CABD030001182    CABD030001183    CABD030001184    CABD030001185    CABD030001186    CABD030001187    CABD030001188    CABD030001189    CM001276    EHH49571.1    JSUE03000465    JSUE03000466    JSUE03000467    JSUE03000468    JSUE03000469    JU476075    CM001253    AFH32879.1    EHH14368.1    GBZA01000224    JAG69544.1    AEMK02000044    DQIR01221874    HDB77351.1    JV047426    AFI37497.1    AAQR03021005    AAQR03021006    AAQR03021007    AAQR03021008    AAQR03021009    AAQR03021010    AAQR03021011    AEFK01121966    AEFK01121967    AEFK01121968    AEFK01121969    AEFK01121970    AEFK01121971    GAMT01000858    GAMS01006022    GAMR01009480    GAMQ01007016    GAMP01005824    JAB11003.1    JAB17114.1    JAB24452.1    JAB34835.1    JAB46931.1    GDIQ01174759    GDIQ01056612    JAK76966.1    AHZZ02015349    AHZZ02015350    AQIA01005664    AQIA01005665    AQIA01005666    AQIA01005667    AQIA01005668    AQIA01005669    AQIA01005670   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    UP000078540    + More
UP000078541    UP000078492    UP000078542    UP000075809    UP000007755    UP000215335    UP000242457    UP000000311    UP000076502    UP000008237    UP000279307    UP000009046    UP000019118    UP000030742    UP000006813    UP000053641    UP000002254    UP000054359    UP000248482    UP000001595    UP000245341    UP000008912    UP000245340    UP000261680    UP000291021    UP000000715    UP000248481    UP000240080    UP000001073    UP000005640    UP000002277    UP000233220    UP000233040    UP000053605    UP000001519    UP000009130    UP000006718    UP000008227    UP000233120    UP000233060    UP000005225    UP000233020    UP000233140    UP000233160    UP000007648    UP000008225    UP000233180    UP000028761    UP000233100   

PRIDE

Q5RDA9    Q6P3S6    F1SUS5   

Pfam

PF12937   F-box-like        + More
PF07646   Kelch_2
PF01344   Kelch_1

Interpro

IPR001810   F-box_dom        + More
IPR015915   Kelch-typ_b-propeller       
IPR036047   F-box-like_dom_sf       
IPR011498   Kelch_2       
IPR006652   Kelch_1       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF117281   SSF117281        + More
SSF81383   SSF81383       

Gene 3D

2.120.10.80    

ProteinModelPortal

A0A2H1X0A5   A0A2A4JSH6   A0A194PU57   S4P9T6   A0A194R3L6   A0A212ESC4   + More
A0A0L7LBA5   A0A1Y1KPV2   A0A195BD88   A0A195FT29   A0A195DI98   A0A195C311   A0A151WNR2   F4WBU6   A0A232FE77   A0A023EXH6   A0A0A9YZ53   A0A2A3E384   E2AR77   A0A154PJ48   A0A1B6LAL1   T1JLR5   E2BK30   A0A3L8DR07   E0W278   A0A1B6FR62   J3JWR2   U4U9L6   A0A1B6DFU0   G5BRU7   A0A099YX92   J9PBL7   A0A091U4B5   A0A087U2J6   U6CVW6   A0A2Y9KLX1   A0A093HZI3   Q5RDA9   A0A2U3Y227   D2HGZ9   A0A2U3VPQ8   A0A384CDI4   M3YXW8   A0A2Y9GKV9   A0A2R9B1R0   K7BHJ8   G1R8I2   H2N8X3   A0A024QZB0   Q6P3S6   H2PY50   A0A2K6T2G6   A0A2K5PX86   A0A091WL62   G3RF74   G7NU98   F7ETH8   A0A0B8RSX9   F1SUS5   I0FSS1   A0A2K6B8E3   A0A2K5LBK2   H0WRB2   A0A2K5CIU2   A0A2K5ZU41   A0A2K6GHP2   G3W8W5   F7EA52   A0A2K6L7D4   A0A0P5LR56   A0A096NFK8   A0A2K5WBP3  

PDB

6DO5     E-value=6.01428e-10,     Score=155

KEGG

101745254    K10317 F-box protein 42 | (RefSeq) F-box only protein 42

GO

GO:0003676   GO:0005515   GO:0006351   GO:0032549   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Length:

541

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.312

Exp number, first 60 AAs:

5e-05

Total prob of N-in:

0.01655

outside

1  -  541

 

 

Pi

122.420195

Theta

127.909732

Tajima's D

-1.830268

CLR

0.208409

CSRT

0.0255987200639968

Interpretation

Uncertain