Gene

KWMTBOMO02158

Pre Gene Modal

BGIBMGA003015

Annotation

PREDICTED:_WD_repeat-containing_protein_59_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr4(+):12963447-12975404      View in EpiBrowser

Full name

GATOR complex protein WDR59      

Alternative Name

CUL4- and DDB1-associated WDR protein 12
WD repeat-containing protein 59

Location in the cell

Extracellular   Reliability : 1.545 Nuclear   Reliability : 1.256 PlasmaMembrane   Reliability : 1.524

CDS

ATGTCAGTTCACTGGAGTTCTGAAATATTAAAATGGGAATATCGCGAGCTCCAGGCCACTGCAATGACCGTGGATTACACGGGCAACAACGTACTACTAGCAGGTCGCAGGTGCCTGGCCATAAAACAAATAAATCAGGAAGAAGATGGCAACGCGGTAAAAAAATATCCTCGCCAAAGTAAATATGATGCTGCCGGTGCTGAGTGGTGTCAATCGTATCACGGGCAAAAATTATGTGCTATTGCAAGCAACCAGAGAGTTGATGTGTATGAATGGAGAGATGGCAATGATTTGACATGTATATGTTCACTCCGTGGCCACACACGGGTTGTTAGTGACACACACTTCCACAGACAAGATCACAATCTTATAGCAACTTGCTCCATAGATACATTCACTCATATGTGGGATTTGAGAGATGCTCGAAAACCTGTTGTGTCGCTATGTGCAGTGGCTGGTGCTTCACAAGTGCAGTGGAATAAAGTAGCATCACACATAGTAGCCACAGCCCATGACGGTGATATTAAAATATGGGATTATCGAAAGCCATCCTCTCCAATACATTACATATCTGCACATTTATGTAAAATCCACGGAGTAGACTGGAGCCCGCACCATGAGTATCAGCTAGTTACATCTAGTCATGATGGAAGCATTAAATACTTTGATATTAACAACGCAAGAAGACCTGAGAATGTAATTATGACAAACTTCCCAGTATGGCGAGCCATTTATACTCCATTTGGCAGTGGTTTGTTGACAATTGGTGTGGGCTGGGGTGGTCTGCCTCGTGCTGAACAAGCGGGAGTTATTGGTATATGGGTTGGAGGTACTCTAACACATAGACTAGTGGGACATACAGACACGGTTCAAACTATGGTGTGGAGATCAAATACCTCCCCATCAAATTATCAGTTGGTTACATGGGGAAGAGATCAATCTTTAAGAGTTTGGGCTATGCATCCATCTTTGTTAAAAATGTGTAACCATTATCTACCAGATGATGAAAATGATGAAGACAACAATAGTGACGCAGTGAGCTATGCCTCTACAGCTGGTTCAACAAATGATGTTTCTTTTGGTGACAAAGGACAAGATATGAATAAACTACCGCATAAAACCTCAATAGATGAAGAATTTGAATCAATTAGAGAAATGGCAAATATTGAAGTTACAGACATGAATATAGAAACACGAACTTGTCAAATCCATTCCGAACGAAATGGTTATGTAGCCAATTTACAGGTTACTTTCCCTAGGAATGTTACTGAACAGATCATACCAAAGTTCTCGTGGCTGTCAGGAACTAATGTGGACAGTCTCATAACCATAAAGATACTGCAAAGCATTAATAGAACTGCTTATCGTAAAAAGAAAGAAGGACACAGATGTTTGTTACATTGTTTAAAAACATTAGCAAAGTCAATTGATGAGATACCCGTGAAGAATGACGACACAGACTCGATGAAATCGAGTCAAAGAAGTCAGTCGGAGTGTGAGAATGCAGGCGATTCGTGTATTCCTTTCCCTCGAACATGCGGGGCTAAGTGGTGCGGTGTTAGTACGTTAGTGGTATTCAACCGTCCCCCGAACACCAGGAGGCTGTCATTGAAGCACGAGACTGGAACACCTCGGTCAATGTCATCGTTATCCTTGATGCCGGGTTTATTCAACACCGGCTACAGTTCTGTGTCGCCTCACGCCACCACGACTCCGTCGCCGACGAACCCGCCGGGCTTCCCGCAATTACATCACAAGCACCCGTCCTATTCAATCACAACGTTCTATTTTCAAGATCGATGGAAGGCACAAGGTCGCCGCGCGGGCAGCATCCGCAGTCGCGGAAGTATATCCGGGTGCTCATCGCCTAGAGTGGTACTGTATGCTGCGACAGATCTCTTCCCACTTAATCGTACTCTTGCTGAAAAATACGTAATTAATTCTGATAATCCGATCGACATGTGCGAAACAAACGCTAAAGTGGCAACGGAAGAAGGAGAACGTGACCTCGCGCACGCCTGGTCTCTGGCCGCGCTTACCGCTAAAGCTCTGAAAGCGAAAGTTGTCGATCATCTGACTTCCAGCGAAGAAAGCATGGGCTGGGTTGGACATCCTCTGTGCTGTAATCTACTGCAATCCTTAATATCGCATTACGCTAAAGCGTCGAACGTGCAGATGGCCGCAATGTTGGCCTGTGCGTTTTCAATATTTAACGAAACTAGTAATTCTAGTTCCCAATCAACTATCAGTAGTTCCAGTTATGGCAATGGAACTTCACCGTACAGCACCGTAAATCAGTACAGTGAAATCAGCGCTGACGGTTGGACCCTGCCCATAGTGCTCCGAAGCAACTCTTGTTCGGAGGCGGAGAATTTCTACACGGACTCGACCGTTTCGAAATCCGAACGCACATCATCGTGCGTACTGGACGAGACGACCGTCCACTCGTACCACTGCTTCAAGAGAGTCTACGCCGACATATTACATCGATGGCAACTGATATACAAGAAAACGGAGGTGATGAAACAAGTGAGCGGGCGGCAGCAGACGGGCGAGGTGCGGTACGCGGGCCCCGAGTCGCTGTCGGAGTGTGCGTGGTGCGGCGCGGGACGCAGCGGCGTGCGCTGTGCGGCGTGCGGCCGTGCGGCGCTGCGGTGCGCGGTGTGCGCGCTCGCCGTCCGCGGCCTCGCCTGCGCGTGCGCCTACTGCGGACACGCCGGCCACGCCGCACACATGCTCGCCTGGTTTGCGGAACGCGACACTTGCCCCACGGGTTGCGGATGCAAATGCGTTATGGAAGGAAATTCAGGATGGAAAGGAGTGAAATTAGAATACGAAAACCTGATCGCAGGAGCACGTACCGTGGACGCAATCAAAGATTCAACATTTAAATCAGTATATTCTTACTTTAATATCATATCAAATATGGGGCGAGATATTAAAATGATCAGCCGGTAA

Protein

MSVHWSSEILKWEYRELQATAMTVDYTGNNVLLAGRRCLAIKQINQEEDGNAVKKYPRQSKYDAAGAEWCQSYHGQKLCAIASNQRVDVYEWRDGNDLTCICSLRGHTRVVSDTHFHRQDHNLIATCSIDTFTHMWDLRDARKPVVSLCAVAGASQVQWNKVASHIVATAHDGDIKIWDYRKPSSPIHYISAHLCKIHGVDWSPHHEYQLVTSSHDGSIKYFDINNARRPENVIMTNFPVWRAIYTPFGSGLLTIGVGWGGLPRAEQAGVIGIWVGGTLTHRLVGHTDTVQTMVWRSNTSPSNYQLVTWGRDQSLRVWAMHPSLLKMCNHYLPDDENDEDNNSDAVSYASTAGSTNDVSFGDKGQDMNKLPHKTSIDEEFESIREMANIEVTDMNIETRTCQIHSERNGYVANLQVTFPRNVTEQIIPKFSWLSGTNVDSLITIKILQSINRTAYRKKKEGHRCLLHCLKTLAKSIDEIPVKNDDTDSMKSSQRSQSECENAGDSCIPFPRTCGAKWCGVSTLVVFNRPPNTRRLSLKHETGTPRSMSSLSLMPGLFNTGYSSVSPHATTTPSPTNPPGFPQLHHKHPSYSITTFYFQDRWKAQGRRAGSIRSRGSISGCSSPRVVLYAATDLFPLNRTLAEKYVINSDNPIDMCETNAKVATEEGERDLAHAWSLAALTAKALKAKVVDHLTSSEESMGWVGHPLCCNLLQSLISHYAKASNVQMAAMLACAFSIFNETSNSSSQSTISSSSYGNGTSPYSTVNQYSEISADGWTLPIVLRSNSCSEAENFYTDSTVSKSERTSSCVLDETTVHSYHCFKRVYADILHRWQLIYKKTEVMKQVSGRQQTGEVRYAGPESLSECAWCGAGRSGVRCAACGRAALRCAVCALAVRGLACACAYCGHAGHAAHMLAWFAERDTCPTGCGCKCVMEGNSGWKGVKLEYENLIAGARTVDAIKDSTFKSVYSYFNIISNMGRDIKMISR

Description

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.

Subunit

Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (By similarity). The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (By similarity).

Similarity

Belongs to the WD repeat WDR59 family.

Keywords

Alternative splicing   Complete proteome   Lysosome   Membrane   Phosphoprotein   Reference proteome   Repeat   WD repeat  

Feature

chain  GATOR complex protein WDR59
splice variant  In isoform 3.

Uniprot

H9J0H8   A0A2H1X3A7   A0A2A4JEM0   A0A194PPM4   A0A0N1PHS0   A0A1E1WK22   + More
A0A212F718   A0A0L7LDE9   A0A067R0D6   A0A1B6JHN4   A0A1B6FHE0   A0A1B6LD05   A0A1B6L4P6   A0A0L7R5L3   A0A026WWM6   A0A088A1Q1   A0A154P6G4   A0A0T6BAB1   A0A1B6EDS3   A0A1Y1KZD6   A0A1B6D6G7   D6WN20   A0A2J7RPG8   A0A1Y1L1S8   E9IBV7   E2A3R2   A0A195FB84   E2BIK5   A0A158NKA2   A0A195BAT9   A0A195EIT5   U4UEM6   F4W8K1   A0A0M8ZXT8   A0A1B6CVN7   A0A1Q3F6H0   B0WTA1   A0A2A3EP07   A0A1Q3F7P8   A0A151I859   A0A0V0G8I0   A0A146M4X9   A0A151WIN6   A0A023F022   N6UFD5   Q16G37   A0A0A9X3R7   A0A3L8DAG8   A0A146LRT8   C3YFB9   E9H1V0   A0A084VEC9   A0A182LSV2   E0VY62   A0A182K5T9   A0A182RMA3   A0A182IRC8   A0A182Y3C0   A0A182L0R3   A0A182NTU7   A0A182ULT9   R7TMI9   A0A182QNN6   A0A1S4GXZ3   Q7Q4C4   A0A182P8L4   H9GBV1   A0A182ICB7   A0A1S4HD45   A0A182XLA7   A0A0K8VW37   A0A0A1X9H2   A0A151MSN7   R4GCZ0   W8BB68   A0A2M4AM79   A0A2M4AM55   A0A336LRA9   A0A224Z4X1   W5J5S2   A0A131YR22   A0A182F1E3   W5LZT8   A0A1S3J0W8   A0A1S3PX28   A0A131XHT8   A0A131YP78   A0A2M4BDA9   A0A1S3J0C7   A0A1A7YT73   A0A293LUA5   A0A1S3J248   A0A1S3J0C9   A0A2I4D1D6   A0A1A8GKB0   A0A182KK58   Q8C0M0-2  

Pubmed

19121390    26354079    22118469    26227816    24845553    24508170    + More
28004739    18362917    19820115    21282665    20798317    21347285    23537049    21719571    26823975    25474469    17510324    25401762    30249741    18563158    21292972    24438588    20566863    25244985    20966253    23254933    12364791    21881562    25830018    22293439    24495485    28797301    20920257    23761445    26830274    28049606    17041588    15368895    16141072    15489334    21183079   

EMBL

BABH01010404    BABH01010405    BABH01010406    ODYU01012677    SOQ59114.1    NWSH01001661    + More
PCG70507.1    KQ459598    KPI94684.1    KQ460709    KPJ12724.1    GDQN01003695    JAT87359.1    AGBW02009947    OWR49518.1    JTDY01001595    KOB73430.1    KK852829    KDR15357.1    GECU01009057    GECU01001812    JAS98649.1    JAT05895.1    GECZ01020162    JAS49607.1    GEBQ01018400    JAT21577.1    GEBQ01021513    JAT18464.1    KQ414652    KOC66133.1    KK107105    EZA59534.1    KQ434819    KZC06934.1    LJIG01002801    KRT84139.1    GEDC01021410    GEDC01001258    JAS15888.1    JAS36040.1    GEZM01071285    GEZM01071284    JAV65908.1    GEDC01029868    GEDC01016025    JAS07430.1    JAS21273.1    KQ971343    EFA04339.1    NEVH01001358    PNF42724.1    GEZM01071289    GEZM01071287    JAV65905.1    GL762137    EFZ21987.1    GL436457    EFN71954.1    KQ981693    KYN37678.1    GL448516    EFN84452.1    ADTU01018755    KQ976537    KYM81335.1    KQ978881    KYN27774.1    KB632288    ERL91487.1    GL887908    EGI69492.1    KQ435803    KOX73127.1    GEDC01029526    GEDC01019867    JAS07772.1    JAS17431.1    GFDL01011893    JAV23152.1    DS232082    EDS34325.1    KZ288215    PBC32761.1    GFDL01011512    JAV23533.1    KQ978406    KYM94147.1    GECL01001854    JAP04270.1    GDHC01003791    JAQ14838.1    KQ983082    KYQ47729.1    GBBI01004326    JAC14386.1    APGK01037599    APGK01037600    KB740948    ENN77367.1    CH478338    EAT33205.1    GBHO01029298    JAG14306.1    QOIP01000011    RLU17142.1    GDHC01009499    JAQ09130.1    GG666509    EEN60882.1    GL732584    EFX74304.1    ATLV01012268    KE524777    KFB36323.1    AXCM01005211    DS235843    EEB18318.1    AMQN01002462    KB309292    ELT94839.1    AXCN02000806    AAAB01008964    EAA12424.4    AAWZ02033305    AAWZ02033306    APCN01000793    GDHF01009212    JAI43102.1    GBXI01006927    JAD07365.1    AKHW03005169    KYO27527.1    GAMC01008090    JAB98465.1    GGFK01008574    MBW41895.1    GGFK01008516    MBW41837.1    UFQT01000047    SSX18937.1    GFPF01010915    MAA22061.1    ADMH02002157    ETN58215.1    GEDV01008216    JAP80341.1    AHAT01010677    GEFH01001467    JAP67114.1    GEDV01008215    JAP80342.1    GGFJ01001884    MBW51025.1    HADX01011169    SBP33401.1    GFWV01007364    MAA32094.1    HAEC01002762    SBQ70839.1    EF011622    AK173301    AK030644    AK040807    AK052262    AK136303    AK170910    BC066082    ABK41112.1    BAD32579.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000027135    UP000053825    UP000053097    UP000005203    UP000076502    UP000007266    UP000235965    UP000000311    UP000078541    UP000008237    UP000005205    UP000078540    UP000078492    UP000030742    UP000007755    UP000053105    UP000002320    UP000242457    UP000078542    UP000075809    UP000019118    UP000008820    UP000279307    UP000001554    UP000000305    UP000030765    UP000075883    UP000009046    UP000075881    UP000075900    UP000075880    UP000076408    UP000075882    UP000075884    UP000075903    UP000014760    UP000075886    UP000007062    UP000075885    UP000001646    UP000075840    UP000076407    UP000050525    UP000000673    UP000069272    UP000018468    UP000085678    UP000087266    UP000192220    UP000000589   

PRIDE

H9J0H8    Q8C0M0   

Pfam

PF00400   WD40        + More
PF05773   RWD
PF17034   zinc_ribbon_16

Interpro

IPR017986   WD40_repeat_dom        + More
IPR001680   WD40_repeat       
IPR019775   WD40_repeat_CS       
IPR036322   WD40_repeat_dom_sf       
IPR006575   RWD-domain       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR039456   WDR59_mRING-H2-C3H3C2       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR031488   Zn_ribbon_mio       
IPR020472   G-protein_beta_WD-40_rep       
IPR001138   Zn2-C6_fun-type_DNA-bd       

SUPFAM

SSF50978   SSF50978        + More
SSF54495   SSF54495       

Gene 3D

3.10.110.10     2.130.10.10    

CDD

cd16692  mRING-H2-C3H3C2_WDR59
cd00067  GAL4

ProteinModelPortal

H9J0H8   A0A2H1X3A7   A0A2A4JEM0   A0A194PPM4   A0A0N1PHS0   A0A1E1WK22   + More
A0A212F718   A0A0L7LDE9   A0A067R0D6   A0A1B6JHN4   A0A1B6FHE0   A0A1B6LD05   A0A1B6L4P6   A0A0L7R5L3   A0A026WWM6   A0A088A1Q1   A0A154P6G4   A0A0T6BAB1   A0A1B6EDS3   A0A1Y1KZD6   A0A1B6D6G7   D6WN20   A0A2J7RPG8   A0A1Y1L1S8   E9IBV7   E2A3R2   A0A195FB84   E2BIK5   A0A158NKA2   A0A195BAT9   A0A195EIT5   U4UEM6   F4W8K1   A0A0M8ZXT8   A0A1B6CVN7   A0A1Q3F6H0   B0WTA1   A0A2A3EP07   A0A1Q3F7P8   A0A151I859   A0A0V0G8I0   A0A146M4X9   A0A151WIN6   A0A023F022   N6UFD5   Q16G37   A0A0A9X3R7   A0A3L8DAG8   A0A146LRT8   C3YFB9   E9H1V0   A0A084VEC9   A0A182LSV2   E0VY62   A0A182K5T9   A0A182RMA3   A0A182IRC8   A0A182Y3C0   A0A182L0R3   A0A182NTU7   A0A182ULT9   R7TMI9   A0A182QNN6   A0A1S4GXZ3   Q7Q4C4   A0A182P8L4   H9GBV1   A0A182ICB7   A0A1S4HD45   A0A182XLA7   A0A0K8VW37   A0A0A1X9H2   A0A151MSN7   R4GCZ0   W8BB68   A0A2M4AM79   A0A2M4AM55   A0A336LRA9   A0A224Z4X1   W5J5S2   A0A131YR22   A0A182F1E3   W5LZT8   A0A1S3J0W8   A0A1S3PX28   A0A131XHT8   A0A131YP78   A0A2M4BDA9   A0A1S3J0C7   A0A1A7YT73   A0A293LUA5   A0A1S3J248   A0A1S3J0C9   A0A2I4D1D6   A0A1A8GKB0   A0A182KK58   Q8C0M0-2  

PDB

5WJC     E-value=3.80683e-10,     Score=159

KEGG

101746492    K20409 WD repeat-containing protein 59 | (RefSeq) WD repeat-containing protein 59

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0061700   GO:0032008   GO:0003743   GO:0016021   GO:0005765   GO:0034198   GO:0000981   GO:0005634   GO:0008270   GO:0005515   GO:0007264   GO:0007165   GO:0005694   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Lysosome membrane  

Length:

985

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.844679999999998

Exp number, first 60 AAs:

0.00597

Total prob of N-in:

0.02962

outside

1  -  985

 

 

Pi

168.055506

Theta

143.183599

Tajima's D

0.132321

CLR

0.393646

CSRT

0.407979601019949

Interpretation

Uncertain